Альдостерон стимулирует:

•реабсорбцию Nа+;

•секрецию K+, Н+ и Мg2+ в почках, толстом кишечнике и других эпителиях;

•потребление йода.

Гиперальдостеронизм приводит к гипертонии в результате задержки в организме Nа+ и воды, а к гипокалиемии и алкалозу — из-за экскреции K+ и Н+. Гипоальдостеронизм приводит к снижению АД за счет экскреции Na+ и воды почкам, к гиперкалиемии и ацидозу — из-за усиления всасывания K+ и Н+.

Литература

Ben-Shlomo A (2010) Pituitary gland predictors of acromeg- aly-associated mortality. Nat Rev Endocrinol 6 (2): 67–9 Chrousos GP (2009) Stress and disorders of the stress sys-

tem. Nat Rev Endocrinol 5 (7): 374–81

Cooper MS, Stewart PM (2003) Corticosteroid insufficiency in acutely ill patients. N Engl J Med 348: 727–734 Deswergne B, Michalik L, Wahli W (2006) Transcriptional regulation of metabolism. Physiol Rev 86 (2): 465–514 Donaldson ZR, young LJ (2008) Oxitozin, Vasopressin, and

the Neurogenetics of Sociality. Science 322: 900–904 Elston MS, McDonald KL, Clifton-Bligh RJ, Robinson BG

(2009) Familial pituitary tumor syndromes. Nat Rev Endocrinol 5 (8): 453–61

Franklyn JA (2009) Thyroid gland: Antithyroid therapy — best choice of drug and dose. Nat Rev Endocrinol 5 (11): 592–594

Greenspan FS, Gardner DG (2004) Basic and clinical endocrinology, 7th edn. McGraw-Hill, New York

Katznelson L (2009) Pituatary function: Acromegaly: where are we now? Nat Rev Endocrinol 5 (8): 420–422

Kopp P (2002) Perspective: Genetic defects in the etiology of congenital hypothyroidism. Endocrinology 143: 2019– 2024

Lang (ed) (2009) Enciclopedia of Molecular Mechanisms of Disease. Springer, Heidelberg, New York

Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-See- bohm N, Vallon V (2006) (Pathp)physiological significance of the serum and glucocorticoid-inducible kinase isoforms. Physiol Rev 86 (4): 1151–1178

Lauberg P (2009) Thyroid function: Thyroid hormones, iodine and the brainan important concern. Nat Rev Endocrinol 5 (9): 475–6

McMillen, IC Robinsen JS (2005) Developemtal origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85 (2): 571–633

Olson LE, Rosenfeld MG (2002) Perspective: genetic and genomic approaches in elucidating mechanisms of pituitary development. Endocrinology 143: 2007–2011

O’Rahilly S (2009) Human genetics illuminates the paths to metabolic disease. Natur 462: 307–14

Prudente S, Morini E, Trischitta V (2009) Insulin signaling regulating genes: effect on T2DM and cardiovascular risk. Nat Rev Endocrinol 5 (12): 682–93

Saltiel AR, Kahn CR (2001) Insulin signaling and the regulation of glucose and lipid metabolism Nature 414: 799– 806

Speiser PW (2010) Growth and development: congenital adrenal hyperplasia-glucocorticoids and height. Nat Rev Endocrinol 6 (1): 14–5

Tomaschitz A, Pilz S, Ritz E, Obermayer-Pietsch B, Pieber TR (2010) Aldosterone and arterial hypertension. Nat Rev Endocrinal 6 (2): 83–93