CST 2015 / Adherens_Junction
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CELL SIGNALING TECHNOLOGY |
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Adherens Junction Dynamics
Cytoplasm
Extracellular |
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Maintenance |
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Formation |
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Disassembly |
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Space |
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PTPμ |
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Cadherin |
RTK |
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Nectin |
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RTK |
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Fyn |
Gβ1 |
Rac |
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Csk |
δ-cat |
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δ-cat |
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Clathrin |
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IQGAP |
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SNIP/ |
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Afadin Afadin |
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c-Cbl |
SH2D1A |
δ-cat β-cat |
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α-cat |
β |
-cat |
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Caveolin |
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α-cat |
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Srcp140Cap |
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UbUb |
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Cytoplasm |
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p190 RhoA |
p130 Cas |
Synaptophysin |
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Tiam1 |
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E3 |
Ub |
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γ-cat |
β-cat |
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Rac |
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LAMTOR1 |
PRK1 |
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Rac |
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WASP |
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Stabilizes |
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α-cat Formin |
Axin1 |
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Par3/6 aPKC |
RhoA |
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PI3K |
Adherens |
CK2 |
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Ajuba |
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ARHGAP1 |
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Junctions |
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Src |
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Actin bundles |
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Cip4 |
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δ-cat |
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IQGAP |
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Cortactin |
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Akt |
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PTP1B |
α |
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α |
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cdc42 |
mDIA |
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β-cat |
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α-cat |
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IQGAP |
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α |
α-actinins |
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• Glycogen Synthesis |
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t |
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WASP |
IRSp53 |
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APC |
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y |
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• Metabolic Energy |
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o |
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Arp2/3 |
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c |
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Adherens |
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• Anti-Apoptotic Signals |
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Arp2/3 |
Actin |
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GSK-3 |
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Junction |
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• Apoptosis |
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Dissasembly |
E |
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n |
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Remodeling |
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• Angiogenesis |
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n |
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β-cat |
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r |
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h |
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Src |
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d |
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β-cat |
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α-cat |
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a |
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• Actin Nucleation |
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ROCK |
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Cadherin |
RaIA |
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C |
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APC |
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• Actin Dynamics |
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Recycling |
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Ub |
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VE-Cadherin |
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Rap1 |
β-cat |
Ub |
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Ub |
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Occludin |
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Ub |
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δ-cat |
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β-cat |
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Wnt |
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Cadherin |
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Kaiso |
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β-cat |
Signaling |
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Degradation |
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Caveolin/Clathrin |
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β-catenin |
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LEF/TCF |
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Cytoplasm Nucleus |
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Cell Growth & Differentiation |
Phagosome |
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Degradation |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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© 2006 – 2014 Cell Signaling Technology, Inc.