Myxedema
Rheumatologic:
Polyarthritis,
polysynovitisт, progressive polyarthrosis
Masks of hypothyroidism
Gastroenterologic
Constipation, gall ducts dyskynesia gall stones, chronic hepatitis
Neurologic: Tunnel
syndromes
Depression
Cardiologic:
Diastolic hypertension, dyslipidemia, pericardial effusion, heart failure
Hematologic Anemia
Laboratory findings
•High TSH
•Low T3 and T4
•Anemia
•High TC and TG
•Possible presence of autoantibodies: anti-TPO and anti-TSH-receptor antibody
Screening for hypothyroidism is recommended in all patients > 60 years old
Treatment
•Levothyroxine (synthetic T4)
•Dose depends on the clinical presentation and the level of TSH and free T4
•Hormones control after 4-8 weeks of treatment
•Control of TSH and fT4 every 6-12 months in stable dose
Syndrome of hypercorticism (Cushing`s syndrome)
•Cushing`s disease: primary increase of ACTH secretion by pituitary gland
•Tumors of adrenal cortex: adenomatosis, adenoma, adenocarcinoma
•ACTH-ectopic syndrome
•Treatment-induced
Иценко Николай Михайлович |
Harvey Williams Cushing |
1889-1954 |
1869-1939 |
Minnie G., 23 years old, first patient with the disease, described by Cushing
Clinical presentation of Cushing`s syndrome
