медиаторами (цАМФ или Са2+) и необходимых для поддержания постоянства внутренней среды, то они, наоборот, расположены в апикальных доменах клеточных мембран дистальных («плотных») отделов эпителия (например, в толстой кишке, дистальных почечных канальцах и семявыносящем протоке). Одни и те же транспортеры в зависимости от их локализации могут обеспечивать различные эффекты.

Литература

Alberts B, Johnson A, Walter P, Lewis J, Raff M, Roberts K, Orme N (2008) Molecular biology of the cell, 5th edn. Garland, New York

Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J,

Schulzke JD, Fromm M (2002) Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 15: 4969–4976

Devuyst O, Guggino WB (2002) Chloride channels in the kidney: lessons learned from knockout animals. Am J Physiol Renal Physiol 283: F1176—F1191

Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA (2004) The ABCs of solute carriers: physiological, pathophysiological and therapeutic implications of human membrane transport proteins. Pflügers Arch 447:

465–468

Hübner CA, Jentsch TJ (2002) Ion channels diseases. Hum

Mol Genet 11: 2435–2445

Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J, Blasig IE (2008) Structure and function of claudins. Biochim Biophys Acta 1778: 631–645

Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D,

Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol Biol Cell 20: 3713–3724

Kunzelmann K, Mall M (2002) Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 82: 245–289

Lang F, Vallon V, Knipper M, Wangemann P (2007) functional significance of channels and transporters expressed in the inner ear and kidney. Am J Physiol Cell Physiol 293: C1187—C1208

Lodish H, Berk A, Kaiser CA, Krieger M, Scott MP, Bretscher A (2007) Molecular cell biology. 6th edn. Freeman, New York