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- •Kidney:
- •Kidney functions
- •Nephron - functional unit of the kidney
- •Electronic microscopy: glomerular capillary loops
- •Scheme of glomerulus structur
- •Investigation methods of kidneys and urinary tract
- •Complains
- •Anamnesis
- •Anamnesis
- •Laboratory methods
- •Laboratory methods
- •Proteinuria
- •erythrocytes in 1 ml
- •Haematuria
- •Haematuria
- •CAUSES OF RED OR DARK URINE
- •Dysmorphic erythrocytes on electronic microscopy (A – normal erythrocyte)
- •Leucocyturia - more then 2000 cells in 1 ml
- •Crystalluria
- •Measurement of the glomerular filtration rate
- •Markers of renal functional state
- •Calculation of GFR with Cokroft- Gault formula
- •MDRD formula
- •Image investigations of kidney and urinary tract
- •Эхоангиография правой почки
- •Пиелоуретероэктазии справа (экскреторная урография)
- •Аплазия правой почки (КТ)
- •Нефрокальциноз
- •Опухоль почки (ангиография)
- •Проходимость артерии восстановлена после стентирования
- •Scintigraphy of female patient of
- •Female patient of 67
- •RENAL BIOPSY
- •Normal glomerulus
- •Electronic microscopy
- •Poststreptococcal glomerulonephritis: immunofluorecent staining of deposits
- •Creschendic nephritis with “demilunes” of proliferating cells with rapture of Bowman capsule
- •Creschendic nephritis: immunofluorecent staining shows the lineal deposition of antibodies to basal membrane
- •RENAL SYNDROMS
- •Urinary syndrome
- •Nephritic syndrome
- •Clinical case 1
- •Nephrotic syndrome
- •Edema (nephrotic syndrome)
- •COMMOM CAUSES OF NEPHROTIC SYNDROME
- •CONSEQUENCES AND COMPLICATIONS
- •Hypertensive syndrome
- •Hypertensive syndrome
- •Tubular abnormalitis
- •Incidence of AKI*
- •Staging of AKI
- •Conceptual model for AKI
- •Causes of AKI and diagnostic tests
- •Exposure and susceptibility risk factors for non-specific AKI
- •Classification of AKI
- •Intrinsic Renal Damage
- •Post-renal
- •Natural history of AKI
- •Principles of AKI
- •Management of AKI
- •Chronic renal failure
- •Causes of chronic renal failure
- •Signs of chronic renal failure
- •Mechanisms of progression
- •REVERSIBLE FACTORS IN CHRONIC RENAL FAILURE
- •Markers of activity of renal disease
Markers of renal functional state
•Serum creatinin
•Glomerular filtration rate (creatinin clearance– depuration of N volume of blood in a unit of, ml/min)
Calculation of GFR with Cokroft- Gault formula
(140-age) х body mass (kg) х 88 |
72 х |
serum creatinin (mkmol/l) |
|
for female the result [x 0.85
this method can’t be used in patients with low muscle mass, low protein diet, vegetarians, in pregnancy and massive edema
MDRD formula
(creatinin in mkmol/l, age in years, urea in mmol/l, albumin in g/l)
GFR = 170 х (Scr х 0.0113)-0.999 х age0.176 х
X(urea х 2.8)-0.17 х albumin0.318
•For black х 1.18
•For female х 0.762
Image investigations of kidney and urinary tract
ULTRASOUND
INTRAVENOUS UROGRAPHY
MICTURATING CYSTOURETHEROGRAMME
RETROGRADE URETOPELOGRAPHY
RENAL ARTERIOGRAPHY
ISOTOPE RENAL SCANS
ANTEGRADE NEPHROGRAPHY
36
Эхоангиография правой почки
Пиелоуретероэктазии справа (экскреторная урография)
Аплазия правой почки (КТ)
Нефрокальциноз
Опухоль почки (ангиография)
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