- •The family of non-receptor protein tyrosine kinases
- •T-cell receptor signalling
- •More than one lymphocyte receptor must be engaged to ensure activation
- •T cell receptor signal-complex formation
- •Down-regulation of the TCR response
- •The lipid raft hypothesis
- •Signalling through interferon receptors
- •Alternative signalling pathways
- •Down-regulation of the JAK-STAT pathway
- •Nuclear dephosphorylation and recycling of STATs
- •STAT signalling without phosphorylation
- •Oncogenes, malignancy, and signal transduction
- •Viral oncogenes
- •Non-viral oncogenes
- •Essay: Non-receptor protein tyrosine kinases and their regulation
- •References
Signal Transduction
Abbreviation |
Full name/description |
SwissProt |
Other names, OMIM |
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entry |
links |
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PTP-1B |
protein tyrosine-phosphatase-1 |
P18031 |
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SHP-1 |
SH2-containing tyrosine phosphatase-1 |
P29350 |
PTPN6, PTP1C |
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SHP-2 |
SH2-containing tyrosine phosphatases-2 |
Q06124 |
MIM:151100 |
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SLP76 |
SH2-domain containing leukocyte protein |
Q13094 |
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76 kDa |
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SOCS1 |
suppressor of cytokine signalling-1 |
O15524 |
Tec-interacting protein |
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Src |
Sarcoma |
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Src-c |
cellular sarcoma protein |
P12931 |
p60-Src |
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Src-v |
viral sarcoma protein (transforming protein |
P25020 |
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from strain H-19) |
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STAT1 |
signal transducer and activator of |
P42224 |
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transcription-1 |
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STAT2 |
signal transducer and activator of |
P52630 |
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transcription-2 |
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SYK |
spleen tyrosine protein kinase |
P43405 |
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TCR |
T cell receptor |
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TEC |
tyrosine kinase expressed in hepatocellular |
P42680 |
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carcinoma |
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TYK2 |
tyrosine kinase-2 |
P29597 |
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ZAP70 |
zeta-chain associated protein kinase 70 kDa |
P43403 |
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References
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