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Acute
Radiation injury to large bowel
(<3 months)
SMALL INTESTINE 421
Versus
Chronic
(>3 months)
Symptoms self-limited
supportive management
Antiemetics
Antidiarrheals
Low-residue diet
Antispasmodics Anticholinergics
Octreotide
Elemental or specific exclusion diets
FIGURE 80-2 Management of radiation colitis. NG, Nasogastric.
Conservative:
NG tube decompression
Nutritional supplementation
Total parenteral nutrition
Radiation proctitis as a complication of prostate radiation is a spe­cic condition that is commonly seen. e eect of the radiation is to produce telangiectases in the rectal mucosa that are fragile and bleed easily. eir distribution is in the anterior rectal wall adjacent to the prostate. Sometimes they overlap the internal hemorrhoids, and the prolapse that occurs here can make the bleeding worse.
Topical Therapy
Short-chain fatty acid enemas are eective for acute symptoms of radiation proctitis but do not aect the incidence or severity of late proctitis (Fig. 80-3). Steroids and 5-ASA compounds are not associ- ated with any benet. Indeed, some series report worsening symp­toms with use of these drugs. One study showed improvement in rectal bleeding and diarrhea when metronidazole was used in com­bination with antiinammatory agents such as 5-ASA or steroids. Sucralfate creates a protective barrier to promote epithelial healing, and one randomized controlled trial showed that oral sucralfate decreased diarrhea symptoms in both the acute and chronic phase. In addition, sucralfate showed greater clinical improvement for proctitis than antiinammatory medications. Formalin (4% solution) applica­tion is used to control bleeding from radiation telangiectases and is indicated specically for extensive changes that would be dicult to treat with argon plasma coagulation. Two methods of applying the formalin have been described: rectal irrigation and application of formalin-soaked gauze or use of large cotton-tipped applicators. It has a 70% to 75% success rate in the treatment of severe hemorrhagic radiation proctitis, although several applications may be required. 
Hyperbaric Oxygen
Hyperbaric oxygen is thought to promote neovascularization and sub­sequently reversal of tissue hypoxia, which should be useful in a disease characterized by a brosing vasculitis. In a systematic review, based on the evidence and expert consensus opinion, hyperbaric oxygen may provide some benet in treating chronic radiation damage to the rectum and anus. 
Medical Therapy
Loperamide and other antidiarrheal medications decrease bowel frequency and improve bile acid absorption. However, antidiar­rheal agents treat symptoms and do not treat the underlying disease. A pilot study of 20 patients who used antioxidant vitamins E and C demonstrated symptomatic improvement with respect to bleeding, diarrhea, and urgency, but not pain. 
Obstruction
Partial Near/complete
Surgery
Fecal diversion with ostomy
Bowel resection
with or without ostomy
Endoscopic Management
Options for endoscopic thermal therapy include the neodymium: yttrium-aluminum-garnet (Nd:YAG) and argon lasers. Both are eective in stopping bleeding from radiation-induced telangiectases throughout the gastrointestinal tract. e biggest risk is perforation through transmural necrosis with resultant stula formation, which is common with the Nd:YAG laser. Argon plasma coagulation (APC), a nontouch thermoablative therapy, is becoming the rst line of therapy for endoscopic treatment of radiation enteritis and proctitis, especially with the rather limited but intensely symptomatic radiation proc­titis aer prostate cancer radiation. Here the telangiectases are “spot welded” with the APC. However, multiple treatments are sometimes required, and this treatment has up to a 50% failure rate in persons with severe radiation proctitis. For persons who were successfully treated with APC, 90% remained in remission aer 18 months.
e use of radiofrequency ablation for refractory hemorrhage has been extrapolated from studies showing its ecacy in gastric antral vascular ectasia and Barrett esophagus. No complications have been associated with transmural injury, and hemostasis can be achieved in one to two sessions.
Balloon dilatation has been shown to be eective in short- segment strictures; however, the risk of perforation increases when balloon dilatation is used to treat long-segment or angulated strictures. 
Surgery
Surgery is reserved for refractory cases. Indications include bleeding, perforation, obstruction, and stulae. Fecal diversion, in the form of an ileostomy or colostomy, decreases pain, tenesmus, and drainage, and although it does not completely resolve bleeding, it improves quality of life.
Fistulae may develop between any of the pelvic organs—vagina, bladder, or urethra—and the rectum or sigmoid colon. ese patients usually require fecal and/or urinary diversion (with either a ure­thral catheter or a suprapubic catheter). Ninety percent of patients will need denitive repair, and 9.6% heal spontaneously. A variety of surgical approaches exist: transabdominal, abdominoperineal, transperineal, transanal, trans-sphincteric (i.e., York-Mason), and trans-sacral. Small, simple rectourethral stulae are most commonly repaired through an anterior transperineal repair, which allows better visualization of the operative eld and advancement of muscle aps to separate the organs of stulization. A transabdominal approach is performed in patients with severe radiation damage, large-caliber s­tulae, or signicant symptoms requiring extensive resections. Tissue
Radiation EntERitis and PRoctocolitis422
Radiation Injury to Rectum
Conservative
management
Topical therapy
SCFA enemas
Steroids, oral or enema
± metronidazole
5-ASA, oral or enema
± metronidazole
Sucralfate, oral or enema
Formalin application
Fistulae
Small Large
Local repair with muscle
interposition or buccal flap
Medical therapy
Antiemetics
Antidiarrheals
Refractory to other management
Hyperbaric oxygen
Proctectomy with
pull-through
Endoscopy
Nd:YAG laser
APC RFA
Cryoablation
Balloon dilation
Surgery
Bleeding/pain/proctitis
Intersphincteric
abdominoperineal
resection
Cystoprostatectomy with
ileal conduit
Proctectomy with coloanal
anastomosis and diverting
loop ileostomy
FIGURE 80-3 Management of radiation proctitis. APC, Argon plasma coagulation; 5-ASA, 5-aminosalycilic
Pelvic exenteration
acid; Nd:YAG, neodymium: yttrium-aluminum-garnet; RFA, radiofrequency ablation; SCFA, short-chain fatty acid.
interposition aps are used in most repairs; the gracilis muscle ap is the most common ap used, followed by omental aps.
Rectourethral stulae are oen accompanied by urethral stric­tures. Buccal mucosal onlay gras are commonly used to close the stula while simultaneously performing urethral reconstruction.
A proctectomy with a colostomy has been shown to have better out­comes in bleeding, strictures, and stulizing disease than a coloanal anastomosis or pelvic exenteration. If an anastomosis is considered, then wide excision to include all irradiated bowel is required. If a pelvic exenteration is performed with primary closure of the irradiated tissue bed, perineal wound complications can be as high as 70%. A perineal ap reconstruction performed using nonirradiated tissue (such as the gracilis or rectus abdominis) decreases wound complications to 15%. 

CONCLUSION

Radiation therapy is becoming more prevalent as a treatment for pel­vic malignancies. As life expectancy increases, radiation enteritis and proctocolitis are becoming more prevalent. However, improvements in radiation delivery techniques to the target organ may minimize radiation to normal tissue. Many treatment options exist, but there is
no cure. Surgery is reserved for the most refractory cases because of its high associated risks and complications.

S u g g e S t e d R e a d i n g S

Amiot A, Joly F, Lefevre JH, etal. Long-term outcome aer extensive intestinal
resection for chronic radiation enteritis. Dig Liver Dis. 2013;45:110–114.
Craighead P, Shea-Budgell MA, Nation J, etal. Hyperbaric oxygen therapy
for late radiation tissue injury in gynecologic malignancies. Curr Oncol. 2011;18:220–227.
Denton A, Forbes A, Andreyev J, Maher EJ. Non surgical interventions for late
radiation proctitis in patients who have received radical radiotherapy to the pelvis. Cochrane Database Syst Rev. 2002;(1):CD003455.
Dietz DW, Remzi FH, Fazio VW. Strictureplasty for obstructing small-bowel
lesions in diuse radiation enteritis—successful outcome in ve patients. Dis Colon Rectum. 2001;44:1772–1777.
Karamanolis G, Psatha P, Triantafyllou K. Endoscopic treatments for chronic
radiation proctitis. World J Gastrointest Endosc. 2013;5:308–312.
Kennedy GD, Heise CP. Radiation colitis and proctitis. Clin Colon Rectal Surg.
2007;20:64–72.
Kennedy M, Bruninga K, Mutlu EA, etal. Successful and sustained treatment
of chronic radiation proctitis with antioxidant vitamins E and C. Am J Gastroenterol. 2001;96:1080–1084.
SMALL INTESTINE 423
Kountouras J, Zavos C. Recent advances in the management of radiation coli-
tis. World J Gastroenterol. 2008;14:7289–7301.
Li N, Zhu W, Gong J, etal. Ileal or ileocecal resection for chronic radiation en-
teritis with small bowel obstruction: outcome and risk factors. Am J Surg. 2013;206:739–747.
Mathai V, Seow-Choen F. Endoluminal formalin therapy for haemorrhagic
radiation proctitis. Br J Surg. 1995;82:190.
Parikh S, Hughes C, Salvati EP, et al. Treatment of hemorrhagic radiation
proctitis with 4 percent formalin. Dis Colon Rectum. 2003;46:596–600.
Saclarides TJ, King DG, Franklin JL, Doolas A. Formalin instillation for re-
fractory radiation-induced hemorrhagic proctitis. Report of 16 patients. Dis Colon Rectum. 1996;39:196–199.
Sarin A, Safar B. Management of radiation proctitis. Gastroenterol Clin North
Am. 2013;42:913–925.
Scolapio JS, Ukleja A, Burnes JU, Kelly DG. Outcome of patients with radia-
tion enteritis treated with home parenteral nutrition. Am J Gastroenterol. 2002;97:662–666.
Shadad AK, Sullivan FJ, Martin JD, Egan LJ. Gastrointestinal radiation in-
jury: symptoms, risk factors and mechanisms. World J Gastroenterol. 2013;19:185–198.
Shadad AK, Sullivan FJ, Martin JD, Egan LJ. Gastrointestinal radiation injury:
prevention and treatment. World J Gastroenterol. 2013;19:199–208.
Shibata D, Hyland W, Busse P, etal. Immediate reconstruction of the perineal
wound with gracilis muscle aps following abdominoperineal resection and intraoperative radiation therapy for recurrent carcinoma of the rec­tum. Ann Surg Oncol. 1999;6:33–37.
Tagkalidis PP, Tjandra JJ. Chronic radiation proctitis. ANZ J Surg.
2001;71:230–237.
eis VS, Sripadam R, Ramani V, Lal S. Chronic radiation enteritis. Clin On-
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Tubiana M. Can we reduce the incidence of second primary malignancies oc-
curring aer radiotherapy? A critical review. Radiother Oncol. 2009;91: 4–15; discussion 1–3.
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COMPLICATIONS
(AND OTHER MISCELLANEOUS TOPICS)
81. Colorectal Surgery in the High-Risk Patient 427
82.
Reoperative Pelvic Surgery 434
83.
Nutritional Support in Colorectal Surgery 439
84.
Prevention and Management of Sepsis 445
85.
Management of Anastomotic Leak 448
86.
Complications of Colonoscopy 452
87.
Management of Hemorrhage During Pelvic
Surgery 456
88.
Urologic Issues in Colorectal Surgery 462
89.
Prevention and Treatment of Complications of
Laparoscopic Colorectal Surgery 468
90.
Prevention and Management of Ostomy
Complications 472
91.
Stoma and Wound Considerations: Nursing
Management 477
92.
Measuring Outcomes 486
93.
Medical Documentation and Coding for the Colorectal
Surgeon 490
94.
Enhanced Recovery Pathways After Colorectal
Surgery 493
95.
Managing Complex Ventral/Parastomal Hernias in
Colorectal Surgical Patients 496
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C S 
 H-R P
Walter A. Koltun and Tara M. Connelly


INTRODUCTION

Increasing life expectancy coupled with the growing incidence of both benign and malignant colorectal disease has resulted in a greater need for surgeons to operate on patients with a variety of comorbidi­ties. It has been estimated that elderly persons require surgery four times more oen than the remainder of the population. is elderly group has a high incidence of cardiac and pulmonary disease, and other comorbidities may be the result of other primary disease pro­cesses (e.g., malnutrition in the patient with inammatory bowel dis­ease). Patients with such comorbidities represent unique challenges and oen require an individualized and multidisciplinary approach. 

IDENTIFICATION OF THE HIGH-RISK PATIENT

e identication and management of preoperative risks is an inte­gral part of preparation for surgery. Such an evaluation is critically important because it may guide the anesthetic and surgical strategy and provide the patient with realistic postoperative expectations. When determining risk, both patient and operative factors should be taken into account. As the number or severity of comorbidities rises, and/or the operative complexity increases, the risk of postoperative complications rises. Many studies have established specic, validated criteria that relate morbidity aer surgery to preoperative risk factors. Many of these studies have looked specically at colorectal surgery.
One of the oldest risk-calculating tools is Ondrula’s multifactorial index, which assigns points to dened risk factors, which can then be correlated to postoperative morbidity and mortality (Table 81-1). To create their index, Ondrula’s group reviewed 972 colorectal pro­cedures using multivariate discriminant function analysis and deter­mined 11 factors that predicted operative outcomes. Each of these factors was assigned a point value, with highest point values given to emergency (vs. elective) surgery, age of 75 years or older, and conges­tive heart failure. ese values were then combined to determine a “risk score.” e mortality rate in four patient groups was found to be directly proportional to the risk score (0-4 points = 1% mortality, 5-8 points = 10% mortality, 9-13 points = 19% mortality, and >13 points = 33% mortality). However, cirrhosis and renal insuciency were excluded because values could not be assigned to them accurately as a result of a very strong association with mortality and because a small number of patients with either comorbidity caused a dispro­portionate statistical eect. Notably, Ondrula’s model contains both nonmodiable factors (e.g., age and previous treatment with radia­tion) and modiable factors (e.g., albumin level and the presence of congestive heart failure) that can be optimized prior to surgery and presumably improve outcomes.
e American Society of Anesthesiologists score is commonly used by anesthetists and surgeons to broadly describe a patient’s health. Although it is not commonly used to predict postoperative
outcomes, this score is used internationally and provides a standard­ized way to describe a patient’s health preoperatively. is system was developed in 1963 and has since been adapted to include six catego­ries of physical status ranging from “normal/healthy” to “moribund” to “declared brain dead, for organ harvesting” (Table 81-2).
Other scoring systems, such as the Physiological and Operative Severity Score for enumeration of Mortality and Morbidity (POS­SUM), which originally was designed for auditing purposes, have been developed to allow comparison among dierent institutions using validated formulas of predicted and observed morbidity and mortality. Because of concerns about overprediction of complica­tions, variations such as the Portsmouth modication have been applied, permitting the direct comparison of outcomes in specic patient groups such as those undergoing colorectal or laparoscopic surgery or the elderly. First published by Copeland etal. in 1991, the POSSUM score was developed by analyzing patient comorbidities, intraoperative ndings (such as blood loss and peritoneal soiling), and operative outcomes of 1372 nontrauma, elective, and emergency surgeries. Initially 62 individual factors were included in the analysis. rough multiple multivariate analyses, this number was rst reduced to 35 and then again to the presently used 18-factor score. Although 432 gastrointestinal surgeries were included in the analysis for the design of the original POSSUM score, Tekkis et al noted the need for a colorectal-specic scoring system. Similar to the original POS­SUM design, physiologic and operative parameters were recorded and related to outcomes. Procedures ranging from minor (such as hemorrhoidal sclerotherapy) to complex major (such as abdominal perineal resection) were included, and a 10-parameter, colorectal surgery–specic scoring system was then devised (Table 81-3).
Most recently, Web-based scoring tools have been developed. ese online tools are gaining popularity because of their convenience and easy-to-use formats, as well as the increased availability of tablets and other smart devices in the hospital setting. e American College of Surgeons Risk Calculator is the most commonly used tool of this kind. Twenty-one preoperative factors including patient comorbidities and procedure type may be entered into this publicly available Web page. With these data, eight 30-day postoperative outcomes are calculated. ese outcomes include morbidity, mortality, the more general “any complication” and “serious complication” categories, and specic com­plications such as pneumonia, cardiac events, surgical site infections, venous thromboembolism, renal failure, and urinary tract infection. To develop this calculator, standardized clinical data from more than 300 American College of Surgeons National Surgical Quality Improve­ment Program hospitals and more than 1.4 million operations from 2009 to 2012 were analyzed. A subjective “surgeon adjustment score” was incorporated into the initial computerized algorithm to account for varying outcomes due to experience between surgeons, and the model’s validity was tested by 80 surgeons using 10 case scenarios.
In addition to calculating patient risk based on comorbidities, the operative risk of the individual procedure also must be taken into account. In general, longer operative times, increased blood loss,
427
ColoreCtal Surgery in the high-riSk Patient428
TABLE 81-1: Ondrula’s Risk Factors and Relative
Values Predicting Morbidity and Mortality in Colon and Rectal Surgery
Risk Factor Relative Value
Emergent surgery 6
Age ≥75 yr 4
Congestive heart failure 4
Prior treatment with radiation 3
Albumin <2.7 g/dL 2
Prior myocardial infarction 2
Chronic obstructive pulmonary disease 1
Diabetes 1
Steroid therapy 1
e estimated mortality rate according to the score is: 0-4 points = 1% mor­tality; 5-8 points = 10% mortality; 9-13 points = 19% mortality; >13 points = 33% mortality.
TABLE 81-2: American Society of Anesthesiologists
Physical Status Classification
ASA Score Patient Description
I Normal/healthy
II Mild systemic disease
III Severe systemic disease
IV Severe systemic disease that is a constant threat
to life
V Moribund, not expected to survive without the
operation
VI Declared brain dead, for organ harvesting
ASA, American Society of Anesthesiologists.
emergency surgery, and surgery in the presence of fecal spillage all confer additional risk. When developing the colorectal-specic POS­SUM model, Tekkis etal evaluated more than 6000 patients undergo­ing colorectal surgery in 15 United Kingdom hospitals between 1993 and 2001. e work of these investigators provides a general overview of which procedures carry high and low risk of mortality in both the emergency and elective setting, with right hemicolectomy and ante­rior resection having the highest number of mortalities. In this large cohort, it was also noted that increasing age was signicantly associ­ated with worse outcomes. e odds ratios of mortality, when com­pared with a control group of patients younger than 60 years, rose from 4.5 in the 61- to 70-year age group to 8.4 in persons aged 71 to 80 years and 16.1 in persons older than 80 years. 

MINIMIZING RISK ASSOCIATED WITH EMERGENCY SURGERY

Emergency surgery is associated with worse outcomes and higher mortality than elective surgery and is a key factor in many risk­scoring systems. Emergency surgery was given the highest index
TABLE 81-3: Original versus Colorectal Possum
Scoring Systems
Parameters Original POSSUM Colorectal POSSUM
Physiologic Age Age group
Cardiac failure Cardiac failure Systolic blood pressure Systolic blood pressure Pulse Pulse Urea Urea Hemoglobin Hemoglobin White blood cell count
Sodium Potassium Respiratory status Glasgow coma scale
Electrocardiogram
Operative Operative severity
(minor/moderate/
major/ major+) Peritoneal soiling Peritoneal soiling Elective, emergency with
>2 h of resuscitation,
emergency with <2 h
of resuscitation Presence of malignancy Cancer staging
No. of procedures Total blood loss
In both the original and colorectal POSSUM scoring systems, three to four cat­egories or grades with corresponding point values are given for each parameter. Each patient receives a single score for that parameter that is based on his or her individual results. For example, in the colorectal POSSUM score, systolic blood pressure of 100-170 mm Hg is given 1 point, ≥170 mm Hg or 90-99 mm Hg is given 2 points, and <90 is given 3 points. e minimum score in the colorectal POSSUM is 10, and the maximum score is 45. All scores are added together. Increased risk of postoperative complications is associated with a higher score. POSSUM, Physiologic and Operative Severity Score for enumeration of Mortality and Morbidity.
value in Ondrula’s study, with a mortality of 2.8% in the elective setting and 12% in the study by Tekkis etal. is negative impact on surgical outcomes is likely due to a combination of factors, includ­ing advanced presentation of disease, an unprepared colon, and the eects of acute sepsis, stress, and/or dehydration on many organ systems.
Clearly, the patient with an acute abdomen or signs and symp­toms of an intra-abdominal catastrophe cannot avoid the operating room for long. rough the use of increasingly sophisticated radio­logic and endolaparoscopic modalities, however, careful initial non­operative management of the emergency colorectal patient may allow a subsequent denitive operation to take place under semi-elective or even fully elective circumstances, thus decreasing operative risk. e indications for emergency colorectal surgery generally fall into one of three categories:
1. Sepsis (e.g., acute diverticulitis and pelvic abscess)
2. Obstruction (e.g., large bowel cancer, volvulus, and stricturing
Crohn disease [CD])
3. Bleeding (e.g., diverticular disease and colitis)
e initial management for any colorectal emergency is uid resus­citation with use of blood products if required. Diagnostic maneuvers including radiologic imaging (e.g., an abdominal radiograph and
Operative severity
(minor/intermediate/ major/complex major)
Urgent vs. elective
(None-Dukes D)
Sepsis Obstruction Bleeding
*If patient deteriorates at any point, immediate surgery may be required.
Intravenous fluid rehydration ± blood products
and appropriate diagnostic work-up*
COMPLICATIONS 429
Plain film CT ± contrast
Intervention to decrease likelihood of emergency procedure/resection
IV antibiotics Radiographically guided Drainage Laparoscopic washout ± Stoma
Plain film Gastrografin enema CT endoscopy
Endoscopic decompression ± stenting Proximal trephine stoma
computed tomography [CT] with or without use of contrast mate­rial), endoscopic techniques (e.g., sigmoidoscopy and full colonos­copy), or angiography should follow (Fig. 81-1). Such diagnostic techniques may be used in conjunction with treatment modalities in an eort to further stabilize the patient and control sepsis so there is time to optimize nutrition and correct anemia, coagulopathy, and electrolyte imbalances. When such “bridging techniques” are used, a denitive surgical procedure in an appropriately prepared bowel on an elective basis with a more favorable outcome may then be possible. Procedures performed electively in such a manner oen result in the resection of signicantly less bowel when compared with the same procedures performed as an emergency. One example is CT-guided percutaneous drainage of an intra-abdominal abscess from diver­ticulitis or CD, which frequently can be followed by the subsequent performance of a single-stage resection. Similarly, a colonoscopy or a Gastrogran enema can be therapeutic when acute obstruction is caused by a volvulus and diagnostic when caused by a malignancy or severe stricturing CD. In many cases, the obstruction can be relieved by either a colonoscopically placed stent or a “trephine” stoma cre­ated proximal to the obstruction in less than an hour, without lapa­rotomy or even laparoscopy, aer induction of light general or spinal anesthesia. When the obstruction is due to a distal colorectal cancer, chemotherapy or chemoradiation may then be considered, reduc­ing tumor size for later denitive resection. In cases of CD strictures without an abscess, high-dose intravenous steroids may relieve the obstruction, allowing time for nutritional optimization prior to a more denitive future procedure. 

MINIMIZING RISK ASSOCIATED WITH CARDIAC DISEASE

Numerous studies have been performed to determine factors predic­tive of cardiac complications in patients undergoing major noncar­diac general surgery. History or presence of congestive heart failure, previous myocardial infarction, old age, diabetes, and emergency surgery are recurring features in these studies. It should be noted that up to 60% of patients who have peripheral vascular disease
Proctoscopy Red cell nuclear scan Angiography Colonoscopy
FIGURE 81-1 Algorithm for cardiac
workup of the elective colorectal surgery with and without active cardiac condi­tions. In physically fit patients, stress testing can be performed on a treadmill. For patients who are less fit, pharmaco­logic stress testing may be required. (See
Endoscopic vessels clipping Angiographic embolization
the section “Minimizing Risk Associated with Cardiac Disease” in this chapter). MET, Metabolic equivalent; two METs = walking up two flights of stairs. Good functional status is demonstrated by the ability to climb four flights of stairs (which equals four METs).
(PVD) also have signicant silent coronary vascular disease. Carotid stenosis may be asymptomatic, but it carries a risk of intra- or post­operative cerebrovascular accident. If carotid stenosis is suspected or indicated, including the presence of PVD, carotid Doppler scan­ning should be performed. Colorectal procedures can add cardiac stress through blood loss and prolonged reverse Trendelenburg positioning.
e categories of cardiac risk in noncardiac surgery can be divided into three groups, all of which predict negative outcomes: (1) le ventricular (LV) dysfunction; (2) myocardial ischemia; and (3) heart valve abnormalities.
Preoperative investigations are tailored to these categories. Examples of such investigations by category include serum brain natriuretic peptide, echocardiography and cardiac CT or magnetic resonance imaging (MRI) for LV dysfunction, an electrocardiogram, serum troponin and creatine kinase–myocardial bound for acute ischemia, exercise treadmill in the t patient or nuclear perfusion imaging, a dipyridamole, adenosine, or dobutamine stress test in the less t patient for chronic ischemia, and echocardiography, an elec­trocardiogram, and cardiac CT or MRI scanning to assess for valvular anomalies. Several guidelines are in place to determine the appro­priate preoperative test for cardiac risk assessment. Many guidelines are the result of collaborations between expert groups such as the European Societies of Cardiology and Anaesthesiology’s guide and the guidelines from the American College of Cardiology and the American Heart Association, who have worked together since 1980 to produce such recommendations.
A common feature of cardiac evaluation guidelines is deter­mination of functional capacity, usually in metabolic equivalents (METs). For example, one MET equals the basal metabolic rate at rest, climbing two ights of stairs is two METs, and walking two blocks is three METs. Inability to perform activities that require four METS (e.g., climbing four ights of stairs) predicts increased incidence of postoperative cardiac events. For patients with known cardiac comorbidities or poor functional capacity, stress echocar­diography using exercise or pharmacologic agents such as dobuta­mine or dipyridamole is performed. Coronary angiography should be performed if ischemia is suspected. Stress echocardiography has
ColoreCtal Surgery in the high-riSk Patient430
a high negative predictive value (90% to 100%), but the positive predictive value is relatively low (25% to 45%). us a positive test demands further evaluation. MRI can assess cardiac perfusion and wall motion and can assist in detecting ischemia. CT may be used as a noninvasive angiographic modality for the detection of coronary calcium reective of atherosclerosis.
e Goldman index and its modications, the Lee index and the Modied Multifactorial Index by Detsky etal, are commonly used to predict cardiac risk in patients undergoing noncardiac surgery. e Lee index is the most concise of the three indices and was developed by prospectively following up on more than 2800 patients undergo­ing a variety of procedures and validated with an additional 1400 patients. e independent determinants of perioperative cardiac events are listed later (Table 81-4). In the Lee index, each determinant is given one point. e risk of major cardiac complications according to the Lee index is as follows: 0 points = 0.4%, 1 point = 0.9%, 2 points = 7%, and 3 or more points =11%.
Perioperatively, cardiac medications should be continued, espe­cially β-blockers, both to avoid rebound tachycardia and to prevent the myocardial ischemic eects of catecholamines released during surgery. Eective pain control is similarly very important. Pulmo­nary artery catheter monitoring is usually reserved for patients of at least moderate risk. If used, it should be maintained through the postoperative period of uid mobilization—usually 48 to 72 hours aer surgery. 
TABLE 81-4: Indices of Cardiac Risk in Noncardiac
Surgery
Modified Multifactorial
Lee Index Goldman Index
Ischemic heart
MI within 6 mo MI within 6 mo
disease
Cerebrovascu-
lar disease
Congestive heart
failure
Heart failure >5 Premature ventric-
ular contractions
Index
Coronary artery disease
>5 Premature ventricular
contractions

MINIMIZING RISK ASSOCIATED WITH PULMONARY DISEASE

Generally, pulmonary disease is likely in patients who cannot climb two ights of stairs at a steady pace without dyspnea, patients with a smoking history, and patients with less than 70% of predicted values for timed forced expiration on pulmonary testing (Table 81-5). Such pre-existing pulmonary disease can lead to an increased risk of atel­ectasis during induction of general anesthesia, diculty in ventilator weaning, and postoperative pneumonia. Patients with more exten­sive resections and larger incisions whose ability to cough may be hindered by postoperative pain are particularly at risk of respiratory complications. In addition, carbon dioxide retention or an oxygen tension of less than 50 mm Hg on a room air blood gas value predicts postoperative ventilator dependency.
Pain control is a key to preventing shallow postoperative breath­ing, as is chest physiotherapy with incentive spirometry. In higher risk patients, epidural anesthesia with the patient in an awake state can be used for the surgery to avoid intubation and general anesthe­sia; this option, coupled with excellent postoperative pain control, facilitates pulmonary function and may even minimize some of the other adverse eects associated with the stress of surgery.
e Canet risk index has been developed to evaluate pulmonary and other prognostic indicators based on results from approximately 2500 patients. is index incorporates values for age, oxygen satura­tion taken by pulse oximetry, the presence of a respiratory infection in the month preceding the surgery, hemoglobin levels, urgent versus elective status of the procedure, and procedure length. A point score is assigned to each value, and risk can then be assessed as low, inter­mediate, or high based on this point score. Odds ratios (ORs) of the development of postoperative complications are highest in persons older than 80 years (OR = 5.1), with arterial oxygen saturation less than 90% on room air (OR = 10.7), recent respiratory infection (OR = 5.5), hemoglobin <10 g/dL (OR = 3), surgery of more than 3 hours’ duration (OR = 9.7), and emergency surgery (OR = 2.2).
In persons with known pulmonary disease, preoperative prepara­tion should include the culture of sputum with appropriate antibiotic treatment if necessary, the institution of bronchodilators if necessary, abstinence from smoking (ideally for at least 8 weeks), and incentive spirometry instruction. 
Insulin-
dependent diabetes mellitus
Impaired renal
Cardiac rhythm
other than sinus or premature atrial contraction
Age >70 yr Age >70 yr
Cardiac rhythm other
than sinus or premature atrial contraction
function
“High-risk”
surgery
Abdominal/thoracic
or aorta surgery
Pulmonary edema
Emergency surgery Emergency operation
Aortic stenosis Canadian Cardiovascular
Society angina class 3 or 4 or unstable angina within 3 mo
Poor metabolic con-
dition
Poor general medical
status
Valvular disease
Risk of an adverse cardiac event correlates with total score in each of these indi­ces. In the Lee index, each determinant is given 1 point. Estimated risk of major cardiac complications is: Lee index of 0 = 0.4%, 1 = 0.9%, 2 = 7%, ≥3 = 11%. MI, Myocardial infarction.
TABLE 81-5: Pulmonary Variables/Test Results with
Negative Prognostic Value
Variable/Test Negative Prognosticator
Preexisting pulmonary
disease
Smoking history Current smokers (prognosis is improved if
Chest radiograph Consolidation, pleural eusion, atelectasis
Pulse oximetry Sa
Pulmonary function
test
Hemoglobin <10 g/dL
ABG Pa
ABG, Arterial blood gas; COPD, chronic obstructive pulmonary disorder; FEV1, forced expiratory volume in the rst second of expiration; FVC, forced
vital capacity; Paco2, partial pressure of carbon dioxide, arterial; Sao2, arterial oxygen saturation.
COPD, asthma, brotic lung disease,
previous resection
smoking is ceased >8 wk preoperatively)
<90% on room air
2
<70% of predicted values for timed forced
expiration, FEV
>45 mm Hg on room air
2
/FVC ratio <65%
1
Oxygen tension <50 mm Hg on room air