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- •Preface
- •Contents
- •Contributors
- •Endovascular Aneurysm Repair
- •Clinical Applications
- •Aortic Procedures Planning
- •Performance Assessment
- •Future Prospects
- •References
- •References
- •Introduction
- •Medical Error
- •Traditional Training
- •Animal Simulation Labs
- •Virtual Reality Simulation
- •3: Radiation Safety
- •Introduction
- •Basic Radiation Physics Units
- •Personnel Dose Limits
- •Pregnant Personnel
- •References
- •4: Tools of the Trade
- •Needles, Catheters, and Wires
- •Vascular Access
- •Double Wall
- •Single Wall
- •Advantages/Disadvantages
- •Nonvascular Needles (Table 4.1)
- •Guidewires
- •Curved
- •Straight/Angled
- •Stiffness
- •Flexibility
- •Coating
- •Torqueability
- •Opacity
- •Catheters
- •Flush Catheters
- •Visceral Catheters
- •Multipurpose Catheters
- •Cerebral Catheters
- •Guiding Catheters
- •Microcatheters
- •Vascular Sheaths
- •Vessel Dilators
- •Accessories
- •Embolic Agents
- •Temporary Agents
- •Permanent Agents
- •Pushable Coils
- •Detachable Coils
- •Coiling Techniques (Fig. 4.48)
- •Vascular Plugs
- •Particulates
- •Liquid Embolics
- •Fogarty Balloons
- •Angioplasty Balloons
- •Drug-Coated Balloons
- •Vascular Stents
- •Balloon Expandable Stents
- •Self-Expandable Stents
- •Specialty Stents
- •References
- •Consults
- •Pre-procedure Evaluation
- •Consent
- •Code Status
- •Laboratory Testing
- •Antibiotic Prophylaxis
- •Anticoagulation
- •Antihypertensives
- •Contrast Allergy Prophylaxis
- •Procedure Plan
- •Post-procedure Management
- •Hospital Admission
- •Discharge
- •Follow-up Visits
- •IR Clinic
- •Conclusion
- •References
- •6: The IR Road Map: Vascular Anatomy Overview
- •Introduction
- •Imaging Modalities
- •Ultrasound
- •Computed Tomography
- •Magnetic Resonance Imaging
- •Cross-Sectional Anatomy
- •Chest
- •Segmental Lung Anatomy
- •Mediastinum
- •Pulmonary Arteries
- •Pulmonary Veins
- •Bronchial Arteries
- •Liver
- •Arterial Access
- •Double-Wall Technique
- •Common Femoral Artery Access
- •Kidneys
- •Ureters
- •Bladder
- •Uterus
- •References
- •Alternative Arterial Access Sites
- •Venous Access
- •Manual Compression
- •Closure Devices
- •Compression Devices
- •Topical Agents
- •Invasive Devices
- •References
- •9: Central Venous Access
- •Pathophysiology
- •Non-tunneled Central Catheters (NTCCs)
- •Tunneled Central Catheters (TCCs)
- •Implantable Ports
- •Peripherally Inserted Central Catheters (PICCs)
- •Clinical Indication
- •Conventional Therapy
- •Non-tunneled Central Catheters
- •Tunneled Central Catheters
- •Ports
- •PICCs
- •Interventional Therapy
- •Ports
- •PICCs
- •Pre-procedural Prep
- •History
- •Physical Exam
- •Imaging
- •Complex Venous Access
- •Post-procedural Management
- •Complications
- •Acute Complications
- •Long-Term Complications
- •Device Removal
- •Tunneled Catheter Removal
- •Port Removal
- •References
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •11: IVC Filters
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •IVC Filter Placement
- •VTE Prevention
- •Preprocedural Preparation
- •Complication
- •Access Site
- •Device-Related
- •Postprocedural Management
- •IVC Filter Retrieval
- •Advanced IVC Filter Retrieval Techniques
- •Conclusion
- •References
- •Pathophysiology
- •Arteriovenous Fistula
- •Arteriovenous Graft
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •AVG Angioplasty
- •AVF Angioplasty
- •References
- •13: Pelvic Congestion Syndrome
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •References
- •14: Varicocele
- •Pathophysiology
- •Conventional Therapy
- •Interventional Therapy
- •References
- •15: Varicose Veins
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •16: Vascular Malformations
- •Pathophysiology
- •Hemangiomas
- •Vascular Malformations
- •Arteriovenous Malformations (High Flow)
- •Venous Malformations (Low Flow)
- •Lymphatic Malformations
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •High-Flow AVMs
- •Low-Flow Venous Malformations
- •Klippel-Trenaunay Syndrome
- •Lymphatic Malformations
- •References
- •Pathophysiology
- •Abdominal Aortic Aneurysm (AAA)
- •Thoracic Aortic Aneurysm (TAA)
- •Clinical Indication
- •Abdominal Aortic Aneurysm
- •Thoracic Aortic Aneurysm
- •Conventional Therapy
- •Abdominal Aortic Aneurysm
- •Thoracic Aortic Aneurysm
- •Interventional Therapy
- •Abdominal Aortic Aneurysm
- •Thoracic Aortic Aneurysm
- •Common Complications
- •Access
- •Contrast Nephropathy
- •Spinal Cord Ischemia
- •Postoperative Monitoring
- •References
- •18: Aortic Dissection
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Preprocedure Work-Up
- •Post-procedural Management
- •References
- •19: Endoleak
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Type II Endoleaks
- •Type III Endoleaks
- •Type IV Endoleaks
- •Type V Endoleaks
- •References
- •20: Traumatic Aortic Injury
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Pre-procedural Prep
- •Pre-procedural Imaging
- •Post-procedural Management
- •Post-procedural Imaging
- •References
- •21: Bronchial Artery Embolization
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Outcomes
- •References
- •Pathophysiology
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •Clinical Indication
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •Conventional Therapy
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •Interventional Therapy
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •References
- •23: Lymphatic Interventions
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Pedal Lymphangiography (PL)
- •Intranodal Lymphangiography (IL)
- •Dynamic Contrast Enhanced MR Lymphangiography (DCMRL)
- •Thoracic Duct Embolization
- •Plastic Bronchitis
- •References
- •24: Mesenteric Ischemia
- •Pathophysiology
- •Acute Mesenteric Ischemia
- •Chronic Mesenteric Ischemia
- •Clinical Indication
- •Acute Mesenteric Ischemia
- •Arterial Occlusive Disease
- •Nonocclusive Mesenteric Ischemia (NOMI)
- •Portomesenteric Vein Thrombosis
- •Chronic Mesenteric Ischemia
- •Conventional Therapy
- •Acute Mesenteric Ischemia
- •Arterial Occlusive Disease
- •Nonocclusive Mesenteric Ischemia (NOMI)
- •Portomesenteric Vein Thrombosis
- •Chronic Mesenteric Ischemia
- •Interventional Therapy
- •Acute Mesenteric Ischemia
- •Chronic Mesenteric Ischemia
- •References
- •25: Visceral Aneurysms
- •Pathophysiology
- •Visceral Artery True Aneurysms (VATAs)
- •Visceral Artery Pseudoaneurysm (VAPA)
- •Clinical Indication
- •VATA
- •VAPA
- •Conventional Therapy
- •Interventional Therapy
- •Splenic Artery Aneurysms
- •Renal Artery Aneurysms
- •Hepatic Artery Aneurysms
- •Celiac Artery Aneurysms
- •Complications
- •Splenic Aneurysm
- •Renal Aneurysm
- •Hepatic Aneurysm
- •References
- •26: Renal Artery Stenosis
- •Pathophysiology
- •Clinical Indications
- •Conventional Therapy
- •Interventional Therapy
- •Post-procedural Care
- •Conclusion
- •References
- •27: GI Bleeding
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Complications
- •References
- •28: Uterine Artery Embolization
- •Pathophysiology
- •Fibroids
- •Adenomyosis
- •Postpartum Hemorrhage
- •Clinical Indication
- •Conventional Therapy
- •Fibroids
- •Adenomyosis
- •Postpartum Hemorrhage
- •Interventional Therapy
- •Fibroids
- •Adenomyosis
- •Postpartum Hemorrhage
- •AV Fistula
- •References
- •29: Prostate Artery Embolization
- •Pathophysiology
- •Benign Prostatic Hyperplasia
- •Prostate Cancer/Hematuria
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •30: Aortoiliac Disease
- •Pathophysiology
- •Blue Toe Syndrome
- •Leriche Syndrome
- •Fibromuscular Dysplasia
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Abdominal Aorta
- •Aortic Bifurcation
- •Common Iliac Artery
- •External Iliac Artery
- •Internal Iliac Artery
- •Blue Toe Syndrome
- •References
- •31: Infrainguinal Disease
- •Pathophysiology
- •Claudication (Rutherford Categories 1–3)
- •Critical Limb Ischemia: Rest Pain (Rutherford Category 4)
- •Critical Limb Ischemia: Skin Lesions (Rutherford Categories 5–6)
- •Acute Limb Ischemia
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Percutaneous Transluminal Angioplasty
- •Stents
- •Acute Limb Ischemia
- •References
- •Pathophysiology
- •Spleen
- •Liver
- •Kidney
- •Clinical Indication
- •Spleen
- •Liver
- •Kidney
- •Conventional Therapy
- •Spleen
- •Liver
- •Kidney
- •Interventional Therapy
- •Spleen
- •Pre-procedure
- •Post-procedure
- •Liver
- •Pre-procedure
- •Post-procedure
- •Kidney
- •Pre-procedure
- •Post-procedure
- •References
- •Pathophysiology
- •Pelvic Fractures
- •Extremity Fractures
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •34: Transarterial Chemoembolization
- •Pathophysiology
- •Clinical Indications
- •Conventional Therapy
- •Medical Management
- •Surgical Management
- •Interventional Therapy
- •Post-procedure
- •References
- •35: Transarterial Radioembolization (TARE)
- •Introduction
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Primary Liver Cancers
- •Hepatic Metastatic Disease
- •References
- •36: Liver Ablation
- •Pathophysiology
- •Liver Cancer
- •Liver Metastases
- •Liver Cysts
- •Clinical Indication
- •Conventional Therapy
- •Liver Cancer
- •Liver Metastases
- •Liver Cysts
- •Interventional Therapy
- •References
- •Pathophysiology
- •Lung Cancer
- •Renal Cell Carcinoma
- •Bone Lesions
- •Clinical Indication
- •Lung Cancer
- •Kidney Cancer
- •Bone Lesions
- •Conventional Therapy
- •Lung Cancer
- •Kidney Cancer
- •Bone Lesions
- •Interventional Therapy
- •Radiofrequency Ablation (RFA)
- •Microwave Ablation (MWA)
- •Cryoablation
- •Irreversible Electroporation (IRE)
- •Lung Cancer
- •Kidney Cancer
- •Bone Lesions
- •References
- •Pathophysiology
- •Conventional Therapy
- •Ascites
- •Varices
- •Interventional Therapy
- •References
- •Pathophysiology
- •Etiology
- •Clinical Indication
- •Conventional Therapy
- •Medical Management
- •Surgical Management
- •Interventional Therapy
- •Post-procedural Management
- •Complications
- •References
- •40: Biliary Drainage
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Conclusion
- •References
- •41: Biopsy Techniques
- •Introduction
- •Clinical Indication
- •Interventional Therapy
- •Needle Selection
- •Biopsy Techniques
- •References
- •Introduction
- •Pathophysiology
- •Ascites
- •Clinical Indication
- •Ascites
- •Conventional Therapy
- •Ascites
- •Interventional Therapy
- •Ascites
- •References
- •43: Obstructive Uropathy
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Urolithiasis
- •Infection
- •Urothelial Carcinoma
- •Neurogenic Bladder
- •Interventional Therapy
- •References
- •Pathophysiology
- •Clinical Indications
- •Percutaneous Radiologic Gastrojejunostomy (PRGJ) Tube
- •Percutaneous Jejunostomy (PJ) Tube
- •Conventional Therapy
- •Interventional Therapy
- •Percutaneous Radiologic Gastrostomy (PRG)
- •Post-procedural Management
- •Percutaneous Radiologic Gastrojejunostomy (PRGJ)
- •Percutaneous Jejunostomy (PJ)
- •References
- •45: Stroke
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Complications
- •Post-procedure Management
- •References
- •46: Cerebral Angiography: Aneurysms
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Pre-procedural Preparation
- •Post-procedural Management
- •Complications
- •References

36 Liver Ablation
Percutaneous ethanol injection (PEI) has fallen out of
use in the treatment of early HCC as multiple studies have
demonstrated superiority of RFA ablation compared to
PEI [36]. However, PEI still has a role as it is often used
for liver sclerosis and treatment of symptomatic hepatic
cysts. It can be done in a single or multiple sessions [37].
The procedure itself involves percutaneously accessing
the cyst, aspirating the contents, and then injecting alcohol that is retained for a period of time prior to removal.
The procedural goal is symptomatic relief even if the
actual cystic cavity is not completely destroyed. Unique
side effects include hypotension and the signs and symptoms of alcohol intoxication such as nausea, dizziness,
and ushing.
Trans-arterial embolization, including both chemoembolization and radioembolization, has been a dening role of
interventionists in the treatment of HCC and liver metastasis.
These techniques are discussed in Chaps. 34 and 35,
respectively.
Prior to the procedure, the patient should have crosssectional imaging (CT or MRI) to delineate the target lesion, the
anatomy, evaluate a safe window, determine ideal ablative
modality, as well as assess potential complications and remedies. Patient with increased risk for infections, or hepatic
abscess (those with prior sphincterotomy or biliary-enteric
anastomosis), should be premedicated with an antibiotic
prophylaxis regimen. Immediately prior to procedure, it
should also be determined if the patient will need a
hydrodissection.
401
36.2a). For HCC, contrast-
enhanced arterial phase images are often needed to
visualize the tumor. The ablation zone consists of
the tumor with a 5–10-mm rim of healthy tissue
(safety margin). The number of probes, length, and
amount of energy delivered will vary depending on
the size of the desired ablation zone, manufacturer
-
ogy used.
3. If hydrodissection is needed, any device with an
initial sharp needle that can be exchanged for a
blunt introducer may be used to access the space
between the tumor and organ at risk. The blunt
introducer can be upsized to a catheter through
-
eter can be removed or left in place in case more
place as they interfere with the ablation.) Some
cases may require multiple areas of hydrodissection. Balloon interposition and biliary lavage are
additional protective techniques.
4. The thermal ablation probe is advanced under
36.2b). The probes can be
advanced into the lesion or on each side (bracket
technique). Computer software is sometimes used
to help plan the trajectory. Once positioned, some
devices allow the probes to be placed in tissue-lock
mode preventing respiratory motion from dislodg-
The How to: Radiofrequency and Microwave Ablation
1. Patients can be placed under general anesthesia or
conscious sedation. Some patients may have pain
and discomfort due to the positioning or the ablation itself. Patients are usually placed supine or left
lateral decubitus with the right arm out of the way.
Ultrasound is often used for needle positioning,
although with RFA the “gas out” (gas emitted by
the burning of tissues) limits its value once the ablation has started. RFA requires grounding pads be
placed on the patient’s thigh due to the electrical
current.
2. Conventional computed tomography (CT), cone
beam CT (CBCT), or ultrasound in combination or
alone have been used for image guidance during
ablations. Imaging is typically obtained at the time
of the procedure once the patient is positioned to
of adequate probe positioning is essential prior to
energy delivery. Needless to say, large vessels and
organs, such as adrenal, kidney, and bowel, should
be outside the projected ablation zone.
5. With MWA and some RFA devices, ablation is per-
a certain amount of time depending on the size of
the desired ablation zone. For most RFA machines,
however, tissue impedance is used to determine
when ablation is complete. Once char is achieved,
the impedance goes up and treatment is complete.
Repeat imaging with and without contrast should
be performed to ensure adequate tumor coverage
including a safety margin appropriate for the type
of tumor being treated (generally wider for metastatic disease). Note that most probes can coagulate
the tract as they are being removed. If a second
ablation is required, the probe may be repositioned
and the process repeated.
6.
removed, and imaging is repeated to rule out com-
36.2c).

402
J. Ton et al.
Fig. 36.2 A 79-year-old male with hepatitis B and HCC undergoing microwave ablation therapy for a hepatic segment 6 lesion. (a) Pre-ablation,
(b) ablation probe positioning, (c) post-ablation, and (d) 6-month follow-up images are shown demonstrating good treatment response
lowed up clinic visits can be performed every 3months for
Key Point
Complications:
the rst year, every 6 months for the second year, and as
appropriate thereafter.
• Bleeding
• Tumor seeding
• Hepatic infarction
• Infection (peritonitis, abscess)
• Bile duct injury or bile leak
• Pneumothorax
• Pleural effusion or hemothorax
• Skin burns
For post-procedural care after thermal ablation, it is
customary for patients to stay overnight for observation
and pain control. Routine post-procedure labs are not
needed. Patients are typically discharged the next day with
plans to follow up with a clinic visit at 1month, which
should include labs and imaging to assess response (see
Fig. 36.2d). If indicated, surveillance imaging and fol-
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Lung, Kidney, andBone Ablation
DavidM.Mauro
Pathophysiology
Lung Cancer
Within the United States, primary lung cancer is the second
most common cancer among men and women (behind prostate and breast, respectively), but is the number one cause of
cancer-related death with an estimated 158,080 deaths and
224,390 new cases in 2016 [1]. While the incidence of lung
cancer has been declining, it still accounts for approximately
one in four cancer deaths. Primary lung cancer is classied
as either small cell or non-small cell lung cancer, with nonsmall cell lung cancer encompassing 83% of cases.
Key Point
Subtypes of lung cancer:
• Non-small cell
– Adenocarcinoma
– Squamous cell
– Large cell
• Small cell
Primary lung cancer is often asymptomatic in its early
stages but may manifest with persistent cough, bloody sputum production, pain, increasing shortness of breath, or
recurrent pulmonary infections [1]. Cigarette smoking
remains the most important risk factor [1]. Other environ-
D. M. Mauro (*)
University of North Carolina, Department of Radiology,
Chapel Hill, NC, USA
e-mail: david_mauro@med.unc.edu
37
Table 37.1 Simplied TNM staging system for lung cancer [2]
Lung cancer TNM staging system
T (primary tumor)
T0 No primary tumor or carcinoma in situ
T1
Tumor ≤3cm
T2
Tumor >3 but ≤5cm or tumor involving the visceral pleural,
main bronchus, or with atelectasis to the hilum
T3
Tumor >5cm but ≤7cm or tumor invading the chest wall,
pericardium, phrenic nerve, or separate tumor nodule (s) in the
same lobe
T4
Tumor ≥7cm or tumor invading the mediastinum, diaphragm,
heart, great vessels, recurrent laryngeal nerve, carina, trachea,
esophagus, spine, or tumor nodule(s) in different ipsilateral lobe
N (regional lymph nodes)
N0 No regional node metastases
N1 Metastases in ipsilateral pulmonary or hilar lymph nodes
N2 Metastases in ipsilateral mediastinal or subcarinal lymph nodes
N3 Metastases in contralateral mediastinal or hilar lymph nodes or
supraclavicular lymph nodes
M (distant metastasis)
M0 No distant metastases
M1 Distant metastases including malignant pleural or pericardial
effusions
mental exposures, such as radon gas, pollution, secondhand
smoke, asbestos, and certain metals and chemical exposures,
are also signicant risk factors [1].
Non-small cell lung cancer is staged using the TNM
(tumor, node, metastasis) staging system from the American
Joint Committee on Cancer [2]. In 2017, Detterbeck et al.
published the eighth edition of lung cancer stage classication. A simplied version of the staging system is depicted in
Table37.1.
The lungs are a common site for metastatic disease, with
pulmonary metastases found during autopsy in 50% of
patients with a cancer-related death in a 1000 patient series
[3]. The presence of pulmonary metastasis usually indicates
widespread dissemination of the primary cancer. Pulmonary
metastases are frequently asymptomatic and are typically
found during surveillance imaging or at initial diagnosis.
© Springer International Publishing AG, part of Springer Nature 2018
N. A. Keefe et al. (eds.), IR Playbook, https://doi.org/10.1007/978-3-319-71300-7_37
405

406
D. M. Mauro
Renal Cell Carcinoma
The American Cancer Society estimated that there would
be nearly 63,000 new diagnoses of kidney cancer in 2016,
the vast majority being renal cell carcinoma (with the
remaining predominantly being urothelial cancer or Wilms
tumor) [1]. The incidence of kidney cancer had been
increasing over time, partially attributed to increased
abdominal imaging and incidental diagnosis; however,
rates have recently stabilized [1]. There are multiple subtypes of renal cell carcinoma with the clear cell subtype
being the most common. Small renal cell carcinomas are
typically asymptomatic. Later stage tumors can preset with
hematuria, abdominal or ank pain, ank mass, weight
loss, and/or fatigue. Risk factors include obesity, cigarette
smoking, hypertension, chronic kidney disease, environmental exposures, and certain genetic conditions such as
von Hippel-Lindau disease or hereditary papillary renal
cell carcinoma [1].
Key Point
Subtypes of renal cell carcinoma:
• Clear cell (most common).
• Papillary.
• Chromophobe.
• Collecting duct, medullar, and sarcomatoid are rare.
Renal cell carcinoma is staged using the TNM staging
system from the American Joint Committee on Cancer [4].
The seventh edition of the staging system, updated in 2010 is
shown in Table37.2.
Table 37.2 Simplied TNM staging system for renal cell carcinoma [4]
Renal cell carcinoma TNM staging system
T (primary tumor)
T0 No primary tumor
T1
Tumor conned to the kidney and ≤7cm
T1a
Tumor ≤4cm
T1b
Tumor >4cm but ≤7cm
T2 Tumor conned to the kidney and >7cm
T3 Tumor with extrarenal extension or involvement of the renal
vein or inferior vena cava
T4 Tumor extends through Gerota’s fascia
N (regional lymph nodes)
N0 No regional node metastases
N1 Regional lymph node metastases
M (distant metastasis)
M0 No distant metastases
M1 Metastases present in distant lymph nodes or organs
Bone Lesions
Osteoid osteomas are benign osseous tumors that account for
10–12% of benign bone tumors [5]. While the lesions can
present at almost any age, 85% of the cases have symptom
onset between 5 and 24years of age, with a male predominance. Osteoid osteomas classically present with pain, worse
at night, which is relieved by nonsteroidal anti-inammatory
drugs [6]. If untreated, lesions can lead to growth disturbance, muscle atrophy, and clinical disability. The femur and
tibia are the most common sites of disease [7].
Metastatic bone lesions are common in patients with primary breast, prostate, and lung cancer [8]. Bone metastases
can present with pain, pathologic fracture or can be found
incidentally on serial imaging. In cases of intractable pain or
impaired mobility, metastases result in decreased quality of
life and performance status.
Clinical Indication
Lung Cancer
Chest CT is the initial study of choice for the evaluation of a
patient with suspected primary lung cancer or pulmonary metastatic disease. Primary lung cancer often presents as a solitary
pulmonary nodule or hilar mass. Primary benign and malignant lesions can have similar imaging ndings; however, certain imaging ndings suggest malignancy, including size and
lesion margins [9]. The larger the nodule, the higher risk of
cancer, with a 10–20% risk of cancer if the nodule measures
approximately 8 mm. Nodules with a speculated (jagged or
sunburst) margin are more likely to be cancer than a smooth
contour. Metastatic lesions are often rounded single or multiple nodules of various sizes scattered throughout the lung.
In high-risk patients with characteristic lesions, biopsy is
frequently not required prior to treatment. Treatment options
include surgical resection, radiation therapy, chemotherapy,
and percutaneous ablation.
Kidney Cancer
Physical examination does not play a signicant role in diagnosis of renal cell carcinoma. However, a thorough physical
exam can detect signs of advanced or metastatic disease.
Abdominal ultrasound or CT frequently detects renal masses
incidentally. Non-cystic renal masses are characterized with
CT or MRI utilizing a multiphase renal mass protocol. On
CT, small renal cell carcinomas tend to be homogeneous on
non-contrast imaging; however, larger lesions can be heterogeneous secondary to necrosis and/or hemorrhage [9]. The
majority of renal cell carcinomas show avid enhancement.
Masses are best visualized during the nephrographic phase

37 Lung, Kidney, andBone Ablation
407
when the normal renal parenchyma is homogeneously
enhancing. Enhancement is similar with MRI; however, noncontrast imaging can suggest subtype histology.
Historically, renal mass biopsies were rarely performed
due to the high false-negative rate, risk of complications, risk
of tumoral seeding of the biopsy tract, and high accuracy of
cross-sectional imaging. Recently, renal biopsy has become
more common, as small renal masses have been found to be
benign in approximately 20% of patients [10], and biopsy
techniques have improved.
Bone Lesions
Osteoid osteomas are suspected based on patient age, history
of nocturnal pain relieved by nonsteroidal anti- inammatories,
and the lack of other physical exam ndings. On CT or plain
lm, an osteoid osteoma appears as a lucent, oval nidus that is
usually less than 1.5cm in diameter with an adjacent periosteal reaction causing thickening/sclerosis of the cortex [11]. A
central density may be seen within the nidus. There is frequently adjacent soft tissue swelling. While osteoid osteomas
are benign and may spontaneously resolve, most experts recommend treatment to prevent long- term sequelae [12].
Bone metastases may be detected incidentally, on imaging
for surveillance or metastatic work-up or as part of a diagnostic evaluation for patient-directed complaints. The lung,
breast, and prostate represent the most common primary cancers, with osseous metastases found in up to 85% of patients
at autopsy [8]. Most metastatic lesions are asymptomatic, but
they may present with pain or pathologic fracture. Breast and
prostate metastases are most commonly blastic, while lung
metastases are more often lytic lesions. Plain lm may demonstrate the lytic or blastic changes from metastatic disease,
but CT is better for evaluating disease extent. MRI also demonstrates bone marrow changes at sites of bony metastasis.
Nuclear medicine bone scans provide a whole-body overview
and will show increased uptake (blastic lesions) or photopenic areas (lytic lesions) with high sensitivity.
Conventional Therapy
Treatment algorithms for most cancers are complex and multifactorial; treatment decisions are frequently made through
multidisciplinary tumor boards. There is consensus on some
principles on the role of ablation.
Lung Cancer
Surgical resection is the gold standard treatment for early
stage (stage I and II) non-small cell lung cancer [13]. Surgical
resection consisting of lobectomy with lymph node dissection demonstrates the best disease-free survival in patients
with early stage non-small cell lung cancer [14].
Unfortunately, approximately two-thirds of patients are medically inoperable at diagnosis [15]. For these patients, stereotactic ablative radiotherapy (SABR) and percutaneous
ablation can be considered for denitive therapy. For patients
with locoregional recurrence after surgery, repeat surgery,
SABR, or percutaneous ablation can be considered for continued treatment. Current National Comprehensive Cancer
Network guidelines recommend SABR for medically inoperable stage IA non-small cell lung cancer [13]. However,
percutaneous ablation is noted to be an option for select
patients. To date, there has not been a head to head trial comparing SABR to percutaneous ablation.
Key Point
Stereotactic ablative radiotherapy and percutaneous
ablation are the denitive treatment option for medically inoperable non-small cell lung cancer.
Kidney Cancer
Surgery remains the gold standard for small renal masses
[16]. Current National Comprehensive Cancer Network
guidelines recommend partial nephrectomy as the preferred
treatment for stage 1A kidney cancer. The guidelines include
ablation as a primary treatment option in select patients.
Ablation can be performed either laparoscopically or percutaneously. While laparoscopic cryoablation has shown to
have fewer complications and result in shorter hospital stays
compared with laparoscopic or robotic partial nephrectomy,
the ablation group also had higher rates of local tumor progression and metastases [17]. A large retrospective study
from Thompson etal. demonstrated similar recurrence-free
survival between partial nephrectomy, percutaneous cryoablation, and percutaneous radiofrequency ablation [18].
However, metastases-free survival was higher for both partial nephrectomy and cryoablation compared to radiofrequency ablation. The partial nephrectomy group had superior
overall survival; however, the population was younger and
healthier compared to the ablation groups. A 2008 metaanalysis comparing percutaneous to laparoscopic tumor
ablation using both cryoablation and radiofrequency ablation
demonstrated higher primary effectiveness within the surgical group, 94% versus 87%, respectively [19]. However,
with secondary effectiveness, the percutaneous ablation
group achieved 95% effectiveness. Additionally, major complications were 7% for laparoscopic ablation compared to
3% for percutaneous ablation.

408
Key Point
Renal mass ablation is indicated for masses less than
4cm in patients who are:
• Poor surgical candidates
• In need of nephron-sparing treatment due to medical renal disease, prior surgery, or risk of future carcinoma (genetic syndrome)
D. M. Mauro
Table 37.3 Hallmark papers describing the use of ablative technolo-
gies in various organs
Ablation type Organ Year Hallmark paper
Radiofrequency Liver 1990 McGahan etal. [23], Rossi etal. [24]
Radiofrequency Bone 1992 Rosenthal etal. [25]
Radiofrequency Lung 1995 Goldberg etal. [26]
Cryoablation Kidney 1995 Uchida etal. [27]
Radiofrequency Kidney 1997 Zlota etal. [28]
Interventional Therapy
Bone Lesions
There are a vast number of treatment options for bone
tumors, including surgery, external beam radiation, ablation,
hormonal therapy, and chemotherapy. Historically, surgery
was performed for treatment of osteoid osteoma. However,
due to similar recurrence rates, quicker recovery, and favorable complication prole, radiofrequency ablation has
become the preferred treatment [7]. In a comparison between
surgery and ablation, recurrence rate was 9% and 12%,
respectively, which was not statistically signicant [20]. A
subsequent literature review in 2013 concluded an average
recurrence rate of 4.9% following ablation [21].
Key Point
Radiofrequency ablation is the preferred treatment for
osteoid osteoma.
Traditionally, external beam radiation or surgery is the
primary treatment for oligometastatic disease with chemotherapy used for disseminated disease [7]. Surgery is typically an option for pathologic fractures or impending
pathologic fractures. While 60% of patients have pain relief
following external beam radiation, the results are frequently
temporary. Patients with recurrent pain after irradiation
may not be candidates for further external beam radiation
due to quantitative dose [6]. Pathologic compression fractures can be treated with a combination of radiofrequency
ablation and vertebral augmentation using polymethyl
methacrylate [22].
Percutaneous image-guided thermal ablation was rst
described in the 1990s (Table 37.3). As technology has
improved the safety and efcacy prole of percutaneous
tumor ablation, it has become a common alternative to surgical therapy. With a wide variety of modalities and technologies available, there is a heterogeneity in ablation practice
with signicant operator variability and preference. Below is
a brief review of the more common ablation technologies.
Key Point
RFA=electrical current to produce heat.
MWA=agitation of water molecules to produce heat.
Cryoablation=cooling cells to cytotoxic temperatures.
IRE=rapid alternating currents create holes in the cell
membrane to increase cell permeability.
Radiofrequency Ablation (RFA)
During radiofrequency ablation, an oscillating electrical current is created between an electrode (ablation probe) and
grounding pad or between two electrodes [29]. Due to poor
conduction of electricity within tissue, frictional heat is produced from the owing electrical current causing ionic agitation in the adjacent tissue. Thermal conduction through the
tissue creates a larger ablation zone [11]. Immediate cell
death occurs between temperatures of 60 and 100°C. The
ablation zone is limited by tissue dehydration and charring;
however, newer technologies attempt to limit this from
occurring during the ablation process.
Key Point
Radiofrequency ablation combined with vertebro-
plasty or kyphoplasty can be used to treat compression
fractures secondary to osseous metastatic disease.
Microwave Ablation (MWA)
Microwave energy agitates water molecules, creating frictional heat and cell death [11]. During ablation, an oscillating electromagnetic eld is created by the antennae (ablation
probe). Distinct from radiofrequency ablation, an electrical
current is not involved; therefore, the ablation continues to

37 Lung, Kidney, andBone Ablation
409
be effective in tissues with poor electrical conductivity, [29]
and grounding pads are not necessary [15].
Heat sink occurs when adjacent blood vessels dissipate
thermal energy thereby interfering with the tissue heating or
cooling [29]. Heat sink leads to a decrease in the size of the
ablation zone with vessels greater than 3mm thought to be
signicant causes of heat sink, affecting the ablation zone
size. Microwave ablation appears to be less affected by heat
sink compared to other thermal ablation modalities.
Cryoablation
In contrast to radiofrequency and microwave ablation, cryoablation induces cell death by cooling cells to cytotoxic temperatures [29]. Cryoablation utilizes the Joule-Thomson
effect, a decrease in temperature resulting from a change in
gas pressure. The tip of a cryoablation probe can reach a temperature of −185 °C [11]. Cryoablation procedures typically
utilizes two freeze-thaw cycles, with an active freezing
period induced by the cryoablation probe followed by a passive thaw period [30].
Irreversible Electroporation (IRE)
Unlike the three ablation modalities described above, irreversible electroporation is a nonthermal process. Rapid electrical impulses create microscopic pores within the cellular
membrane resulting in increased membrane permeability
and cell death [11]. An advantage of irreversible electroporation is that the target is the cell membrane, therefore, theoretically sparring connective tissue such as the collecting
system within the kidney. However, the electrical impulses
can also result in cardiac arrhythmia and muscle contractions; therefore, cardiac monitoring and general anesthesia
with neuromuscular blockade are necessary. As a nonthermal
ablation modality, irreversible electroporation is not susceptible to heat sink.
Modality choice is driven by tissue type, specic pathology, lesion size, operator preference, and modality availability. Radiofrequency ablation, microwave ablation, and
cryoablation are all used within the lung, kidney, and bone.
Microwave ablation may be preferred in larger tumors.
Irreversible electroporation is not as common and is frequently reserved for perivascular lesions or lesions adjacent
to the renal collecting system.
Lung Cancer
Lung ablation is an option for patients with early stage (surgically resectable) disease who are not surgical candidates,
either due to poor pulmonary reserve or medical comorbidities (Fig.37.1). Ablation has also been used in patients with
oligometastatic disease who cannot undergo surgical metastastectomy. Additionally, ablation can be considered for disease recurrence within a previous treatment zone or as
symptomatic palliation from tumor burden. The majority of
the data uses radiofrequency ablation; however, microwave
ablation, cryoablation, and irreversible electroporation have
produced positive outcomes in the literature [31]. In 2000
Dupuy etal. reported the rst series of radiofrequency ablation for inoperable non-small cell lung cancer [32]. Tissue
characteristics within the lung provide a favorable prole for
thermal ablation as the lung parenchyma provides heat insulation and is a poor electrical conductor [31].
Outcome data for lung ablation is variable throughout the
literature due to variance in tumor size and ablation modality. In 2008, a review of 17 reports, which included both primary and metastatic disease, demonstrated rates of complete
ablation ranging from 38% to 97% following radiofrequency
ablation [33]. Multiple reports have shown excellent success
with ablation of tumors smaller than 2 cm, with complete
ablation ranging from 78% to 96% [34]. In a recent review of
the literature, overall survival rates at 1, 3, and 5years were
reported between 77.1% and 97.7%, 36% and 72.9%, and
20.7% and 55.7%, respectively [35]. Multiple reports have
shown tumor size, tumoral contact to blood vessels greater
than 3mm, and ground-glass ablation margin to be predictive factors in recurrence. In a 153-patient series undergoing
radiofrequency ablation including stage I non-small cell lung
cancer and colorectal pulmonary metastatic disease, 1-, 3-,
and 5-year survival was found to be 78%, 36%, and 27% for
primary cancer and 87%, 57%, and 57% for metastatic disease [36]. Additionally, the 1-, 3-, and 5-year local tumor
progression-free rates was 83%, 57%, and 47% for tumors
3cm or smaller but 45%, 25%, and 25% for larger tumors.
Kidney Cancer
Percutaneous renal mass ablation is considered for patients
with small renal masses (less than 4 cm, T1a tumors,
Fig.37.2) [30]. Ideal lesions are noncentral and without metastatic disease, renal vein invasion, or extension through
Gerota’s fascia. Ablation may be favored over surgical resection in patients who are poor surgical candidates due to
comorbidities, chronic kidney disease necessitating maximal
nephron preservation, or hereditary syndromes with a high
risk of subsequent renal carcinomas. The American
Urological Association and International Consensus panels
support ablation for lesions less than 4cm, among other indications [37].
There is no prospective, randomized controlled trial comparing partial nephrectomy to ablation. In 2015 Thompson

410
D. M. Mauro
Fig. 37.1 An 88-year-old male with a 2.7 cm left lower lobe biopsy
proven non-small cell lung cancer. The lesion was found during work up for prolonged cough. The patient declined surgical intervention. (a,
b) PET-CT demonstrating a 2.7 cm uorodeoxyglucose (FDG)-avid
lesion in the left lower lobe. (c) Initial placement of two cryoablation
etal. compared partial nephrectomy, percutaneous cryoablation, and percutaneous radiofrequency ablation with similar
recurrence-free survival [18]. However, partial nephrectomy
and percutaneous cryoablation demonstrated improved
metastases-free survival compared with percutaneous radiofrequency ablation. In 2013 Atwell et al. retrospectively
probes with mild surrounding hemorrhage from placement. (d) Intraprocedural imaging showing ground-glass opacities surrounding the
lesion representing the ablation zone. A small pneumothorax and effusion are noted. (e, f) Follow-up PET-CT 3-month post-ablation showing
cavitation at the ablation site and no FDG avidity
reviewed recurrence of tumors less than 3cm treated with
cryoablation and radiofrequency ablation [38]. At 1, 3, and
5 years, recurrence-free survival was found to be 97.3%,
90.6%, and 90.6%, respectively, for cryoablation and 100%,
98.1%, and 98.1%, respectively, for radiofrequency ablation.
The complication rates were not statistically different

37 Lung, Kidney, andBone Ablation
411
Fig. 37.2 A 67-year-old male with a history of bilateral renal cell carci-
nomas status post partial nephrectomies found to have a new 1.4cm left
renal cell carcinoma on surveillance imaging. (a, b) T1, contrast
enhanced MRI in the arterial and nephrographic phases demonstrating a
left-sided exophytic 1.4cm enhancing lesion consistent with a renal cell
carcinoma. (c) Scout CT from the ablation procedure. The renal cell
carcinoma appears as a hyperdense exophytic lesion. (d) Intra- procedural
imaging with two cryoablation probes. (e) Imaging after rst thaw cycle
showing a hypodense ablation zone. (f) Two-month follow-up MRI, T1
post-contrast in the nephrographic phase with no enhancement or evidence of residual tumor. Note the hyperintensity in the ablation zone was
present on pre-contrast T1 imaging and consistent with hemorrhage. (g)
Three-year follow-up MRI, T1 post-contrast in the nephrographic phase.
The ablation zone has scared with no evidence of enhancement
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