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138
Fig. 16.3 Algorithm for anal ssure
J. Zhang and H. M. Ross
lar, and patients present with severe, unre­mitting pain. These cavitating ulcers can be highly associated with concomitant proctitis.
B. The majority of ssures will heal with con-
servative management. Medical treatments are recommended rst-line therapy. Available topical treatments include topical nitrates and calcium channel blockers. Topical nitrates have been shown in the general population to produce healing rates superior to placebo. Insufcient data is available on healing rates with topical calcium channel blockers, though they tend to produce fewer adverse effects than nitrates. Topical treatments may produce symptom improvement, although some authors suggest that alone they may not ade­quately induce healing, though others have
found these to be successful in a majority of patients.
C. Botulinum toxin injection is another alter-
ative available with healing rates superior to placebo. There are no uniform guidelines on dosage or location of injection. Dilation of the sphincter should be avoided as this can lead to suboptimal healing from uncontrolled trauma to diseased anal mucosa.
D. Surgical treatment can be effective in well-
selected patients with Crohn’s disease with anal ssures refractory to medical manage­ment. Lateral internal sphincterotomy (LIS) has been shown to produce high rates of heal­ing of ssures in patients without active lumi­nal disease; open and closed techniques yield similar results. Traditionally, LIS is performed to the level of the dentate. Other approaches
16 Anorectal Crohn’s Disease: Anal Stenosis andAnal Fissure
139
involve tailoring to the characteristics of the ssure. Smaller wounds that minimize dam­age to the mucosa and external sphincter are benecial in this population where wound healing tends to be problematic.
E. Fissurectomy may be needed if edges of the
ssure are brotic, as these are not likely to heal on their own. However, there are compli­cations associated with operative manage­ment, even in well-selected patients. In their review of 41 patients with CD and anal s­sure, Sileri etal. found 14 failed conservative management and required either Botox with or without ssurectomy or LIS.Eight of those 14 patients had complications including non­healing wound, recurrence, and one trans­sphincteric stula. In a retrospective study by Fleshner etal., 8 of 46 patients with anorectal Crohn’s ssure were managed surgically: three had LIS, two had ssurectomy, and three underwent both sphincterotomy and s­surectomy. At short-term evaluation, seven patients had a healed ssure and the one with no ssure healing underwent LIS. After a median follow-up of 92months, one patient developed an abscess arising from the base of the non-healed ssure and two required proc­tectomy primarily because of persistent ano­rectal sepsis originating from the site of the ssure.
F. The tradition of avoiding surgery for anal
ssures in CD still holds. As with luminal disease, it is reasonable to intervene on perianal manifestations as complications dictate. Caution should be used when pur­suing surgical treatment of ssures in CD as there is a real risk of poor healing and the development of abscess or incontinence postoperatively. Concurrent proctitis must be ruled out and invasive procedures avoided if present, and sphincter preserva­tion is critical. Systemic therapy with inf­liximab has been shown to produce and maintain complete clinical response of perianal CD. This effect is seen in both supercial ssures and cavitating ulcers.
Despite the risk of complications, surgical intervention should not be avoided all together as up to 20–25% of ssures man­aged with medical therapy alone will prog­ress to stula or abscess.

Suggested Reading

Alexander-Williams J, Buchmann P.Perianal Crohn’s dis-
ease. World J Surg. 1980;4:203–8.
Bouguen G, Siproudhis L, Bretagne JF, Bigard MA,
Peyrin-Biroulet L. Nonstulizing perianal Crohn’s disease: clinical features, epidemiology, and treat­ment. Inamm Bowel Dis. 2010;16:1431–42.
D’Ugo S, Franceschilli L, Cadeddu F, Leccesi L, Del
Vecchio Blanco G, Calabrese E, et al. Medical and surgical treatment of haemorrhoids and anal s­sure in Crohn’s disease: a critical appraisal. BMC Gastroenterol. 2013;13:47.
Fleshner PR, Schoetz DJ, Roberts PL, Murray JJ, Coller
JA, Veidenheimer MC. Anal ssure in Crohn’s dis­ease: a plea for aggressive management. Dis Colon Rectum. 1995;38(11):1137–43.
Herzig DO, Lu KC. Anal ssure. Surg Clin N Am.
2010;90:33–44.
Kashkooli SB, Samanta S, Rouhani M, Akbarzadeh
S, Saibil F. Bougie dilators: Simple, safe and cost­effective treatment for Crohn’s-related brotic anal strictures. Can J Surg. 2015;58(5):347–8.
Lee SW, Niec R, Melnitchouk N, Samdani T.Transanal
anorectal stricturoplasty using the Heineke­Mikulicz principle: a novel technique. Color Dis. 2016;18:101–5.
Lewis RT, Maron DJ. Anorectal Crohn’s disease. Surg
Clin N Am. 2010;90:83–97.
Linares L, Moreira LF, Andrews H, Allan RN, Alexander-
Williams J, Keighley MRB.Natural history and treat­ment of anorectal strictures complicating Crohn’s disease. Br J Surg. 1988;75:653–5.
Paine E, Shen B. Endoscopic therapy in inam-
matory bowel diseases. Gastrointest Endosc. 2013;78(6):819–35.
Perry WB, Dykes SL, Buie D, Rafferty JF.Practice param-
eters for the management of anal ssures (3 Dis Colon Rectum. 2010;53:1110–5.
Pikarsky AJ, Gervaz P, Wexner SD. Perianal Crohn
disease: a new scoring system to evaluate and pre­dict outcome of surgical intervention. Arch Surg. 2002;137(7):774–7; discussion 778.
Singh VV, Dragaov P, Valentine J.Efcacy and safety of
endoscopic balloon dilation of symptomatic upper and lower gastrointestinal Crohn’s disease strictures. J Clin Gastroenterol. 2005;39:284–90.
rd
revision).
Management ofInternal Hemorrhoids
AllisonWeaver andScottR.Steele
17
Refer to Algorithm inFig. 17.1
A. Initial evaluation of hemorrhoids should
focus on observation of the perianal area and eliminating more serious etiologies. Many patients will present with painless, bright-red rectal bleeding, and occasionally with pro­lapsing tissue. Colonoscopy or exible sig­moidoscopy is appropriate especially in older patients, to exclude malignant causes even if hemorrhoids are visualized. If bleeding is sig­nicant, performing a CBC may be necessary to allow for identication and treatment of blood-loss anemia. Further assessment of the hemorrhoids with digital exam, anoscopy, and fecal occult blood test will provide more information on size, uctuance, and overall sphincter tone. If the patient is asymptomatic, no further evaluation or treatment is neces­sary although lifestyle modications may be recommended to prevent progression.
B. Grading of internal hemorrhoids is based on
the protrusion of the hemorrhoid through the anal sphincter. Grade I describes hemorrhoids that may bleed, but do not prolapse. Grade II
A. Weaver Case Western Reserve School of Medicine, Cleveland, OH, USA
S. R. Steele (*) Department ofColorectal Surgery, Cleveland Clinic, Cleveland, OH, USA
prolapse with defecation but immediately retract. Grade III prolapse and require manual reduction. Grade IV prolapse and are not able to be manually reduced. Both grade III and IV may become acutely strangulated if blood ow is compromised. Treatment of internal hemorrhoids grades I–III traditionally fol­lows a least-to-most invasive approach, beginning with lifestyle modications and progressing stepwise to surgery if earlier interventions fail to improve symptoms. Grade IV or any acutely strangulated hemor­rhoid generally requires semi-urgent or emer­gent hemorrhoidectomy.
C. Lifestyle modication is the rst-line treatment
of low grade hemorrhoids and in conjunction with surgery for grade IV. Alterations should focus on diet and bowel habits that can cause constipation or hardening of stool, as these problems are associated with hemorrhoid devel­opment and exacerbation. Fiber is inexpensive and effective and can be added into the diet or taken as a supplement. Increasing ber intake is one of the easiest alterations to make and has shown to reduce symptoms and may prevent the need for subsequent surgery. It is important to also drink sufcient quantities of water/uids with the ber to avoid paradoxical constipation. Straining and increased time spent on the toilet are also behaviours that are contributory and should be discouraged. Warm water baths may also alleviate symptoms and, because of the low
© Springer Nature Switzerland AG 2020 S. R. Steele etal. (eds.), Clinical Decision Making in Colorectal Surgery,
https://doi.org/10.1007/978-3-319-65942-8_17
141
142
A. Weaver and S. R. Steele
Fig. 17.1 Algorithm for evaluation and management of internal hemorrhoids. H & P history and physical examination, THD/HAL transanal hemorrhoidal dearterialization/hemorrhoidal artery ligation
cost and ease of availability, can be recom­mended. Counseling patients and encouraging these changes will resolve or manage the symp­toms in many individuals and may avoid further escalation of treatment.
D. Medications to manage internal hemorrhoids
are generally oral or topical preparations that provide mainly symptomatic relief. Phlebotonics such as oral avonoids and cal­cium dobesilate are venotonics that increase venous tone and lymphatic drainage and decrease capillary permeability, but it is not entirely clear how these characteristics aid in hemorrhoidal treatment. Nevertheless, phlebo­tonics have been shown to aid in symptomatic improvement, including bleeding, persistent pain, itching, and recurrence. However, the body of evidence supporting their use is some­what limited and methodologically question­able, necessitating further study to substantiate their effects. Most creams currently on the market have been poorly studied and therefore their clinical efcacy is largely unknown. Preparation H
®
(Pzer, Kings Mountain, NC)
and similar popular creams are available in dif­ferent formulations that generally have some vasoactive properties, but the overall mecha­nism of treatment or symptomatic relief, if present, is unknown. Topical steroids are often used and denitely have a role in symptomatic relief. Their long- term use is limited and has the usual atrophic effects, although they can be extremely useful in situations where invasive procedures are best avoided such as pregnancy. Isosorbide dinitrate is effective in decreasing internal anal sphincter tone, but there is limited evidence for its use in treating most hemor­rhoids outside of acutely strangulated internal hemorrhoids. Overall, medications may offer symptomatic relief that can prevent or delay the need for more invasive procedures.
E. Ofce procedures should be offered as non-
operative management for all hemorrhoids refractive to more conservative treatment and even grade III hemorrhoids that aren’t acutely strangulated. The major issues in hemorrhoidal treatment are recurrence and signicant peri­anal pain and the purpose of non-operative pro-
17 Management ofInternal Hemorrhoids
143
cedures is to try to minimize pain while maximizing outcomes. The most common and effective procedure is rubber- band ligation. The procedure is performed by placing rubber bands around the hemorrhoid pedicle, cutting off the blood supply causing the hemorrhoid to slough resulting brosis that helps to prevent future hemorrhoidal prolapses. Bands should be placed well above the dentate line to avoid pain from the sensory-rich anoderm. Studies have shown it to have outcomes at least equivocal to surgical hemorrhoidectomy, with slightly higher rates of post-procedure bleeding recur­rences but less pain and similar overall satisfac­tion. There is also the very small chance of Fournier’s gangrene with banding. Gangrene may be heralded by increasing pain, drainage, fevers, and an inability to void. Other tech­niques, including sclerotherapy, cryotherapy, and infrared coagulation, employ different modalities to achieve similar results. Sclerotherapy involves injections of sclerosing agents such as sodium tetradecyl, into the sub­mucosa beneath the hemorrhoid. It is quick and inexpensive, but is associated with a higher rate of recurrent symptoms. Cryotherapy requires expensive equipment, has a high rate of recur­rence, and can cause a foul-smelling dis­charge—it is therefore no longer used. Only infrared coagulation has shown results compa­rable to rubber band ligation, with reduced post­operative pain and only minimally inferior outcomes, and is a viable alternative. In general, it requires multiple applications and is not used as commonly any more. New techniques using lasers and radiofrequency ablation offer evolv­ing technologies and more treatment options. Overall, non-operative techniques are associ­ated with reduced morbidity and are all prefer­able to surgery choices.
F. Operative management options for grades I,
II, and III hemorrhoids consist of three main procedures: excisional hemorrhoidectomy, stapled hemorrhoidopexy, and hemorrhoid artery ligation. Surgery can be indicated for grade III or IV hemorrhoids, relapse or con­tinuation of symptoms following a non­operative procedure, or acute strangulation. Excisional hemorrhoidectomy can be per­formed with a variety of techniques and tools
that remove the hemorrhoid. It is associated with greater morbidity than non-operative procedures like banding but is superior at controlling hemorrhoidal symptoms. Stapled hemorrhoidopexy uses a circular stapler to remove and staple a section of rectal mucosa approximately 4 cm above the dentate line. This maneuver elevates and xes the hemor­rhoid, preventing prolapse. Stapled hemor­rhoidopexy has been to shown to offer comparable control of hemorrhoid symp­toms, although these results are somewhat controversial. Studies have shown it to have decreased post-operative pain and recovery time but more severe, though not more fre­quent, complications. Long-term outcomes are similar between these two techniques, though recurrence is higher with the stapled procedure. Hemorrhoid artery ligation can be performed with or without Doppler guidance to ligate the hemorrhoidal arteries and cut off the blood supply to the hemorrhoid. Results have been found to be comparable to rubber­band ligation and stapled hemorrhoidopexy. Patients undergoing any of these procedures benet from post-operative pain control with traditional NSAIDs or opiates, although opi­ates may cause worsening symptoms by decreasing bowel motility. Small trials have evaluated new drugs that may be of benet, including diltiazem and liposome bupiva­caine, but there is not substantial evidence supporting their use. Overall, operative man­agement of internal hemorrhoids should focus on improving symptoms while mini­mizing complications.

Suggested Reading

Alonso-Coello P, Mills E, Heels-Ansdell D, et al. Fiber
for the treatment of hemorrhoids complications: a sys­tematic review and met-analysis. Am J Gastroenterol. 2006;101:181–8.
Alonso-Coello P, Zhou Q, Martinez-Zapata MJ, et al.
Meta-analysis of avonoids for the treatment of haem­orrhoids. Br J Surg. 2006;93:909.
Aytac E, Gorgun E, Erem HH, et al. Long-term out-
comes after circular stapled hemorrhoidopexy ver­sus Ferguson hemorrhoidectomy. Tech Coloproctol. 2015;19(10):653–8.
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Bat L, Pines A, Rabau M, Niv Y, Shemesh E.Colonoscopic
ndings in patients with hemorrhoids, rectal bleeding and normal rectoscopy. Isr J Med Sci. 1985;21(2):139–41.
Briel JW, Zimmerman DD, Schouten WR. Treatment
of acute strangulated internal hemorrhoids by topi­cal application of isosorbide dinitrate ointment. Int J Color Dis. 2000;15(4):253–4.
Brown SR, Tiernan JP, Watson AJM, etal. Haemorrhoidal
artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicen­tre, open-label, randomised controlled trial. Lancet. 2016;388:356–64.
Chung CC, Cheung HY, Chan ES, et al. Stapled hem-
orrhoidopexy vs. Harmonic Scalpel hemorrhoid­ectomy: a randomized trial. Dis Colon Rectum. 2005;48(6):1213–9.
Gagloo MA, Hijaz SW, Nasir SA, Reyaz A, Bakshi IH,
Chowdary NA, et al. Comparative study of hemor­rhoidectomy and rubber band ligation in treatment of second and third degree Hemorrhoids in Kashmir. Indian J Surgery. 2013;75(5):356–60.
Gargh P, Singh P. Adequate dietary ber supplement
along with TONE concept can help avoid surgery in most patients with advanced hemorrhoids. Minerva Gastroenterol Dietol. 2017;63(2):92–6.
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tion in early stage hemorrhoids. Braz J Med Biol Res. 2003;36(10):1433–9.
Haas E, Onel E, Miller H, et al. A double-blind,
randomized, active-controlled study for post­hemorrhoidectomy pain management with liposome bupivacaine, a novel local analgesic formulation. Am Surg. 2012;78(5):574–81.
Infantino A, Altomare DF, Bottini C, et al. Prospective
randomized multicentre study comparing stapler haemorrhoidopexy with Doppler-guided transanal haemorrhoid dearterialization for third-degree haem­orrhoids. Color Dis. 2012;14:205–11.
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2014;371:944–51.
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in hemorrhoid patients and normal subjects. Am J Gastroenterol. 2005;100:401–6.
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rhoids and chronic constipation. An epidemiologic study. Gastroenterology. 1990;98:380–6.
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Anal Conditions: External Hemorrhoids

MichaelSigman andDanaHayden
18

Introduction

Hemorrhoids are a commonly encountered, but often poorly understood clinical entity, both by patients and physicians. They have been reported to affect around 10million Americans per year with a prevalence of 4.4%, making them one of the most common conditions treated by health­care providers. External hemorrhoids are a venous plexus that encircles the anal verge and drain via the inferior rectal veins into the puden­dal vessels. They are covered by anoderm and contain pain bers. Communication exists between the internal and external hemorrhoid plexuses and enlargement of internal hemor­rhoids will predispose to external hemorrhoidal engorgement.
Refer to Algorithm in Fig.18.1
A/C. External hemorrhoids are most commonly
encountered incidentally or when evaluat­ing internal hemorrhoids, but they can be independently symptomatic. They may
M. Sigman Department of General Surgery, Loyola University Medical Center, Maywood, IL, USA
D. Hayden (*) Division of Colon and Rectal Surgery, Rush University Medical Center, Chicago, IL, USA
cause dull pain when they engorge or severe pain if acutely thrombosed. Large external skin tags or external hemorrhoids can affect hygiene or cause feelings of rec­tal pressure and discomfort with sitting or with sexual intercourse. Pruritus ani and perianal irritation from aggressive wiping may also be symptoms associated with external hemorrhoids. Patients are often bothered just by their presence and aes­thetic appearance. Finally skin tags without any hemorrhoidal component may form from resolved engorged or thrombosed external hemorrhoids or after exacerbation of external hemorrhoids following vaginal delivery which can also cause the above symptoms.
B. Acute thrombosis of external hemorrhoids
is typically self-limited. Thrombosed external hemorrhoids present with acute edema, ecchymosis, and signicant pain. They may be precipitated by diarrhea or constipation or signicant straining that causes trauma to the anal canal and/or venous stasis. A patient may report a mass or “marble” palpated externally with wip­ing or in the shower that is extremely ten­der to touch. The usual time course follows a sudden swelling after straining followed by severe pain over the rst 3 days. Bleeding can occur if the overlying ano­derm ulcerates. If left alone, the pain from
© Springer Nature Switzerland AG 2020 S. R. Steele etal. (eds.), Clinical Decision Making in Colorectal Surgery,
https://doi.org/10.1007/978-3-319-65942-8_18
145
146
Fig. 18.1 Algorithm for presentation of external hemorrhoids
M. Sigman and D. Hayden
most acutely thrombosed external hemor­rhoids will completely resolve over the course of 5–7days from onset. Others may resolve with conservative management; only a minority of patients will require sur­gical intervention.
D. If bleeding is one of the symptoms, timing
and type of bleeding is important to dis­cern. If the patient reports clots or dark blood spontaneously, not just with defeca­tion, this could be due to thrombosed exter­nal hemorrhoids. If bright red bleeding occurring with defecation is reported, this is more likely related to internal hemor­rhoids or another anorectal disorder. If there is no acute pain, anoscopy and then colonoscopy likely should be performed.
Refer to Algorithm in Fig.18.2
A. The history and physical examination are
the two most important elements in the clin­ical decision-making involved in the treat­ment of external hemorrhoids. Internal hemorrhoidal bleeding typically occurs after bowel movements and is painless, where as that of external hemorrhoids can be inde­pendent of bowel habits and associated with the pain of thrombosis or ulceration. The physician should ask about bowel habits,
straining with defecation, heavy lifting related to activity or occupation, recent childbirth, changes in medications, diet, or lifestyle, past treatment of hemorrhoids and the history or personal or family history of colorectal cancer or Crohn’s disease. It is key to dene how their symptoms impact the patient’s quality of life (QoL). External hemorrhoids may affect activities like exer­cise, sexual intercourse, even sitting at work. Body image is also commonly affected by external hemorrhoids or skin tags.
B. When undertaking a physical examination,
inspection of the perianal skin is critical. Examination may reveal external skin tags only, external hemorrhoids or internal pro­lapsing hemorrhoids. It is critical to evalu­ate for other conditions including anal cancer, condylomata, perianal excoriations or ssures. Acute thrombosis reveals an edematous lump at the anal verge caused by the clot. Often the blue-purple discolor­ation will conrm the diagnosis (Fig.18.3). The mass may feel like a marble and be tender. If tolerable, digital examination of the anal canal and distal rectum should be performed.
C/D. Anoscopy is a useful adjunct and is per-
formed unless acute thrombosis or anal pain is present. Assessing the internal hem­orrhoids as well as identifying any other
18 Anal Conditions: External Hemorrhoids
Fig. 18.2 Algorithm for evaluation of external hemorrhoids
Fig. 18.3 Acute thrombosis reveals an edematous lump
at the anal verge caused by the clot. Often the blue-purple discoloration will conrm the diagnosis
anorectal abnormalities is important for treatment decisions. If the patient reports rectal bleeding, during defecation or spon­taneously, colonoscopy should likely be performed following resolution of the acute symptoms. Thrombosed external hemorrhoids may become ulcerated or necrotic resulting in bleeding. Most exter­nal hemorrhoids do not bleed and other eti­ologies for the bleeding should be assessed with colonoscopy.
147

Refer to Algorithm in Fig. 18.4

A. Treatment of acutely thrombosed hemor-
rhoids largely depends of symptoms, exam and time course. The pain and edema of acute thrombosis have been shown to peak at 48 h and subside after 4–7 days. If the patient presents within 72hours, we still try a course of conservative management with hydrocortisone, analgesia, warm baths and stool softeners/laxatives. If the patient can­not tolerate this approach or examination reveals extremely enlarged, necrotic hemor­rhoids, surgical intervention should be pur­sued. Early excision of thrombosed external hemorrhoids was found to be associated with signicant reduction in time to pain relief and recurrence compared with con­servative management. Excision is gener­ally well tolerated with the use of local anesthesia only. We perform this using lido­caine with epinephrine delivered via a small needle. We prefer to make an elliptical inci­sion over the thrombosed hemorrhoid with removal of the thrombus. Bleeding is gener­ally not a concern because the hemorrhoidal vessel is occluded with thrombus. If the thrombosis is extensive, intervention should be performed in the operating room. Excisional hemorrhoidectomy can be per­formed, with care not to excise too much
148
Fig. 18.4 Algorithm of treatment for external hemorrhoids
M. Sigman and D. Hayden
anoderm. Excision of the thrombosis is less invasive however is associated with higher recurrence. Excisional hemorrhoidectomy is more difcult in the acute setting due to the edema and excessive clots affecting the planes of the excision, but recurrence rate is very low. In our experience, excision of thrombosed external hemorrhoid is prefer­able to simple incision and extrusion of the thrombus in order to avoid recurrence. A minimum of 1 cm of normal anoderm should be left between columns to ensure the risk of anal stenosis is minimized, as well as avoidance of aggressive perianal skin resection in the acute edematous phase. The incision may be closed or left open to heal by secondary intention. Sitz baths, analgesics, and ber supplements are pre­scribed in the initial post-procedure period.
In a patient who presents with acute thrombosis without necrosis, improving pain and symptom duration >72h, conser­vative therapy should be utilized. This con­sists of warm baths, leg elevation and decreased activity, stool softeners or laxa­tives, avoidance of straining and heavy lift­ing and analgesics. The majority of patients
will improve with this approach even in the setting of extensive thrombosis.
B/C. If the patient has chronic external hemor-
rhoids or external skin tags without acute symptoms, conservative management is the mainstay of treatment. This approach involves improved bowel regimen in order to reduce straining, stool bulking to help improve completion of bowel movements since residual stool can signicantly con­tribute to difcult hygiene and anal itch. A “hands-off” approach is also important in order to avoid over-wiping, use of toilet paper or wet wipes that can cause perianal irritation. If the patient has large hemor­rhoidal components to the external skin tags, then a short course of hydrocortisone cream while improving bowel habits may be helpful. Stopping overuse of steroid creams, suppositories and topicals may also improve symptoms.
D. If the patient reports signicant impact on
QoL due to the external hemorrhoids, other etiologies of their symptoms have been excluded and conservative measures have not improved symptoms, then surgical excision can be considered. There is no role