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Temporomandibular Joint: Review of the Anatomy, Pathology, and Magnetic Resonance Imaging…
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Basic Clinical Management ofTemporomandibular Disorders (TMDs)
CyrilPandarakalam

1 Introduction

Temporomandibular disorders (TMDs) are a group of diseases that affect temporomandibular joint (TMJ), masticatory muscles, and associated structures [1]. The success of treatment of TMD largely depends on a proper diagnosis. An accu­rate diagnosis depends on proper history taking and thoroughness of the exam with appropriate imaging. Early intervention can prevent a revers­ible condition from becoming irreversible.
The initial treatment strategy should mainly involve measures to eliminate pain and provide proper education to patients to reduce recurrence or progression of the disorder. The primary loca­tion of the source of pain should be identied, which can be either within the joints, at the pre­auricular region, or associated with muscles of mastication and cervical muscles. Practitioners should beable to differentiate between locations of the source of pain and site of pain. Treating the referred painlocation which is often the site of pain rather than the source of pain will not help with the condition and its symptoms.
Elimination of etiological factors is the key to the long-term management of TMD.Etiological factors can be parafunctional habits, psychologi­cal factors, or extension of pain from disorders of
C. Pandarakalam (*) Division of Maxillofacial Surgery, Department of Plastic and Reconstructive Surgery, Kaiser Permanente Medical Center, Santa Clara, CA, USA e-mail: Cyril.X.Pandarakalam@kp.org
surrounding structures. Identication of histori­cal factors like falls, motor vehicle accidents, sports accidents, and recent traumatic or extended dental appointments is also important. For some patients, occlusal disturbances can be a causative factor of symptoms.
Initial management of TMD should be directed towards whether the condition is acute or chronic. Acute symptoms require immediate strategies to mitigate pain. Chronic symptoms may need strategies that may require inclusion of methods to address the emotional aspects of pain. Acute conditions have the potential to become chronic if not addressedon time.

2 Patient Education

Patient education is one of the key factors in the successful treatment of many diseases including TMD [25]. An anatomical model will be very helpful for this purpose (Fig.1). It would be ben­ecial to give an anatomical comparison between TMJ and other joints. This will help patients understand better about TMJ and surrounding structures since most patients do not think that TMJ is a type of joint like shoulders, hip, or knee.
Additionally, educate patients that teeth are not supposed to touch each other unless they are eating. Identify if there is a habit of daytime clenching. The resting tongue-jaw position should be taught and reinforced. The tongue is supposed to rest on the anterior part of the palate
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024 B. C. Stack Jr. et al. (eds.), Craniofacial Pain, https://doi.org/10.1007/978-3-031-57563-1_7
123
124
Fig. 1 Practitioner educating patient with the help of ana­tomical model
behind the upper teeth. When keeping the tongue at that position, make sure that the tongue needs to be placed there rather than pressing against the palate or the upper anterior teeth. With the lips closed, the jaw should be dropping or hanging from the joints rather than carrying the jaw, in the same way ashanging or dropping the arms from the shoulder. This mandibular resting position should be carried out during the whole day, and patients should be advised to keep reminders and alarms. These measures need to be maintained during bedtime before sleeping.
Initial management should include resting the joint and muscles. Try to give comparison to the knee or shoulder which are the joints that may become painful. Explain and make the patient aware of the things that they would do if these joints were tender, painful, or swollen. First and foremost, resting the joint is required. For knee, shoulder, or any other joint, resting the joint is easy: just sit down or lie down. These joints can be unused or minimally used for days or weeks if needed. But it is difcult to stop using TMJ and chewing muscles. These structures move while talking, eating, laughing, singing, etc. Resting is the most difcult task regarding TMJ-related dis­orders. Make the patient aware of this difculty, and advise them to eat soft food and to eat slowly. Also advise them not to open their mouth wide. If you explain the difculty by comparing a similar situation with other joints, patients are most
C. Pandarakalam
likely to understand, and they are more likely to follow what you advised them.

3 Avoidance Therapy

Another important step is to identify a patient’s parafunctional habits and educate them to reduce microtraumas to the joint structures [6]. Bruxism (daytime or nighttime) is the most common habit you might identify. Other habits are chewing gums, nail biting, lip and cheek chewing, and chewing objects like pen or pencil. As discussed earlier, daytime clenching needs to be identied [7]. Also observe during the ofce visit if they are biting lips, biting nails, or biting or chewing the cheeks or tongue. Identify and make sure that they understand, and advise to avoid these habits. Avoid poor head and neck posture while working and using the phone. If a patient has clicking or popping, educate them to avoid clicking or pop­ping as much as possible. Mostly they can avoid clicking by limiting the wide opening of the mouth. Advise them to open gently to avoid loud clicking while they open their mouths.

4 Psychological Factors

Psychological disorders have a signicant role in the development of TMD in a portion of patients. Identify anxiety, stress, depression, or other psy­chiatric disorders, and facilitate with appropriate referrals for the management of these disorders [810]. For patients presenting with psychologi­cal diagnoses, there are some antipsychotic and antidepressant medications that can induce brux­ism in patients. Identify these medications while informing the patient and their providers that their substitution or elimination could benet the management of TMD.

5 Obstructive Sleep Apnea

Identify if your patient has any risk for obstruc­tive sleep apnea (OSA). OSA and TMD do coex­ist [11]. Excessive daytime sleeping, snoring, witnessed apnea, being unrefreshed upon wak-
ab
Basic Clinical Management ofTemporomandibular Disorders (TMDs)
125
ing, and sleepy after a meal or while watching television are some of the indicators. OSA might induce bruxism. Use Epworth Sleepiness Scale or STOP-BANG questionnaire. Continuous posi­tive airway pressure (CPAP) is the gold standard and most efcacious for treating OSA.Mandibular advancement device (MAD, oral sleep appliance) can be used if a patient is intolerant to CPAP [12,
13]. When you identify a patient with OSA using
the questionnaires listed above, refer the patient for a sleep study. MAD is an option for OSA, but make sure to educate patients about its possible side effects [14, 15]. Be aware that it is common for some patients to request for MAD after a short and inadequate trial of CPAP usage.

6 Examination

A thorough examination will tell you whether the pain is primarily from the muscles (Fig.2) or the temporomandibular joint (Fig.3). Tenderness to palpation of the preauricular region indicates
joint inammation. Consider imaging in these cases. A panoramic radiograph is a good place to start. A CBCT is ideal to see a three-dimensional image. If there is painful click or lock with dif­culty opening mouth, an MRI with TMJ protocol (closed mouth and open mouth) should be con­sidered to conrm the historical and clinical diagnosis.
Fig. 3 Examination of temporomandibular joint at the preauricular region
Fig. 2 Examination of (a) masseter and (b) temporalis muscle
126
C. Pandarakalam

7 Thermal Application

Cold and heat compresses are very useful for suc­cessful management of TMD [1618]. Generally, a cold compress is benecial if there is inamma­tion and pain (Fig.4). Heat is benecial for mus­cle tightness and aches. Whether the pain source is TMJ or muscle, generally for acute symptoms cold application is recommended and for chronic symptoms heat application is advised. If these recommendations are insufcient, advise the patient to try cold and heat compresses alter­nately for 2–4 weeks to assess and choose the appropriate thermal method which is benecial for their symptoms.
Fig. 4 A patient applying thermal (cold) compress

8 Pharmacologic Management

If you suspect acute joint inammation, an NSAID (ibuprofen) can be prescribed even though these are also benecial for select cases of muscular pain conditions [1921]. The choice of anti-inammatory depends on the practitioner, but make sure that you know the half-life of the medication. For example, ibuprofen needs to be taken every 6–8h, and naproxen needs only a 12-h interval. Since the TMJ and associated structures cannot be rested like other joints, it would be wise to take these medications for a few days in a regimen (10–14days) without break. Generally, the use of oral NSAIDS should be limited to 1–2months.
Avoid oral NSAIDs for elderly patients, preg­nant patients, and patients with gastric issues and kidney problems. Use Tylenol instead even though it is a weak anti-inammatory medica­tion. Alternatives include topical medications. There are several over-the-counter topical pain relievers like Voltaren (TM) gel, Aspercreme (TM), and Biofreeze (TM). You can also discuss with a pharmacist for compounded topical pain options.
Muscle relaxants can be considered if the pain is myogenous in nature. There are several muscle relaxants of choice: cyclobenzaprine, baclofen, and tizanidine are the most common. They are not proven to be good for TMD for more than a month or two. Any medication prescribed should be checked for interaction with existing medica­tions taken by patients. Other medications to be
Basic Clinical Management ofTemporomandibular Disorders (TMDs)
127
considered are tricyclic antidepressants like nor­triptyline, serotonin norepinephrine reuptake inhibitors, selective serotonin reuptake inhibi­tors, and anticonvulsant medications [2224]. These medications should be prescribed by their primary physician or psychiatrist.

9 Physical Therapy

Ofce-based and home-based physical therapy are great tools in the management of TMJ.Even though physical therapy exercises can be utilized for acute conditions like closed lock (disc dis­placement without reduction), they are speci­cally suitable for chronic cases of TMD. A physical therapist trained in the management of TMD is ideal to treat these patients. They can do ofce-based physical therapy and reinforce patients to do certain exercises at home. Physical therapy may not give immediate relief of the symptoms, and the success of the treatment depends on the adherence and consistency of per­forming the exercises (Fig.5). These exercises involve massaging palpable muscles, isometric jaw-strengthening exercises, and active or pas­sive stretching exercises [2527]. For most of the patients, regular self-reminders and reinforce­ment by practitioners are required for adherence to instructions.

10 Acupuncture

Several studies have shown that acupuncture is effective for patients with TMD and is generally used as an adjunctive therapy [2832]. Though acupuncture has been shown to help reduce symptoms, TMD therapy needs a multidimen­sional approach which often requires identica­tion and elimination of its causes.
11 Occlusal Stabilization Splints
(Night Guards or Bite Splints)
There are several philosophies about the design of night guard or bite splints. There are several brands of over-the-counter (OTC) night guards available with varying degrees of thickness, hard­ness, and design. These are generally used to pro­tect the teeth if a patient thinks that they have a habit of bruxism or if their dentist mentions it to them. Without TMD, these are basically enough to be a night guard. These OTC night guards are also benecial for patients with TMD, but prefer­ably it is used only for a short period of time until a custom-made night guard or bite splint is fabri­cated. A custom-made full-coverage night guard (or bite splint) with even occlusion is the most widely used, with least risk of complications, if
ab
Fig. 5 Physical therapy exercises: (a) self-massage, (b) passive stretching, (c) active stretching
c
128
C. Pandarakalam
2–3 and know their indications. Certain MADs are good for bruxers, some are good for esthetics, and others are good for mouth breathers. When making an MAD, make sure that you mention to the patient that there is a high chance of bite changes that will happen over time. Reinforce them to do morning exercises regularly to restore the position of the jaw to minimize permanent occlusal changes.
Fig. 6 A study model with a maxillary bite splint
Fig. 7 Trigger-point injection to the masseter muscle
properly fabricated (Fig. 6). There are other designs available like anterior ramp devices, for example NTI-tss, which may cause occlusal complications if not properly fabricated or fol­lowed up [3336].
There are other devices like anterior reposi­tioning splints, which are used only for a short term to relieve the joint from compression or trauma if injured or inamed. These are also used for disc displacement. These appliances need close follow-ups to minimize occlusal complications.
As mentioned before, MADs are options to manage sleep apnea if the patient is intolerant to CPAP. Learn about different MAD designs, dis­cuss with a lab about their designs, and choose

12 Injections

There are several injection techniques indicated for TMD.For acute closed lock, meaning the disc dislocation is preventing translation of the con­dyle, a joint injection with anesthetic with or without steroid can help manually (self or practi­tioner assisted) reduce the disc from the locked position allowing translation of the condyle. TMJ steroid injection can also be used for acute joint inammation caused by trauma and are-up of arthritis [37, 38].
Another group of injections are muscle injec­tions used for myofascial pain. As discussed, myofascial pain is characterized by trigger points with radiating and referring pain to distant regions. Trigger-point injections are given to break the taut bands of the muscle tissue, which are referred to as trigger points. These injections are performed with a needle without any solution (dry needling) or needle with an anesthetic (wet needling). Occasionally, addition of a small amount of steroid may be benecial for refrac­tory cases of trigger points but needs to be used with caution. Trigger-point injections are per­formed ideally with a 6- to 8-week interval as needed. The main function of trigger-point injec­tion is mechanical disruption of the trigger point, which in turn eliminates the source of pain [39].
Botox injections have recentlybecomea very common treatment modality for TMD. These injection vials contain botulism toxin, initially approved for movement disorders. They are used off-label for myofascial pain disorder, and injec­tion with Botox needs training. The main skill depends on knowing the anatomy of each masti­catory muscle. Masseter and temporalis muscles
Basic Clinical Management ofTemporomandibular Disorders (TMDs)

14 Referrals

There are situations where patients present with ear symptoms with or without symptoms of TMD (jaw pain or joint noises). When your patient presents with ear symptoms, evaluate their ear with an otoscope or, if not comfortable, send the patient to an otolaryngologist to rule out any pri­mary ear disorder. When using an otoscope, you are checking for any signs of infection, inam­mation, or bleeding in the external auditory canal. Also, you may see cerumen impaction. If you nd severe arthritis or structural changes of the joints, a referral to their physician or rheumatolo­gist may be warranted to rule out inammatory arthritis.
Sometimes, a patient with TMD presents with
Fig. 8 Steroid injection to the temporomandibular joint
are easy to identify and palpate (Fig. 7). Pterygoids are not easy to isolate for injection, but these muscles can also be injected with the help of an electromyography (EMG) machine by a trained specialist [40, 41].
Another injection technique utilizes hyal­uronic acid which lubricates the joints. These are commonly used for other larger joints, most com­monly for knees. These agents can also be injected into the TMJ in small quantities (Fig.8). These are used to reduce joint sounds and have also shown to reduce inammation [42].
unusual symptoms like numbness, paresthesia, headaches, and migraines. Therefore, it is very important to get information from the patient about the location of pain, quality or type of pain, and severity of pain. It would be benecial to per­form cranial nerve exam, at least for the fth cra­nial nerve. These patients may need a neurology evaluation to rule out primary headache disor­ders, migraine, or intracranial causes of pain.
Patients who are refractory to any procedures even after multiple specialist evaluations may need referral to the pain medicine department for interventional pain management methods like sphenopalatine nerve block and infusions with lidocaine or ketamine.
129

13 Chronic Pain Management

Occasionally, some patients do not respond to general conservative management strategies. For these patients, we may need to refer them to a pain psychologist, or pain management pro­grams, which may include specialized method­ologies including cognitive behavioral therapy (CBT) and biofeedback. These referrals can be facilitated by the patient’s primary care physi­cian. In these circumstances, identifying the need and proper communication with the physician are very important for the success of management of TMD [43].

15 Surgical Management

For certain patients, surgical management may be necessary. Those are patients who are resistant to conservative management with persistent joint inammation, severe joint noises, severe arthritic changes of the joints, skeletal malocclusion, etc. Arthrocentesis is the least invasive surgical pro­cedure that involves ushing of the TMJ with saline to remove inammatory exudates, adhe­sions, and bony particles or “joint mice” from breakdown of articular surfaces as part of arthritic process. There are other surgical techniques uti­lized based on the severity of TMD, which
130
C. Pandarakalam
include arthroscopy,arthroplasty, modied con­dylotomy, and total joint replacement [44].

16 Initial Consultation

When a patient comes with jaw pain and TMD is suspected, the initial step is to take a thorough history. It is important to gather details of the signs and symptoms since the onset. Another important information needed is about parafunc­tional habits like teeth grinding and clenching (day- or nighttime), gum chewing, pen and pencil chewing, ice cube or crushed ice chewing, and cheek or lip biting.
Next, examine TMJ region, which is the pre­auricular area in front of the ear, and external muscles of mastication (masseter and temporalis) and cervical muscles, mainly the sternocleido­mastoid and trapezius muscles. Also take mea­surements of maximum mouth (interincisal) opening without pain and with pain separately. You need to record any joint sounds while open­ing the mouth during exams and their mouth opening pathway which can be straight, deviated (transiently deviates from the midline), or deected (off to an angle). The next step is to examine intraorally for any dental or periodon­tally related diseases, soft and hard tissue dis­eases, and malocclusion. A mylar strip (shim stock) would be benecial to check occlusion between each tooth.
Initial observation should be to determine whether it is primary TMD or secondary TMD disorder related to other causes like dental or periodontal pain. Once TMD is suspected, the next step is to determine whether the symptoms are from the TMJ or muscles by palpating these areas and observingthe patient’s response.
If one suspects the primary source is from the joint from the response of the patient on exam, a panoramic radiograph can be used to screen for arthritic changes, fractures, or tumors. The most common tumor associated with mandibular con­dyle is osteochondroma. A cone beam computed tomography (CBCT), if available, can also be used to assess bony structures three dimension­ally. It is benecial to attend one of the CBCT
courses offered by a maxillofacial radiologist to learn to read TMJ and other bony structures of head and neck.
If muscles are the primary source of pain, per­form a thorough palpation of the masseter, tem­poralis, and temporalis tendon to exactly nd the location of pain in each muscle and, if possible, include cervical muscles. Identify trigger points, which are taut bands of muscle tissue, that can cause referred pain to distant sites on palpation.

17 Pain

If it is determined that the primary cause of pain is within the joint, and any emergency cause like fracture has been ruled out, the next step is to control the pain.
17.1 Primary Joint Pain
Almost always joint pain is from inammation. The pain could be from a are-up of arthritis or inammation of the retrodiscal tissue from trauma. The trauma can be from a fall or biting on a hard object (nuts, etc.). Inammation of retro­discal tissue is most likely because of displace­ment of the articular disc. The articular disc, which is supposed to act as a cushion between the articular surface of the condyle and the temporal bone, when displaced can cause retrodiscal tis­sue, which is highly vascular and innervated, prone to injury.
As we discussed earlier, the initial measure to control pain is achieved by resting the joint (soft diet, slower chewing, smaller bites) and not open­ing mouth wider. Instruct patients to take an anti­inammatory medication, like ibuprofen or naproxen. In patients who cannot tolerate NSAIDs, Tylenol or a topical NSAID can be given. Patients should also be advised to use cold compresses sev­eral times a day to reduce inammation. A cus­tom-made or a short-term OTC night guard should be considered to reduce joint loading.
Patients should be advised to follow these instructions for 1–2weeks before re-evaluation. If pain persists, the next step is to give a steroid