CST 2015 / Angiogenesis
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CELL SIGNALING TECHNOLOGY |
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Angiogenesis
OH
Tumor |
Cell |
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HIF1α
Akt 
PI3K
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PHDs |
OH |
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mTOR |
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E3 Ligase Complex |
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Normoxia |
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TCEB2 |
Rbx1 |
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S6K |
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TCEB1 Cul2 |
OH |
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4E- |
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VHL HIF1α |
HIF1β |
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HIF1α |
elF4E1 |
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BP1 |
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Ub |
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MNK |
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Nucleus |
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Cytoplasm |
Erk1/2 |
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Ub |
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MEK1/2 |
Ras |
Ub |
Ub |
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CBP/p300 |
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Ub |
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HIF1α |
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HIF1α |
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HIF1β |
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• Growth Factors |
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Degradation |
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HRE |
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Target Genes |
• Cytokines |
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• ECM Proteases |
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Extracellular |
Matrix Remodeling |
MMP |
Cox2 |
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Matrix |
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PAI-1 |
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VEGF 
Erk1/2
Pericyte
Proliferation
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FGFR |
IGFR |
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Tie2 |
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TGFα-R |
SLIT |
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VEGFR2 |
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PDGFR-β |
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ROBO |
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PDGF-BB |
P |
E |
e |
n |
ri |
d |
c |
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y |
t |
et |
h |
e |
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i |
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a |
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C |
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e |
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l |
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PI3K |
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Src |
FAK |
p38 |
Smad2/3 PLCγ |
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MAPK |
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Akt |
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NOS |
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Erk1/2 |
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Survival |
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Vascular |
Migration |
Proliferation |
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Permeability |
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E |
C |
x |
y |
t |
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r |
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c |
p |
e |
l |
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a |
l |
s |
u |
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m |
a |
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S |
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p |
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Vascular
Guidance
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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