Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3657_Библиотеки_им_академика_М_И_Перельмана.pdf
Скачиваний:
0
Добавлен:
30.08.2026
Размер:
49 Мб
Скачать
Visceral andSolid Organ Trauma
KariJ.Nelson andMitchellDaun
32

Pathophysiology

Spleen
The spleen is the most commonly injured solid organ [1, 2]. Overlooked splenic injury is the most common cause of pre­ventable death in trauma patients [3]. CT with intravenous contrast is routinely obtained following trauma and should be carefully analyzed for injury. The American Association for the Surgery of Trauma (AAST) has developed a spleen­specic grading scheme to categorize traumatic injury and aid in determining management (Table32.1 and Fig.32.1).
Key Point
Order of frequency of injured abdominal organs [4]:
1. Spleen
2. Liver
3. Kidneys
4. Small bowel/mesentery
5. Bladder
6. Colon/rectum
7. Diaphragm
8. Pancreas
9. Major vessels
The arterial supply for the spleen is the splenic artery, which gives rise to several non-splenic branches before divid­ing into the terminal branches at the splenic hilum (Fig.32.2).
K. J. Nelson (*) Vascular and Interventional Radiology, University of California, Irvine Medical Center, Department of Radiological Sciences, Orange, CA, USA e-mail: k2nelson@uci.edu
M. Daun University of California, Irvine Medical Center, Department of Radiology, Orange, CA, USA
Table 32.1 AAST spleen injury grading scale
Grade Description of injury I Subcapsular hematoma <10% surface area
II Subcapsular hematoma 10–50% surface area
III Subcapsular hematoma >50% surface area or expanding
IV Laceration of vessels producing major devascularization
V Completely shattered spleen
a
Adapted from Ref. [4]
Capsular tear <1cm of depth
Intraparenchymal hematoma <5cm Capsular tear 1–3cm in depth not involving a trabecular vessel
Ruptured subcapsular or intraparenchymal hematoma 5cm or expanding Laceration >3cm or involving a trabecular vessel
(> 25% of the spleen)
Hilar vascular injury with devascularized spleen
a
The rst two major splenic artery branches are the dorsal pan­creatic artery and greater pancreatic artery, which supply the pancreatic body and tail. Many smaller, unnamed branches supplying the body and tail of the pancreas also typically arise from the splenic artery. The posterior gastric artery, which supplies the posterior gastric body, is not uniformly present and has variable origin, arising from the splenic artery with a frequency of less than 50%. The artery to the tail of the pan­creas, the left gastroepiploic artery, and variable short gastric arteries arise from the distal splenic artery or its terminal branches at the hilum. The artery to the tail of the pancreas feeds the pancreatic tail at the hilum. The left gastroepiploic artery supplies the greater curvature of the stomach and omen­tum. The short gastric arteries, of which there are usually four to ve, supply the gastric fundus and anastomose with branches of the left gastric artery and left gastroepiploic artery.
Liver
The liver is the second most frequently injured abdominal organ [17]. It has dual blood supply provided by the portal vein and hepatic artery. The portal vein provides approxi-
© Springer International Publishing AG, part of Springer Nature 2018 N. A. Keefe et al. (eds.), IR Playbook, https://doi.org/10.1007/978-3-319-71300-7_32
357
358
%
Segmental or
Grade IV Grade V
K. J. Nelson and M. Daun
Laceration <1 cm
Subcapsular hematoma <10% of surface area
Grade I Grade II
Laceration >3 cm
Subcapsular hematoma >50% of surface area
Laceration 1–3 cm
Subcapsular hematoma 10%–50 of surface area
Ruptured subcapsular or parenchymal hematoma
Grade III Grade III
Shattered spleen
Hilar injury
hilar vascular
injury
Devascularization >25% of spleen
Fig. 32.1 The ve AAST grades of splenic injury (Adapted from Ref. [5])
Left gastro-omental
Dorsal pancreati
32 Visceral andSolid Organ Trauma
Left gastric
artery
Celiac trunk
c
artery
Splenic artery
Fig. 32.2 Splenic arterial anatomy with stomach reected cephalad
359
Posterior gastric artery
Short gastric arteries
(gastroepiploic) artery
Artery to tail of pancreas (partially in phantom)
Greater pancreatic artery
Inferior pancreatic artery (phantom)
Table 32.2 AAST liver injury grading scale
Grade Description of injury I Subcapsular hematoma <10% surface area
Capsular tear <1cm of depth
II Subcapsular hematoma 10–50% surface area
Intraparenchymal hematoma <10cm Capsular tear 1–3cm in depth, <10cm in length, not involving a trabecular vessel
III Subcapsular hematoma >50% surface area or expanding
Ruptured subcapsular or intraparenchymal hematoma 10cm or expanding Laceration >3cm in depth
IV Laceration of parenchyma involving 25–75% of hepatic lobe
or 1–3 Couinaud’s segments
V Laceration of parenchyma involving >75% of hepatic lobe or
>3 Couinaud’s segments within a lobe Juxtahepatic venous injuries including IVC or central hepatic vein injury
VI Hepatic avulsion
a
Adapted from Ref. [4]
a
mately 75% of the total hepatic blood ow. Anatomic vari­ability of the arterial supply to the liver is common. Variant anatomy of the celiac trunk and hepatic arteries has been demonstrated in approximately 25% of all patients in a study of 1000 donors [18]. Careful evaluation of arterial anatomy facilitates catheterization and intervention (refer to Chap. 6 for further information on vascular anatomy). The American Association for the Surgery of Trauma (AAST) has devel­oped a liver-specic grading scheme to categorize traumatic injury in order to guide management (Table32.2).
Table 32.3 AAST kidney injury grading scale
Grade Description of injury I Contusion
Subcapsular hematoma without parenchymal lesion
II Nonexpanding perirenal hematoma conned to
retroperitoneum Laceration <1cm in depth, without urinary extravasation
III Laceration through the renal cortex, medulla, and collecting
system Laceration >1cm in depth, without urinary extravasation or collecting system rupture
IV Vascular injury to the main renal artery or vein, with
contained hemorrhage
V Completely shattered kidney
Avulsion of the renal hilum
a
Adapted from Ref. [27]
a
Kidney
Traumatic injury to the kidney accounts for 10% of signi­cant blunt abdominal trauma and represents the most com­mon urologic trauma [27]. Clinically, patients present with ank pain and/or gross hematuria. Injury is most often related to sports or high-speed trauma and is routinely char­acterized by CT with IV contrast or ultrasound. The spec­trum of renal injury includes subcapsular hematoma, contusion, laceration, complete shattering of the organ, avul­sion of the renal pelvis, and injury to the renal vascular ped­icle (Table32.3 and Fig.32.3).
360
Grade V
n
Subcapsular hematoma without laceration
Grade I Grade II
Laceration > 1.0 cm depth without injury to collecting system
Grade III Grade IV
K. J. Nelson and M. Daun
Peri-renal hematoma or laceration < 1.0 cm depth
Laceration extending through cortex, medulla, and collecting system, or main renal artery/vei injury with contained hematoma
Completely shattered kidney, or avulsion of the renal hilum with devascularization
Fig. 32.3 The ve AAST grades of kidney injury (Adapted from Ref. [28])

Clinical Indication

Spleen
Hemodynamically unstable patients with splenic injury are managed operatively. Non-operative management (NOM) of splenic injury was rst employed in pediatrics in the 1970s but gradually has extended to become the standard of care in hemodynamically stable adults [2]. NOM aims for splenic
preservation and consists of medical management with or without splenic artery embolization. NOM of hemodynami­cally stable patients with splenic injury generally involves admission to the ICU or a step-down unit with continuous monitoring of vital parameters. The decision to proceed with splenic arterial embolization (SAE) is multifactorial, involv­ing assessment of patient characteristics including transfusion requirements, degree and type of splenic injury, and presence of intraparenchymal or intraperitoneal contrast material extravasation. A representative management algorithm for
32 Visceral andSolid Organ Trauma
361
Fig. 32.4 Western Trauma Association Algorithm for splenic injury
hemodynamically stable patients is shown in Fig.32.4. The only absolute contraindication to SAE is hemodynamic insta­bility. Some data have shown that SAE for patients who tran­siently establish hemodynamic stability following initial resuscitation can yield good results if SAE is performed early and at a capable center [6]. Relative contraindications to SAE include preexisting splenic disease, multisystem trauma, and associated diaphragmatic or hollow viscous injury [7].
Liver
The liver may be injured with either blunt or penetrating trauma. Contrast-enhanced CT is routinely obtained as part of the integrated trauma algorithm for hemodynamically stable patients and should be carefully analyzed for injury. The American Association for the Surgery of Trauma (AAST) has developed a liver-specic grading scheme to categorize trau­matic injury in order to guide management (Table32.2).
Kidney
Non-operative management (NOM) has become standard for grade I–III renal injuries as these injuries are gener-
ally self- limiting [27, 29]. Controversy remains regarding management of grade IV and V renal injuries. Surgical exploration of high-grade renal injuries usually results in total nephrectomy. The risks of morbidity and mortality with NOM must be weighed with the possibility of renal salvage.

Conventional Therapy

Spleen
Conventional surgical management consists of laparotomy with splenectomy or splenorrhaphy (suturing a ruptured spleen). The most signicant long-term complication of splenectomy is increased infection risk, specically from encapsulated organisms. All splenectomy patients require vaccination against S. pneumoniae, H. inuenza B, and N. meningitidis to help prevent infection. Overwhelmingly post-splenectomy sepsis (OPSI) is more common in cases of elective splenectomy for hematologic disorders but also occurs in approximately 0.5% of post-trauma asplenic patients [8]. Operative management remains the standard of care for hemodynamically unstable patients and may be required in cases of failure of NOM [8].
362
K. J. Nelson and M. Daun
Liver
Similar to splenic injury, historical treatment of traumatic hepatic injury routinely involved laparotomy with partial surgical resection or repair. While non-operative manage­ment has become the standard for most hepatic trauma, surgical intervention remains the standard for hemodynami­cally unstable patients [18]. The focus of care in these patients includes aggressive resuscitation with uids and blood products and rapid mobilization of the surgical team. The surgical approach to traumatic liver injury has evolved, with avoidance of emergency laparotomy when possible and a trend toward abbreviated laparotomy with perihepatic packing when surgery is required [20].
Kidney
Surgical management of blunt renal injury consists of total nephrectomy and has become increasingly rare with the increased efcacy of expectant management and advance­ment in minimally invasive techniques. One large study from 1995 found that surgical intervention was required in fewer than 10% of cases of renal injury [30]. Correlation between AAST renal injury grade and hemodynamic instability was the only demonstrated predictor of need for surgery in a large prospective single center study, with surgical management required in 11% of grade IV and 48% of grade V renal inju­ries [29]. Penetrating trauma to the kidney is nine times less common than blunt trauma [31] and often warrants surgical exploration [29].

Interventional Therapy

Spleen
Splenic artery embolization (SAE) can be performed prox­imally within the splenic artery, distally within intraparen­chymal splenic artery branches, or as a combination of the two techniques (Fig.32.5). Proximal SAE is generally per­formed with deployment of coils or a vascular plug beyond the dorsal pancreatic artery origin but proximal to terminal splenic artery branches, with the goal of complete vascular occlusion at the site of proximal embolization. The pur­pose of proximal SAE is to decrease the splenic arterial pressure while allowing distal reconstitution of the splenic artery via collateral arteries to prevent splenic infarction. Proximal embolization is often preferred in the setting of
high-grade trauma without focal arterial abnormality at angiography. Distal SAE is performed after angiographic localization of a focal arterial abnormality and selective catheterization of the involved intraparenchymal segmen­tal splenic arterial branch. Distal SAE may be performed with a variety of agents including microparticles, liquid embolics, and coils. As distal SAE is associated with splenic infarction, this technique is generally performed in a limited vascular territory in the setting of focal arterial abnormality. Combined proximal and distal SAE is gener­ally reserved for grade IV or V AAST splenic injuries or large hemoperitoneum (refer to Table 32.1 for splenic injury grading).
Key Point
Distal splenic arterial embolization allows for targeted exclusion of a focal arterial injury. Proximal emboliza­tion functions to decrease overall perfusion pressure in the setting of high grade trauma without a focal paren­chymal angiographic abnormality.
Clinical success rate is approximately 90% for SAE man­agement of splenic trauma. Systematic reviews and meta­analyses have demonstrated no signicant difference in rate of SAE failure or splenic rebleeding between proximal and distal SAE [10]. Major infarction and major infection of the spleen requiring splenectomy are uncommon regardless of proximal versus distal SAE technique, while minor splenic infarction occurs more frequently with distal SAE [10]. Other complications including renal insufciency and symptomatic splenic cysts occur with variable incidence [11]. Pancreatic infarction has been reported and may occur with embolization proximal to the dorsal pancreatic artery or with embolization of collateral pancreatic arteries; it can also occur in a patient without signicant pancreatic artery col­lateral vessels [10, 12].
Pre-procedure
Depending upon the availability of anesthesia resources and the condition of the patient, SAE is performed with either IV conscious sedation or general anesthesia. The administration of prophylactic antibiotics in the trauma setting is generally considered for SAE since infarction is a procedural risk. Antibiotic choice should cover skin pathogens [25].
32 Visceral andSolid Organ Trauma
363
Fig. 32.5 A 15-year-old male with a grade V splenic laceration as seen on coronal (a) and axial (b) imaging. Digital subtraction angiography
demonstrates parenchymal injury and active extravasation (c and d) and resolution of active extravasation following Gelfoam and coil emboli­zation (e)
The How To: Splenic Trauma
1. Trauma embolizations are typically performed through the femoral artery approach.
2. The Seldinger technique is used to access the artery using an 18-gauge or 21-gauge needle, with or without US guidance (refer to Chap. 8 for further information).
3. Celiac axis catheterization is typically performed with a 5 Fr catheter followed by digital subtraction
proximal to distal splenic branches to allow
(b) For distal embolization, a microcatheter system
is advanced into the abnormal intraparenchymal segmental splenic artery and embolization is performed with agent of choice. Both proximal and distal embolization techniques may be employed, as needed.
(c) If performing a combination of proximal and
distal embolization, distal embolization should
angiography of the celiac and splenic artery.
4. The splenic artery is then selected with either the 5 Fr catheter or a coaxial microcatheter.
5. Depending upon the type and extent of splenic
6. Post-embolization angiography is performed from the celiac axis or proximal splenic artery through the 5 Fr catheter to ensure vessel occlusion with proxi­mal embolization and/or resolution of extravasation
(a) In proximal embolization, coils or a vascular
plug are deployed in the splenic artery trunk distal to the dorsal pancreatic artery but
with distal occlusion has been achieved and to verify absence of additional angiographic abnormalities warranting treatment.
364
K. J. Nelson and M. Daun
Post-procedure
Treatment failure is dened as the need for operative manage­ment after an attempt of non-operative management. Patients are typically monitored as inpatients for at least 1–3 days [2]. Predictive factors for failure of NOM include high grade of injury and preexisting underlying splenic disease [13]. Although delayed splenic rupture is an important risk of NOM for splenic trauma, follow-up imaging in the inpatient setting is a controversial practice with only a minority of surveyed trauma surgeons performing routine follow- up CT [14]. Follow-up imaging may detect delayed vascular injury such as splenic pseudoaneurysm in 6% of cases [14]. Delayed splenic rupture most frequently occurs 4–8days after injury and carries an increased mortality rate of 5–15%, compared to a 1% mortality rate for overall acute splenic injury [15]. A recent study demonstrated decreased incidence of delayed splenic rupture with the routine use of follow- up CT imaging obtained 48h after NOM [14]. Classically, splenic rupture is characterized by left hemidiaphragm elevation, left lower lobe atelectasis, and left pleural effusion, although this triad is unreliable and often absent [15]. Additional major com­plications include splenic infarction, splenic abscess, and contrast-induced nephropathy. Minor complications include pleural effusion and post- embolization syndrome. Post­embolization syndrome (PES) presents in the rst 3days and is characterized by fever, leukocytosis, nausea, generalized pain, and/or u-like symptoms. Treatment is supportive, and the condition is self-limited. Routine post-discharge follow­up imaging is not recommended [2].
Key Point
Important post-procedural complications following splenic artery embolization include persistent hemor­rhage, splenic rupture, splenic abscess, and nontarget embolization of the pancreas.
Key Point
General complications that may follow any arterial embolization include access-site pseudoaneurysm, dis­section, hematoma, thrombosis, and post-embolization syndrome.
Unlike splenectomy patients who are nearly universally administered vaccines against encapsulated organisms, the majority of patients managed non-operatively do not require vaccination due to preserved spleen function [16]. Return to activity is usually a large concern for patients. Typical rec­ommendation for return to normal daily activity is 2–3months and may be longer in higher grade injuries. A 3-month hiatus prior to return to sports is a frequent recommendation in low­grade injury. There is no clear consensus on return to contact sports in patients with high-grade splenic injury [2].
Liver
Management of hepatic trauma has shifted toward non­operative measures over the past several decades, with suc­cess of nonsurgical intervention approximately 90% [21,
22]. Non-operative management includes clinical observa-
tion with or without transarterial embolization (TAE). Angiography with embolization is considered in hemody­namically stable patients with arterial contrast extravasation on CT, evidence of ongoing bleeding despite resuscitation, hemobilia, or high-grade liver injuries (Fig.32.6) [19, 22].
The success of TAE to control bleeding as part of NOM trauma has been reported as 81–100% [23]. TAE is also uti­lized for hemorrhage control following laparotomy in the setting of hepatic trauma. A systematic review of the litera­ture reported the need for postoperative TAE in 12–28% of surgical patients [23].
The primary embolic materials utilized in hepatic trauma
are Gelfoam and metallic coils. Gelfoam is often preferred for multifocal injury due to its temporary occlusive effect with the potential to preserve normal hepatic parenchyma. Coils are often chosen in the setting of injury to a single larger vessel, including arteriovenous stula, arteriobiliary stula, and pseudoaneurysm. Other microparticles and liq­uid embolics, which are permanent agents, may also be employed depending upon operator preference and the need for permanent distal occlusion. Injury to the major juxtahe­patic venous structures, specically the retrohepatic vena cava and major hepatic and portal veins, is correlated with a higher degree of injury as well as a higher mortality risk. Early recognition and consideration of operative manage­ment are essential [23].
Key Point
Post-embolization syndrome (PES) presents in the rst 3 days and is characterized by fever, leukocytosis, nausea, generalized pain, and/or u-like symptoms. Treatment is supportive, and the condition is self-limited.
Key Point
Gelfoam is a temporary occlusive embolic material,
allowing for partial recanalization of vessels within weeks
to months. Permanent occlusive materials include other
microparticles, liquid embolics, metallic coils, and plugs.
32 Visceral andSolid Organ Trauma
365
Fig. 32.6 A 30-year-old male with grade III liver laceration with extensive subcapsular hematoma and active extravasation as seen on coronal (a)
and axial (b) imaging. Angiography demonstrates focus of active extravasation (c and d). Angiography following selective Gelfoam embolization demonstrates resolution of active extravasation (e)
Pre-procedure
Depending upon the availability of anesthesia resources and the condition of the patient, TAE is performed with either IV conscious sedation or general anesthesia. The administration of prophylactic antibiotics are generally considered for TAE since infarction is a procedural risk [25]. Antibiotic choice should cover skin pathogens. Additional antibiotic coverage for enteric ora may be considered given the possibility of concomitant biliary injury with liver trauma, especially in patients known to have undergone prior sphincterotomy or bilioenteric anastomosis [24].
In the setting of standard anatomy, celiac axis cath­eterization is typically performed with a 5 Fr catheter followed by digital subtraction angiography of the celiac and hepatic arteries. For variant anatomy, the superior mesenteric artery may need to be selected.
4. The common hepatic artery is then selected with either the 5 Fr catheter or a coaxial microcatheter. A coaxial microcatheter system is then advanced through the proper hepatic artery and ipsilateral hepatic artery to the area of injury.
5. Depending upon the type and extent of hepatic arte-
with the operator’s embolic agent of choice.
The How To: Hepatic Trauma
Findings at angiography may include active extrav-
1. Trauma embolizations are typically performed through femoral artery approach.
the site of injury prevents rebleeding via collateral
2. The Seldinger technique is used to access the artery using an 18-gauge or 21-gauge needle with or without US guidance (refer to Chap. 8 for further information).
3. ter if hepatic arterial anatomy is not adequately char­acterized on CT, as arterial variants are common.
-
prior to proximal embolization.
6. Post-embolization angiography is performed initially through the microcatheter and subsequently through the 5 Fr catheter to ensure embolization endpoint has been reached and to verify absence of additional angi­ographic abnormalities warranting treatment.
366
K. J. Nelson and M. Daun
Adverse Eects
A multicenter study found the overall incidence of hepatic related complications in 14% of trauma patients, with 34% of those patients requiring surgical intervention [24]. Risk factors predictive of complications of NOM include high grade of hepatic injury and increased transfusion require­ments [24]. Complications of transcatheter embolization include nontarget embolization (including gallbladder infarction), hepatic necrosis, and hepatic abscess. Bile leak or biloma may occur in the setting of traumatic biliary injury. The development of abdominal compartment syn­drome after NOM has been reported to occur in up to 10% of cases, with 9–30% of TAE patients subsequently requir­ing laparotomy for evacuation of intraperitoneal hematoma to relieve abdominal compartment syndrome or for biliary complication [23].
Key Point
Complications of hepatic arterial embolization include nontarget embolization (including gallbladder infarc­tion), hepatic necrosis, hepatic abscess, and bile leak or biloma.
Post-procedure
It is important to recognize that there is a higher mortality and higher rate of complications associated with NOM of hepatic injury compared with NOM of splenic injury. Delayed hemorrhage has an incidence of approximately 3% and represents the most common cause of death in patients managed non-operatively [26]. Delayed hemor­rhage may present in a variety of ways, including hypoten­sion, drop in hemoglobin, or the presence of blood in intraperitoneal or biliary drains. Routine follow-up imag­ing is not recommended in the asymptomatic patient. However, there should be a low threshold for reimaging in the clinical setting of persistent pain, jaundice, or worsen­ing anemia [9].
Kidney
It has been shown that selective renal artery embolization (RAE) can safely and effectively supplant acute surgery in the vast majority of patients, even those with high grade of injury and those who are hemodynamically unstable (Fig. 32.7) [32]. RAE involves catheterization of the ipsilateral renal artery with subsequent advancement of a microcatheter under uoroscopic guidance to the area of injury. Embolization is performed via microcatheter targeted at the area of trauma. A super selective microcatheter position immediately adjacent to the injury spares the maximum volume of viable renal parenchyma. Modern embolization is typically performed with microparticles, liquid embolics, or coils.
Key Point
Embolization for renal injury is less common than for splenic or hepatic injury.
Intervention in renal trauma also includes endovascular stenting for traumatic renal artery vascular injury. A recent review article showed a high success rate of endovascular stenting without a subsequent need for surgery in 89% of 27 patients [33]. Long-term benet of non-operative manage­ment for blunt renal injury includes preserved renal function. Up to 40% of renal function preservation has been reported following grade IV renal injury with NOM including RAE at 4–6months [29] and contrasts sharply with the loss of func­tion resulting from total nephrectomy.
Pre-procedure
Depending upon the availability of anesthesia resources and the condition of the patient, RAE is performed with either IV conscious sedation or general anesthesia. The administration of prophylactic antibiotics in the trauma setting is generally considered for RAE since infarction is a procedural risk [25]. Antibiotic choice should cover skin pathogens.
Key Point
Non-operative management of the liver is associated with higher mortality and complication rates when compared with NOM of splenic injury, with the most signicant complication being delayed hemorrhage.
The How To: Renal Trauma
1. Trauma embolizations are typically performed through femoral artery approach.
2. The Seldinger technique is used to access the artery using an 18-gauge or 21-gauge needle with or with­out US guidance (refer to Chap. 8 for further information).
3. identify the renal arteries, as variant anatomy, including multiple renal arteries, occurs frequently.
(continued)