- •Kidney:
- •Kidney functions
- •Nephron - functional unit of the kidney
- •Electronic microscopy: glomerular capillary loops
- •Scheme of glomerulus structur
- •Investigation methods of kidneys and urinary tract
- •Complains
- •Anamnesis
- •Anamnesis
- •Laboratory methods
- •Laboratory methods
- •Proteinuria
- •erythrocytes in 1 ml
- •Haematuria
- •Haematuria
- •CAUSES OF RED OR DARK URINE
- •Dysmorphic erythrocytes on electronic microscopy (A – normal erythrocyte)
- •Leucocyturia - more then 2000 cells in 1 ml
- •Crystalluria
- •Measurement of the glomerular filtration rate
- •Markers of renal functional state
- •Calculation of GFR with Cokroft- Gault formula
- •MDRD formula
- •Image investigations of kidney and urinary tract
- •Эхоангиография правой почки
- •Пиелоуретероэктазии справа (экскреторная урография)
- •Аплазия правой почки (КТ)
- •Нефрокальциноз
- •Опухоль почки (ангиография)
- •Проходимость артерии восстановлена после стентирования
- •Scintigraphy of female patient of
- •Female patient of 67
- •RENAL BIOPSY
- •Normal glomerulus
- •Electronic microscopy
- •Poststreptococcal glomerulonephritis: immunofluorecent staining of deposits
- •Creschendic nephritis with “demilunes” of proliferating cells with rapture of Bowman capsule
- •Creschendic nephritis: immunofluorecent staining shows the lineal deposition of antibodies to basal membrane
- •RENAL SYNDROMS
- •Urinary syndrome
- •Nephritic syndrome
- •Clinical case 1
- •Nephrotic syndrome
- •Edema (nephrotic syndrome)
- •COMMOM CAUSES OF NEPHROTIC SYNDROME
- •CONSEQUENCES AND COMPLICATIONS
- •Hypertensive syndrome
- •Hypertensive syndrome
- •Tubular abnormalitis
- •Incidence of AKI*
- •Staging of AKI
- •Conceptual model for AKI
- •Causes of AKI and diagnostic tests
- •Exposure and susceptibility risk factors for non-specific AKI
- •Classification of AKI
- •Intrinsic Renal Damage
- •Post-renal
- •Natural history of AKI
- •Principles of AKI
- •Management of AKI
- •Chronic renal failure
- •Causes of chronic renal failure
- •Signs of chronic renal failure
- •Mechanisms of progression
- •REVERSIBLE FACTORS IN CHRONIC RENAL FAILURE
- •Markers of activity of renal disease
Проходимость артерии восстановлена после стентирования
Scintigraphy of female patient of
52 with chronic glomerulonephritis
Normal kidney function, GFR 70 ml/min
Female patient of 67
Right-sided nephroptosis. Severe (left kidney) and moderate (right kidney) decrease of kidney function
Left – before treatment, GRF 35 ml/min, right – after treatment, GFR 49 ml/min.
RENAL BIOPSY
Indications
Acute kidney injury that is not adequately explained
Chronic renal failure with normal-sized kidneys
Nephrotic syndrome or glomerular proteinuria in adults
Nephrotic syndrome in children that has atypical features or is not responding to treatment
Isolated haematuria with “renal” characteristics or associated abnormalities
Contraindications
Disordered coagulation or thrombocytopenia
Uncontrolled hypertension
Kidneys <60% predicted size
Solitary kidney (except transplants) (relative contraindication)
Complications
Pain, usually mild
Bleeding into urine, usually minor but may produce clot colic and obstruction
Bleeding around the kidney, occasionally massive and requiring angiography with intervention, or surgery
Arteriovenous fistula, rarely clinically significant
47
Normal glomerulus
Poststreptococcal glomerulonephritis
Electronic microscopy
Normal glomerulus
Poststreptococcal glomerulonephritis
(specific ”humps” deposits on basal membran )
Poststreptococcal glomerulonephritis: immunofluorecent staining of deposits
Creschendic nephritis with “demilunes” of proliferating cells with rapture of Bowman capsule
Creschendic nephritis: immunofluorecent staining shows the lineal deposition of antibodies to basal membrane
RENAL SYNDROMS
•URINARY SYNDROME
•NEPHROTIC SYNDROME
•NEPHRITIC SYNDROME
•ACUTE KIDNEY INJURY
•CHRONIC RENAL FAILURE
•TUBULAR DISORDERS
•HYPERTENSION SYNDROME
53