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12 Bioresorbable Composite forOrthopedics andDrug Delivery Applications
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like fracture plates, interference screws, and suture anchors, composite products have mechanical characteristics like elastic modulus that are optimized to resemble natural bone to reduce stress and precise degradation rate proles that promote quicker patient healing [6063].

12.7 Challenges

The development of novel materials with improved functional and technological capabilities depends on the ongoing advancement of bone healing technology. The creation of composite materials for bone regeneration that combine polymers and ceramics is one exciting eld of study [6367]. Compared to conventional bone grafting materials, these materials provide several benets, such as the capacity to be tailored to each patient’s unique requirements and a lower risk of disease trans­mission. The creation of polymer-ceramic biomaterials with enhanced bone regen­eration capabilities has advanced signicantly in recent years [6873].
Alloy design and fabrication plays an integral role in the performances [7480]. Laser-assisted fabrication can be a potential method in surface modication [8183]. Enhancing mechanical characteristics, biodegradability, and biocompatibility have been the main focus of this progress. The difculties in producing bioresorbable polymers, as well as their mechanical strength and cost-effectiveness, are noted. Figure12.5 illustrates a few additional difculties [8490]. In the development of bioresorbable composites for orthopedics and drug delivery, challenges arise in ensuring environmental stability [91, 92], maintaining vacuum conditions [93, 94], and selecting appropriate manufacturing methods. Environmental factors like
Fig. 12.5 Challenges of biocomposites in biomedical applications
338
A. Prasad et al.
temperature and humidity can affect material integrity, while vacuum processing is crucial for eliminating air bubbles and voids. Various manufacturing techniques, such as solvent casting CNC [95], and 3D printing, each have specic requirements and considerations. Additionally, achieving biocompatibility and controlled degra­dation kinetics is essential. Overcoming these challenges demands a multidisci­plinary approach and technological advances to ensure the reliability and efcacy of bioresorbable composites in orthopedic and drug delivery applications.

12.8 Conclusion

Although material that is bioresorbable, biocompatible, supports cell attachment, proliferation, and maturation, and can eventually be resorbed once the new bone has formed, allowing this bone to undergo remodeling, is ideal for a tissue-engineered bone substitute, this goal has not yet been met. Dental implants have been devel­oped to solve the issues with removable dental prostheses and bridges. An articial permanent implant is used to replace the missing or damaged tooth. Prospects for biobased resorbable composites are promising, particularly in nearly all biomedical applications. Further research is required to fully understand the biobased resorb­able composite’s cost-effectiveness, mechanical strength, and processing approaches. The goals of research and clinical practice are complete bone regenera­tion and the prevention of brous encapsulation and epithelial cell migration to the implant. However, more research is required to assess this material’s biocompatibil­ity and biofunction.

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Chapter 13
Wear andFriction Mechanism Study inKnee andHip Rehabilitation: AComprehensive Review
AmitChoudhari, AshishKumarGupta , AbhishekKumar , AvinashKumar , AshutoshGupta , NusratChowdhury , andAshwaniKumar
Abstract Wear and friction mechanisms in knee and hip rehabilitation have been a
focus of intense research due to their critical importance in the longevity and perfor­mance of prosthetic implants. This comprehensive review explores the key factors inuencing the selection of hip and knee prosthetics, ranging from implant longev­ity and wear mechanisms to biological responses to wear debris, material selection,
A. Choudhari (*) Mechanical Engineering Department, Cleveland State University, Cleveland, OH, USA e-mail: a.choudhari@vikes.csuohio.edu
A. K. Gupta School of Mechanical and Aerospace Engineering, Oklahoma State University, Stillwater, OK, USA e-mail: ashish.gupta10@okstate.edu
A. Kumar J.Mike Walker ’66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA
Department of Mechanical Engineering, University of California, Merced, Merced, CA, USA e-mail: akumar71@tamu.edu
A. Kumar Department of Mechanical Engineering, Indian Institute of Information Technology Design & Manufacturing (IIITDM), Kancheepuram, Chennai, Tamil Nadu, India
Department of Mechanical Engineering, Stanford University, Stanford, CA, USA e-mail: avikr@iiitdm.ac.in
A. Gupta Department of Zoology, Dayanand Vedic College, Orai, UP, India
N. Chowdhury University of Illinois Urbana-Champaign, Urbana, IL, USA e-mail: nusratc2@illinois.edu
A. Kumar Department of Mechanical Engineering, Technical Education Department Uttar Pradesh (under Government of Uttar Pradesh), Kanpur, Uttar Pradesh, India
A. Kumar et al. (eds.), Applications of Biotribology in Biomedical Systems,
https://doi.org/10.1007/978-3-031-58327-8_13
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design strategies, and patient-specic considerations. The clinical impact and regu­latory standards governing these prosthetics are also examined. Various musculo­skeletal conditions related to bones, including osteoporosis, bone cancer, congenital anomalies, war-related injuries, and unexpected incidents, collectively result in a yearly economic burden of $136.8 billion on the United States economy. The review further classies types of hip and knee replacements, including total hip replace­ment (THR) and resurfacing hip replacement (RHR). It underscores the clinical signicance of wear and friction in these contexts. Types of wear in knee and hip joints, such as adhesive, abrasive, fatigue, and corrosion/oxidative wear, are dis­cussed, along with materials selection for implants, encompassing metallic, ceramic, polymer, and composite options. Various surface modications for enhancing wear resistance are also explored, including ion implantation, surface coatings, and bio­mimetic modications. Lubrication strategies in hip and knee replacement, the role of synovial uid, and lubrication techniques in articial joints are reviewed along­side emerging surface coatings for wear resistance, such as hydroxyapatite, diamond- like carbon, and metal nitride coatings. Experimental approaches to wear and friction studies, including pin-on-disk testing, joint simulators, tribo-corrosion testing, and wear debris analysis techniques, are analyzed, with a focus on future directions and emerging technologies like additive manufacturing, smart implants, biomaterial innovations, and articial intelligence in wear prediction. This review concludes by summarizing the current state of knowledge in wear and friction mechanisms in knee and hip rehabilitation and outlines future research directions in this critical area.
Keywords Wear and friction mechanisms · Knee and hip joint · Lubrication · Additive manufacturing · Smart implant · Articial intelligence

13.1 Introduction

Since its initial use, hip prosthetic design and material development have advanced steadily. In implant technology, its development is one of the century’s most dif­cult problems. The rst hip operations were performed in England in 1750 to treat cases of arthritis [1]. Early hip prostheses were made from wood, ivory, and natural polymers like rubber. These tended to have poor durability and integration. This treatment was terrible since the body was exposed to wear particles. The earliest suggestion for treating a hip injury was to replace it with a prosthesis in 1840 [2, 3]. It was only possible to replace or resurface the acetabular portion of the femoral head during this treatment. A decade later, around 1930s–1950s, stainless steel, cobalt-chromium alloys and polyethylene became more commonly used in hip implants, though longevity was still a problem. In the 1960s–1970s titanium alloys were introduced. Titanium had improved biocompatibility and corrosion resistance compared to earlier materials. In the 1980s–1990s ceramic materials like alumina and zirconia were explored as alternatives to address wear and durability issues.