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- •Foreword
- •Preface
- •Contents
- •Contributors
- •Future of TAMIS
- •Conclusion
- •References
- •1: Historical Perspectives and Rationale for Development
- •Introduction
- •From Miles Resection to Parks Excision
- •Transanal Endoscopic Microsurgery (TEM)
- •Transanal Minimally Invasive Surgery (TAMIS)
- •Introduction
- •Indications
- •Contraindications
- •Controversial Areas
- •Conclusion
- •References
- •3: An Algorithm for Local Excision for Early-Stage Rectal Cancer
- •Background
- •Techniques for Local Excision
- •Traditional Indications for Local Excision
- •Risk Factors for Failure of Local Excision of Early Rectal Cancer
- •Results of Local Excision of T1 Rectal Cancer
- •Local Excision of T2 Rectal Cancer
- •NCCN and National Guidelines
- •Patient-Related Factors
- •Technical and Surgeon-Related Factors
- •Salvage of Recurrence After Local Excision
- •An Algorithm
- •Conclusions
- •References
- •Introduction
- •Intervals After nCRT
- •Radiological Assessment
- •Transanal Full-Thickness Local Excisions (FTLEs)
- •Outcomes
- •References
- •Introduction
- •Summary
- •Conclusion
- •References
- •Introduction
- •Treatment Options
- •Local Excision
- •Neoadjuvant Therapy Followed by Local Excision
- •Palliative Radiotherapy
- •Radical Surgery
- •Conclusion: Tailoring Palliative Treatment
- •References
- •Introduction
- •History
- •History of Transanal Access Excluding Endoscopy
- •Flexible Sigmoidoscopy
- •Transanal Endoscopic Microsurgery
- •SILS, TAMIS, and the Glove Port
- •Transanal Access Platforms
- •Transanal Retractors
- •Operating Sigmoidoscopes
- •Lone Star Retractor
- •TAMIS
- •GelPOINT Path Transanal Access Platform
- •SILS
- •OCTO Port
- •Robotic-Assisted TAMIS
- •Transanal Instrumentation
- •Ordinary Laparoscopic Instruments
- •Suturing Devices
- •Diathermy
- •Energy Devices
- •The Gas Laws
- •Compliance
- •ISB and EPIX
- •Summary
- •References
- •8: Operating Theater Setup and Perioperative Considerations
- •Introduction
- •Equipment
- •Essential Equipment
- •Recommended
- •Operating Theater Setup
- •Perioperative Considerations
- •Patient Selection
- •TAMIS
- •Other Considerations
- •Postoperative Care
- •Conclusion
- •References
- •Introduction
- •Patient Selection
- •Operative Technique
- •Patients’ Eligibility for ELRR (Pyramidal Local Excision)
- •Basic Exclusion Criteria
- •Conclusions
- •References
- •10: Pyramidal Excision for Early Rectal Cancer and Special Closure Techniques
- •Nomenclature: Excision versus Resection
- •Rationale of Pyramidal Excision
- •Patient Selection
- •Index Staging (Pre-NT)
- •Neoadjuvant Therapy (NT)
- •Anesthesia
- •Pyramidal Excision or ELRR
- •Surgical Dissection
- •Posterior Lesions (Patient Supine)
- •Anteriol Lesions (Patient Prone)
- •Female
- •Male
- •Peritoneal Entry
- •Intraoperative Histological Assessment of the Cranial and Caudal Margins
- •Nucleotide-Guided Mesorectal Excision (NGME)
- •Suture Closure of the Defect
- •Important Tips
- •Conclusions
- •References
- •11: Closure Versus Non-closure After Local Excision
- •Introduction
- •References
- •Introduction
- •Intraoperative Complications
- •Peritoneal Entry
- •Intraoperative Hemorrhage
- •Short-Term Complications
- •Postoperative Hemorrhage
- •Subcutaneous Emphysema
- •Postoperative Pain
- •Fecal Incontinence
- •Long-Term Complications
- •Rectal Stricture
- •Rectovaginal Fistula
- •References
- •Introduction
- •Anorectal Function
- •Measuring Anorectal Function
- •Preoperative Evaluation
- •Physical Exam
- •Intraoperative Factors
- •Transanal Excision (TAE)
- •Transanal Endoscopic Microsurgery (TEM)
- •Fecal Incontinence Scores
- •Transanal Minimally Invasive Surgery (TAMIS)
- •Conclusions
- •References
- •Introduction
- •Recurrence After Local Excision
- •Summary
- •References
- •15: Applications Beyond Local Excision
- •Introduction
- •The TAMIS-Ileal Pouch-Anal Anastomosis (TaIPAA)
- •Pelvic Exenteration
- •Proctectomy
- •Rectal Prolapse
- •Parastomal Hernia
- •Retrorectal Masses
- •Robotic TAMIS
- •Managing Complications
- •Foreign Body Retrieval
- •Conclusions
- •References
- •Introduction
- •Initial Dry Laboratory Experiments
- •References
- •Introduction
- •Flex® Robotic System
- •Future Directions: da Vinci SP Surgical System
- •Future Directions: Pure NOTES Colorectal Surgery
- •Conclusions
- •References
- •Introduction
- •Oncologic Outcomes After Peritoneal Entry During TAMIS
- •Fecal Incontinence
- •Economics
- •Unusual Applications
- •References
- •19: Indications for Malignant Neoplasia of the Rectum
- •Operative Approach for TME
- •Abdominal TME
- •Transanal TME
- •Patient Selection
- •Tumor-Related Factors
- •Local Stage
- •Tumor Height
- •Patient-Related Factors
- •Obesity
- •Narrow Pelvis
- •Procedure-Related Factors
- •Following Local Excision with Transanal Endoscopic Surgery (TES)
- •Low/Ultra-Low Anterior Resection
- •Intersphincteric Dissection
- •Abdominoperineal Resection
- •Patient Counselling
- •Surgeon Training and Experience
- •Summary
- •References
- •Introduction
- •Technique
- •Preliminary Results
- •Surgical Approach
- •Results
- •Heading
- •Surgical Technique
- •Surgical Technique
- •Preliminary Results
- •Miscellaneous Procedures
- •Final Remarks
- •References
- •Introduction
- •Operating Theater Setup
- •Two-Team Coordination: Low Anterior Resection
- •Transanal Team: Transanal Proctectomy
- •Abdominal Team: Upper Rectal Mobilization
- •References
- •22: Single-Team taTME
- •Introduction
- •Considerations
- •Institution
- •Advocating for a Single-Team taTME Program
- •Securing Sustainable Funding
- •Patient Consent
- •Potential Complications
- •Training
- •Required Personnel
- •Surgeon
- •Specialized Assistant
- •Dedicated Nursing Team
- •Equipment
- •Equipment Setup for a Single Team
- •The Procedure
- •Where to Start
- •Transabdominal Approach
- •Transanal Approach
- •When to Transition to the Bottom
- •Roles and Assignments of the Dedicated Nurse and Surgical Assistant
- •Rendezvous: Meeting of the Planes
- •Top-to-Bottom Transfers
- •Extracting the Specimen and Creating the Anastomosis
- •Auditing Your Results
- •Conclusion
- •References
- •Introduction
- •Platform Options
- •Transanal Flexible Platforms (TAMIS Based)
- •Rigid Platforms
- •Semirigid Platforms (TEM/TAMIS Hybrid)
- •Conclusion
- •References
- •Introduction
- •Conclusion
- •References
- •25: Key Aspects of the Abdominal Dissection
- •Introduction
- •Positioning of taTME in Abdominal Maneuvers
- •Key Aspects for Performing TME from the Abdominal Side
- •Understanding the Perirectal Fascia Structure
- •Caution During the Dissection in the Neurovascular Bundle (NVB)
- •Key Aspects for Adequate Blood Flow Preservation in the Colon
- •Caution for the Abdominal Dissection Team in the Dual-Team taTME
- •Summary
- •References
- •Introduction
- •The Setup
- •Purse-String Principles
- •Common Pitfalls
- •Special Considerations
- •The Distal Purse-String
- •Preoperative Preparation
- •One Versus Two Teams
- •Abdominal Approach
- •Transanal Approach
- •Restorative Total Mesorectal Excision
- •Abdominoperineal Excision
- •Partial Mesorectal Excision
- •Critical Anatomic Landmarks
- •Specimen Extraction
- •Anastomosis
- •References
- •28: Strategies for Ultralow-Lying Rectal Cancer
- •Introduction
- •The Development of ISR for Rectal Cancer and a Farewell to the 2 cm Rule
- •Standard Educational Programs for taTME
- •General Technical Principles
- •taTME for Rullier Type I Tumors
- •taTME for Rullier Type II and III Tumors
- •Functional Outcomes
- •Oncologic Outcomes
- •Future Directions
- •References
- •Introduction
- •Conclusion
- •Suggested Reading
- •30: Urethral Injury: The New Challenge for taTME
- •Introduction
- •Incidence of Urethral Injury
- •Understanding the Anatomic Landmarks
- •Recognizing Patients at Risk
- •Intraoperative Prevention Strategies
- •Emerging Technologies
- •Conclusions
- •References
- •31: How to Avoid Urethral Injury in Males
- •Introduction
- •Assessment of Patient Risk for Injury
- •The Rectourethralis Muscle and the Pre-rectal Muscle Fibers of Luschka
- •Morphology of the Prostate Gland and Urethra
- •Anterior Exposure of the Puborectalis Muscle
- •Denonvilliers’ Fascia
- •The Neurovascular Bundle of Walsh
- •Surgeon Misperception and Visual Completion
- •Other Human Factors
- •Methods to Localize the Urethra
- •Urethral Injury Management
- •Related Injuries to the Urinary System
- •References
- •Introduction
- •Transanal Nerve-Sparing Mesorectal Dissection
- •Internal Anal Sphincter Nerves
- •Inferior Rectal Plexus
- •Neurovascular Bundles
- •Pelvic Splanchnic Nerves
- •Inferior Hypogastric Plexus
- •Hypogastric Nerve
- •References
- •Introduction
- •Operative Vectors
- •Gas Flow Mechanics
- •Cyclic Billowing
- •Anatomic Distortion
- •False Planes
- •References
- •Introduction
- •History
- •Nomenclature
- •Anatomy
- •Obtain Unimpeded Mesenteric Access
- •The Splenic Flexure
- •Future Directions
- •References
- •35: The Role for Perfusion Angiography
- •Fluorescence-Guided Surgery
- •Fluorophore Characteristics
- •Indocyanine Green (ICG)
- •Current Status of Perfusion Angiography in Colorectal Surgery
- •Clinical Outcomes in Colorectal Surgery
- •Changes in Management Decisions
- •Decision on the Use of Diverting Ileostomy
- •Ileo-Anal Pouch Assessment
- •Limitations
- •Current State of Data on PA to Reduce Anastomotic Leaks
- •Multifactorial Aetiology of AL
- •Targeted Fluorophores
- •Conclusions and Future Directions
- •References
- •36: Perioperative Preparation and Postoperative Care Considerations
- •Preoperative Assessment
- •History and Physical Examination
- •Preoperative Testing
- •Preoperative Stoma Marking
- •Sphincter Evaluation
- •Enhanced Recovery After Surgery (ERAS)
- •Preoperative
- •Intraoperative
- •Postoperative
- •Conclusion
- •References
- •Introduction
- •Full-Thickness Rectotomy
- •The Anastomosis
- •Other Complications
- •References
- •38: Functional Outcomes to Transanal Minimally Invasive Surgery (TAMIS) and Transanal Total Mesorectal Excision (taTME)
- •Anorectal Function and Assessment
- •Functional Outcomes: TAMIS
- •Functional Outcomes: taTME
- •References
- •39: Oncologic Outcomes
- •Grading of TME Specimen
- •Circumferential Resection Margin
- •Distal Resection Margin
- •Local Recurrence
- •Distant Metastasis
- •References
- •40: TaTME for Radical Exenteration
- •Introduction
- •Patient Indications
- •Anatomical Planning
- •Operative Approach
- •Platforms
- •Sphincter Preservation or En Bloc Perineal Resection
- •The Prostate, Seminal Vesicles, and Bladder
- •Female Patients and taTPE
- •Postoperative Considerations
- •References
- •Introduction
- •Anatomical Considerations
- •Operative Procedure
- •References
- •Introduction
- •Preoperative Planning
- •Operative Setup
- •Technique Description (Table 42.1)
- •taHR: Abdominal Aspects
- •taHR: Transanal Aspects
- •Results
- •Conclusion
- •References
- •43: Pure NOTES Transanal TME
- •Introduction
- •Rationale
- •Patient Selection
- •Surgical Technique
- •Armamentarium
- •Setup
- •Dissection
- •Step 1: Closing the Distal Stump of the Rectum Placing a Purse-String Suture
- •Step 2: Posterior Rectal Space Opening
- •Step 3: Cranial and Lateral Progression of the Dissection
- •Step 4: Extending the Perirectal Dissection Anteriorly
- •Step 6: Proceeding with the Dissection Toward the Root of the Mesorectum and the Retroperitoneal Abdominal Space
- •Step 7: Reaching the Root of the Inferior Mesenteric Vessels
- •Step 8: Dividing the Inferior Mesenteric Vessels and the Sigmoid Mesentery
- •Step 9: Construction of Low Colorectal or Coloanal Anastomosis
- •Postoperative Care
- •Discussion
- •Why Pure taTME?
- •Why TEO® Platform?
- •Why a Retroperitoneal Approach?
- •Is Mobilization of Splenic Flexure Necessary?
- •Teaching and Training
- •Conclusion
- •References
- •Introduction
- •Transanal Total Mesorectal Excision
- •Robotic Transanal Total Mesorectal Excision (Robotic taTME)
- •Surgical Technique
- •Clinical Outcomes
- •Future: New Robotics Platforms
- •References
- •Introduction
- •Flex® Robotic System
- •SPORT™ Surgical System
- •Da Vinci SP® Surgical System
- •References
- •Introduction
- •Mobile Apps
- •Video-in-Picture
- •Deferred Live Surgery
- •Conclusion
- •References
- •Introduction
- •Clinical Application
- •Conclusions
- •References
- •48: Current Controversies and Challenges in Transanal Total Mesorectal Excision (taTME)
- •Introduction
- •Comparison Between Open and Laparoscopic Approach
- •Comparison Between Laparoscopic and Robotic Approach
- •Comparison Between Laparoscopic and taTME Approach
- •Challenges
- •References
- •49: Transanal Total Mesorectal Excision: The Next 10 Years
- •What’s Best When and by Whom?
- •Educational Advances
- •Platform Advances
- •Instrumentation Advances
- •Visualization Advances
- •TaTME: A Killer Robot Application or Robot Killer?
- •Image-Guided Surgery

116
D. Hahnloser
Recommendations andConclusions
The current literature suggests that there is no
difference in morbidity and functional outcome
between closure and non-closure of the rectal
defect after transanal excision. Furthermore, benets of closure remain unclear. However, no
study was specically designed to answer this
particular question. Therefore, the decision to
close rectal wall defects may be left to the surgeon’s preference and skills.
We recommend to close all large full- thickness
defects if possible. It might be sometimes necessary to further mobilize the rectal wall to allow a
tension-free closure. In large defects we start
suturing laterally on both sides joining in the middle. If the defect cannot be closed “watertight,”
we recommend to leave it open. Marsupialization
stitches of the rectal wall to the mesorectum are of
little use. Early endoscopy after 6–10 weeks
might be indicated to exclude or treat narrowing
of the lumen by balloon dilatation. Medium-sized
and small full-thickness defects as well as all partial-thickness excisions are left open as they will
granulate rapidly and be relined with neomucosa;
stricturing and stenosis are extremely rare. Results
from the ESD (endoscopic submucosal dissection) literature with comparable wounds to partial-thickness excisions demonstrate that stenosis
never occurred in cases with <90% circumferential extent of mucosal defect [18]. Because postTAMIS excision bleeding can occur when the
excision defect is left open, keeping the patient
in-house for observation is encouraged.
References
1. Hahnloser D, Cantero R, Salgado G, Dindo D, Rega
D, Delrio P. Transanal minimal invasive surgery for
rectal lesions: should the defect be closed? Color Dis.
2015;17(5):397–402.
2. Molina G, Bordeianou L, Shellito P, Sylla P.Transanal
endoscopic resection with peritoneal entry: a word of
caution. Surg Endosc. 2016;30(5):1816–25.
3. Rimonda R, Arezzo A, Arolfo S, Salvai A, Morino
M.TransAnal Minimally Invasive Surgery (TAMIS)
with SILS Port versus Transanal Endoscopic
Microsurgery (TEM): a comparative experimental
study. Surg Endosc. 2013;27:3762.
4. Restivo A, Zorcolo L, D'Alia G, Cocco F, Cossu A,
Scintu F, etal. Risk of complications and long-term
functional alterations after local excision of rectal tumors with transanal endoscopic microsurgery
(TEM). Int J Color Dis. 2016;31(2):257–66.
5. Bignell MB, Ramwell A, Evans JR, Dastur N, Simson
JN. Complications of transanal endoscopic microsurgery (TEMS): a prospective audit. Color Dis.
2010;12(7 Online):e99–103.
6. Atallah S, Albert M, Larach S.Transanal minimally
invasive surgery: a giant leap forward. Surg Endosc.
2010;24(9):2200–5.
7. Lorenz C, Nimmesgern T, Back M, Langwieler
TE.Transanal single port microsurgery (TSPM) as a
modied technique of transanal endoscopic microsurgery (TEM). Surg Innov. 2010;17(2):160–3.
8. Ragupathi M, Haas EM.Transanal endoscopic videoassisted excision: application of single-port access.
JSLS. 2011;15(1):53–8.
9. Lim SB, Seo SI, Lee JL, Kwak JY, Jang TY, Kim
CW, et al. Feasibility of transanal minimally invasive surgery for mid-rectal lesions. Surg Endosc.
2012;26(11):3127–32.
10. Perez RO, Habr-Gama A, Sao Juliao GP, Proscurshim
I, Scanavini Neto A, Gama-Rodrigues J. Transanal
endoscopic microsurgery for residual rectal cancer
after neoadjuvant chemoradiation therapy is associated with signicant immediate pain and hospital readmission rates. Dis Colon Rectum. 2011;54(5):545–51.
11. Ramirez JM, Aguilella V, Arribas D, Martinez
M. Transanal full-thickness excision of rectal
tumours: should the defect be sutured? A randomized
controlled trial. Color Dis. 2002;4(1):51–5.
12. Lee L, Althoff A, Edwards K, Albert MR, Atallah
SB, Hunter IA, et al. Outcomes of closed versus
open defects after local excision of rectal neoplasms:
a multi-institutional matched analysis. Dis Colon
Rectum. 2018;61(2):172–8.
13. Noura S, Ohue M, Miyoshi N, Yasui M.Signicance
of defect closure following transanal local fullthickness excision of rectal malignant tumors. Mol
Clin Oncol. 2016;5(4):449–54.
14. Brown C, Raval MJ, Phang PT, Karimuddin AA.The
surgical defect after transanal endoscopic microsurgery: open versus closed management. Surg Endosc.
2017;31(3):1078–82.
15. Menahem B, Alves A, Morello R, Lubrano
J. Should the rectal defect be closed following
transanal local excision of rectal tumors? A systematic review and meta-analysis. Tech Coloproctol.
2017;21(12):929–36.
16. Herman RM, Richter P, Walega P, Popiela T.Anorectal
sphincter function and rectal barostat study in patients
following transanal endoscopic microsurgery. Int J
Color Dis. 2001;16(6):370–6.
17. Valsdottir EB, Yarandi SS, Marks JH, Marks
GJ.Quality of life and fecal incontinence after transanal endoscopic microsurgery for benign and malignant rectal lesions. Surg Endosc. 2014;28(1):193–202.
18. Hayashi T, Kudo SE, Miyachi H, Sakurai T, Ishigaki
T, Yagawa Y, et al. Management and risk factor
of stenosis after endoscopic submucosal dissection for colorectal neoplasms. Gastrointest Endosc.
2017;86(2):358–69.

Operative andPerioperative
Outcomes
ElenaA.T.Vikis, Anne-MarieDufresne,
andGeorgeMelich
12
Introduction
Traditionally, rectal neoplasms that were not
resectable by colonoscopy required segmental
oncologic resection, either via abdominoperineal
or low anterior resection. These procedures come
with a high risk of operative and postoperative
complications that can result in signicant patient
morbidity as well as signicant perioperative
costs. Transanal minimally invasive surgery
(TAMIS) emerged in 2009 [1], as there was a
need for a more widely accessible (easier setup,
easier to learn, less expensive) approach to transanal endoscopic excision that was safe and equivalent to transanal endoscopic microsurgery
(TEM) for removal of rectal lesions [2]. TAMIS
is now a well-established technique for removal
of benign lesions and select early rectal cancers
(T1) not resectable by endoscopy. This chapter
describes the operative and perioperative outcomes associated with TAMIS, emphasizing the
technique and complications of this procedure.
E. A. T. Vikis (*)
Royal Columbian and Eagle Ridge Hospitals,
Department of Surgery,
New Westminster, BC, Canada
A.-M. Dufresne
Royal Columbian Hospital, Department of Colorectal
Surgery, New Westminster, BC, Canada
G. Melich
Royal Columbian Hospital, Department of Surgery,
New Westminster, BC, Canada
Intraoperative Complications
Peritoneal Entry
One of the complications of TAMIS is potential
abdominal entry, particularly for rectal lesions
located above the peritoneal reection [3–5]. In
the literature, peritoneal entry ranges from 10%
to 28% [4, 6, 7] and has been described in transanal endoscopic microsurgery (TEM) as an
expected event for high-risk lesions [8]. In the
authors’ (unpublished) experience, there were
nine cases of unplanned intraperitoneal entry out
of 230 (3.9%). Abdominal entry has been
described as primarily in woman of small body
habitus with low peritoneal reections and generally in anterior lesions above 10cm from the anal
verge. Our data suggests a relatively equal distribution of males and females (ve males and four
females) and generally anterior or lateral lesions
ranging from 8 to 12cm from the anal verge [5].
Options for repair include transanal repair via
the TAMIS platform, laparoscopy, or laparotomy.
Occasionally, large defects can even require segmental resection if the defect is not amenable to
simple local closure. Generally, the defect can be
closed via the TAMIS platform using laparoscopic
needle drivers and a 3-0 barbed self- locking absorbable suture. This requires a stable pneumoperitoneum and the conversion to general anesthesia if
the procedure is initiated under spinal anesthesia.
Though local repair is the ideal approach, if unable
© Springer Nature Switzerland AG 2019
S. Atallah (ed.), Transanal Minimally Invasive Surgery (TAMIS) and Transanal Total Mesorectal
Excision (taTME), https://doi.org/10.1007/978-3-030-11572-2_12
117

118
to maintain stable pneumorectum, consideration
can be given to laparoscopic transabdominal repair
either via direct closure of the defect or segmental
resection of the rectum. Generally, given the relative ease of adoption of TAMIS suturing techniques
for those who have mastered laparoscopy, closure
of the defect should be done routinely, so that in
more challenging closures such as peritoneal
breach, conversion to laparoscopy can be avoided.
Caycedo etal. [7] describe ve peritoneal violations in 50 cases (10%). All peritoneal violations were repaired using the TAMIS platform
and AirSeal® Insufation System (ConMed,
Inc., Utica, NY, USA). The authors of this article
recommended not operating on anterior lesions
suspected to be above the peritoneal reection if
the surgeon is not facile at laparoscopic suturing,
as they carry a high risk of peritoneal entry. Our
current data suggests an unplanned intraperitoneal entry rate of 3.9%, where repair was primary
performed by intracorporeal suturing via the
TAMIS platform (6 of 9 patients), while 2 patients
required conversion to laparoscopy to close the
defect and 1 necessitated a laparoscopic low
anterior resection, as the defect was too large to
close primarily. Subcostal needle catheterization
using a 14-gauge needle in the left upper abdomen at Palmer’s point was used to evacuate the
intra-abdominal CO2 and facilitate transanal
repair, with successful completion of the surgery
in 3 of the 6 patients who had repair transanally.
Interestingly, one patient who sustained a peritoneal violation went on to have two further TAMIS
procedures for recurring adenomas in the same
position (despite clear circumferential margins
on previous TAMIS excisions), and these two
further TAMIS local excisions were not complicated by peritoneal entry, likely secondary to
scarring from the initial procedure [5].
In a series (pending publication), the application of a transanal laparoscopic stapling device is
described that could circumvent this complication by simultaneously removing lesions while
closing the defect that are suspected to be above
the peritoneal reection [9]. This article examines TAMIS operations for local excision
whereby a laparoscopic stapler is used to dene,
remove, and seal the defect, all with full- thickness
E. A. T. Vikis et al.
Fig. 12.1 Intraoperative view of the rectal polyp being
stapled with a laparoscopic Echelon stapler
complete excisions of the rectal lesions (see
Figs.12.1, 12.2, and 12.3).
Diverting ileostomy has also been described
[10] but is generally not advised if no major fecal
contamination has occurred and primary repair is
successful.
Vaginal Entry andRectovaginal
Fistulae
Vaginal entry can occur for anterior lesions in
women. Inltrating the rectovaginal septum with
local anesthetic and digitizing the vagina during
dissection can help to dene the planes and prevent vaginal trauma. Keller etal. [10] describe an
electrocautery injury to the vaginal wall that
healed with conservative measures. Very early in
our own TAMIS experience, we described one
case of vaginal entry that occurred for removal of
an anteriorly located neuroendocrine tumor. This
was recognized intraoperatively and primarily
repaired but recurred within 30days with a clinically apparent rectovaginal stula. The approach
to wound care was irrigation with daily enemas
and broad-spectrum oral antibiotics to encourage
healing as per treatment of other traumatic rectovaginal injuries. The stula was deemed closed at
60days and has remained closed. Of course, if
rectovaginal stula occurs, other operative
techniques can be employed as described in the
section below on long-term complications.

12 Operative andPerioperative Outcomes
Fig. 12.2 End result of the closure of the rectal defect with a laparoscopic stapler
dissection (nb: care must be taken to assure the
gauze sponge does not “drift up” due to the active
pneumorectum, as this has been described by
TAMIS surgeons). Retrieval of this sponge after
suturing of the defect conrms an open lumen. In
addition, if there is any doubt, or the sponge was
not utilized, a patent lumen can be conrmed with
a rigid proctosigmoidoscope in the operating room
or by simply advancing the camera lens (used for
TAMIS) beyond the area of local excision.
119
Fig. 12.3 Flexible sigmoidoscopy 3months after a stapled TAMIS
Inadvertent Closure ofRectal Lumen
Closure of the rectal lumen is a potential risk in any
anorectal procedure, and, therefore, extreme vigilance is required when doing any signicant intervention after removal of the specimen in TAMIS,
particularly after removal of large or circumferential lesions. This has been described in stapled
hemorrhoidopexy [11] and could potentially be an
issue in TAMIS as well. A simple approach to identify the rectal lumen and keep it patent throughout
the procedure is to insert a small sponge into the
rectal lumen proximal to the lesion at the start of
Intraoperative Hemorrhage
Intraoperative bleeding is rare, as electrocautery
is usually sufcient for hemostasis. However, a
laparoscopic tissue sealer device or laparoscopic
clip applier via the TAMIS platform can always
be used, if necessary.
Short-Term Complications
Postoperative Hemorrhage
Generally, postoperative bleeding is uncommon
if hemostasis has been maintained throughout the
procedure. Nevertheless, it has been described in
up to 10% of patients, occasionally even requiring

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E. A. T. Vikis et al.
blood transfusion [5, 7, 12]. As our most common short-term complication, postoperative rectal bleeding occurred in 25 of 230 cases, with
only 5 requiring intervention (2.2%). Of the ve
patients who required blood transfusion, one was
taken back to the operating room the same operative day, while two others were treated endoscopically on postoperative days 16 and 17,
respectively. Successful cessation of bleeding
was achieved by hemostatic agent placement or
endoscopic clipping [5].
Closure of the defect has been thought to
inuence hemostasis. While numerous studies
demonstrate a trend toward a higher bleeding
incidence [12–16] leaving the defect open, none
show statistical signicance. Regardless, an
attempt to close all defects could potentially
inuence clinically signicant bleeding and is a
mandatory technique to master in cases of potential peritoneal breach. Since TAMIS is a novel
procedure, utilizing existing techniques for
hemostasis postoperatively in other anorectal
procedures, such as hemorrhoidectomy, can be
useful. Rosen et al. [17] treated posthemorrhoidectomy bleeding using hemostatic
agent (Gelfoam) packing at the site of the defect.
In TAMIS, in addition to suturing, placement of a
hemostatic agent, such as Surgicel or Gelfoam,
can be considered.
Urinary Retention andInfection
lesions, and 13 had not been taking prophylactic
perioperative tamsulosin, which has now been
introduced at our center as part of a routine protocol. A clinical trial in progress TEMPOUR [19]
addresses the use of perioperative tamsulosin in
TEM, which is hypothesized to decrease the incidence of urinary retention, and this data may be
translatable to TAMIS practices for local excision of rectal neoplasia. This could be a simple
and cost-effective approach to minimizing this
complication.
Subcutaneous Emphysema
Subcutaneous emphysema has been described
previously in TAMIS [4] and is generally an
uneventful complication in similar transanal procedures [20]. However, it can lead to intraoperative hypercapnia [21] and is occasionally an
indication of peritoneal breach. If ventilatory difculty is encountered secondary to hypercarbia,
decreasing the rectal insufation pressure, completing the procedure quickly, and potentially
delaying extubation can all be utilized [22]. At
our center, the overall rate of subcutaneous
emphysema for n=230 was 0.4%. Generally, this
is a self-limited complication and is managed
conservatively. Rarely, patients can become
symptomatic and may even develop free air on
plain radiographs [5].
Urinary retention is a frequent postoperative
complication of anorectal procedures and certainly can occur after TAMIS.Generally, urinary
catheter insertion is not required for a short operation with no hospital stay. When utilized, catheters increase the risk of urinary retention and
infection. In TAMIS, it has been suggested that
circumferential lesions predispose patients to urinary retention [7] and replacement of the Foley
catheter for urinary retention has been shown to
increase the incidence of urinary tract infection
[18]. Urinary retention is reported to occur from
2% to 19% of patients after TAMIS [7, 12, 18].
Our data suggest a rate of 7% with 13 men and 2
women, having clinically signicant urinary
retention. Of these 15 patients, 8 had anterior
Postoperative Pain
For most patients, pain is minimal after TAMIS.It
is a concern mostly for lesions below or near the
dentate line. A common practice with other anorectal procedures is to prescribe metronidazole to
patients to reduce postoperative pain. A metaanalysis in 2018 [23] demonstrated that both topical and oral metronidazole were effective in
managing postoperative pain after hemorrhoidectomy. Given its anti-inammatory effects and
proven safety in other anorectal procedures, metronidazole can be prescribed for a total of 5–7days
as an efcient and cost-effective treatment for
post-TAMIS pain, particularly for patients who
have undergone ultra-low-lying excisions [24].

12 Operative andPerioperative Outcomes
121
Fecal Incontinence
The equipment for TAMIS includes an access
channel that is placed into the anal canal for the
duration of the procedure. This sustained anal
dilatation could potentially be a concern for continence after the surgery. A descriptive, prospective study was published in 2015 studying the
impact of an anal port on anorectal function during TEM/TEO procedures [25]. The baseline and
the voluntary contraction pressures were
decreased at 1 and 4 months after the surgery.
However, there was no correlation with clinical
incontinence. The TEM/TEO instrumentation is
rigid at 40mm in diameter, compared to 30mm
for the exible TAMIS port [26], suggesting that
there would be less inuence on continence with
the TAMIS procedure.
Schiphorst and Clermonts [27, 28] examined
long-term functional outcomes post TAMIS, and,
ultimately, there was no clinically signicant
impact on continence. Schiphorst’s study measured functional results after TAMIS.While 51%
of the patients had normal continence prior to the
surgery, 17% (3/18) of those had worse continence
after TAMIS.Interestingly, in the remaining 49%
of patients with previously impaired continence,
continence was seen to improve in 88% of patients,
likely secondary to removal of the inciting lesion
causing poor preoperative anorectal function and
symptomology consistent with outlet obstructive
defecation due to the mass effect of the lesion prior
to excision. In conclusion, short-term functional
results are good, with the majority of patients preserving their continence.
Long-Term Complications
strictures can be treated with endoscopic dilatation or Hegar dilators as outpatients, particularly
for low-lying strictures [29].
Rectovaginal Fistula
The distal two thirds of the rectum anteriorly lie
in close proximity to the posterior vaginal wall.
The identication of the vagina, as well as the
rectovaginal septum, is essential when operating
on an anterior rectal lesion transanally. Any
trauma to these structures can potentially result
in a rectovaginal stula. Keller [10] described
one case of rectovaginal stula (1.3%) in TAMIS
secondary to electrocautery injury. It was managed conservatively, as previously described in
the section on vaginal entry.
A surgical approach may be required if conservative management fails. Transanal or transvaginal operations are options for local repair.
Depending on the location of the defect, consideration could be given to transanal repair with
endorectal advancement ap, which can be created using the TAMIS platform [5]. Generally,
endorectal advancement aps are effective in
about 50% of patients with previously normal
sphincter function [29]. At our center, six patients
have undergone successful endorectal advancement ap repair of rectovaginal stulae via
TAMIS.Other local repairs would include endovaginal advancement ap, brin glue, mesh interposition, or sphincteroplasty. Complex cases that
fail local repair may require more aggressive
options, such as a pedicled muscular ap
interpostion, low anterior resection, or, very
rarely, abdominoperineal resection.
Rectal Stricture
Rectal strictures have been described in 1–3% of
patients after TAMIS [5, 7, 10, 18]. Generally
they are managed with serial dilations either via
rigid proctoscopy or endoscopy. These were seen
after large, circumferential adenomas and recurrent rectal lesions. Failed endoscopic dilation has
been reported, however, and salvage with TAMIS
re-excision of the rectal stenosis has been successfully utilized [18]. Nevertheless, most rectal
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Functional Outcomes After Local
Excision forRectal Neoplasia
ElizabethR.Raskin
13
Introduction
The transanal approach can be a viable surgical
option for most benign and select malignant rectal neoplasms. The decision to proceed with
transanal surgery is typically based upon the size
of a lesion, its location within the anorectal canal,
and its particular pathologic characteristics.
Advances in technology, such as the advent of
transanal endoscopic microsurgery (TEM) and
transanal minimally invasive surgery (TAMIS),
have allowed for improved optics and access
within the anorectum, translating into superior
surgical margins and enhanced oncologic outcomes [1, 2]. While a large focus has been
placed on the safety, feasibility, and oncologic
soundness of transanal techniques compared to
traditional proctectomy, functional outcomes
following transanal surgery have received much
less attention.
Postoperative anorectal functional outcomes
can be summarized as gas and stool continence,
fecal frequency/urgency, and quality of life following surgery. Multiple factors play a role in
postoperative function, such as preoperative
baseline function, tumor characteristics, surgical
technique, and the extent of resection.
E. R. Raskin (*)
Loma Linda University, Loma Linda, CA, USA
VA Hospital Loma Linda, Department of Surgery,
Loma Linda, CA, USA
Preoperative measurement, both with qualitative
and quantitative tools, is critical to establishing a
baseline from which to assess the effect of transanal surgery on function. This chapter aims to
dene anorectal function, elucidate preoperative
and intraoperative factors that contribute to functional outcomes, and compare postoperative outcomes after traditional transanal (TA) surgery,
transanal endoscopic microsurgery (TEM), and
transanal minimally invasive surgery (TAMIS).
Anorectal Function
Normal anorectal continence involves complex
contributions from the pelvic and perineal musculature, rectal compliance and capacity, as well
as neuronal pathways which potentiate various
reexes.
Anatomy ofAnorectal Continence
The pelvic oor– or levator ani, perineal body,
and the internal and external anal sphincter muscles– comprises the muscular framework for the
continence mechanism. Parasympathetic innervation of the pelvic oor arises from S4, while
S1–S3 and S2–S4 innervate the internal and
external sphincter, respectively. These branches
of the pelvic plexus help coordinate activity of
both the striated and smooth muscle of the pelvis
© Springer Nature Switzerland AG 2019
S. Atallah (ed.), Transanal Minimally Invasive Surgery (TAMIS) and Transanal Total Mesorectal
Excision (taTME), https://doi.org/10.1007/978-3-030-11572-2_13
123

124
E. R. Raskin
and perineum, although it is unclear in the exact
manner they behave. Unquestionably, excitatory
activity is elicited from sympathetic innervation
from the hypogastric and pelvic plexus.
Anal canal sensation originates from the
inferior rectal branch of the pudendal nerve,
which arises from S2 to S4, and helps to discriminate between gas and liquid/solid stool. In
contrast, the rectum senses only distention; it
also receives innervation from S2 to S4. The
perception of atus is attributed to receptors in
the walls of the rectum and the fascia of the pelvis. Surgical trauma to either the mucosa of
the anal canal or the wall of the rectum can
distort the ability to differentiate stool consistency and lead to incontinence and/or urgency.
In addition, postoperative inflammation can
lead to hyper-acute sensation, precipitating
poor accommodation and subsequent fecal
frequency.
Compliance andCapacity
Rectal compliance and capacity refer to the distensibility of the walls and the volume of the rectal reservoir, which directly impact continence.
Compliance can be altered in the early postoperative period by inammation and edema and, in
the later postoperative phase, by brosis.
Similarly, prior radiotherapy can negatively
impact the reservoir function, resulting in fecal
urgency, frequency, and stool fragmentation.
Anorectal Reexes
The rectoanal inhibitory reex (RAIR) describes
the relaxation of the IAS upon distention of the
rectum, and it allows for the sampling process
within the anal canal. This enables stool and/or gas
to make contact with receptors within the walls of
the anal canal to signal the nature of the substance
above in the rectal vault. While this reex can be
lost following low anterior resection, it typically
remains intact following transanal surgery, as it is
contingent upon intrinsic innervation.
The rectoanal excitatory reflex (RAER)
denotes the contraction of the EAS upon rectal
distention, which manifests as an anorectal
squeeze. Unlike the RAIR, this reflex is determined by S2–S4 innervation and can be disrupted by injury to the pudendal nerve endings.
Continence can be disrupted if the RAER is
either blunted or abolished secondary to
pudendal nerve block or surgical trauma.
Specifically, the external anal sphincter is
largely responsible for maintaining continence
with increases in intraabdominal pressure,
such as during coughing, sneezing, or heavy
lifting [3].
Measuring Anorectal Function
Functional assessment tools such as the Fecal
Incontinence Severity Index (FISI) and the Fecal
Incontinence Quality of Life (FIQL) scale have
been utilized to quantify the magnitude of incontinence and the impact it has on patients’ lives
[4, 5].
The FISI, a severity rating score for fecal
incontinence (FI), assesses the types of leakage
experienced by those with FI (gas, mucus, liquid,
or solid) and the frequency of the occurrences of
incontinence [4]. This validated score has been
shown to be a useful measure of anorectal function, with good concordance between patient and
surgeon assessment of the condition.
On the other hand, the FIQL scale is a tool for
specically measuring the impact of FI on the
quality of life (QOL) [5]. There are 29 items
addressed in 4 general categories: (1) lifestyle, (2) coping/behavior, (3) depression/selfperception, and (4) embarrassment. Given the
reliability of this score, it has become a standard
instrument in subsequent studies for qualifying
QOL after interventions [6, 7].
Multiple other incontinence scores exist, such
as the Pescatori score, the Wexner Continence
Scale, and the American Medical Systems score.
These grading systems evaluate the type of incontinence experienced, the frequency, severity, and
impact of incontinence on lifestyle [8].

13 Functional Outcomes After Local Excision forRectal Neoplasia
125
Preoperative Evaluation
A thorough preoperative evaluation should be
performed to understand a patient’s baseline
function and to anticipate the potential risks for
postoperative anorectal disturbance. Direct questions regarding continence are warranted to
understand preoperative status. If FI is described,
validated questionnaires, as described above, can
be helpful for accurate assessment and documentation. In addition to prior anorectal and/or pelvic
surgery, a history of pelvic malignancy, obstetrical injury, or pelvic radiation therapy should be
elicited.
Physical Exam
Visual inspection of the anal and perineal areas can
reveal scarring from prior treatment, trauma, or surgery. In women, the width of the perineum should
be noted, as a thin perineal body may be associated
with prior injury and a weakened sphincter mechanism. Anal canal resting tone and squeeze, as well
as moderate to large sphincter defects, can be subjectively assessed on digital exam. Intact sensation
of the perianal skin and anus can be tested with a
cotton swab or electrical stimulation.
Imaging andFunctional Assessment
Technology
Endoanal ultrasonography and magnetic resonance imaging (MRI) can provide anatomic
detail such as sphincter width and integrity. These
modalities are useful for classication of sphincter defects, noting level, depth, and size within
the anal canal [9]. Interestingly, there is no direct
correlation between the presence of a sphincter
injury and incontinence. In a study of 1495
women with prior third- or fourth-degree obstetrical tears who underwent endoanal ultrasonography, no signicant difference was noted in
continence scores between those with residual
sphincter defects and those with normal sphincters [10] (Fig.13.1).
Anorectal manometry and rectal barostat measurements can give more objective functional
data in the form of anal resting pressure, anal
squeeze pressure, rectal wall compliance, and
rectal perception [11] (Figs.13.2 and 13.3).
Fig. 13.1 Endoanal
ultrasound
demonstrating anterior
internal and external
sphincter injury. (Photo
credit: Dr. Yan Zhao)
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