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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_927_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Contributors
- •Acknowledgments
- •Contents
- •Inferior Mesenteric Artery
- •Collateral Circulation
- •VENOUS DRAINAGE
- •Superior Mesenteric Vein
- •Inferior Mesenteric Vein
- •LYMPHATIC DRAINAGE
- •INNERVATION
- •COLON AND RECTUM PHYSIOLOGY
- •Colonic Physiology
- •Absorption and Secretion
- •Digestion
- •Propulsion and Storage
- •ANAL CANAL ANATOMY
- •Lining
- •Muscles of the Anorectal Region
- •Perineal Body
- •Pelvic Floor Muscles
- •Innervation of the Anus
- •Motor Innervation
- •Sensory Innervation
- •Arterial Supply of the Anus
- •Lymphatic Drainage of the Anus
- •Venous Drainage of the Anus
- •ANAL CANAL PHYSIOLOGY
- •Mechanisms of Continence
- •Defecation
- •Physiologic Testing
- •Anal Manometry
- •Defecography by Fluoroscopy or Magnetic Resonance Imaging
- •Balloon Expulsion Test
- •Colon
- •Saline Continence Test
- •Rectal Compliance
- •Electromyography
- •Nerve Stimulation Techniques
- •Course and Peritoneal Coverings
- •Rectum
- •Peritoneal Relations and Fascial Attachments
- •ARTERIAL SUPPLY
- •Superior Mesenteric Artery
- •Suggested Reading
- •EXTERNAL HEMORRHOIDS
- •CLINICAL EVALUATION
- •NONEXCISIONAL OPTIONS
- •Medical Management
- •Sclerotherapy
- •Energy-Based Destruction
- •Hemorrhoidal Ligation with Rubber Bands
- •EXCISIONAL HEMORRHOIDECTOMY
- •Instrumentation for Excisional Hemmorrhoidectomy
- •PROCEDURE FOR PROLAPSING HEMORRHOIDS (STAPLED HEMMORHOIDOPEXY)
- •DOPPLER-GUIDED HEMORRHOIDAL DEARTERIALIZATION
- •POSTOPERATIVE MANAGEMENT AFTER HEMORRHOID SURGERY
- •CONCLUSION
- •Suggested Reading
- •INTRODUCTION
- •DIAGNOSIS
- •PATHOPHYSIOLOGY
- •High-Pressure Chronic Anal Fissure
- •Low- and Normal-Pressure Chronic Anal Fissure
- •MANAGEMENT
- •Topical Creams
- •Botulinum Toxin
- •Fissurectomy
- •Cutaneous Advancement Flap
- •Lateral Internal Sphincterotomy
- •Surgical Technique
- •Risk of Incontinence
- •Tailored Sphincterotomy
- •SUMMARY: CHOICE OF TREATMENT
- •Suggested Reading
- •CLASSIFICATION
- •PRESENTATION
- •DIAGNOSIS AND EVALUATION
- •Preparation and Examination
- •TREATMENT
- •INTERSPHINCTERIC ANAL FISTULA
- •Clinical Findings
- •TREATMENT
- •Incontinence Risk
- •TRANSSPHINCTERIC ANAL FISTULA
- •Clinical Findings
- •Treatment
- •Cutting Seton
- •Sphincter-Preserving Techniques
- •LIFT
- •ADVANCEMENT FLAP
- •PARTIAL FISTULOTOMY
- •SUPRASPHINCTERIC ANAL FISTULA
- •Fistula Plugs
- •EXTRASPHINCTERIC ANAL FISTULA
- •SPECIAL SITUATIONS
- •Crohn Disease
- •Deep Postanal Space Abscess with a Horseshoe Fistula
- •SUMMARY
- •Suggested Reading
- •DEFINITION
- •CAUSES
- •HISTORY AND PHYSICAL EXAMINATION
- •SURGICAL ANATOMY
- •ETIOLOGY
- •NATURAL HISTORY OF THE DISEASE AND SPREAD PATHWAYS
- •CLINICAL FEATURES
- •Perianal Abscess
- •Ischiorectal Abscess
- •Intersphincteric Abscess
- •Supralevator Abscess
- •Deep Postanal Abscess
- •Submucosal Abscess
- •DIAGNOSIS
- •Treatment of Anorectal Abscesses
- •Large Abscesses
- •Searching for a Fistula
- •Ischiorectal Abscess
- •Intersphincteric Abscesses
- •Supralevator Abscess
- •Submucosal Abscess
- •Role of Antibiotics and Biopsy
- •Postoperative Care
- •Complications
- •RECURRENCE AND THE DEVELOPMENT OF FISTULA IN ANO
- •Suggested Reading
- •INTRODUCTION
- •ETIOLOGY
- •TREATMENT OPTIONS
- •Medical
- •Nonsurgical Closure
- •Fistula Plug
- •Fibrin Glue
- •Surgical Closure
- •Anal Approach
- •Rectal Advancement Flap
- •Advancement Sleeve Flap
- •Turnbull-Cutait Anastomosis
- •Transvaginal Approach
- •Perineal Approach
- •Ligation of the Intersphincteric Fistula Tract
- •Episioproctotomy
- •Tissue Interposition
- •SPECIAL CONSIDERATIONS
- •Use of a Stoma
- •Postoperative Care
- •Sexual Function/Vaginal Dryness
- •Recurrence
- •CONCLUSION
- •Suggested Reading
- •ETIOLOGY
- •PRESENTATION
- •TREATMENT
- •Asymptomatic Pilonidal Sinus
- •Pilonidal Abscess
- •Chronic Pilonidal Sinus
- •NONOPERATIVE MANAGEMENT
- •Hair Removal
- •SURGERY
- •Lateral Drainage, Curettage, and Midline Pit Excision
- •Local Excision and Healing by Secondary Intention
- •FLAP-BASED PROCEDURES
- •Karydakis Procedure
- •Cleft Lift Procedure
- •Rhomboid Excision and Flap Repair
- •Cavity Drainage
- •CONCLUSION
- •Suggested Reading
- •ETIOLOGY
- •CLINICAL PRESENTATION AND EVALUATION
- •ANTIBIOTIC TREATMENT
- •NONANTIBIOTIC TREATMENT
- •SURGICAL TREATMENT
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •ETIOLOGY
- •PRIMARY CAUSES OF PRURITUS ANI
- •Pathophysiology
- •HISTORY
- •EXAMINATION
- •TREATMENT
- •SECONDARY PRURITUS ANI TREATMENT
- •Anorectal Conditions
- •Infections
- •Dermatologic Conditions
- •Neoplastic Causes
- •Systemic Disease
- •REFRACTORY OR PERSISTENT PRURITUS ANI
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •DEFINITION
- •CLASSIFICATION OF ANAL STENOSIS
- •Cause
- •Spasm
- •Postoperative Scarring
- •Stenosis Due to Chronic Diarrhea
- •Age-Related Stenosis
- •SYMPTOMS
- •Examination Findings
- •PREVENTION OF POSTOPERATIVE ANAL STENOSIS
- •TREATMENT
- •Nonoperative Management
- •Anal Dilation
- •Surgical Management
- •Anoplasty
- •Postoperative Complications of Anoplasty
- •Suggested Reading
- •BACKGROUND AND EPIDEMIOLOGY
- •PRESENTATION OF DISEASE AND DIAGNOSIS
- •TREATMENT OF ANAL CONDYLOMA
- •Medical Therapies
- •Trichloracetic and Bichloracetic Acid
- •Imiquimod
- •Other Medical Treatments
- •Ablative Therapies
- •Cryotherapy
- •Surgical Excision/Fulguration
- •Laser
- •Recurrent Disease
- •Treatment Algorithm
- •CONCLUSION
- •Suggested Reading
- •BACTERIAL INFECTIONS
- •Gonorrhea
- •Preferred Clinical Approach
- •Chlamydia trachomatis and Lymphogranuloma venereum
- •Preferred Clinical Approach
- •Chancroid
- •Preferred Clinical Approach
- •Granuloma Inguinale
- •Preferred Clinical Approach
- •Syphilis (“The Great Masquerader”)
- •Preferred Clinical Approach
- •VIRAL INFECTIONS
- •Herpes Simplex Virus
- •Preferred Clinical Approach
- •Condylomata Acuminata
- •Clinical Manifestations
- •Treatment
- •Preferred Clinical Approach
- •Electrocautery
- •OTHER DISORDERS
- •Suggested Reading
- •INTRODUCTION
- •HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (FORMERLY BOWEN DISEASE)
- •Management
- •PERIANAL PAGET DISEASE
- •Management
- •Suggested Reading
- •INTRODUCTION
- •EPIDEMIOLOGY AND RISK FACTORS
- •PATHOPHYSIOLOGY
- •CLINICAL PRESENTATION AND DIAGNOSIS
- •SURGERY
- •Management of the Primary Tumor
- •Management of Lymph Nodes
- •SURVIVAL
- •BASAL CELL CANCER OF THE PERIANAL REGION
- •Suggested Reading
- •INTRODUCTION
- •ANATOMIC CONSIDERATIONS
- •EPIDEMIOLOGY
- •SQUAMOUS CELL CARCINOMA OF THE ANAL CANAL
- •Surveillance
- •Local Excision
- •Inguinal Lymph Node Management
- •Extrapelvic Metastases
- •PERIANAL SQUAMOUS CELL CARCINOMA
- •ANAL CANCER AND HIV INFECTION
- •Suggested Reading
- •A GENERAL APPROACH
- •CHRONIC PROCTALGIA
- •LEVATOR ANI SYNDROME
- •Diagnosis
- •Treatment
- •PROCTALGIA FUGAX
- •COCCYGODYNIA
- •CONCLUSION
- •Selected Readings
- •DESCRIPTION OF DEFECTS
- •Perineal Fistula
- •Rectal Atresia
- •Vestibular Fistula
- •Imperforate Anus without Fistula
- •Rectourethral Bulbar Fistula
- •Rectourethral Prostatic Fistula
- •Cloaca
- •Recto-Bladder-Neck Fistula
- •NEONATAL MANAGEMENT
- •Anoplasty
- •Management of Functional Sequelae
- •ETIOLOGY, PATHOPHYSIOLOGY, AND INCIDENCE
- •DIAGNOSIS
- •Anorectal Manometry
- •Rectal Biopsy
- •Resuscitation
- •Main Repair
- •Duhamel Procedure
- •Soave Procedure
- •Dehiscence and Retraction
- •Constipation
- •ASSESSMENT
- •Medical Management
- •Postanal Repair
- •Anal Encirclement
- •Muscle Transposition
- •Continence Enemas
- •Stem Cells, Bulking Agents, and Other Techniques
- •Fecal Diversion
- •CONCLUSIONS
- •DEFINITION
- •ETIOLOGY
- •BENIGN RECTAL STRICTURES
- •Medical Treatment
- •Digital Evacuation
- •Enemas and Colonic Lavage
- •Oral Solutions
- •Stool Softeners
- •Laxatives
- •Endoscopic Disimpaction
- •SURGERY
- •Acute
- •PREVENTION
- •CONCLUSION
- •PATHOPHYSIOLOGY
- •Recommendations
- •Nonoperative Management
- •CONCLUSIONS
- •DEFINITION
- •DIAGNOSIS
- •Transanal Repairs
- •Transvaginal Repairs
- •EPIDEMIOLOGY
- •Location of the Foreign Body
- •Intraperitoneal or Extraperitoneal
- •Tailgut Cysts
- •Duplication Cysts
- •Transanal Excision
- •Anterior Resection
- •Physical Examination
- •Locoregional Evaluation
- •Nodal Staging
- •Extramural Venous Invasion
- •Locoregional Imaging Synoptic Reports
- •Distant Metastatic Evaluation
- •RADIATION-RELATED TOXICITIES
- •Boosting the Dose
- •HIGH-DOSE-RATE ENDORECTAL BRACHYTHERAPY
- •Total Mesorectal Excision
- •Ligation of the Inferior Mesenteric Artery
- •Distal Resection Margins
- •Drainage
- •Positioning and Equipment
- •Trocar Placement
- •Exposure of the Operating Field
- •Division of the Vessels and Splenic Flexure Mobilization
- •Mobilization and Division of the Rectum
- •Exteriorization of the Specimen
- •Creation of the Anastomosis
- •Abdominoperineal Resection
- •Closure of the Anal Opening
- •Mobilization of the Rectum
- •Proximal Division of the Left Colon
- •Perineal Dissection and Exteriorization
- •Closure of Pelvic Wound and Trocar Incisions and Creation of the Colostomy
- •INITIAL SELECTION
- •Patient Preparation
- •Transanal Excision
- •MANAGEMENT OF THE SPECIMEN
- •Salvage Resection after Local Excision
- •Axial Recurrences
- •Anterior Recurrences
- •Posterior Recurrences
- •Lateral Recurrences
- •THERAPY
- •Patient Selection
- •Procedures
- •Complications
- •PREVENTION
- •SUMMARY
- •RISK ASSESSMENT
- •PREOPERATIVE PULMONARY ASSESSMENT AND MANAGEMENT
- •MANAGEMENT OF PATIENTS RECEIVING ANTITHROMBOTIC THERAPY
- •Diagnosis
- •Diet
- •5-Aminosalycilic Acid
- •Mild to Moderate Ulcerative Colitis
- •Proctitis and Left-Sided Ulcerative Colitis
- •Left-Sided Disease
- •Extensive Disease
- •Lack of Response to 5-Aminosalycilic Acid
- •Oral Budesonide
- •Corticosteroids
- •Severe Ulcerative Colitis
- •Cyclosporine
- •Azathioprine and 6-Mercaptopurine
- •Biologic Agents
- •Adalimumab
- •Golimumab
- •How to Choose an Anti-TNF-α Agent
- •Complications
- •What to Do Before Starting Anti-TNF-α Therapy
- •What to Do Once Treatment with an Anti-TNF-α Agent Is Started
- •Antiadhesion Molecules
- •Alternative Therapies
- •Nicotine
- •Clinical Scenarios
- •Quiescent Disease
- •Fulminant or Toxic Colitis
- •Flexible Sigmoidoscopy with Biopsies
- •Deep Vein Thrombosis Prophylaxis
- •Evaluate for Tuberculosis and Hepatitis B
- •Avoid Narcotics and Antidiarrheal Medications
- •Do Not Use Antibiotics
- •Diet as Tolerated
- •Perform Close Observation and Consult Colorectal Surgery upon Admission
- •Vaccinations
- •Pregnancy
- •Cancer Risk
- •Drug-Induced Colitis
- •Proctectomy Surgical Technique
- •Staging the Procedure
- •Technique of Creation of an Ileoanal J Pouch
- •Problems with Reach of the Pouch
- •Complications after Ileal Pouch–Anal Anastomosis
- •Overall Quality of Life
- •Function of the Pouch
- •Pouchitis
- •Pouch Failure
- •Salvage of the Failed Pelvic Pouch
- •PRESENTATION
- •EVALUATION
- •Surgical Options
- •CONCLUSION
- •Pelvis Sepsis and Anastomotic Leak
- •Postoperative Bleeding from the Pouch
- •Pouch-Perineal and Pouch-Vaginal Fistulae
- •Outlet Dysfunction
- •POUCHITIS
- •Genetic Factors
- •CONCLUSIONS
- •Late Complications
- •Valve Slippage
- •Parastomal Hernia
- •Crohn Disease
- •Pouchitis
- •Valve Stenosis
- •Pouch Excision
- •CONCLUSIONS
- •Crohn Disease
- •Radiation
- •PREVENTION
- •Reconstruction of the Perineum with a Flap
- •5-Aminosalicylates
- •Antibiotics
- •Biologic Agents
- •SMOKING
- •NUTRITION
- •Disease of the Colon and Rectum
- •SPECIAL SITUATIONS
- •Medications
- •Abscess
- •Fistula
- •Neoplasia
- •OUTCOME
- •Anal Sepsis
- •Stenosis
- •CONCLUSION
- •CONCLUSION
- •CYTOMEGALOVIRUS COLITIS
- •KAPOSI SARCOMA
- •COMPLICATED DIVERTICULITIS
- •INTRODUCTION
- •ETIOLOGY
- •Right-Sided Obstruction
- •Left-Sided Obstruction
- •Self-Expanding Metallic Stents
- •COLONIC VOLVULUS
- •Signs and Symptoms
- •Diagnostic Imaging
- •Signs and Symptoms
- •Diagnostic Imaging
- •TRANSVERSE COLON VOLVULUS
- •Pathophysiology
- •Diagnostic Imaging
- •Signs and Symptoms
- •Treatment
- •EPIDEMIOLOGY
- •ETIOLOGY
- •Initial Management
- •Pharmacologic Management
- •BIOLOGY
- •MARGIN
- •NODES
- •COMORBIDITIES
- •SUMMARY
- •SCREENING FOR COLORECTAL CANCER
- •Flexible Sigmoidoscopy
- •Stool DNA
- •Surveillance Colonoscopy after Endoscopic Resection of a Malignant Polyp
- •Surveillance Colonoscopy in Patients with Colorectal Cancer
- •Surveillance Colonoscopy in Patients with a Family History of Colorectal Cancer or Adenomatous Polyps
- •CONCLUSION
- •INTRODUCTION
- •GROWTH CONTROL
- •DNA REPAIR
- •COMPLEXITY
- •REGISTRIES
- •DEFINITIONS
- •Genotype/Phenotype
- •Surgical Options for the Large Bowel
- •Extracolonic Manifestations
- •Hepatoblastoma
- •Surveillance
- •The IRA
- •The IPAA
- •Oligopolyposis/Attenuated Familial Adenomatous Polyposis
- •PTEN Tumor Hamartoma Syndrome
- •INTRODUCTION
- •BIOLOGY
- •EPIDEMIOLOGY
- •GENETICS AND DESMOID RISK
- •DESMOID SEVERITY: A STAGING SYSTEM
- •MANAGEMENT
- •Setting Expectations
- •A Philosophy of Care
- •Extra-abdominal Desmoid Tumors
- •Abdominal Wall Tumors
- •Intra-abdominal Desmoid Disease
- •Workup
- •Medical Treatment
- •Role of Surgery
- •Complications of Desmoid Disease
- •Small Bowel Obstruction
- •Ureteric Obstruction
- •Abscess/Enterocutaneous Fistula
- •Superior Mesenteric Artery Aneurysm
- •Points about Operating on Persons with Desmoid Disease
- •SUMMARY AND GENERAL COMMENTS ABOUT THE EFFECT OF DESMOID DISEASE ON SURGICAL STRATEGY IN FAMILIAL ADENOMATOUS POLYPOSIS
- •Suggested Reading
- •INTRODUCTION
- •HISTORICAL PERSPECTIVE AND CLARIFICATION OF TERMS
- •GENETIC AND MOLECULAR CAUSE OF LYNCH SYNDROME
- •HISTOLOGIC FEATURES OF LYNCH TUMORS
- •DIAGNOSING LYNCH SYNDROME
- •Clinical Criteria
- •Models
- •Tumor Testing
- •GENETIC COUNSELING AND TESTING
- •CLINICAL MANIFESTATIONS AND MANAGEMENT
- •COLORECTAL CANCER RISK MANAGEMENT
- •Surveillance Colonoscopy and Polypectomy
- •Chemoprevention
- •Surgery
- •Colectomy in the Absence of Cancer
- •Treatment of Colon Cancer
- •Rectal Cancer in Persons with Lynch Syndrome
- •RISK MANAGEMENT OF EXTRACOLONIC MANIFESTIONS
- •Endometrial and Ovarian Cancer
- •Upper Gastrointestinal Tract
- •Urinary Tract
- •Skin Neoplasms
- •Other Cancers
- •CLINICAL VARIATIONS OF HNPCC AND LYNCH SYNDROME
- •Familial Colorectal Cancer Type X
- •Tumor Lynch
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •PATHOLOGY OF APPENDICEAL MALIGNANT TUMORS
- •Carcinoid Tumors
- •Epithelial (Noncarcinoid) Tumors of the Appendix
- •Mucinous Adenoma and Adenocarcinoma
- •Nonmucinous Adenocarcinoma
- •DIAGNOSIS OF APPENDICEAL MALIGNANT TUMORS
- •Carcinoid
- •Adenocarcinoma and Mucinous Adenocarcinoma
- •Pseudomyxoma Peritonei Syndrome
- •Carcinoid Tumors
- •Appendiceal Adenocarcinoma
- •Management of Appendiceal Neoplasms with Peritoneal Dissemination
- •Perioperative Chemotherapy
- •Serial Debulking
- •CYTOREDUCTIVE SURGERY AND PERIOPERATIVE CHEMOTHERAPY
- •Survival by Completeness of Cytoreduction
- •Survival by Histologic Assessment
- •Survival by Prior Surgical Score
- •Morbidity and Mortality Rates
- •Peritonectomy
- •Perioperative Chemotherapy
- •Suggested Reading
- •INTRODUCTION
- •EPIDEMIOLOGY
- •Prognostic Factors
- •PREOPERATIVE EVALUATION
- •PREOPERATIVE PREPARATION
- •OPERATIVE PRINCIPLES AND TECHNIQUES
- •Exploration
- •Surgical Treatment of Right Colon Cancer
- •Surgical Treatment of Transverse Colon Cancer
- •Surgical Treatment of Splenic Flexure and Descending Colon Cancer
- •Surgical Treatment of Sigmoid Colon Cancer
- •LAPAROSCOPIC COLECTOMY
- •SPECIAL CONSIDERATIONS
- •Obstruction and Perforation
- •Prophylactic Oophorectomy
- •POSTOPERATIVE SURVEILLANCE
- •SUMMARY
- •Suggested Readings
- •INTRODUCTION
- •CHEMOTHERAPY
- •5-Fu
- •Capecitabine
- •Irinotecan
- •Oxaliplatin
- •MAINTENANCE CHEMOTHERAPY
- •BIOLOGIC AGENTS
- •FIRST-LINE TARGETED OPTIONS
- •THIRD- AND FOURTH-LINE OPTIONS
- •OLIGOMETASTATIC DISEASE
- •ROLE OF RESECTION OF PRIMARY LESION
- •IMMUNOTHERAPY
- •CONCLUSIONS
- •Suggested Reading
- •INTRODUCTION
- •DIAGNOSIS AND PREOPERATIVE WORKUP
- •Imaging
- •Serologic and Molecular Markers
- •Histology
- •Needle Biopsy
- •Multidisciplinary Planning
- •STAGING AND PROGNOSIS
- •PROGNOSTIC SCORES
- •TREATMENT
- •Chemotherapy
- •Neoadjuvant Chemotherapy for Resectable Liver Disease
- •Neoadjuvant Chemotherapy for Unresectable Liver Disease
- •Adjuvant Chemotherapy
- •Hepatic Arterial Infusion
- •Resectability
- •Resectable Liver Disease
- •Synchronous Liver Metastasis
- •Unresectable Liver Disease
- •Repeat Resections for Multiple Liver Metastases
- •Local Ablative Therapy
- •Radiofrequency Ablation
- •Microwave Ablation
- •Cryotherapy
- •Irreversible Electroporation
- •Colorectal Liver Metastases with Extrahepatic Spread
- •Lung
- •Peritoneal
- •Lymph Node Involvement
- •Inferior Vena Cava
- •Recurrence
- •SURVEILLANCE
- •CONCLUSION
- •Suggested Readings
- •INTRODUCTION
- •INDICATIONS FOR RESECTION OF COLORECTAL METASTASES
- •OUTCOMES OF PATIENTS UNDERGOING RESECTION AND PROGNOSTIC FACTORS
- •LUNG AND LIVER METASTASIS
- •SURGICAL APPROACH
- •DEVELOPMENT OF A PROSPECTIVE RANDOMIZED TRIAL: THE PULMONARY METASTASECTOMY IN COLORECTAL CANCER TRIAL
- •CONCLUSION
- •Suggested Reading
- •INTRODUCTION
- •BENIGN NONADENOMATOUS LESIONS OF THE COLON AND RECTUM
- •Benign Lymphoid Hyperplasia
- •Lipomas
- •Treatment
- •CAVERNOUS HEMANGIOMA
- •Characteristic Features
- •Treatment
- •Surgery (Laparotomy/Laparoscopic)
- •LEIOMYOMA AND LEIOMYOSARCOMA
- •Characteristic Features
- •Surgery
- •PRIMARY LYMPHOMA OF THE COLON AND RECTUM
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •ETIOLOGY AND PATHOGENESIS
- •CLASSIFICATION
- •CLINICAL PRESENTATION
- •DIAGNOSIS
- •MANAGEMENT
- •OUTCOME
- •SPECIAL TOPICS
- •Ischemic Colitis after Aortic Surgery
- •Colonic Ischemia after Cardiopulmonary Bypass
- •Ischemic Colitis Associated with Colon Carcinoma and Obstructing Colon Lesions
- •Total Colonic Ischemia
- •Ischemic Proctosigmoiditis
- •CONCLUSION
- •Suggested Readings
- •INTRODUCTION
- •ETIOLOGY
- •DIAGNOSIS
- •Physical Examination
- •Imaging
- •Diagnostic Peritoneal Lavage
- •Laparoscopy
- •TREATMENT
- •Colon Injuries
- •Damage Control
- •Rectal Injuries
- •Overview
- •Diversion
- •Direct Repair
- •Drainage
- •Distal Washout
- •Rectal Foreign Bodies
- •Suggested Reading
- •INTRODUCTION
- •PAIN
- •INFERTILITY
- •DIAGNOSIS
- •Physical Examination
- •Endoscopy
- •Imaging
- •SURGICAL MANAGEMENT
- •Results after Surgical Therapy
- •Combined Medical and Surgical Therapy
- •CONCLUSION
- •Suggested Reading
- •INTRODUCTION
- •ETIOLOGY
- •CLASSIFICATION
- •HISTOLOGY AND GROSS PATHOLOGY
- •SYMPTOMS
- •DIAGNOSIS
- •TREATMENT
- •Suggested Readings
- •INTRODUCTION
- •CAUSES
- •CLASSIFYING CONSTIPATION
- •ASSESSMENT
- •History
- •Physical Examination
- •INVESTIGATIONS
- •TREATMENT
- •Medical
- •Newer Promotility Agents
- •Biofeedback for Pelvic Floor Dyssynergia
- •Change in Position of Defecation
- •Surgery
- •Outlet Obstruction Constipation
- •Suggested Reading
- •EXTENT OF THE PROBLEM
- •CLINICAL PRESENTATION
- •IMAGING
- •MRI and Ultrasound
- •MANAGEMENT OF SMALL BOWEL OBSTRUCTION
- •Nonadhesive Obstruction
- •Hernias
- •Crohn Disease
- •Malignancy
- •Intussusception
- •Gallstone Ileus
- •Bariatric Patient
- •Surgical Technique
- •Adhesive Obstruction
- •Hernias
- •Malignancy
- •Intussusception
- •Gallstone Ileus
- •The Bariatric Patient
- •Laparoscopic versus Open Lysis of Adhesions
- •Early Postoperative Bowel Obstruction
- •Prevention of Adhesions
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •DIETARY MANAGEMENT OF SHORT BOWEL SYNDROME
- •PHARMACOLOGIC TREATMENT OF SHORT BOWEL SYNDROME
- •PARENTERAL AND ENTERAL NUTRITION
- •HORMONAL TREATMENT FOR SHORT BOWEL SYNDROME
- •COMPLICATIONS ASSOCIATED WITH SHORT BOWEL SYNDROME
- •CONCLUSION
- •Suggested Reading
- •INTRODUCTION
- •GUT ADAPTATION
- •MEDICAL MANAGEMENT
- •SURGICAL REHABILITATION
- •Strategy
- •Autologous Reconstruction
- •Intestinal Lengthening
- •INTESTINAL AND MULTIVISCERAL TRANSPLANTATION
- •Types
- •Indications
- •Contraindications
- •Early Referral
- •Transplantation Surgery
- •Postoperative Management
- •Current Global Activities
- •Long-Term Survival
- •Allograft Function
- •Quality of Life
- •New Insights
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •CLINICAL PRESENTATION
- •INVESTIGATIONS IN UPPER GASTROINTESTINAL CROHN DISEASE
- •MEDICAL TREATMENT
- •ENDOSCOPIC TREATMENT
- •SURGERY
- •SUMMARY
- •Suggested Readings
- •INTRODUCTION
- •MEDICAL MANAGEMENT
- •INDICATIONS FOR SURGERY
- •PREOPERATIVE CONSIDERATIONS
- •OPERATIVE APPROACH
- •SURGICAL OPTIONS
- •Bypass
- •Resection
- •Strictureplasty
- •SPECIAL SITUATIONS
- •Medications
- •Abscess
- •Free Perforation
- •Hemorrhage
- •Growth Retardation
- •Fistula
- •Neoplasia
- •Obstruction
- •OUTCOME
- •SUMMARY
- •Selected Reading
- •INTRODUCTION
- •PRESENTATION
- •DIAGNOSIS
- •MANAGEMENT
- •Adenocarcinoma without Metastatic Disease
- •Carcinoid Tumors
- •Lymphomas
- •GIST Tumors
- •CONCLUSION
- •ACKNOWLEDGMENT
- •Suggested Readings
- •DEFINITION
- •INCIDENCE, EPIDEMIOLOGY, AND RESEARCH
- •CLINICAL PRESENTATION
- •DIAGNOSIS
- •CLASSIFICATION
- •SURGICAL TREATMENT
- •Small Intestine
- •Appendix
- •Colon
- •Rectum
- •Locally Advanced and Metastatic Disease
- •Hedinger Syndrome
- •ADJUVANT THERAPY
- •FOLLOW-UP
- •PROGNOSIS
- •Suggested Reading
- •INTRODUCTION
- •PATHOGENESIS
- •GENERAL ASPECTS OF CARE
- •COMPLICATIONS
- •PLAN OF CARE
- •Prevention
- •Stabilization
- •Wound Care
- •Nutritional Support
- •Nasogastric Tubes and Other Drainage Tubes
- •Protection of the Gastric, Duodenal, and Upper Gastrointestinal Tract Mucosa from Ulceration
- •Other Supplements
- •Investigation/Elucidation
- •Therapeutic Decisions
- •Will It Close?
- •The Decision to Operate
- •Timing of Surgery
- •Surgery
- •Choice of Incision
- •The Operation Itself
- •Anastomosis
- •Abdominal Wound Closure
- •What Type of Operation Should One Undertake?
- •Gastrostomy and Feeding Jejunostomy
- •The Healing Phase
- •Fibrin Glue
- •Short Bowel Syndrome
- •PROGNOSIS
- •Suggested Reading
- •INTRODUCTION
- •ACUTE MESENTERIC ISCHEMIA
- •Clinical Presentation
- •Evaluation
- •Treatment
- •SMA Embolus
- •SMA Thrombus
- •Mesenteric Venous Thrombosis
- •Nonocclusive Mesenteric Ischemia
- •Bowel Viability
- •Laparoscopy
- •CHRONIC MESENTERIC ISCHEMIA
- •Presentation
- •Evaluation
- •Operative Treatment
- •Angioplasty
- •CONCLUSION
- •Suggested Readings
- •BACKGROUND
- •PATHOPHYSIOLOGY
- •PREDISPOSING RISK FACTORS
- •GRADING SYSTEMS
- •DIAGNOSTIC WORKUP
- •PREVENTION
- •MANAGEMENT OF RADIATION ENTERITIS
- •Management of Radiation Injury to the Small Bowel
- •Acute Radiation Enteritis
- •Chronic Radiation Enteritis
- •Management of Radiation Injury to the Colon
- •Acute Radiation Colitis
- •Chronic Radiation Colitis
- •Management of Radiation Injury to the Rectum
- •Topical Therapy
- •Hyperbaric Oxygen
- •Medical Therapy
- •Endoscopic Management
- •Surgery
- •CONCLUSION
- •Suggested Readings
- •INTRODUCTION
- •IDENTIFICATION OF THE HIGH-RISK PATIENT
- •MINIMIZING RISK ASSOCIATED WITH EMERGENCY SURGERY
- •MINIMIZING RISK ASSOCIATED WITH CARDIAC DISEASE
- •MINIMIZING RISK ASSOCIATED WITH PULMONARY DISEASE
- •MINIMIZING RISK ASSOCIATED WITH IMMUNOSUPPRESSION
- •Steroids
- •Diabetes
- •Chemoradiotherapy
- •MINIMIZING RISK ASSOCIATED WITH MALNUTRITION
- •MINIMIZING RISK ASSOCIATED WITH HEPATIC DISEASE
- •MINIMIZING RISK ASSOCIATED WITH RENAL DISEASE
- •MINIMIZING RISK IN MORBIDLY OBESE PATIENTS
- •Suggested Reading
- •INTRODUCTION
- •ANATOMIC FACTORS
- •The Ureters
- •Presacral Veins
- •Pelvic Nerves
- •POSTOPERATIVE CHANGES IN THE PELVIS
- •Approach to Reoperative Pelvic Surgery
- •Preoperative Planning
- •Timing
- •Patient Preparation
- •Functional Considerations
- •Intraoperative Conduct
- •Patient Positioning
- •Optimizing Visibility and Exposure
- •Access to the Pelvis
- •Ureter
- •Bladder
- •Rectal Stump
- •Vagina
- •Autonomic Nerves
- •Control of Bleeding
- •Drainage
- •SPECIFIC CLINICAL SITUATIONS
- •Reversal of Hartmann Procedure for Diverticulitis
- •Recurrent Rectal Cancer
- •Redo Ileoanal Pelvic Pouch Procedure
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •NUTRITIONAL ASSESSMENT
- •INDICATIONS FOR NUTRITIONAL SUPPORT
- •General Indications
- •Severe Malnutrition
- •Postoperative Nutrition
- •Colorectal Cancer
- •ESTIMATION OF NUTRIENT REQUIREMENTS
- •Calories
- •Protein
- •PREVENTION
- •Preventive Measures
- •Bowel Preparation
- •Prophylactic Antibiotics
- •Intact Anastomosis
- •Tension-Free Anastomosis
- •Well-Vascularized Anastomosis
- •Consideration for Diversion
- •Appropriate Use of Drains
- •Goal-Directed Hemodynamic Support
- •Evaluation
- •Nonoperative Interventions
- •Operation versus Observation
- •Open Abdomen
- •Return to the Operating Room
- •Suggested Readings
- •INTRODUCTION
- •WHAT DEFINES A LEAK?
- •PRINCIPLES OF MANAGEMENT
- •EARLY DIAGNOSIS
- •IMAGING
- •CRP LEVELS
- •ENDOSCOPY
- •VARIABLES DIRECTING MANAGEMENT
- •Location: Intraperitoneal versus Extraperitoneal
- •Symptoms: Sepsis versus Symptomatic versus Asymptomatic
- •Previously Diverted: Proximal Diverting Ostomy versus Nondiverted
- •LEAK MANAGEMENT TOOLS
- •ENDO-VACUUM ASSISTED CLOSURE
- •ENDOSCOPIC STENTS, CLIPS, AND GLUE
- •DIETARY COMPOSITION AND DELIVERY
- •Hospital-Based Diets
- •Clear Liquid Diet
- •Regular Diet
- •Low-Residue Diet
- •Oral Supplements
- •Liquid Formula Diets
- •Enteral Nutrition
- •Access for EN
- •Early Postoperative Feeding: “Fast Track”
- •Parenteral Nutrition
- •Access for PN
- •Concomitant EN and PN
- •Overfeeding
- •NEW DIRECTIONS
- •Immunonutrition
- •Preoperative Carbohydrate Loading
- •SUMMARY
- •Suggested Reading
- •BACKGROUND
- •TRANSANAL REPAIR TECHNIQUES
- •TURNBULL-CUTAIT PULL THROUGH
- •SUMMARY
- •Suggested Reading
- •INTRODUCTION
- •RISK MANAGEMENT
- •HEMORRHAGE
- •Steps Prior to Colonoscopy
- •Risk Factors for Bleeding
- •Prevention of Bleeding
- •Treatment of Bleeding
- •PERFORATION
- •Causes of Perforation
- •Diagnosis of Perforation
- •Management of Perforation
- •Suggested Readings
- •INTRODUCTION
- •PERTINENT ANATOMY
- •BLEEDING
- •Major Vessel Bleeding
- •Iliac Vessels
- •Minor Vessel Bleeding
- •Presacral Bleeding
- •Pelvic Packing
- •Suture Ligation
- •Thumbtacks
- •Muscle Fragment Welding
- •Bipolar Electrocautery
- •Hemostasis Step-by-Step Technique
- •Hemostatic Agents
- •Mechanical Hemostatic Agents
- •Active Hemostatic Agents
- •Flowable Hemostatic Agents
- •Fibrin Sealants
- •CONCLUSION
- •Selected Reading
- •INTRODUCTION
- •INFECTION
- •URETER
- •BLADDER
- •URETHRA
- •REPRODUCTIVE STRUCTURES
- •NERVES
- •BLOOD VESSELS
- •Suggested Readings
- •INTRODUCTION
- •GENERAL COMPLICATIONS
- •Contraindications
- •Peritoneal Access Complications
- •Pneumoperitoneum Complications
- •Thromboembolic Complications
- •Electrosurgical Complications
- •Positioning Complications
- •Bleeding Complications
- •Contamination
- •Anastomosis Complications
- •Urologic Complications
- •CONCLUSIONS
- •Suggested Reading
- •INTRODUCTION
- •OSTOMY CREATION
- •Preoperative Discussion and Consent
- •Siting the Stoma
- •Creating and Maturing the Stoma
- •End Ileostomy
- •Loop Ileostomy
- •COMPLICATIONS
- •Early Complications
- •Appliance Issues/Skin Irritation
- •Ischemia
- •Stoma Stenosis
- •Retraction
- •Late Complications
- •Parastomal Hernia
- •Prolapse
- •Stricture
- •Peristomal Pyoderma
- •Parastomal Ulcer
- •Abscess and Fistula
- •SUMMARY
- •Suggested Reading
- •PREOPERATIVE PREPARATION
- •Preoperative Counseling
- •Stoma Site Marking
- •POSTOPERATIVE MANAGEMENT
- •SPECIAL CONSIDERATIONS
- •Continent ileostomy
- •WOUND MANAGEMENT
- •POSTDISCHARGE FOLLOW-UP
- •COLOSTOMY IRRIGATION

Acute
Radiation injury to large bowel
(<3 months)
SMALL INTESTINE 421
Versus
Chronic
(>3 months)
Symptoms self-limited
supportive management
Antiemetics
Antidiarrheals
Low-residue diet
Antispasmodics
Anticholinergics
Octreotide
Elemental or specific exclusion diets
FIGURE 80-2 Management of radiation colitis. NG, Nasogastric.
Conservative:
NG tube decompression
Nutritional supplementation
Total parenteral nutrition
Radiation proctitis as a complication of prostate radiation is a specic condition that is commonly seen. e eect of the radiation is to
produce telangiectases in the rectal mucosa that are fragile and bleed
easily. eir distribution is in the anterior rectal wall adjacent to the
prostate. Sometimes they overlap the internal hemorrhoids, and the
prolapse that occurs here can make the bleeding worse.
Topical Therapy
Short-chain fatty acid enemas are eective for acute symptoms of
radiation proctitis but do not aect the incidence or severity of late
proctitis (Fig. 80-3). Steroids and 5-ASA compounds are not associ-
ated with any benet. Indeed, some series report worsening symptoms with use of these drugs. One study showed improvement in
rectal bleeding and diarrhea when metronidazole was used in combination with antiinammatory agents such as 5-ASA or steroids.
Sucralfate creates a protective barrier to promote epithelial healing,
and one randomized controlled trial showed that oral sucralfate
decreased diarrhea symptoms in both the acute and chronic phase. In
addition, sucralfate showed greater clinical improvement for proctitis
than antiinammatory medications. Formalin (4% solution) application is used to control bleeding from radiation telangiectases and is
indicated specically for extensive changes that would be dicult to
treat with argon plasma coagulation. Two methods of applying the
formalin have been described: rectal irrigation and application of
formalin-soaked gauze or use of large cotton-tipped applicators. It
has a 70% to 75% success rate in the treatment of severe hemorrhagic
radiation proctitis, although several applications may be required.
Hyperbaric Oxygen
Hyperbaric oxygen is thought to promote neovascularization and subsequently reversal of tissue hypoxia, which should be useful in a disease
characterized by a brosing vasculitis. In a systematic review, based on the
evidence and expert consensus opinion, hyperbaric oxygen may provide
some benet in treating chronic radiation damage to the rectum and anus.
Medical Therapy
Loperamide and other antidiarrheal medications decrease bowel
frequency and improve bile acid absorption. However, antidiarrheal agents treat symptoms and do not treat the underlying disease.
A pilot study of 20 patients who used antioxidant vitamins E and C
demonstrated symptomatic improvement with respect to bleeding,
diarrhea, and urgency, but not pain.
Obstruction
Partial Near/complete
Surgery
Fecal diversion with ostomy
Bowel resection
with or without ostomy
Endoscopic Management
Options for endoscopic thermal therapy include the neodymium:
yttrium-aluminum-garnet (Nd:YAG) and argon lasers. Both are
eective in stopping bleeding from radiation-induced telangiectases
throughout the gastrointestinal tract. e biggest risk is perforation
through transmural necrosis with resultant stula formation, which is
common with the Nd:YAG laser. Argon plasma coagulation (APC), a
nontouch thermoablative therapy, is becoming the rst line of therapy
for endoscopic treatment of radiation enteritis and proctitis, especially
with the rather limited but intensely symptomatic radiation proctitis aer prostate cancer radiation. Here the telangiectases are “spot
welded” with the APC. However, multiple treatments are sometimes
required, and this treatment has up to a 50% failure rate in persons with
severe radiation proctitis. For persons who were successfully treated
with APC, 90% remained in remission aer 18 months.
e use of radiofrequency ablation for refractory hemorrhage has
been extrapolated from studies showing its ecacy in gastric antral
vascular ectasia and Barrett esophagus. No complications have been
associated with transmural injury, and hemostasis can be achieved in
one to two sessions.
Balloon dilatation has been shown to be eective in short- segment
strictures; however, the risk of perforation increases when balloon
dilatation is used to treat long-segment or angulated strictures.
Surgery
Surgery is reserved for refractory cases. Indications include bleeding,
perforation, obstruction, and stulae. Fecal diversion, in the form of
an ileostomy or colostomy, decreases pain, tenesmus, and drainage,
and although it does not completely resolve bleeding, it improves
quality of life.
Fistulae may develop between any of the pelvic organs—vagina,
bladder, or urethra—and the rectum or sigmoid colon. ese patients
usually require fecal and/or urinary diversion (with either a urethral catheter or a suprapubic catheter). Ninety percent of patients
will need denitive repair, and 9.6% heal spontaneously. A variety
of surgical approaches exist: transabdominal, abdominoperineal,
transperineal, transanal, trans-sphincteric (i.e., York-Mason), and
trans-sacral. Small, simple rectourethral stulae are most commonly
repaired through an anterior transperineal repair, which allows better
visualization of the operative eld and advancement of muscle aps
to separate the organs of stulization. A transabdominal approach is
performed in patients with severe radiation damage, large-caliber stulae, or signicant symptoms requiring extensive resections. Tissue

Radiation EntERitis and PRoctocolitis422
Radiation Injury to Rectum
Conservative
management
Topical
therapy
SCFA enemas
Steroids, oral or enema
± metronidazole
5-ASA, oral or enema
± metronidazole
Sucralfate, oral or enema
Formalin application
Fistulae
Small Large
Local repair with muscle
interposition or buccal flap
Medical therapy
Antiemetics
Antidiarrheals
Refractory to other management
Hyperbaric oxygen
Proctectomy with
pull-through
Endoscopy
Nd:YAG laser
APC
RFA
Cryoablation
Balloon dilation
Surgery
Bleeding/pain/proctitis
Intersphincteric
abdominoperineal
resection
Cystoprostatectomy with
ileal conduit
Proctectomy with coloanal
anastomosis and diverting
loop ileostomy
FIGURE 80-3 Management of radiation proctitis. APC, Argon plasma coagulation; 5-ASA, 5-aminosalycilic
Pelvic exenteration
acid; Nd:YAG, neodymium: yttrium-aluminum-garnet; RFA, radiofrequency ablation; SCFA, short-chain fatty acid.
interposition aps are used in most repairs; the gracilis muscle ap is
the most common ap used, followed by omental aps.
Rectourethral stulae are oen accompanied by urethral strictures. Buccal mucosal onlay gras are commonly used to close the
stula while simultaneously performing urethral reconstruction.
A proctectomy with a colostomy has been shown to have better outcomes in bleeding, strictures, and stulizing disease than a coloanal
anastomosis or pelvic exenteration. If an anastomosis is considered,
then wide excision to include all irradiated bowel is required. If a pelvic
exenteration is performed with primary closure of the irradiated tissue
bed, perineal wound complications can be as high as 70%. A perineal
ap reconstruction performed using nonirradiated tissue (such as the
gracilis or rectus abdominis) decreases wound complications to 15%.
CONCLUSION
Radiation therapy is becoming more prevalent as a treatment for pelvic malignancies. As life expectancy increases, radiation enteritis and
proctocolitis are becoming more prevalent. However, improvements
in radiation delivery techniques to the target organ may minimize
radiation to normal tissue. Many treatment options exist, but there is
no cure. Surgery is reserved for the most refractory cases because of
its high associated risks and complications.
S u g g e S t e d R e a d i n g S
Amiot A, Joly F, Lefevre JH, etal. Long-term outcome aer extensive intestinal
resection for chronic radiation enteritis. Dig Liver Dis. 2013;45:110–114.
Craighead P, Shea-Budgell MA, Nation J, etal. Hyperbaric oxygen therapy
for late radiation tissue injury in gynecologic malignancies. Curr Oncol.
2011;18:220–227.
Denton A, Forbes A, Andreyev J, Maher EJ. Non surgical interventions for late
radiation proctitis in patients who have received radical radiotherapy to
the pelvis. Cochrane Database Syst Rev. 2002;(1):CD003455.
Dietz DW, Remzi FH, Fazio VW. Strictureplasty for obstructing small-bowel
lesions in diuse radiation enteritis—successful outcome in ve patients.
Dis Colon Rectum. 2001;44:1772–1777.
Karamanolis G, Psatha P, Triantafyllou K. Endoscopic treatments for chronic
radiation proctitis. World J Gastrointest Endosc. 2013;5:308–312.
Kennedy GD, Heise CP. Radiation colitis and proctitis. Clin Colon Rectal Surg.
2007;20:64–72.
Kennedy M, Bruninga K, Mutlu EA, etal. Successful and sustained treatment
of chronic radiation proctitis with antioxidant vitamins E and C. Am J
Gastroenterol. 2001;96:1080–1084.

SMALL INTESTINE 423
Kountouras J, Zavos C. Recent advances in the management of radiation coli-
tis. World J Gastroenterol. 2008;14:7289–7301.
Li N, Zhu W, Gong J, etal. Ileal or ileocecal resection for chronic radiation en-
teritis with small bowel obstruction: outcome and risk factors. Am J Surg.
2013;206:739–747.
Mathai V, Seow-Choen F. Endoluminal formalin therapy for haemorrhagic
radiation proctitis. Br J Surg. 1995;82:190.
Parikh S, Hughes C, Salvati EP, et al. Treatment of hemorrhagic radiation
proctitis with 4 percent formalin. Dis Colon Rectum. 2003;46:596–600.
Saclarides TJ, King DG, Franklin JL, Doolas A. Formalin instillation for re-
fractory radiation-induced hemorrhagic proctitis. Report of 16 patients.
Dis Colon Rectum. 1996;39:196–199.
Sarin A, Safar B. Management of radiation proctitis. Gastroenterol Clin North
Am. 2013;42:913–925.
Scolapio JS, Ukleja A, Burnes JU, Kelly DG. Outcome of patients with radia-
tion enteritis treated with home parenteral nutrition. Am J Gastroenterol.
2002;97:662–666.
Shadad AK, Sullivan FJ, Martin JD, Egan LJ. Gastrointestinal radiation in-
jury: symptoms, risk factors and mechanisms. World J Gastroenterol.
2013;19:185–198.
Shadad AK, Sullivan FJ, Martin JD, Egan LJ. Gastrointestinal radiation injury:
prevention and treatment. World J Gastroenterol. 2013;19:199–208.
Shibata D, Hyland W, Busse P, etal. Immediate reconstruction of the perineal
wound with gracilis muscle aps following abdominoperineal resection
and intraoperative radiation therapy for recurrent carcinoma of the rectum. Ann Surg Oncol. 1999;6:33–37.
Tagkalidis PP, Tjandra JJ. Chronic radiation proctitis. ANZ J Surg.
2001;71:230–237.
eis VS, Sripadam R, Ramani V, Lal S. Chronic radiation enteritis. Clin On-
col (R Coll Radiol). 2010;22:70–83.
Tubiana M. Can we reduce the incidence of second primary malignancies oc-
curring aer radiotherapy? A critical review. Radiother Oncol. 2009;91:
4–15; discussion 1–3.
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2008;143:46–52.

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COMPLICATIONS
(AND OTHER MISCELLANEOUS TOPICS)
81. Colorectal Surgery in the High-Risk Patient 427
82.
Reoperative Pelvic Surgery 434
83.
Nutritional Support in Colorectal Surgery 439
84.
Prevention and Management of Sepsis 445
85.
Management of Anastomotic Leak 448
86.
Complications of Colonoscopy 452
87.
Management of Hemorrhage During Pelvic
Surgery 456
88.
Urologic Issues in Colorectal Surgery 462
89.
Prevention and Treatment of Complications of
Laparoscopic Colorectal Surgery 468
90.
Prevention and Management of Ostomy
Complications 472
91.
Stoma and Wound Considerations: Nursing
Management 477
92.
Measuring Outcomes 486
93.
Medical Documentation and Coding for the Colorectal
Surgeon 490
94.
Enhanced Recovery Pathways After Colorectal
Surgery 493
95.
Managing Complex Ventral/Parastomal Hernias in
Colorectal Surgical Patients 496

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C S
H-R P
Walter A. Koltun and Tara M. Connelly
INTRODUCTION
Increasing life expectancy coupled with the growing incidence of
both benign and malignant colorectal disease has resulted in a greater
need for surgeons to operate on patients with a variety of comorbidities. It has been estimated that elderly persons require surgery four
times more oen than the remainder of the population. is elderly
group has a high incidence of cardiac and pulmonary disease, and
other comorbidities may be the result of other primary disease processes (e.g., malnutrition in the patient with inammatory bowel disease). Patients with such comorbidities represent unique challenges
and oen require an individualized and multidisciplinary approach.
IDENTIFICATION OF THE HIGH-RISK PATIENT
e identication and management of preoperative risks is an integral part of preparation for surgery. Such an evaluation is critically
important because it may guide the anesthetic and surgical strategy
and provide the patient with realistic postoperative expectations.
When determining risk, both patient and operative factors should be
taken into account. As the number or severity of comorbidities rises,
and/or the operative complexity increases, the risk of postoperative
complications rises. Many studies have established specic, validated
criteria that relate morbidity aer surgery to preoperative risk factors.
Many of these studies have looked specically at colorectal surgery.
One of the oldest risk-calculating tools is Ondrula’s multifactorial
index, which assigns points to dened risk factors, which can then
be correlated to postoperative morbidity and mortality (Table 81-1).
To create their index, Ondrula’s group reviewed 972 colorectal procedures using multivariate discriminant function analysis and determined 11 factors that predicted operative outcomes. Each of these
factors was assigned a point value, with highest point values given to
emergency (vs. elective) surgery, age of 75 years or older, and congestive heart failure. ese values were then combined to determine a
“risk score.” e mortality rate in four patient groups was found to be
directly proportional to the risk score (0-4 points = 1% mortality, 5-8
points = 10% mortality, 9-13 points = 19% mortality, and >13 points
= 33% mortality). However, cirrhosis and renal insuciency were
excluded because values could not be assigned to them accurately
as a result of a very strong association with mortality and because a
small number of patients with either comorbidity caused a disproportionate statistical eect. Notably, Ondrula’s model contains both
nonmodiable factors (e.g., age and previous treatment with radiation) and modiable factors (e.g., albumin level and the presence of
congestive heart failure) that can be optimized prior to surgery and
presumably improve outcomes.
e American Society of Anesthesiologists score is commonly
used by anesthetists and surgeons to broadly describe a patient’s
health. Although it is not commonly used to predict postoperative
outcomes, this score is used internationally and provides a standardized way to describe a patient’s health preoperatively. is system was
developed in 1963 and has since been adapted to include six categories of physical status ranging from “normal/healthy” to “moribund”
to “declared brain dead, for organ harvesting” (Table 81-2).
Other scoring systems, such as the Physiological and Operative
Severity Score for enumeration of Mortality and Morbidity (POSSUM), which originally was designed for auditing purposes, have
been developed to allow comparison among dierent institutions
using validated formulas of predicted and observed morbidity and
mortality. Because of concerns about overprediction of complications, variations such as the Portsmouth modication have been
applied, permitting the direct comparison of outcomes in specic
patient groups such as those undergoing colorectal or laparoscopic
surgery or the elderly. First published by Copeland etal. in 1991, the
POSSUM score was developed by analyzing patient comorbidities,
intraoperative ndings (such as blood loss and peritoneal soiling),
and operative outcomes of 1372 nontrauma, elective, and emergency
surgeries. Initially 62 individual factors were included in the analysis.
rough multiple multivariate analyses, this number was rst reduced
to 35 and then again to the presently used 18-factor score. Although
432 gastrointestinal surgeries were included in the analysis for the
design of the original POSSUM score, Tekkis et al noted the need
for a colorectal-specic scoring system. Similar to the original POSSUM design, physiologic and operative parameters were recorded
and related to outcomes. Procedures ranging from minor (such as
hemorrhoidal sclerotherapy) to complex major (such as abdominal
perineal resection) were included, and a 10-parameter, colorectal
surgery–specic scoring system was then devised (Table 81-3).
Most recently, Web-based scoring tools have been developed. ese
online tools are gaining popularity because of their convenience and
easy-to-use formats, as well as the increased availability of tablets and
other smart devices in the hospital setting. e American College of
Surgeons Risk Calculator is the most commonly used tool of this kind.
Twenty-one preoperative factors including patient comorbidities and
procedure type may be entered into this publicly available Web page.
With these data, eight 30-day postoperative outcomes are calculated.
ese outcomes include morbidity, mortality, the more general “any
complication” and “serious complication” categories, and specic complications such as pneumonia, cardiac events, surgical site infections,
venous thromboembolism, renal failure, and urinary tract infection.
To develop this calculator, standardized clinical data from more than
300 American College of Surgeons National Surgical Quality Improvement Program hospitals and more than 1.4 million operations from
2009 to 2012 were analyzed. A subjective “surgeon adjustment score”
was incorporated into the initial computerized algorithm to account
for varying outcomes due to experience between surgeons, and the
model’s validity was tested by 80 surgeons using 10 case scenarios.
In addition to calculating patient risk based on comorbidities, the
operative risk of the individual procedure also must be taken into
account. In general, longer operative times, increased blood loss,
427

ColoreCtal Surgery in the high-riSk Patient428
TABLE 81-1: Ondrula’s Risk Factors and Relative
Values Predicting Morbidity and Mortality in Colon
and Rectal Surgery
Risk Factor Relative Value
Emergent surgery 6
Age ≥75 yr 4
Congestive heart failure 4
Prior treatment with radiation 3
Albumin <2.7 g/dL 2
Prior myocardial infarction 2
Chronic obstructive pulmonary disease 1
Diabetes 1
Steroid therapy 1
e estimated mortality rate according to the score is: 0-4 points = 1% mortality; 5-8 points = 10% mortality; 9-13 points = 19% mortality; >13 points =
33% mortality.
TABLE 81-2: American Society of Anesthesiologists
Physical Status Classification
ASA Score Patient Description
I Normal/healthy
II Mild systemic disease
III Severe systemic disease
IV Severe systemic disease that is a constant threat
to life
V Moribund, not expected to survive without the
operation
VI Declared brain dead, for organ harvesting
ASA, American Society of Anesthesiologists.
emergency surgery, and surgery in the presence of fecal spillage all
confer additional risk. When developing the colorectal-specic POSSUM model, Tekkis etal evaluated more than 6000 patients undergoing colorectal surgery in 15 United Kingdom hospitals between 1993
and 2001. e work of these investigators provides a general overview
of which procedures carry high and low risk of mortality in both the
emergency and elective setting, with right hemicolectomy and anterior resection having the highest number of mortalities. In this large
cohort, it was also noted that increasing age was signicantly associated with worse outcomes. e odds ratios of mortality, when compared with a control group of patients younger than 60 years, rose
from 4.5 in the 61- to 70-year age group to 8.4 in persons aged 71 to
80 years and 16.1 in persons older than 80 years.
MINIMIZING RISK ASSOCIATED WITH EMERGENCY SURGERY
Emergency surgery is associated with worse outcomes and higher
mortality than elective surgery and is a key factor in many riskscoring systems. Emergency surgery was given the highest index
TABLE 81-3: Original versus Colorectal Possum
Scoring Systems
Parameters Original POSSUM Colorectal POSSUM
Physiologic Age Age group
Cardiac failure Cardiac failure
Systolic blood pressure Systolic blood pressure
Pulse Pulse
Urea Urea
Hemoglobin Hemoglobin
White blood cell count
Sodium
Potassium
Respiratory status
Glasgow coma scale
Electrocardiogram
Operative Operative severity
(minor/moderate/
major/ major+)
Peritoneal soiling Peritoneal soiling
Elective, emergency with
>2 h of resuscitation,
emergency with <2 h
of resuscitation
Presence of malignancy Cancer staging
No. of procedures
Total blood loss
In both the original and colorectal POSSUM scoring systems, three to four categories or grades with corresponding point values are given for each parameter.
Each patient receives a single score for that parameter that is based on his or her
individual results. For example, in the colorectal POSSUM score, systolic blood
pressure of 100-170 mm Hg is given 1 point, ≥170 mm Hg or 90-99 mm Hg is
given 2 points, and <90 is given 3 points. e minimum score in the colorectal
POSSUM is 10, and the maximum score is 45. All scores are added together.
Increased risk of postoperative complications is associated with a higher score.
POSSUM, Physiologic and Operative Severity Score for enumeration of
Mortality and Morbidity.
value in Ondrula’s study, with a mortality of 2.8% in the elective
setting and 12% in the study by Tekkis etal. is negative impact on
surgical outcomes is likely due to a combination of factors, including advanced presentation of disease, an unprepared colon, and the
eects of acute sepsis, stress, and/or dehydration on many organ
systems.
Clearly, the patient with an acute abdomen or signs and symptoms of an intra-abdominal catastrophe cannot avoid the operating
room for long. rough the use of increasingly sophisticated radiologic and endolaparoscopic modalities, however, careful initial nonoperative management of the emergency colorectal patient may allow
a subsequent denitive operation to take place under semi-elective or
even fully elective circumstances, thus decreasing operative risk. e
indications for emergency colorectal surgery generally fall into one
of three categories:
1. Sepsis (e.g., acute diverticulitis and pelvic abscess)
2. Obstruction (e.g., large bowel cancer, volvulus, and stricturing
Crohn disease [CD])
3. Bleeding (e.g., diverticular disease and colitis)
e initial management for any colorectal emergency is uid resuscitation with use of blood products if required. Diagnostic maneuvers
including radiologic imaging (e.g., an abdominal radiograph and
Operative severity
(minor/intermediate/
major/complex major)
Urgent vs. elective
(None-Dukes D)

Sepsis Obstruction Bleeding
*If patient deteriorates at any point, immediate surgery may be required.
Intravenous fluid rehydration ± blood products
and appropriate diagnostic work-up*
COMPLICATIONS 429
Plain film
CT ± contrast
Intervention to decrease likelihood of emergency procedure/resection
IV antibiotics
Radiographically guided
Drainage
Laparoscopic washout ±
Stoma
Plain film
Gastrografin enema
CT endoscopy
Endoscopic decompression
± stenting
Proximal trephine stoma
computed tomography [CT] with or without use of contrast material), endoscopic techniques (e.g., sigmoidoscopy and full colonoscopy), or angiography should follow (Fig. 81-1). Such diagnostic
techniques may be used in conjunction with treatment modalities in
an eort to further stabilize the patient and control sepsis so there
is time to optimize nutrition and correct anemia, coagulopathy, and
electrolyte imbalances. When such “bridging techniques” are used, a
denitive surgical procedure in an appropriately prepared bowel on
an elective basis with a more favorable outcome may then be possible.
Procedures performed electively in such a manner oen result in the
resection of signicantly less bowel when compared with the same
procedures performed as an emergency. One example is CT-guided
percutaneous drainage of an intra-abdominal abscess from diverticulitis or CD, which frequently can be followed by the subsequent
performance of a single-stage resection. Similarly, a colonoscopy or
a Gastrogran enema can be therapeutic when acute obstruction is
caused by a volvulus and diagnostic when caused by a malignancy or
severe stricturing CD. In many cases, the obstruction can be relieved
by either a colonoscopically placed stent or a “trephine” stoma created proximal to the obstruction in less than an hour, without laparotomy or even laparoscopy, aer induction of light general or spinal
anesthesia. When the obstruction is due to a distal colorectal cancer,
chemotherapy or chemoradiation may then be considered, reducing tumor size for later denitive resection. In cases of CD strictures
without an abscess, high-dose intravenous steroids may relieve the
obstruction, allowing time for nutritional optimization prior to a
more denitive future procedure.
MINIMIZING RISK ASSOCIATED WITH CARDIAC DISEASE
Numerous studies have been performed to determine factors predictive of cardiac complications in patients undergoing major noncardiac general surgery. History or presence of congestive heart failure,
previous myocardial infarction, old age, diabetes, and emergency
surgery are recurring features in these studies. It should be noted
that up to 60% of patients who have peripheral vascular disease
Proctoscopy
Red cell nuclear scan
Angiography
Colonoscopy
FIGURE 81-1 Algorithm for cardiac
workup of the elective colorectal surgery
with and without active cardiac conditions. In physically fit patients, stress
testing can be performed on a treadmill.
For patients who are less fit, pharmacologic stress testing may be required. (See
Endoscopic vessels clipping
Angiographic embolization
the section “Minimizing Risk Associated
with Cardiac Disease” in this chapter).
MET, Metabolic equivalent; two METs
= walking up two flights of stairs. Good
functional status is demonstrated by
the ability to climb four flights of stairs
(which equals four METs).
(PVD) also have signicant silent coronary vascular disease. Carotid
stenosis may be asymptomatic, but it carries a risk of intra- or postoperative cerebrovascular accident. If carotid stenosis is suspected
or indicated, including the presence of PVD, carotid Doppler scanning should be performed. Colorectal procedures can add cardiac
stress through blood loss and prolonged reverse Trendelenburg
positioning.
e categories of cardiac risk in noncardiac surgery can be
divided into three groups, all of which predict negative outcomes: (1)
le ventricular (LV) dysfunction; (2) myocardial ischemia; and (3)
heart valve abnormalities.
Preoperative investigations are tailored to these categories.
Examples of such investigations by category include serum brain
natriuretic peptide, echocardiography and cardiac CT or magnetic
resonance imaging (MRI) for LV dysfunction, an electrocardiogram,
serum troponin and creatine kinase–myocardial bound for acute
ischemia, exercise treadmill in the t patient or nuclear perfusion
imaging, a dipyridamole, adenosine, or dobutamine stress test in the
less t patient for chronic ischemia, and echocardiography, an electrocardiogram, and cardiac CT or MRI scanning to assess for valvular
anomalies. Several guidelines are in place to determine the appropriate preoperative test for cardiac risk assessment. Many guidelines
are the result of collaborations between expert groups such as the
European Societies of Cardiology and Anaesthesiology’s guide and
the guidelines from the American College of Cardiology and the
American Heart Association, who have worked together since 1980
to produce such recommendations.
A common feature of cardiac evaluation guidelines is determination of functional capacity, usually in metabolic equivalents
(METs). For example, one MET equals the basal metabolic rate at
rest, climbing two ights of stairs is two METs, and walking two
blocks is three METs. Inability to perform activities that require
four METS (e.g., climbing four ights of stairs) predicts increased
incidence of postoperative cardiac events. For patients with known
cardiac comorbidities or poor functional capacity, stress echocardiography using exercise or pharmacologic agents such as dobutamine or dipyridamole is performed. Coronary angiography should
be performed if ischemia is suspected. Stress echocardiography has

ColoreCtal Surgery in the high-riSk Patient430
a high negative predictive value (90% to 100%), but the positive
predictive value is relatively low (25% to 45%). us a positive test
demands further evaluation. MRI can assess cardiac perfusion and
wall motion and can assist in detecting ischemia. CT may be used as
a noninvasive angiographic modality for the detection of coronary
calcium reective of atherosclerosis.
e Goldman index and its modications, the Lee index and the
Modied Multifactorial Index by Detsky etal, are commonly used to
predict cardiac risk in patients undergoing noncardiac surgery. e
Lee index is the most concise of the three indices and was developed
by prospectively following up on more than 2800 patients undergoing a variety of procedures and validated with an additional 1400
patients. e independent determinants of perioperative cardiac
events are listed later (Table 81-4). In the Lee index, each determinant
is given one point. e risk of major cardiac complications according
to the Lee index is as follows: 0 points = 0.4%, 1 point = 0.9%, 2 points
= 7%, and 3 or more points =11%.
Perioperatively, cardiac medications should be continued, especially β-blockers, both to avoid rebound tachycardia and to prevent
the myocardial ischemic eects of catecholamines released during
surgery. Eective pain control is similarly very important. Pulmonary artery catheter monitoring is usually reserved for patients of
at least moderate risk. If used, it should be maintained through the
postoperative period of uid mobilization—usually 48 to 72 hours
aer surgery.
TABLE 81-4: Indices of Cardiac Risk in Noncardiac
Surgery
Modified Multifactorial
Lee Index Goldman Index
Ischemic heart
MI within 6 mo MI within 6 mo
disease
Cerebrovascu-
lar disease
Congestive heart
failure
Heart failure >5 Premature ventric-
ular contractions
Index
Coronary artery disease
>5 Premature ventricular
contractions
MINIMIZING RISK ASSOCIATED WITH PULMONARY DISEASE
Generally, pulmonary disease is likely in patients who cannot climb
two ights of stairs at a steady pace without dyspnea, patients with a
smoking history, and patients with less than 70% of predicted values
for timed forced expiration on pulmonary testing (Table 81-5). Such
pre-existing pulmonary disease can lead to an increased risk of atelectasis during induction of general anesthesia, diculty in ventilator
weaning, and postoperative pneumonia. Patients with more extensive resections and larger incisions whose ability to cough may be
hindered by postoperative pain are particularly at risk of respiratory
complications. In addition, carbon dioxide retention or an oxygen
tension of less than 50 mm Hg on a room air blood gas value predicts
postoperative ventilator dependency.
Pain control is a key to preventing shallow postoperative breathing, as is chest physiotherapy with incentive spirometry. In higher
risk patients, epidural anesthesia with the patient in an awake state
can be used for the surgery to avoid intubation and general anesthesia; this option, coupled with excellent postoperative pain control,
facilitates pulmonary function and may even minimize some of the
other adverse eects associated with the stress of surgery.
e Canet risk index has been developed to evaluate pulmonary
and other prognostic indicators based on results from approximately
2500 patients. is index incorporates values for age, oxygen saturation taken by pulse oximetry, the presence of a respiratory infection
in the month preceding the surgery, hemoglobin levels, urgent versus
elective status of the procedure, and procedure length. A point score
is assigned to each value, and risk can then be assessed as low, intermediate, or high based on this point score. Odds ratios (ORs) of the
development of postoperative complications are highest in persons
older than 80 years (OR = 5.1), with arterial oxygen saturation less
than 90% on room air (OR = 10.7), recent respiratory infection (OR
= 5.5), hemoglobin <10 g/dL (OR = 3), surgery of more than 3 hours’
duration (OR = 9.7), and emergency surgery (OR = 2.2).
In persons with known pulmonary disease, preoperative preparation should include the culture of sputum with appropriate antibiotic
treatment if necessary, the institution of bronchodilators if necessary,
abstinence from smoking (ideally for at least 8 weeks), and incentive
spirometry instruction.
Insulin-
dependent
diabetes
mellitus
Impaired renal
Cardiac rhythm
other than sinus
or premature atrial
contraction
Age >70 yr Age >70 yr
Cardiac rhythm other
than sinus or
premature atrial
contraction
function
“High-risk”
surgery
Abdominal/thoracic
or aorta surgery
Pulmonary edema
Emergency surgery Emergency operation
Aortic stenosis Canadian Cardiovascular
Society angina class 3
or 4 or unstable angina
within 3 mo
Poor metabolic con-
dition
Poor general medical
status
Valvular disease
Risk of an adverse cardiac event correlates with total score in each of these indices. In the Lee index, each determinant is given 1 point. Estimated risk of major
cardiac complications is: Lee index of 0 = 0.4%, 1 = 0.9%, 2 = 7%, ≥3 = 11%.
MI, Myocardial infarction.
TABLE 81-5: Pulmonary Variables/Test Results with
Negative Prognostic Value
Variable/Test Negative Prognosticator
Preexisting pulmonary
disease
Smoking history Current smokers (prognosis is improved if
Chest radiograph Consolidation, pleural eusion, atelectasis
Pulse oximetry Sa
Pulmonary function
test
Hemoglobin <10 g/dL
ABG Pa
ABG, Arterial blood gas; COPD, chronic obstructive pulmonary disorder;
FEV1, forced expiratory volume in the rst second of expiration; FVC, forced
vital capacity; Paco2, partial pressure of carbon dioxide, arterial; Sao2, arterial
oxygen saturation.
COPD, asthma, brotic lung disease,
previous resection
smoking is ceased >8 wk preoperatively)
<90% on room air
2
<70% of predicted values for timed forced
expiration, FEV
>45 mm Hg on room air
2
/FVC ratio <65%
1
Oxygen tension <50 mm Hg on room air
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