CST 2015 / SAPK_JNK
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CELL SIGNALING TECHNOLOGY |
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SAPK/JNK Signaling Cascades
FasL, UV
Cellular Stress, Inflammatory Cytokines
γ Radiation
Growth Factors, UV |
Oxidative |
G12/13-coupled |
Stress |
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RTKs |
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Receptors |
CrkII
CrkL
Shc GRB2 |
SOS |
Ras |
Rac |
Cdc42 Rho |
TRADD TRAF2 RIP Daxx |
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PI3K |
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MEKK1/4 |
GCK |
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MAPKKKs : |
MLK2/3 |
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DLK |
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TpI-2 |
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HPK1 |
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TAO1/2 |
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ASK1 |
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MLKsPOSH |
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Rac Cdc42
Gα12/13 Gβγ
PI3Kγ
MAPKKKs
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TAK1 |
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c-Abl 14-3-3 |
14-3-3 |
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Cytoplasm |
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Nucleus |
c-Abl |
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MKK4/7 JIP1,2,3 |
Apoptosis |
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JNK1/2/3 |
14-3-3 |
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IRS-1 |
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14-3-3 Bax |
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MKPs |
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Bax |
Mitochondrial
Translocation/
NO 
JNK 
Apoptosis
JNK
c-Jun ATF-2 |
Elk-1 Smad4 |
p53 |
NFAT4 NFATc1 Stat3 |
HSF1 |
Growth
Transcription Differentiation
Survival
Apoptosis
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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