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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5983_Библиотеки_им_академика_М_И_Перельмана.pdf
248
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
8.2.1 POLYMER SOLUTION CONCENTRATION AND VISCOSITY
-
tration plays an important role. Whereas the viscosity also plays a great
8.2.2 MOLECULAR WEIGHT OF POLYMER
-
tion (Haghi and Akbari, 2007).
8.2.3 SURFACE TENSION
8.2.4 ELECTRICAL CONDUCTIVITY
Nanofiber Technology in Biomedical Applications
249
Mit-uppatham et al., 2004).
8.2.5 APPLIED VOLTAGE
8.2.6 FEED RATE/FLOW RATE
8.2.7 TEMPERATURE AND HUMIDITY
al., 2013).
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
8.3 METHOD OF PREPARATION FOR NANOFIBERS
8.3.1 ELECTROSPINNING
-
al., 2009).
8.3.2 SELF-ASSEMBLY
Nanofiber Technology in Biomedical Applications
251
-
amine and its deacetylated derivative. Here the individual components
ranging in nanometers than the electrospinning technique (Jayaraman et
et al., 2003).
8.3.3 PHASE SEPARATION
-
FIGURE 8.1
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
-
Ramakrishna, 2005).
FIGURE 8.2
8.3.4 DRAWING OF NANOFIBERS
-
et al., 2011).
Nanofiber Technology in Biomedical Applications
253
FIGURE 8.3
8.3.5 TEMPLATE SYNTHESIS
structure. Generally nanoporous metal oxide membranes such as aluminum
8.4 BIOMEDICAL APPLICATIONS OF NANOFIBERS
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
TABLE 8.1
Biomedical
application
System name Drug used Polymer used References
Wound
dressing
Electrospun
Cloxacillin PLA and poly(butylene
adipate-co-terephthalate)
Schneider et
al., 2018
Electrospun
acetate
CS and PVA Abbaspour
et al., 2015
engineering
Electrospun
polymeric
NA Cellulose acetate and
iron acetate
Mousa et al.,
2021
Electrospun
NA PCL and CS Semnani et
al., 2017
Cancer
therapy
Electrospun
5-Fluorouracil PCL and CS
al., 2018
Electrospun
Paclitaxel PLGA and CS
2020
FIGURE 8.4
Nanofiber Technology in Biomedical Applications
255
8.4.1 WOUND DRESSING
-
have been introduced incorporating various antibiotics that are required
-
Staphylococcus aureus
concluded that the prepared cloxacillin-loaded biocompatible electrospun
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
enhanced antimicrobial activity against Pseudomonas aeruginosa and S.
aureus
al., 2015).
8.4.2 TISSUE ENGINEERING
skin, bone, dentin, collagen, and liver. Both natural and synthetic
possess the ability to repair, replace, and regenerate the required tissues,
nature, high quality mechanical properties, high porosity, ability to
osteoblastic adhesion, and extracellular matrix secretion on the carbon
-
-
(Eatemadi et al., 2016).
Nanofiber Technology in Biomedical Applications
257
-
(Mousa et al., 2021).
-
-
the cells (Semnani et al., 2017).
8.4.3 IN CANCER THERAPY
healthy tissue, and a high removal rate by the reticuloendothelial system.
has the potential to rule out the various disadvantages and it also can be
-
drugs such as dichloroacetate, cisplatin, paclitaxel, and doxorubicin can