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- •Foreword
- •Preface
- •Contents
- •Contributors
- •Future of TAMIS
- •Conclusion
- •References
- •1: Historical Perspectives and Rationale for Development
- •Introduction
- •From Miles Resection to Parks Excision
- •Transanal Endoscopic Microsurgery (TEM)
- •Transanal Minimally Invasive Surgery (TAMIS)
- •Introduction
- •Indications
- •Contraindications
- •Controversial Areas
- •Conclusion
- •References
- •3: An Algorithm for Local Excision for Early-Stage Rectal Cancer
- •Background
- •Techniques for Local Excision
- •Traditional Indications for Local Excision
- •Risk Factors for Failure of Local Excision of Early Rectal Cancer
- •Results of Local Excision of T1 Rectal Cancer
- •Local Excision of T2 Rectal Cancer
- •NCCN and National Guidelines
- •Patient-Related Factors
- •Technical and Surgeon-Related Factors
- •Salvage of Recurrence After Local Excision
- •An Algorithm
- •Conclusions
- •References
- •Introduction
- •Intervals After nCRT
- •Radiological Assessment
- •Transanal Full-Thickness Local Excisions (FTLEs)
- •Outcomes
- •References
- •Introduction
- •Summary
- •Conclusion
- •References
- •Introduction
- •Treatment Options
- •Local Excision
- •Neoadjuvant Therapy Followed by Local Excision
- •Palliative Radiotherapy
- •Radical Surgery
- •Conclusion: Tailoring Palliative Treatment
- •References
- •Introduction
- •History
- •History of Transanal Access Excluding Endoscopy
- •Flexible Sigmoidoscopy
- •Transanal Endoscopic Microsurgery
- •SILS, TAMIS, and the Glove Port
- •Transanal Access Platforms
- •Transanal Retractors
- •Operating Sigmoidoscopes
- •Lone Star Retractor
- •TAMIS
- •GelPOINT Path Transanal Access Platform
- •SILS
- •OCTO Port
- •Robotic-Assisted TAMIS
- •Transanal Instrumentation
- •Ordinary Laparoscopic Instruments
- •Suturing Devices
- •Diathermy
- •Energy Devices
- •The Gas Laws
- •Compliance
- •ISB and EPIX
- •Summary
- •References
- •8: Operating Theater Setup and Perioperative Considerations
- •Introduction
- •Equipment
- •Essential Equipment
- •Recommended
- •Operating Theater Setup
- •Perioperative Considerations
- •Patient Selection
- •TAMIS
- •Other Considerations
- •Postoperative Care
- •Conclusion
- •References
- •Introduction
- •Patient Selection
- •Operative Technique
- •Patients’ Eligibility for ELRR (Pyramidal Local Excision)
- •Basic Exclusion Criteria
- •Conclusions
- •References
- •10: Pyramidal Excision for Early Rectal Cancer and Special Closure Techniques
- •Nomenclature: Excision versus Resection
- •Rationale of Pyramidal Excision
- •Patient Selection
- •Index Staging (Pre-NT)
- •Neoadjuvant Therapy (NT)
- •Anesthesia
- •Pyramidal Excision or ELRR
- •Surgical Dissection
- •Posterior Lesions (Patient Supine)
- •Anteriol Lesions (Patient Prone)
- •Female
- •Male
- •Peritoneal Entry
- •Intraoperative Histological Assessment of the Cranial and Caudal Margins
- •Nucleotide-Guided Mesorectal Excision (NGME)
- •Suture Closure of the Defect
- •Important Tips
- •Conclusions
- •References
- •11: Closure Versus Non-closure After Local Excision
- •Introduction
- •References
- •Introduction
- •Intraoperative Complications
- •Peritoneal Entry
- •Intraoperative Hemorrhage
- •Short-Term Complications
- •Postoperative Hemorrhage
- •Subcutaneous Emphysema
- •Postoperative Pain
- •Fecal Incontinence
- •Long-Term Complications
- •Rectal Stricture
- •Rectovaginal Fistula
- •References
- •Introduction
- •Anorectal Function
- •Measuring Anorectal Function
- •Preoperative Evaluation
- •Physical Exam
- •Intraoperative Factors
- •Transanal Excision (TAE)
- •Transanal Endoscopic Microsurgery (TEM)
- •Fecal Incontinence Scores
- •Transanal Minimally Invasive Surgery (TAMIS)
- •Conclusions
- •References
- •Introduction
- •Recurrence After Local Excision
- •Summary
- •References
- •15: Applications Beyond Local Excision
- •Introduction
- •The TAMIS-Ileal Pouch-Anal Anastomosis (TaIPAA)
- •Pelvic Exenteration
- •Proctectomy
- •Rectal Prolapse
- •Parastomal Hernia
- •Retrorectal Masses
- •Robotic TAMIS
- •Managing Complications
- •Foreign Body Retrieval
- •Conclusions
- •References
- •Introduction
- •Initial Dry Laboratory Experiments
- •References
- •Introduction
- •Flex® Robotic System
- •Future Directions: da Vinci SP Surgical System
- •Future Directions: Pure NOTES Colorectal Surgery
- •Conclusions
- •References
- •Introduction
- •Oncologic Outcomes After Peritoneal Entry During TAMIS
- •Fecal Incontinence
- •Economics
- •Unusual Applications
- •References
- •19: Indications for Malignant Neoplasia of the Rectum
- •Operative Approach for TME
- •Abdominal TME
- •Transanal TME
- •Patient Selection
- •Tumor-Related Factors
- •Local Stage
- •Tumor Height
- •Patient-Related Factors
- •Obesity
- •Narrow Pelvis
- •Procedure-Related Factors
- •Following Local Excision with Transanal Endoscopic Surgery (TES)
- •Low/Ultra-Low Anterior Resection
- •Intersphincteric Dissection
- •Abdominoperineal Resection
- •Patient Counselling
- •Surgeon Training and Experience
- •Summary
- •References
- •Introduction
- •Technique
- •Preliminary Results
- •Surgical Approach
- •Results
- •Heading
- •Surgical Technique
- •Surgical Technique
- •Preliminary Results
- •Miscellaneous Procedures
- •Final Remarks
- •References
- •Introduction
- •Operating Theater Setup
- •Two-Team Coordination: Low Anterior Resection
- •Transanal Team: Transanal Proctectomy
- •Abdominal Team: Upper Rectal Mobilization
- •References
- •22: Single-Team taTME
- •Introduction
- •Considerations
- •Institution
- •Advocating for a Single-Team taTME Program
- •Securing Sustainable Funding
- •Patient Consent
- •Potential Complications
- •Training
- •Required Personnel
- •Surgeon
- •Specialized Assistant
- •Dedicated Nursing Team
- •Equipment
- •Equipment Setup for a Single Team
- •The Procedure
- •Where to Start
- •Transabdominal Approach
- •Transanal Approach
- •When to Transition to the Bottom
- •Roles and Assignments of the Dedicated Nurse and Surgical Assistant
- •Rendezvous: Meeting of the Planes
- •Top-to-Bottom Transfers
- •Extracting the Specimen and Creating the Anastomosis
- •Auditing Your Results
- •Conclusion
- •References
- •Introduction
- •Platform Options
- •Transanal Flexible Platforms (TAMIS Based)
- •Rigid Platforms
- •Semirigid Platforms (TEM/TAMIS Hybrid)
- •Conclusion
- •References
- •Introduction
- •Conclusion
- •References
- •25: Key Aspects of the Abdominal Dissection
- •Introduction
- •Positioning of taTME in Abdominal Maneuvers
- •Key Aspects for Performing TME from the Abdominal Side
- •Understanding the Perirectal Fascia Structure
- •Caution During the Dissection in the Neurovascular Bundle (NVB)
- •Key Aspects for Adequate Blood Flow Preservation in the Colon
- •Caution for the Abdominal Dissection Team in the Dual-Team taTME
- •Summary
- •References
- •Introduction
- •The Setup
- •Purse-String Principles
- •Common Pitfalls
- •Special Considerations
- •The Distal Purse-String
- •Preoperative Preparation
- •One Versus Two Teams
- •Abdominal Approach
- •Transanal Approach
- •Restorative Total Mesorectal Excision
- •Abdominoperineal Excision
- •Partial Mesorectal Excision
- •Critical Anatomic Landmarks
- •Specimen Extraction
- •Anastomosis
- •References
- •28: Strategies for Ultralow-Lying Rectal Cancer
- •Introduction
- •The Development of ISR for Rectal Cancer and a Farewell to the 2 cm Rule
- •Standard Educational Programs for taTME
- •General Technical Principles
- •taTME for Rullier Type I Tumors
- •taTME for Rullier Type II and III Tumors
- •Functional Outcomes
- •Oncologic Outcomes
- •Future Directions
- •References
- •Introduction
- •Conclusion
- •Suggested Reading
- •30: Urethral Injury: The New Challenge for taTME
- •Introduction
- •Incidence of Urethral Injury
- •Understanding the Anatomic Landmarks
- •Recognizing Patients at Risk
- •Intraoperative Prevention Strategies
- •Emerging Technologies
- •Conclusions
- •References
- •31: How to Avoid Urethral Injury in Males
- •Introduction
- •Assessment of Patient Risk for Injury
- •The Rectourethralis Muscle and the Pre-rectal Muscle Fibers of Luschka
- •Morphology of the Prostate Gland and Urethra
- •Anterior Exposure of the Puborectalis Muscle
- •Denonvilliers’ Fascia
- •The Neurovascular Bundle of Walsh
- •Surgeon Misperception and Visual Completion
- •Other Human Factors
- •Methods to Localize the Urethra
- •Urethral Injury Management
- •Related Injuries to the Urinary System
- •References
- •Introduction
- •Transanal Nerve-Sparing Mesorectal Dissection
- •Internal Anal Sphincter Nerves
- •Inferior Rectal Plexus
- •Neurovascular Bundles
- •Pelvic Splanchnic Nerves
- •Inferior Hypogastric Plexus
- •Hypogastric Nerve
- •References
- •Introduction
- •Operative Vectors
- •Gas Flow Mechanics
- •Cyclic Billowing
- •Anatomic Distortion
- •False Planes
- •References
- •Introduction
- •History
- •Nomenclature
- •Anatomy
- •Obtain Unimpeded Mesenteric Access
- •The Splenic Flexure
- •Future Directions
- •References
- •35: The Role for Perfusion Angiography
- •Fluorescence-Guided Surgery
- •Fluorophore Characteristics
- •Indocyanine Green (ICG)
- •Current Status of Perfusion Angiography in Colorectal Surgery
- •Clinical Outcomes in Colorectal Surgery
- •Changes in Management Decisions
- •Decision on the Use of Diverting Ileostomy
- •Ileo-Anal Pouch Assessment
- •Limitations
- •Current State of Data on PA to Reduce Anastomotic Leaks
- •Multifactorial Aetiology of AL
- •Targeted Fluorophores
- •Conclusions and Future Directions
- •References
- •36: Perioperative Preparation and Postoperative Care Considerations
- •Preoperative Assessment
- •History and Physical Examination
- •Preoperative Testing
- •Preoperative Stoma Marking
- •Sphincter Evaluation
- •Enhanced Recovery After Surgery (ERAS)
- •Preoperative
- •Intraoperative
- •Postoperative
- •Conclusion
- •References
- •Introduction
- •Full-Thickness Rectotomy
- •The Anastomosis
- •Other Complications
- •References
- •38: Functional Outcomes to Transanal Minimally Invasive Surgery (TAMIS) and Transanal Total Mesorectal Excision (taTME)
- •Anorectal Function and Assessment
- •Functional Outcomes: TAMIS
- •Functional Outcomes: taTME
- •References
- •39: Oncologic Outcomes
- •Grading of TME Specimen
- •Circumferential Resection Margin
- •Distal Resection Margin
- •Local Recurrence
- •Distant Metastasis
- •References
- •40: TaTME for Radical Exenteration
- •Introduction
- •Patient Indications
- •Anatomical Planning
- •Operative Approach
- •Platforms
- •Sphincter Preservation or En Bloc Perineal Resection
- •The Prostate, Seminal Vesicles, and Bladder
- •Female Patients and taTPE
- •Postoperative Considerations
- •References
- •Introduction
- •Anatomical Considerations
- •Operative Procedure
- •References
- •Introduction
- •Preoperative Planning
- •Operative Setup
- •Technique Description (Table 42.1)
- •taHR: Abdominal Aspects
- •taHR: Transanal Aspects
- •Results
- •Conclusion
- •References
- •43: Pure NOTES Transanal TME
- •Introduction
- •Rationale
- •Patient Selection
- •Surgical Technique
- •Armamentarium
- •Setup
- •Dissection
- •Step 1: Closing the Distal Stump of the Rectum Placing a Purse-String Suture
- •Step 2: Posterior Rectal Space Opening
- •Step 3: Cranial and Lateral Progression of the Dissection
- •Step 4: Extending the Perirectal Dissection Anteriorly
- •Step 6: Proceeding with the Dissection Toward the Root of the Mesorectum and the Retroperitoneal Abdominal Space
- •Step 7: Reaching the Root of the Inferior Mesenteric Vessels
- •Step 8: Dividing the Inferior Mesenteric Vessels and the Sigmoid Mesentery
- •Step 9: Construction of Low Colorectal or Coloanal Anastomosis
- •Postoperative Care
- •Discussion
- •Why Pure taTME?
- •Why TEO® Platform?
- •Why a Retroperitoneal Approach?
- •Is Mobilization of Splenic Flexure Necessary?
- •Teaching and Training
- •Conclusion
- •References
- •Introduction
- •Transanal Total Mesorectal Excision
- •Robotic Transanal Total Mesorectal Excision (Robotic taTME)
- •Surgical Technique
- •Clinical Outcomes
- •Future: New Robotics Platforms
- •References
- •Introduction
- •Flex® Robotic System
- •SPORT™ Surgical System
- •Da Vinci SP® Surgical System
- •References
- •Introduction
- •Mobile Apps
- •Video-in-Picture
- •Deferred Live Surgery
- •Conclusion
- •References
- •Introduction
- •Clinical Application
- •Conclusions
- •References
- •48: Current Controversies and Challenges in Transanal Total Mesorectal Excision (taTME)
- •Introduction
- •Comparison Between Open and Laparoscopic Approach
- •Comparison Between Laparoscopic and Robotic Approach
- •Comparison Between Laparoscopic and taTME Approach
- •Challenges
- •References
- •49: Transanal Total Mesorectal Excision: The Next 10 Years
- •What’s Best When and by Whom?
- •Educational Advances
- •Platform Advances
- •Instrumentation Advances
- •Visualization Advances
- •TaTME: A Killer Robot Application or Robot Killer?
- •Image-Guided Surgery

33 Operative Vectors, Anatomic Distortion, andtheInherent Eects ofInsuation
not subject to collapse as this can dramatically
limit the ability to continue with safe dissection.
Traditional insufators were designed to distend the relatively large volume of the peritoneal
cavity. Such insufation technology was actually
based on a quite rudimentary mechanical model.
In simple terms, the system delivers CO2 gas in a
pulsed fashion via a singular disposable insufation tubing. The laparoscopic insufator then
senses the pressure via sampling and delivers or
ceases to deliver gas in response to an arbitrary
set pressure. Thus, when the pressure in the insufated cavity falls to below the set level, gas is
actively pumped into the cavity until the designated pressure set point is reestablished. Minor
Fig. 33.4 The faceplate of the TAMIS port commonly
used for taTME is shown. One of the cannulas has been
replaced by an 8mm valveless trocar (AirSEAL®), which
maintains a pressure barrier seal pneumatically rather than
with the trapdoor design that typically smudges the lens
during camera lens entry. As can be seen, the trocar is
completely transparent along its long access
uctuations in pressure do not exhibit an appreciable effect on larger spaces such as the abdominal cavity and insufation through this modality
is quite reliable. However, minor uctuations in
pressure in a small operative eld can result in
collapse of the workspace– before the insufation system can respond to the change, thereby
resulting in noticeable loss of the operative eld
of view (since this eld is essentially created by
pneumatic distension which must remain stable).
Furthermore, the restricted view is also limited as
plumes of smoke often accumulate as there is
poor smoke dissipation, since the smoke is not
able to be distributed over the larger volume of
the peritoneal cavity.
Most insufators for laparoscopy have not
evolved since their inception, and have essentially remained unchanged in their technology
over the decades. Existing systems had worked
quite well for laparoscopy and given there had
not been any incentive to alter this technology it
remained perfectly well suited for most rudimentary laparoscopic procedures. However, the
increasing use of complex laparoscopy and especially robotics in MIS leads to renements that
would serendipitously benet transanal platforms
and especially TAMIS-based procedures.
Insufation system that had been developed to
improve clarity with abdominal (and especially
robotic) minimally invasive surgery emerged. In
particular, one system (AirSEAL® iFS) was
developed (originally by SurgiQuest and currently, ConMed, Inc.) with the objective of utiliz-
ing a valveless trocar system that would create an
invisible pressure barrier [20] so as to prevent
smudging of the camera’s lens with repeated trocar withdraws and reinsertions– a known problem with trapdoor style trocars (Fig.33.4). The
system also was designed to maintain stable
pneumatics and to address the problem of smoke
accumulation. Specically, by adapting a specialized, no-valve trocar to triple lumen insufation
tubing, (a) smoke evacuation, (b) pressure monitoring, and (c) CO2 delivery could be separately
managed. While these were considered important
advantages for advanced robotic and laparoscopic abdominal surgery [21, 22], it should be
underscored that the AirSEAL® system was not
designed for transanal surgery per se, nor was the
system designed to rectify the problem of cyclic
billowing with TAMIS. Instead, like TAMIS
itself, the advantage of AirSEAL® iFS for transanal access in resolving the issue of pelvic breathing and smoke accumulation was realized
completely by accident [23, 24].
Today, AirSEAL® iFS is the commonest insufation system preferred by experts for use in conjunction with the TAMIS platform for both local
excision and taTME to resolve the issue of cyclic
billowing, which is otherwise considered to be one
of the most signicant intraoperative limitations
based on European Registry data [25]. However,
AirSEAL® iFS may or not be available, and thus
other substitutes can be considered, including a
347

348
S. Atallah et al.
hand-fashioned apparatus, whereby a surgical
sterile glove is used as an interposition in the CO2
tubing [26], providing a reservoir that serves as a
proxy for operative space, thereby minimizing the
effect of billowing, but not necessarily smoke
accumulation. This makeshift solution is a useful
construct and represents an important low-cost
alternative to the valveless trocar system.
Furthermore, in 2018, the manufacturer of the
GelPOINT Path Transanal Access Platform
(Applied Medical, Inc.) began including a reservoir bag (at no additional cost) which reduces billowing in the same manner [27]. There are other
options that have recently become available,
including PneumoClear® Insufation (Stryker,
Inc. Kalamazoo, MI, USA) with TAMIS mode
that is designed to achieve a more stable pneumorectum and pneumopelvis than standard laparoscopic insufators.
The AirSEAL® iFS system is often incorrectly classied as a “high-ow” insufator. In
actuality, however, in AirSEAL Mode, the typical
rate of ow during taTME is quite low at 8L/
min, and pressure limits are set to ~8–12mmHg.
The system is designed to respond instantly to
pressure changes by increasing the rate of ow.
For example, if plumes of smoke or blood require
ancillary suctioning to clear the eld, the process
of suctioning will result in a quite sudden
decrease in the pressure which can threaten the
stability of the pneumatic distention essential in
maintaining the operative eld of view. To compensate for this, the AirSEAL® iFS system is
designed to increase ow to up to 40L/min transiently. This rapid, real-time response is one of
the important factors that allows for TAMIS and
taTME to be performed with a stable operative
view that has minimal billowing. Cyclic billowing is also greatly dampened (if not completely
eliminated) by the constant sampling of gas pressure by this system.
Even with AirSEAL® iFS and other advanced
platforms, during taTME at the point of peritoneal entry, there is potential for loss of the operative eld of view as pneumatic distention
diminishes when the taTME insufation pressure
“competes” with the abdominal insufation pressure. With the two-team approach, laparoscopic
access and insufation are present, and pressure
settings should always be slightly less for abdominal insufation relative to taTME insufation.
This is to maintain a positive down-to-up pres-
sure gradient, otherwise the actualized workspace will collapse. This is true even if there is
only one AirSEAL® iFS system in use, and a
traditional laparoscopic insufator is being used
to insufate the abdominal cavity. In such a setting, cyclic billowing can occur at the point of
peritoneal entry. In general, the peritoneal entry,
which is most commonly achieved along the
anterior reection (as this is the shortest distance
to the abdominal cavity) should be the last major
step in the taTME dissection. After this step, even
with correct pressure settings, a diminished operative view can often be observed.
Anatomic Distortion
With abdominal minimally invasive surgery
(MIS), whether laparoscopic or robotic, the
insufation applied does not substantially distort
the native viscera as the insufation is evenly distributed over a large area, and the only noticeable
distortion is the symmetrical doming of the anterior abdominal wall. However, during the transanal portion of taTME, anatomical distortion can
be quite pronounced. This occurs as the operative
insufation vector exerts an effect which aids in
establishing the taTME dissection plane but, at
the same time, creates gross anatomic distortion
as the mesorectal envelope and rectum proper
become mobilized (Fig. 33.5) [6]. Classically,
this produces a concavity of the mesorectal envelope and also a forward compression of the entire
rectum and mesentery that can sometimes render
the anatomy unrecognizable. During the posterior dissection, the mesenteric distortion creates a
central concavity with a ventral bend to the mesenteric envelope (Fig.33.6a, b). As the lateral and
anterior dissections are completed, the distortion
compresses the entire rectum and its mesentery
cephalad.
Because of the distortive effects imparted by
operative vectors, the mesentery does not
typically appear elliptical, and its completeness

33 Operative Vectors, Anatomic Distortion, andtheInherent Eects ofInsuation
Fig. 33.5 Gas ow for
taTME is delivered via
transanal access. This
insufation vector
matures planes naturally
and is considered a
fundamental component
of the operation, greatly
assisting with sharp
dissection and with
actualizing the
subperitoneal
workspace. However, as
the planes develop,
especially posteriorly,
the rectum and
mesentery exhibit a
characteristic gross
anatomic distortion, as
illustrated
349
Fig. 33.6 (a) The
posterior plane of
dissection during taTME
is shown with separation
between the angel hair
(cheveux d’ange) and
the mesenteric envelope
correctly established.
Clearly shown is a
concavity of the dorsal
mesentery which
represents gross
anatomic distortion that
occurs due to the
insufation vector
required during
taTME.On occasion,
such anatomic distortion
can challenge the
surgeon’s understanding
of the operative
anatomy, and this may
lead to wrong-plane
surgery. (b) An artist’s
rendition of anatomic
distortion illustrating the
classic concavity of the
mesorectal envelope
a
Anatomic distortion
Cheveux d’ange
b

350
S. Atallah et al.
cannot be assessed until the specimen is extracted.
This implies that the operator must instead rely
on the interpretation of the fusion planes and
must understand and appreciate the typical
appearance of anatomic distortion during the
transanal portion of the operation. This is one
reason that taTME dissection presents unfamiliar
anatomy to the novice surgeon and why signicant experience is required to gain prociency
with this challenging technique.
Triangles andHalos
As a result of pneumatic dissection, release along
natural anatomical planes of fusion is observed,
but occasionally there are tethering points which
are adherent and must be released through deliberate sharp dissection. As the tethered point tents
the fascia in the shape of a triangle, this is often
recognizable as such, and thus fascial plane “triangles” can be an important clue as to the location
of the correct plane. Such triangles occur in all
aspects of surgical dissection, particularly when
tissue is placed on stretch, and when a lead point
has not been released. Such phenomena are not
infrequently encountered during dissection with
laparoscopic and robotic colorectal surgery.
Thus, triangles from tethering of unreleased
points are not unique to taTME, but tend to be
quite pronounced with this operation in particular. When the point of tethering (usually the ventral tip of the triangle) is not recognized and the
dissection proceeds dorsal to this point, the fascia is violated, and it results in disruption of the
fascia plane. Because the pneumatic force is uniformly distributed at this point of violation, the
appearance of a linear fascial disruption will
take on the shape of a circle and has thus been
termed the “halo sign” [28]. Triangles and halos
are important signs in maintaining plane recognition during taTME.Due to the unique fascial
layering patterns, entry into false planes is quite
typical during the natural course of taTME dissection. Especially along the posterior dissection, it is critical that the triangle and halo
phenomena are recognized and appropriately
managed (Fig.33.7).
Tethering
point
creates
‘Triangle’
Insufflation vector
Fig. 33.7 Triangles and halos are pneumatic phenomena
observed during all minimally invasive surgery, but are
particularly important with taTME. As originally
described by Bernardi and colleagues, triangles are created when a tethering point of a fascial plane has not been
released by sharp dissection. Such a point must be recognized and dissected free, thereby releasing the adherent
fascia. This is of particular importance along the posterior
dissection where the endopelvic fascia tends to be adher-
Mesorectum with mesorectal fascia
Endopelvic fascia
Mesorectum with mesorectal fascia
Halo effect or “O” Sign
ent, and when the mesentery is projected anteriorly by the
insufation vector, the tethered plane “stands up” in the
shape of a triangle. If this or any fascial plane is violated
at a point other than its fusion point, a linear cut along the
fascia takes on the appearance of a halo or circle since the
pneumatic force evenly distributes tension. Triangles and
halos are important clues, and taTME surgeons must
remain vigilant, making plane adjustments accordingly

33 Operative Vectors, Anatomic Distortion, andtheInherent Eects ofInsuation
351
False Planes
The insufation vector of taTME affects the anterior dissection differently than it does to the posterior dissection, and this is one of the most
fundamental principles to understand that is quite
unique to this operative approach. For the anterior dissection, there is no appreciable difference
in the opening of fascial planes, and operative
progress is similar to the standard, up-to-down
approach. This is because there is no directional
layering of fascia anteriorly. In contradistinction,
during the posterior and lateral dissections, there
is a specic orientation to the extra-mesorectal
fascia, which layers in such a way that when the
dissection is carried out from below, fascial
planes are pneumatically opened, as they tend to
“stand up” during the taTME dissection
(Fig. 33.8). Thus, during the posterior and to
some degree the lateral dissection, the planes
beyond the mesenteric envelope are exposed as
dissection proceeds “against the grain” of fascial
layering. The most pronounced effect of this is
observed along (a) Waldeyer’s fascia, (b) the lateral fat pillars (Fig. 33.9), and (c) the inferior
hypogastric roots of S2 and S3 autonomic nerve
plexi (Fig.33.10).
Importantly, the tapered distal mesenteric
envelope can be dissected by airow jets causing
the mesentery itself, in some instances, to take on
an areolar appearance that can be confused for a
plane of dissection. However, this often leads to
one of the most common errors in taTME surgery,
namely, intramesorectal dissection and violation
of the mesenteric envelope with consequent oncologic compromise (when the operation is per-
Fig. 33.8 The transanal approach to taTME with the
applied insufation vector from the perineum tends to
“stand up” fascial planes that may lead a surgeon to enter
a plane that is too deep. Here shown is the standing up of
Waldeyer’s fascia. The correct plane is to proceed ventrally along the mesorectal envelop, but a more dorsal
plane deep to the endopelvic fascia is often incorrectly
selected. The standing up of planes is not typical of the
abdominal approach to TME and is a characteristic specic to taTME
Lateral fat pad
CO
dissection lateral to correct plane
2
Fig. 33.9 Between 6 and 8cm from the anal verge at the
3 and 9 o’clock position lie avascular fat pads that are
separate from the TME plane and do not follow its elliptical shape (curved arrow). Pneumatic dissection due to the
Correct TME plane
insufation vectors creates a misleading, areolar plane of
dissection that can incorrectly direct the surgeon to this
lateral plane, which often results in sacral bleeding

352
S. Atallah et al.
Fig. 33.10 Posterior taTME dissection is shown,
whereby dashed lines in green delineate the correct plane
of dissection, while a dashed red line overlies a lateral,
areolar area that is an incorrect plane. Between the correct
and incorrect plane lie the inferior hypogastric nerve roots
from the S2 and S3 tributaries. These nerve roots, denoted
Exposed rectal wall
Fig. 33.11 It is classically stated by RJ Heald that the
correct TME plane is the “innermost dissectable plane.”
However, insufation vectors can dissect the mesentery
itself, giving it the appearance of being correct. Here, the
posterior TME plane is being dissected. Note that the
by dashed purple lines, “stand up” in a vertical orientation, and they often take on the shape of a bow or shoe
strings. It is imperative that taTME surgeons recognize
these roots and are not drawn to more lateral areolar
planes which would result in signicant autonomic nerve
injury
‘Areolar’ mesentery
mesentery appears quite areolar and thus dissectable.
However, in fact, it is not and instead dissection of this
areolar mesentery has exposed the rectal muscle tube,
which is clearly visible in this video still frame
formed for cancer). The innermost dissectable
plane– as described by RJ Heald– can thus give
a false appearance of having yet a more inner dissectable plane as the mesenteric envelope presents an areolar appearance due to constant-pressure
pneumatics, delivered from the taTME vantage
point. In surgical practice, this error tends to occur
in the initial posterior dissection. It happens not
only because of the mesentery itself becomes
areolar (Fig.33.11), but because the mesenteric
envelope itself may have a steep posterior slope
along the sacrum requiring compulsory steep

33 Operative Vectors, Anatomic Distortion, andtheInherent Eects ofInsuation
353
angulation of the instruments during this portion
of the operation to accommodate the patient’s pelvic geometry [29].
CO2 Entrainment andEmbolization
CO2 embolization during laparoscopy can be
lethal [30, 31]. While most abdominal laparoscopic operations present at least some risk of
CO2 venous entrainment and subsequent air
embolization, this risk is generally nominal, and
the incidence of clinically relevant air embolization during such procedures is exceedingly rare
[32]. However, one of the rst small series to
report outcomes with taTME by Rouanet et al.
included CO2 embolism as a morbidity [33], and
although unreported in the initial registry data
series [34], it has now become apparent that this
risk may be moderately higher than with conventional laparoscopy and at the time of this writing
is actively being studied [35]. The most likely
mechanism for this is exogenous gas entrainment
into low-pressure venous vessels which may
become injured during the process of taTME dissection [6]. This may be further exacerbated by
the type of insufator being used and the insufator’s operational mode; however, this remains an
area of ongoing investigation.
When the pressure of the venous system is
less than the pneumatic pressure of insufation,
insufated CO2 gas enters into the venous system
where it can result in cardiovascular collapse as it
creates a right ventricular airlock. In the observed
events, the venous bleeding is not excessive and
tends to tamponade by the force of pneumatic
insufation. Because CO
when the pressure exceeds venous pressure, it is
strongly recommended that insufation pressure
be set to less than normal venous pressure and to
the lowest possible setting which allows for
maintenance of the visual eld – particularly
when constant ow systems such as AirSEAL®
iFS are employed. Furthermore, it should be
noted that venous pressure may be decreased by
steep Trendelenburg positioning while ow
increases by gravity and via respiration. These
are factors which can exacerbate the rate of CO2
gas entrainment into lacerated vessels.
entrainment results
2
Paroxysmal and otherwise unexplained alteration in end-tidal CO2 (ET-CO2) should immediately alert the taTME surgeon and anesthesiologist
to the possibility of air embolization. This sudden
change in ET-CO2 is usually the sentinel event
detected, heralding the onset of cardiovascular
compromise. In most instances, ET- CO2
decreases, but an increase in this parameter has
also been observed during air embolization.
Treatment of CO2 embolization requires rapid
intervention and mandates that surgeon and anesthetist work in concert to rectify the problem.
These steps include the immediate cessation of
CO2 gas delivery, ooding of the operative eld
with saline, or gauze soaked in saline to prevent
further gas entrainment, while controlling ongoing venous hemorrhage. Simultaneously, the
anesthetist should perform Durant’s maneuver –
that is, maintain moderate Trendelenburg (head
lower than level of feet) while placing the patient
in left lateral decubitus position (left-side rotation of the operating table); this is believed to
decrease or at least limit gas from traveling
through the right side of the heart into the pulmonary arterial tree where right ventricular outow
can become obstructed due to an air lock.
Furthermore, increasing positive end-expiratory
pressure (PEEP) can decrease the pressure gradient between the lacerated venous vessels and the
central cardiovascular system, thereby limiting
the potential of further gas entrainment [36, 37].
Investigation into understanding the process
of gas embolization during taTME remains an
area of active research. Alternative exogenous
gases, unfortunately, are not currently feasible
for use with taTME. For example, helium,
although essentially inert with no pharmacologic
effects and although noncombustible, is relatively insoluble in blood and more likely to result
in embolization [38], leaving exogenous CO
gas
2
as the only practical option at present.
CO2 Aerosolization ofBacteria
andTumor Cells
Among the pragmatic differences between
taTME and other sphincter-preserving, anterior
operations for extirpation of the rectum is that an

354
S. Atallah et al.
intentional rectal wall violation (rectotomy distal
to the purse string) is performed [6, 29, 39].
Theoretically, bacteria and even live exfoliated
tumor cells can shed [40–45], thereby seeding the
pelvis during taTME.This could be related to the
following factors: (a) poor mechanical bowel
preparation, or, in the case of invasive cancer,
observation of a friable tumor; (b) improper purse
string, or purse string/rectal wall violation during
taTME dissection; and (c) the aerosolization of
cells by the force of CO2 insufation during the
process of dissection. The theoretical implications are, in the immediate postoperative timeframe, pelvic sepsis and abscess formation can
ensue, and perhaps more importantly, in the long
term, an increased risk of local recurrence due to
tumor cell implantation may be observed. It
should be noted that the latter has not been realized by clinically available data, which, it should
be cautioned, only includes short- and midterm
follow-up.
Due to the complexity of metastasis, tumor
cell deposit volume, and the requirements to successfully implant a viable metastatic focus, it is
probable that even live exfoliated tumor cells that
seed the resection bed do not result in cancer
recurrence in most instances. In contradistinction, bacterial cells are easily able to thrive in the
abdominopelvic cavity and probably require a
lower inoculum to result in clinically relevant
infection. This is particularly true when the inoculum is a mixed ora of anaerobes and facultative
bacteria which exhibit a synergistic effect in sepsis [46, 47].
To minimize the risk of cell spillage, the purse
string should be tightly and securely fastened and
tested prior to rectotomy by insufation. Small
gaps and imperfections should be oversewn.
Prior to and after purse-string application, most
experts recommend antiseptic-tumoricidal irrigation [28]. Even meticulous care may not fully
prevent bacterial and (potentially) tumor cell
spillage into the operative space as it is developed, in part, by pneumatic dissection. In 2015
Velthuis etal. examined intra-abdominal contamination of bacteria during TAMIS-based taTME
[48]. In this study, 23 patients underwent the
operation with povidone iodine rinsing of the
rectal lumen before and after purse-string application and prior to commencing the transanal dissection. Next, during the course of taTME
dissection, cultures were obtained from the sterile, laparoscopic ports from the four quadrants of
the pelvis, and later the patients were followed
clinically. The data revealed that 39% had positive cultures for enteric microbes (e.g.,
Escherichia Coli). Furthermore, 17% of patients
had localized infections within the pelvis managed nonoperatively with systemic antibiotics
with or without percutaneous drainage. These
data suggest that despite irrigation, contamination of the sterile abdominopelvic cavity occurs
not infrequently during taTME and pneumatic
insufation with aerosolization of microbes may
be a contributing factor in some circumstances,
although the exact mechanism is not known. A
powerful tool in the assessment and safe implementation of taTME has been the registry data,
which at the time of this writing includes over
3000 cases which have been entered into the
European taTME Registry [49]. These data
extracted from this invaluable resource are
expected to greatly enrich our understanding of
this emerging operation in the coming years.
Acknowledgments The authors appreciate the invaluable assistance of Stephanie Philippaerts and the iLappSurgery Foundation in the development of the medical
illustrations contained in this chapter.
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