CST 2015 / Apoptosis_Inhibition
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
Inhibition of Apoptosis |
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TNF-α |
Survival Factors: |
Growth Factors, |
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Cytokines, etc. |
TNF-R1 |
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NIK
cIAP
TRAF2 TRADD
TAK1
TAB
CYLD
RIP1 
FLIP
A20 |
PTEN |
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HSP27 |
PI3K |
Ras |
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Raf |
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HSP90 |
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Casp-8 |
JNK |
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PIP3 |
IKKγ |
CDC37 |
IKKα IKKβ |
FADD |
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HSP70 |
Bax |
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IKKβ |
HSP90 |
IKKγ |
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BID |
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GSK-3 |
Akt |
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HSP90 |
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FoxO1 |
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IκB |
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Smac/ |
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Bax |
Bcl-2 |
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Diablo |
tBID |
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NF-κB |
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XIAP |
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IκB |
Casp-3,-6,-7 |
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Bax |
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Mcl-1 |
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HSP27 |
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Apoptosis |
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NF-κB |
Casp-9 |
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Cyto c HECTH9 HSP70 |
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Akt |
Apaf-1 |
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HSP90 HSP70 |
HSP27 |
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PDK1
p70S6K Erk1/2 PKC
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Bim |
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Bcl-xL |
Bad |
p90RSK |
Bim |
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PKA |
FoxO1 CREB |
Bim |
[cAMP] |
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Cytoplasm
HSP90
Jak Src
Stat1 Stat3
Cytoplasm
Nucleus
FLIP
XIAP
NF-κB A20
FAS |
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Bcl-2 |
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CREB |
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Stat1 |
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Bim |
FoxO1 |
Bcl-xL |
Stat3 |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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