CST 2015 / Apoptosis_Mitochondrial
.pdfCELL SIGNALING TECHNOLOGY |
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Mitochondrial Control of Apoptosis |
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FasL |
Death Stimuli: |
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Survival Factors: |
Survival Factor Withdrawal |
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Growth Factors, Cytokines, etc. |
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Fas/
CD95
FADD
Casp-8,-10
Bim LC8
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Microtubules |
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PI3K |
HECTH9 |
DLC2 |
JNK |
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Erk1/2 |
Bmf |
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BID |
Mcl-1 |
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JNK |
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Hrk |
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PKC |
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Bcl-xL Bim |
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DP5 |
ARD1 |
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tBID |
Bcl-2 |
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Bmf |
NatA |
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Akt p70 S6K |
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PKA |
p90RSK |
Bak |
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Hrk |
Bax |
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Bax |
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DP5 |
Acetyl-CoA |
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Bcl-2 |
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tBID |
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Bax |
CaMKII |
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Calcineurin |
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Bax |
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14-3-3 |
Bad |
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Bak |
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Bak |
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Bcl-2 |
Casp-2 |
14 Bad
Cytosolic
Sequestration
HSP60
Casp-3
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Bad |
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Bcl-xL |
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Apaf-1 |
Cyto c |
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Casp-9 |
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Arts |
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HtrA2 |
Noxa |
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RAIDD |
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PIDD |
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Bcl-2 |
[NAD] |
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Puma |
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Mcl |
SirT2 |
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1 |
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HECTH9 |
p53 |
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XIAP |
Smac/ |
Endo G |
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Diablo |
ATM/ |
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ub |
AIF |
ATR |
ING2 |
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Bcl-2 Family |
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DNA Damage |
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Apoptosis |
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Pro-Apoptotic |
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Genotoxic Stress |
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Pro-Survival |
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Pathway Diagram Keys |
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Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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