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- •Preface
- •Contents
- •Contributors
- •Endovascular Aneurysm Repair
- •Clinical Applications
- •Aortic Procedures Planning
- •Performance Assessment
- •Future Prospects
- •References
- •References
- •Introduction
- •Medical Error
- •Traditional Training
- •Animal Simulation Labs
- •Virtual Reality Simulation
- •3: Radiation Safety
- •Introduction
- •Basic Radiation Physics Units
- •Personnel Dose Limits
- •Pregnant Personnel
- •References
- •4: Tools of the Trade
- •Needles, Catheters, and Wires
- •Vascular Access
- •Double Wall
- •Single Wall
- •Advantages/Disadvantages
- •Nonvascular Needles (Table 4.1)
- •Guidewires
- •Curved
- •Straight/Angled
- •Stiffness
- •Flexibility
- •Coating
- •Torqueability
- •Opacity
- •Catheters
- •Flush Catheters
- •Visceral Catheters
- •Multipurpose Catheters
- •Cerebral Catheters
- •Guiding Catheters
- •Microcatheters
- •Vascular Sheaths
- •Vessel Dilators
- •Accessories
- •Embolic Agents
- •Temporary Agents
- •Permanent Agents
- •Pushable Coils
- •Detachable Coils
- •Coiling Techniques (Fig. 4.48)
- •Vascular Plugs
- •Particulates
- •Liquid Embolics
- •Fogarty Balloons
- •Angioplasty Balloons
- •Drug-Coated Balloons
- •Vascular Stents
- •Balloon Expandable Stents
- •Self-Expandable Stents
- •Specialty Stents
- •References
- •Consults
- •Pre-procedure Evaluation
- •Consent
- •Code Status
- •Laboratory Testing
- •Antibiotic Prophylaxis
- •Anticoagulation
- •Antihypertensives
- •Contrast Allergy Prophylaxis
- •Procedure Plan
- •Post-procedure Management
- •Hospital Admission
- •Discharge
- •Follow-up Visits
- •IR Clinic
- •Conclusion
- •References
- •6: The IR Road Map: Vascular Anatomy Overview
- •Introduction
- •Imaging Modalities
- •Ultrasound
- •Computed Tomography
- •Magnetic Resonance Imaging
- •Cross-Sectional Anatomy
- •Chest
- •Segmental Lung Anatomy
- •Mediastinum
- •Pulmonary Arteries
- •Pulmonary Veins
- •Bronchial Arteries
- •Liver
- •Arterial Access
- •Double-Wall Technique
- •Common Femoral Artery Access
- •Kidneys
- •Ureters
- •Bladder
- •Uterus
- •References
- •Alternative Arterial Access Sites
- •Venous Access
- •Manual Compression
- •Closure Devices
- •Compression Devices
- •Topical Agents
- •Invasive Devices
- •References
- •9: Central Venous Access
- •Pathophysiology
- •Non-tunneled Central Catheters (NTCCs)
- •Tunneled Central Catheters (TCCs)
- •Implantable Ports
- •Peripherally Inserted Central Catheters (PICCs)
- •Clinical Indication
- •Conventional Therapy
- •Non-tunneled Central Catheters
- •Tunneled Central Catheters
- •Ports
- •PICCs
- •Interventional Therapy
- •Ports
- •PICCs
- •Pre-procedural Prep
- •History
- •Physical Exam
- •Imaging
- •Complex Venous Access
- •Post-procedural Management
- •Complications
- •Acute Complications
- •Long-Term Complications
- •Device Removal
- •Tunneled Catheter Removal
- •Port Removal
- •References
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •11: IVC Filters
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •IVC Filter Placement
- •VTE Prevention
- •Preprocedural Preparation
- •Complication
- •Access Site
- •Device-Related
- •Postprocedural Management
- •IVC Filter Retrieval
- •Advanced IVC Filter Retrieval Techniques
- •Conclusion
- •References
- •Pathophysiology
- •Arteriovenous Fistula
- •Arteriovenous Graft
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •AVG Angioplasty
- •AVF Angioplasty
- •References
- •13: Pelvic Congestion Syndrome
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •References
- •14: Varicocele
- •Pathophysiology
- •Conventional Therapy
- •Interventional Therapy
- •References
- •15: Varicose Veins
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •16: Vascular Malformations
- •Pathophysiology
- •Hemangiomas
- •Vascular Malformations
- •Arteriovenous Malformations (High Flow)
- •Venous Malformations (Low Flow)
- •Lymphatic Malformations
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •High-Flow AVMs
- •Low-Flow Venous Malformations
- •Klippel-Trenaunay Syndrome
- •Lymphatic Malformations
- •References
- •Pathophysiology
- •Abdominal Aortic Aneurysm (AAA)
- •Thoracic Aortic Aneurysm (TAA)
- •Clinical Indication
- •Abdominal Aortic Aneurysm
- •Thoracic Aortic Aneurysm
- •Conventional Therapy
- •Abdominal Aortic Aneurysm
- •Thoracic Aortic Aneurysm
- •Interventional Therapy
- •Abdominal Aortic Aneurysm
- •Thoracic Aortic Aneurysm
- •Common Complications
- •Access
- •Contrast Nephropathy
- •Spinal Cord Ischemia
- •Postoperative Monitoring
- •References
- •18: Aortic Dissection
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Preprocedure Work-Up
- •Post-procedural Management
- •References
- •19: Endoleak
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Type II Endoleaks
- •Type III Endoleaks
- •Type IV Endoleaks
- •Type V Endoleaks
- •References
- •20: Traumatic Aortic Injury
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Pre-procedural Prep
- •Pre-procedural Imaging
- •Post-procedural Management
- •Post-procedural Imaging
- •References
- •21: Bronchial Artery Embolization
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Outcomes
- •References
- •Pathophysiology
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •Clinical Indication
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •Conventional Therapy
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •Interventional Therapy
- •Pulmonary Arteriovenous Malformation
- •Pulmonary Artery Pseudoaneurysm
- •References
- •23: Lymphatic Interventions
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Pedal Lymphangiography (PL)
- •Intranodal Lymphangiography (IL)
- •Dynamic Contrast Enhanced MR Lymphangiography (DCMRL)
- •Thoracic Duct Embolization
- •Plastic Bronchitis
- •References
- •24: Mesenteric Ischemia
- •Pathophysiology
- •Acute Mesenteric Ischemia
- •Chronic Mesenteric Ischemia
- •Clinical Indication
- •Acute Mesenteric Ischemia
- •Arterial Occlusive Disease
- •Nonocclusive Mesenteric Ischemia (NOMI)
- •Portomesenteric Vein Thrombosis
- •Chronic Mesenteric Ischemia
- •Conventional Therapy
- •Acute Mesenteric Ischemia
- •Arterial Occlusive Disease
- •Nonocclusive Mesenteric Ischemia (NOMI)
- •Portomesenteric Vein Thrombosis
- •Chronic Mesenteric Ischemia
- •Interventional Therapy
- •Acute Mesenteric Ischemia
- •Chronic Mesenteric Ischemia
- •References
- •25: Visceral Aneurysms
- •Pathophysiology
- •Visceral Artery True Aneurysms (VATAs)
- •Visceral Artery Pseudoaneurysm (VAPA)
- •Clinical Indication
- •VATA
- •VAPA
- •Conventional Therapy
- •Interventional Therapy
- •Splenic Artery Aneurysms
- •Renal Artery Aneurysms
- •Hepatic Artery Aneurysms
- •Celiac Artery Aneurysms
- •Complications
- •Splenic Aneurysm
- •Renal Aneurysm
- •Hepatic Aneurysm
- •References
- •26: Renal Artery Stenosis
- •Pathophysiology
- •Clinical Indications
- •Conventional Therapy
- •Interventional Therapy
- •Post-procedural Care
- •Conclusion
- •References
- •27: GI Bleeding
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Complications
- •References
- •28: Uterine Artery Embolization
- •Pathophysiology
- •Fibroids
- •Adenomyosis
- •Postpartum Hemorrhage
- •Clinical Indication
- •Conventional Therapy
- •Fibroids
- •Adenomyosis
- •Postpartum Hemorrhage
- •Interventional Therapy
- •Fibroids
- •Adenomyosis
- •Postpartum Hemorrhage
- •AV Fistula
- •References
- •29: Prostate Artery Embolization
- •Pathophysiology
- •Benign Prostatic Hyperplasia
- •Prostate Cancer/Hematuria
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •30: Aortoiliac Disease
- •Pathophysiology
- •Blue Toe Syndrome
- •Leriche Syndrome
- •Fibromuscular Dysplasia
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Abdominal Aorta
- •Aortic Bifurcation
- •Common Iliac Artery
- •External Iliac Artery
- •Internal Iliac Artery
- •Blue Toe Syndrome
- •References
- •31: Infrainguinal Disease
- •Pathophysiology
- •Claudication (Rutherford Categories 1–3)
- •Critical Limb Ischemia: Rest Pain (Rutherford Category 4)
- •Critical Limb Ischemia: Skin Lesions (Rutherford Categories 5–6)
- •Acute Limb Ischemia
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Percutaneous Transluminal Angioplasty
- •Stents
- •Acute Limb Ischemia
- •References
- •Pathophysiology
- •Spleen
- •Liver
- •Kidney
- •Clinical Indication
- •Spleen
- •Liver
- •Kidney
- •Conventional Therapy
- •Spleen
- •Liver
- •Kidney
- •Interventional Therapy
- •Spleen
- •Pre-procedure
- •Post-procedure
- •Liver
- •Pre-procedure
- •Post-procedure
- •Kidney
- •Pre-procedure
- •Post-procedure
- •References
- •Pathophysiology
- •Pelvic Fractures
- •Extremity Fractures
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •References
- •34: Transarterial Chemoembolization
- •Pathophysiology
- •Clinical Indications
- •Conventional Therapy
- •Medical Management
- •Surgical Management
- •Interventional Therapy
- •Post-procedure
- •References
- •35: Transarterial Radioembolization (TARE)
- •Introduction
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Primary Liver Cancers
- •Hepatic Metastatic Disease
- •References
- •36: Liver Ablation
- •Pathophysiology
- •Liver Cancer
- •Liver Metastases
- •Liver Cysts
- •Clinical Indication
- •Conventional Therapy
- •Liver Cancer
- •Liver Metastases
- •Liver Cysts
- •Interventional Therapy
- •References
- •Pathophysiology
- •Lung Cancer
- •Renal Cell Carcinoma
- •Bone Lesions
- •Clinical Indication
- •Lung Cancer
- •Kidney Cancer
- •Bone Lesions
- •Conventional Therapy
- •Lung Cancer
- •Kidney Cancer
- •Bone Lesions
- •Interventional Therapy
- •Radiofrequency Ablation (RFA)
- •Microwave Ablation (MWA)
- •Cryoablation
- •Irreversible Electroporation (IRE)
- •Lung Cancer
- •Kidney Cancer
- •Bone Lesions
- •References
- •Pathophysiology
- •Conventional Therapy
- •Ascites
- •Varices
- •Interventional Therapy
- •References
- •Pathophysiology
- •Etiology
- •Clinical Indication
- •Conventional Therapy
- •Medical Management
- •Surgical Management
- •Interventional Therapy
- •Post-procedural Management
- •Complications
- •References
- •40: Biliary Drainage
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Conclusion
- •References
- •41: Biopsy Techniques
- •Introduction
- •Clinical Indication
- •Interventional Therapy
- •Needle Selection
- •Biopsy Techniques
- •References
- •Introduction
- •Pathophysiology
- •Ascites
- •Clinical Indication
- •Ascites
- •Conventional Therapy
- •Ascites
- •Interventional Therapy
- •Ascites
- •References
- •43: Obstructive Uropathy
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Urolithiasis
- •Infection
- •Urothelial Carcinoma
- •Neurogenic Bladder
- •Interventional Therapy
- •References
- •Pathophysiology
- •Clinical Indications
- •Percutaneous Radiologic Gastrojejunostomy (PRGJ) Tube
- •Percutaneous Jejunostomy (PJ) Tube
- •Conventional Therapy
- •Interventional Therapy
- •Percutaneous Radiologic Gastrostomy (PRG)
- •Post-procedural Management
- •Percutaneous Radiologic Gastrojejunostomy (PRGJ)
- •Percutaneous Jejunostomy (PJ)
- •References
- •45: Stroke
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Complications
- •Post-procedure Management
- •References
- •46: Cerebral Angiography: Aneurysms
- •Pathophysiology
- •Clinical Indication
- •Conventional Therapy
- •Interventional Therapy
- •Pre-procedural Preparation
- •Post-procedural Management
- •Complications
- •References

Visceral andSolid Organ Trauma
KariJ.Nelson andMitchellDaun
32
Pathophysiology
Spleen
The spleen is the most commonly injured solid organ [1, 2].
Overlooked splenic injury is the most common cause of preventable death in trauma patients [3]. CT with intravenous
contrast is routinely obtained following trauma and should
be carefully analyzed for injury. The American Association
for the Surgery of Trauma (AAST) has developed a spleenspecic grading scheme to categorize traumatic injury and
aid in determining management (Table32.1 and Fig.32.1).
Key Point
Order of frequency of injured abdominal organs [4]:
1. Spleen
2. Liver
3. Kidneys
4. Small bowel/mesentery
5. Bladder
6. Colon/rectum
7. Diaphragm
8. Pancreas
9. Major vessels
The arterial supply for the spleen is the splenic artery,
which gives rise to several non-splenic branches before dividing into the terminal branches at the splenic hilum (Fig.32.2).
K. J. Nelson (*)
Vascular and Interventional Radiology, University of California,
Irvine Medical Center, Department of Radiological Sciences,
Orange, CA, USA
e-mail: k2nelson@uci.edu
M. Daun
University of California, Irvine Medical Center, Department of
Radiology, Orange, CA, USA
Table 32.1 AAST spleen injury grading scale
Grade Description of injury
I Subcapsular hematoma <10% surface area
II Subcapsular hematoma 10–50% surface area
III Subcapsular hematoma >50% surface area or expanding
IV Laceration of vessels producing major devascularization
V Completely shattered spleen
a
Adapted from Ref. [4]
Capsular tear <1cm of depth
Intraparenchymal hematoma <5cm
Capsular tear 1–3cm in depth not involving a trabecular
vessel
Ruptured subcapsular or intraparenchymal hematoma
≥5cm or expanding
Laceration >3cm or involving a trabecular vessel
(> 25% of the spleen)
Hilar vascular injury with devascularized spleen
a
The rst two major splenic artery branches are the dorsal pancreatic artery and greater pancreatic artery, which supply the
pancreatic body and tail. Many smaller, unnamed branches
supplying the body and tail of the pancreas also typically arise
from the splenic artery. The posterior gastric artery, which
supplies the posterior gastric body, is not uniformly present
and has variable origin, arising from the splenic artery with a
frequency of less than 50%. The artery to the tail of the pancreas, the left gastroepiploic artery, and variable short gastric
arteries arise from the distal splenic artery or its terminal
branches at the hilum. The artery to the tail of the pancreas
feeds the pancreatic tail at the hilum. The left gastroepiploic
artery supplies the greater curvature of the stomach and omentum. The short gastric arteries, of which there are usually four
to ve, supply the gastric fundus and anastomose with
branches of the left gastric artery and left gastroepiploic artery.
Liver
The liver is the second most frequently injured abdominal
organ [17]. It has dual blood supply provided by the portal
vein and hepatic artery. The portal vein provides approxi-
© Springer International Publishing AG, part of Springer Nature 2018
N. A. Keefe et al. (eds.), IR Playbook, https://doi.org/10.1007/978-3-319-71300-7_32
357

358
%
Segmental or
Grade IV Grade V
K. J. Nelson and M. Daun
Laceration <1 cm
Subcapsular
hematoma <10%
of surface area
Grade I Grade II
Laceration >3 cm
Subcapsular
hematoma >50%
of surface area
Laceration 1–3 cm
Subcapsular
hematoma 10%–50
of surface area
Ruptured
subcapsular or
parenchymal
hematoma
Grade III Grade III
Shattered spleen
Hilar injury
hilar vascular
injury
Devascularization
>25% of spleen
Fig. 32.1 The ve AAST grades of splenic injury (Adapted from Ref. [5])

Left gastro-omental
Dorsal pancreati
32 Visceral andSolid Organ Trauma
Left gastric
artery
Celiac trunk
c
artery
Splenic artery
Fig. 32.2 Splenic arterial anatomy with stomach reected cephalad
359
Posterior
gastric artery
Short gastric
arteries
(gastroepiploic)
artery
Artery to tail of
pancreas (partially
in phantom)
Greater pancreatic
artery
Inferior pancreatic
artery (phantom)
Table 32.2 AAST liver injury grading scale
Grade Description of injury
I Subcapsular hematoma <10% surface area
Capsular tear <1cm of depth
II Subcapsular hematoma 10–50% surface area
Intraparenchymal hematoma <10cm
Capsular tear 1–3cm in depth, <10cm in length, not
involving a trabecular vessel
III Subcapsular hematoma >50% surface area or expanding
Ruptured subcapsular or intraparenchymal hematoma
≥10cm or expanding
Laceration >3cm in depth
IV Laceration of parenchyma involving 25–75% of hepatic lobe
or 1–3 Couinaud’s segments
V Laceration of parenchyma involving >75% of hepatic lobe or
>3 Couinaud’s segments within a lobe
Juxtahepatic venous injuries including IVC or central hepatic
vein injury
VI Hepatic avulsion
a
Adapted from Ref. [4]
a
mately 75% of the total hepatic blood ow. Anatomic variability of the arterial supply to the liver is common. Variant
anatomy of the celiac trunk and hepatic arteries has been
demonstrated in approximately 25% of all patients in a study
of 1000 donors [18]. Careful evaluation of arterial anatomy
facilitates catheterization and intervention (refer to Chap. 6
for further information on vascular anatomy). The American
Association for the Surgery of Trauma (AAST) has developed a liver-specic grading scheme to categorize traumatic
injury in order to guide management (Table32.2).
Table 32.3 AAST kidney injury grading scale
Grade Description of injury
I Contusion
Subcapsular hematoma without parenchymal lesion
II Nonexpanding perirenal hematoma conned to
retroperitoneum
Laceration <1cm in depth, without urinary extravasation
III Laceration through the renal cortex, medulla, and collecting
system
Laceration >1cm in depth, without urinary extravasation or
collecting system rupture
IV Vascular injury to the main renal artery or vein, with
contained hemorrhage
V Completely shattered kidney
Avulsion of the renal hilum
a
Adapted from Ref. [27]
a
Kidney
Traumatic injury to the kidney accounts for 10% of signicant blunt abdominal trauma and represents the most common urologic trauma [27]. Clinically, patients present with
ank pain and/or gross hematuria. Injury is most often
related to sports or high-speed trauma and is routinely characterized by CT with IV contrast or ultrasound. The spectrum of renal injury includes subcapsular hematoma,
contusion, laceration, complete shattering of the organ, avulsion of the renal pelvis, and injury to the renal vascular pedicle (Table32.3 and Fig.32.3).

360
Grade V
n
Subcapsular
hematoma
without laceration
Grade I Grade II
Laceration
> 1.0 cm depth
without injury to
collecting system
Grade III Grade IV
K. J. Nelson and M. Daun
Peri-renal hematoma
or laceration
< 1.0 cm depth
Laceration extending
through cortex,
medulla, and
collecting system,
or main renal artery/vei
injury with contained
hematoma
Completely
shattered kidney,
or avulsion of the
renal hilum with
devascularization
Fig. 32.3 The ve AAST grades of kidney injury (Adapted from Ref. [28])
Clinical Indication
Spleen
Hemodynamically unstable patients with splenic injury are
managed operatively. Non-operative management (NOM) of
splenic injury was rst employed in pediatrics in the 1970s but
gradually has extended to become the standard of care in
hemodynamically stable adults [2]. NOM aims for splenic
preservation and consists of medical management with or
without splenic artery embolization. NOM of hemodynamically stable patients with splenic injury generally involves
admission to the ICU or a step-down unit with continuous
monitoring of vital parameters. The decision to proceed with
splenic arterial embolization (SAE) is multifactorial, involving assessment of patient characteristics including transfusion
requirements, degree and type of splenic injury, and presence
of intraparenchymal or intraperitoneal contrast material
extravasation. A representative management algorithm for

32 Visceral andSolid Organ Trauma
361
Fig. 32.4 Western Trauma Association Algorithm for splenic injury
hemodynamically stable patients is shown in Fig.32.4. The
only absolute contraindication to SAE is hemodynamic instability. Some data have shown that SAE for patients who transiently establish hemodynamic stability following initial
resuscitation can yield good results if SAE is performed early
and at a capable center [6]. Relative contraindications to SAE
include preexisting splenic disease, multisystem trauma, and
associated diaphragmatic or hollow viscous injury [7].
Liver
The liver may be injured with either blunt or penetrating
trauma. Contrast-enhanced CT is routinely obtained as part of
the integrated trauma algorithm for hemodynamically stable
patients and should be carefully analyzed for injury. The
American Association for the Surgery of Trauma (AAST) has
developed a liver-specic grading scheme to categorize traumatic injury in order to guide management (Table32.2).
Kidney
Non-operative management (NOM) has become standard
for grade I–III renal injuries as these injuries are gener-
ally self- limiting [27, 29]. Controversy remains regarding
management of grade IV and V renal injuries. Surgical
exploration of high-grade renal injuries usually results in
total nephrectomy. The risks of morbidity and mortality
with NOM must be weighed with the possibility of renal
salvage.
Conventional Therapy
Spleen
Conventional surgical management consists of laparotomy
with splenectomy or splenorrhaphy (suturing a ruptured
spleen). The most signicant long-term complication of
splenectomy is increased infection risk, specically from
encapsulated organisms. All splenectomy patients require
vaccination against S. pneumoniae, H. inuenza B, and N.
meningitidis to help prevent infection. Overwhelmingly
post-splenectomy sepsis (OPSI) is more common in cases of
elective splenectomy for hematologic disorders but also
occurs in approximately 0.5% of post-trauma asplenic
patients [8]. Operative management remains the standard of
care for hemodynamically unstable patients and may be
required in cases of failure of NOM [8].

362
K. J. Nelson and M. Daun
Liver
Similar to splenic injury, historical treatment of traumatic
hepatic injury routinely involved laparotomy with partial
surgical resection or repair. While non-operative management has become the standard for most hepatic trauma,
surgical intervention remains the standard for hemodynamically unstable patients [18]. The focus of care in these
patients includes aggressive resuscitation with uids and
blood products and rapid mobilization of the surgical team.
The surgical approach to traumatic liver injury has evolved,
with avoidance of emergency laparotomy when possible and
a trend toward abbreviated laparotomy with perihepatic
packing when surgery is required [20].
Kidney
Surgical management of blunt renal injury consists of total
nephrectomy and has become increasingly rare with the
increased efcacy of expectant management and advancement in minimally invasive techniques. One large study from
1995 found that surgical intervention was required in fewer
than 10% of cases of renal injury [30]. Correlation between
AAST renal injury grade and hemodynamic instability was
the only demonstrated predictor of need for surgery in a large
prospective single center study, with surgical management
required in 11% of grade IV and 48% of grade V renal injuries [29]. Penetrating trauma to the kidney is nine times less
common than blunt trauma [31] and often warrants surgical
exploration [29].
Interventional Therapy
Spleen
Splenic artery embolization (SAE) can be performed proximally within the splenic artery, distally within intraparenchymal splenic artery branches, or as a combination of the
two techniques (Fig.32.5). Proximal SAE is generally performed with deployment of coils or a vascular plug beyond
the dorsal pancreatic artery origin but proximal to terminal
splenic artery branches, with the goal of complete vascular
occlusion at the site of proximal embolization. The purpose of proximal SAE is to decrease the splenic arterial
pressure while allowing distal reconstitution of the splenic
artery via collateral arteries to prevent splenic infarction.
Proximal embolization is often preferred in the setting of
high-grade trauma without focal arterial abnormality at
angiography. Distal SAE is performed after angiographic
localization of a focal arterial abnormality and selective
catheterization of the involved intraparenchymal segmental splenic arterial branch. Distal SAE may be performed
with a variety of agents including microparticles, liquid
embolics, and coils. As distal SAE is associated with
splenic infarction, this technique is generally performed in
a limited vascular territory in the setting of focal arterial
abnormality. Combined proximal and distal SAE is generally reserved for grade IV or V AAST splenic injuries or
large hemoperitoneum (refer to Table 32.1 for splenic
injury grading).
Key Point
Distal splenic arterial embolization allows for targeted
exclusion of a focal arterial injury. Proximal embolization functions to decrease overall perfusion pressure in
the setting of high grade trauma without a focal parenchymal angiographic abnormality.
Clinical success rate is approximately 90% for SAE management of splenic trauma. Systematic reviews and metaanalyses have demonstrated no signicant difference in rate
of SAE failure or splenic rebleeding between proximal and
distal SAE [10]. Major infarction and major infection of the
spleen requiring splenectomy are uncommon regardless of
proximal versus distal SAE technique, while minor splenic
infarction occurs more frequently with distal SAE [10].
Other complications including renal insufciency and
symptomatic splenic cysts occur with variable incidence
[11]. Pancreatic infarction has been reported and may occur
with embolization proximal to the dorsal pancreatic artery or
with embolization of collateral pancreatic arteries; it can also
occur in a patient without signicant pancreatic artery collateral vessels [10, 12].
Pre-procedure
Depending upon the availability of anesthesia resources and
the condition of the patient, SAE is performed with either IV
conscious sedation or general anesthesia. The administration
of prophylactic antibiotics in the trauma setting is generally
considered for SAE since infarction is a procedural risk.
Antibiotic choice should cover skin pathogens [25].

32 Visceral andSolid Organ Trauma
363
Fig. 32.5 A 15-year-old male with a grade V splenic laceration as seen on coronal (a) and axial (b) imaging. Digital subtraction angiography
demonstrates parenchymal injury and active extravasation (c and d) and resolution of active extravasation following Gelfoam and coil embolization (e)
The How To: Splenic Trauma
1. Trauma embolizations are typically performed
through the femoral artery approach.
2. The Seldinger technique is used to access the artery
using an 18-gauge or 21-gauge needle, with or
without US guidance (refer to Chap. 8 for further
information).
3. Celiac axis catheterization is typically performed
with a 5 Fr catheter followed by digital subtraction
proximal to distal splenic branches to allow
(b) For distal embolization, a microcatheter system
is advanced into the abnormal intraparenchymal
segmental splenic artery and embolization is
performed with agent of choice. Both proximal
and distal embolization techniques may be
employed, as needed.
(c) If performing a combination of proximal and
distal embolization, distal embolization should
angiography of the celiac and splenic artery.
4. The splenic artery is then selected with either the 5
Fr catheter or a coaxial microcatheter.
5. Depending upon the type and extent of splenic
6. Post-embolization angiography is performed from
the celiac axis or proximal splenic artery through the
5 Fr catheter to ensure vessel occlusion with proximal embolization and/or resolution of extravasation
(a) In proximal embolization, coils or a vascular
plug are deployed in the splenic artery trunk
distal to the dorsal pancreatic artery but
with distal occlusion has been achieved and to verify
absence of additional angiographic abnormalities
warranting treatment.

364
K. J. Nelson and M. Daun
Post-procedure
Treatment failure is dened as the need for operative management after an attempt of non-operative management. Patients
are typically monitored as inpatients for at least 1–3 days
[2]. Predictive factors for failure of NOM include high grade
of injury and preexisting underlying splenic disease [13].
Although delayed splenic rupture is an important risk of
NOM for splenic trauma, follow-up imaging in the inpatient
setting is a controversial practice with only a minority of
surveyed trauma surgeons performing routine follow- up CT
[14]. Follow-up imaging may detect delayed vascular injury
such as splenic pseudoaneurysm in 6% of cases [14]. Delayed
splenic rupture most frequently occurs 4–8days after injury
and carries an increased mortality rate of 5–15%, compared
to a 1% mortality rate for overall acute splenic injury [15].
A recent study demonstrated decreased incidence of delayed
splenic rupture with the routine use of follow- up CT imaging
obtained 48h after NOM [14]. Classically, splenic rupture
is characterized by left hemidiaphragm elevation, left lower
lobe atelectasis, and left pleural effusion, although this triad
is unreliable and often absent [15]. Additional major complications include splenic infarction, splenic abscess, and
contrast-induced nephropathy. Minor complications include
pleural effusion and post- embolization syndrome. Postembolization syndrome (PES) presents in the rst 3days and
is characterized by fever, leukocytosis, nausea, generalized
pain, and/or u-like symptoms. Treatment is supportive, and
the condition is self-limited. Routine post-discharge followup imaging is not recommended [2].
Key Point
Important post-procedural complications following
splenic artery embolization include persistent hemorrhage, splenic rupture, splenic abscess, and nontarget
embolization of the pancreas.
Key Point
General complications that may follow any arterial
embolization include access-site pseudoaneurysm, dissection, hematoma, thrombosis, and post-embolization
syndrome.
Unlike splenectomy patients who are nearly universally
administered vaccines against encapsulated organisms, the
majority of patients managed non-operatively do not require
vaccination due to preserved spleen function [16]. Return to
activity is usually a large concern for patients. Typical recommendation for return to normal daily activity is 2–3months
and may be longer in higher grade injuries. A 3-month hiatus
prior to return to sports is a frequent recommendation in lowgrade injury. There is no clear consensus on return to contact
sports in patients with high-grade splenic injury [2].
Liver
Management of hepatic trauma has shifted toward nonoperative measures over the past several decades, with success of nonsurgical intervention approximately 90% [21,
22]. Non-operative management includes clinical observa-
tion with or without transarterial embolization (TAE).
Angiography with embolization is considered in hemodynamically stable patients with arterial contrast extravasation
on CT, evidence of ongoing bleeding despite resuscitation,
hemobilia, or high-grade liver injuries (Fig.32.6) [19, 22].
The success of TAE to control bleeding as part of NOM
trauma has been reported as 81–100% [23]. TAE is also utilized for hemorrhage control following laparotomy in the
setting of hepatic trauma. A systematic review of the literature reported the need for postoperative TAE in 12–28% of
surgical patients [23].
The primary embolic materials utilized in hepatic trauma
are Gelfoam and metallic coils. Gelfoam is often preferred
for multifocal injury due to its temporary occlusive effect
with the potential to preserve normal hepatic parenchyma.
Coils are often chosen in the setting of injury to a single
larger vessel, including arteriovenous stula, arteriobiliary
stula, and pseudoaneurysm. Other microparticles and liquid embolics, which are permanent agents, may also be
employed depending upon operator preference and the need
for permanent distal occlusion. Injury to the major juxtahepatic venous structures, specically the retrohepatic vena
cava and major hepatic and portal veins, is correlated with a
higher degree of injury as well as a higher mortality risk.
Early recognition and consideration of operative management are essential [23].
Key Point
Post-embolization syndrome (PES) presents in the rst
3 days and is characterized by fever, leukocytosis,
nausea, generalized pain, and/or u-like symptoms.
Treatment is supportive, and the condition is
self-limited.
Key Point
Gelfoam is a temporary occlusive embolic material,
allowing for partial recanalization of vessels within weeks
to months. Permanent occlusive materials include other
microparticles, liquid embolics, metallic coils, and plugs.

32 Visceral andSolid Organ Trauma
365
Fig. 32.6 A 30-year-old male with grade III liver laceration with extensive subcapsular hematoma and active extravasation as seen on coronal (a)
and axial (b) imaging. Angiography demonstrates focus of active extravasation (c and d). Angiography following selective Gelfoam embolization
demonstrates resolution of active extravasation (e)
Pre-procedure
Depending upon the availability of anesthesia resources and
the condition of the patient, TAE is performed with either IV
conscious sedation or general anesthesia. The administration
of prophylactic antibiotics are generally considered for TAE
since infarction is a procedural risk [25]. Antibiotic choice
should cover skin pathogens. Additional antibiotic coverage
for enteric ora may be considered given the possibility of
concomitant biliary injury with liver trauma, especially in
patients known to have undergone prior sphincterotomy or
bilioenteric anastomosis [24].
In the setting of standard anatomy, celiac axis catheterization is typically performed with a 5 Fr catheter
followed by digital subtraction angiography of the
celiac and hepatic arteries. For variant anatomy, the
superior mesenteric artery may need to be selected.
4. The common hepatic artery is then selected with
either the 5 Fr catheter or a coaxial microcatheter. A
coaxial microcatheter system is then advanced
through the proper hepatic artery and ipsilateral
hepatic artery to the area of injury.
5. Depending upon the type and extent of hepatic arte-
with the operator’s embolic agent of choice.
The How To: Hepatic Trauma
Findings at angiography may include active extrav-
1. Trauma embolizations are typically performed
through femoral artery approach.
the site of injury prevents rebleeding via collateral
2. The Seldinger technique is used to access the artery
using an 18-gauge or 21-gauge needle with or
without US guidance (refer to Chap. 8 for further
information).
3.
ter if hepatic arterial anatomy is not adequately characterized on CT, as arterial variants are common.
-
prior to proximal embolization.
6. Post-embolization angiography is performed initially
through the microcatheter and subsequently through
the 5 Fr catheter to ensure embolization endpoint has
been reached and to verify absence of additional angiographic abnormalities warranting treatment.

366
K. J. Nelson and M. Daun
Adverse Eects
A multicenter study found the overall incidence of hepatic
related complications in 14% of trauma patients, with 34%
of those patients requiring surgical intervention [24]. Risk
factors predictive of complications of NOM include high
grade of hepatic injury and increased transfusion requirements [24]. Complications of transcatheter embolization
include nontarget embolization (including gallbladder
infarction), hepatic necrosis, and hepatic abscess. Bile leak
or biloma may occur in the setting of traumatic biliary
injury. The development of abdominal compartment syndrome after NOM has been reported to occur in up to 10%
of cases, with 9–30% of TAE patients subsequently requiring laparotomy for evacuation of intraperitoneal hematoma
to relieve abdominal compartment syndrome or for biliary
complication [23].
Key Point
Complications of hepatic arterial embolization include
nontarget embolization (including gallbladder infarction), hepatic necrosis, hepatic abscess, and bile leak
or biloma.
Post-procedure
It is important to recognize that there is a higher mortality
and higher rate of complications associated with NOM of
hepatic injury compared with NOM of splenic injury.
Delayed hemorrhage has an incidence of approximately
3% and represents the most common cause of death in
patients managed non-operatively [26]. Delayed hemorrhage may present in a variety of ways, including hypotension, drop in hemoglobin, or the presence of blood in
intraperitoneal or biliary drains. Routine follow-up imaging is not recommended in the asymptomatic patient.
However, there should be a low threshold for reimaging in
the clinical setting of persistent pain, jaundice, or worsening anemia [9].
Kidney
It has been shown that selective renal artery embolization
(RAE) can safely and effectively supplant acute surgery in the
vast majority of patients, even those with high grade of injury
and those who are hemodynamically unstable (Fig. 32.7)
[32]. RAE involves catheterization of the ipsilateral renal
artery with subsequent advancement of a microcatheter under
uoroscopic guidance to the area of injury. Embolization is
performed via microcatheter targeted at the area of trauma. A
super selective microcatheter position immediately adjacent
to the injury spares the maximum volume of viable renal
parenchyma. Modern embolization is typically performed
with microparticles, liquid embolics, or coils.
Key Point
Embolization for renal injury is less common than for
splenic or hepatic injury.
Intervention in renal trauma also includes endovascular
stenting for traumatic renal artery vascular injury. A recent
review article showed a high success rate of endovascular
stenting without a subsequent need for surgery in 89% of 27
patients [33]. Long-term benet of non-operative management for blunt renal injury includes preserved renal function.
Up to 40% of renal function preservation has been reported
following grade IV renal injury with NOM including RAE at
4–6months [29] and contrasts sharply with the loss of function resulting from total nephrectomy.
Pre-procedure
Depending upon the availability of anesthesia resources and
the condition of the patient, RAE is performed with either IV
conscious sedation or general anesthesia. The administration
of prophylactic antibiotics in the trauma setting is generally
considered for RAE since infarction is a procedural risk [25].
Antibiotic choice should cover skin pathogens.
Key Point
Non-operative management of the liver is associated
with higher mortality and complication rates when
compared with NOM of splenic injury, with the most
signicant complication being delayed hemorrhage.
The How To: Renal Trauma
1. Trauma embolizations are typically performed
through femoral artery approach.
2. The Seldinger technique is used to access the artery
using an 18-gauge or 21-gauge needle with or without US guidance (refer to Chap. 8 for further
information).
3.
identify the renal arteries, as variant anatomy,
including multiple renal arteries, occurs frequently.
(continued)
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