CST 2015 / Regulation_Microtubule
.pdf
CELL SIGNALING TECHNOLOGY |
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Regulation of Microtubule Dynamics
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LPR |
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cdc42 |
Gαq/o |
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Erk |
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Neurotrophins
RTK
PI3K
Spred1 |
TAOK |
Par6 |
aPKC |
Dvl |
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Akt |
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PIP3 |
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PTEN |
ROCK |
MAPKAPK |
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Actin Filaments |
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Par3 |
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TESK Par1 |
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MARK2 |
GSK-3β |
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MARK |
Rac1 |
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Cofilin |
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CRMP2 |
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LIMK |
PIP3 |
Tau |
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MAP1b |
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Rho |
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TPPP |
LL5β |
mDIA |
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MAP1b |
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PKA |
PAK |
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APC |
Plus End |
ICIS |
Cdk1 |
CaMK |
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Erk |
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mDIA |
EB1 |
Proteins |
XMAP215 |
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Aurora B |
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CLASP |
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Stathmin |
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EB1 |
CLIP |
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MCAK |
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CLIP |
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MT Stability |
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+ end Growth |
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Stat3 |
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MT |
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Promoting |
+/- end |
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Polymerization |
CLIP |
Destabilizing |
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Delivery to |
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MT Catastrophe |
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Ends |
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CLASP |
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Minus End |
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Src |
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Plus End |
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EB1 |
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c-Abl |
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APC |
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“Dynamic |
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Tiam1 |
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Microtubules” |
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RhoGEF |
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mDIA1 |
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Rho |
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Rac1 |
Trio |
Rho |
Gα |
Focal Adhesions |
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Rho |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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