CST 2015 / Apoptosis_Overview
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Regulation of Apoptosis Overview
TNF, FasL, TRAIL
TNF, FasL, TRAIL |
Trophic Factors |
Cytoplasm
TAK1
TRAF2IAP -
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FADD |
Itch |
RIP c-IAP TRAF2 |
TRADD |
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RIP1 |
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CYLD FLIP RIP RAIDD
TRADD PIDDCasp-2 FADD
TRADDFADD
ASK1 |
PKC |
PI3K |
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p90RSK |
Cell Cycle |
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Erk1/2 |
IKKα |
IKKβ |
NIK |
Casp-8,-10 |
p53 |
JNK |
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Bcl-2 |
Bad |
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cdc2 |
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IKKγ |
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RIP |
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SirT2 |
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Bak |
Bcl-xL |
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TRAF2 |
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Bax |
14-3-3 |
Akt |
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BID |
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Bim |
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HtrA2 |
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Casp-12 |
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tBID |
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Noxa |
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Cellular Stress |
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Arts |
Puma |
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IκBα |
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FoxO1 |
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XIAP |
Smac/ |
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Mcl-1 |
HECTH9 |
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NF-κB |
Calpain |
Casp-9 |
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Diablo |
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IκBα |
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Cyto c |
AIF |
Endo G |
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JNK |
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NF-κB |
[Ca2+] |
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Casp-3,-6,-7 |
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Casp-9 |
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Apaf-1 |
Chk1/2 |
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ROCK |
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DFF45 |
ATM/ATR |
p53 |
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DFF40 |
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ER Stress |
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APP |
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Cytoplasm
• Cell shrinking
• Membrane
blebbing
p53
Nucleus
DFF40 |
AIF Endo G |
FoxO1 |
JNK |
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FLIP |
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Puma |
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Bim |
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XIAP |
NF-κB |
DNA |
Noxa |
p53 |
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c-Jun |
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Fragmentation DNA Damage |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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