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128
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
Protein
type
Disease Drug Special comment References
disease
(Bashir et al., 2022,
Bashir et al., 2023)
Gelatin
Gallic acid
Gadolinium
magnetic resonance imaging contrast agent.
(Kimura et al., 2021)
Glioblastoma
Paclitaxel Paclitaxel encapsulated in dual stimuli-responsive in situ
(Kang et al., 2021)
Ischemic stroke Estradiol
(Joachim et al., 2020)
Silk
Fibroin
Brain tumor Doxorubicin
and enhance the blood–brain barrier transverses through their
(Pandey et al., 2020a,
Pandey et al., 2020b)
Photothermal
glioblastoma
Indocyanine green
mice
(Xu et al., 2018)
Neurodegenerative
diseases such
disease
Crocin
(Song et al., 2022)
Quercetin
astrocyte marker GFAP.
(Moreno et al., 2017)
TABLE 4.3
(Continued)
Natural Biocarriers for Brain Targeting
129
Protein
type
Disease Drug Special comment References
Glioblastoma Curcumin
nanoparticles.
Casein Glioma Hydroxycamptothecin
(Gao et al., 2019)
Iron overloaded (Adel et al., 2021)
TABLE 4.3
(Continued)
130
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
2019).
-
-
-
technique to overcome the restricted brain permeability and to augment
macrophage-derived exosomes and blood serum-derived exosomes delivery
et al., 2019).
Natural Biocarriers for Brain Targeting
131
-
TABLE 4.4
Exosomes
sources
Drug Disease Special comment References
Blood Dopamine
disease
receptor interaction.
(Qu et al.,
2018)
Macrophages
derived
exosomes
Ginsenoside
Rg1
Rg1 could inhibit the
exosomes-miR-21 release
the brain, enhancing tissue
3 protein expression,
matrix metalloproteinases
proteolysis, and restricting
proteins degradation thus
protecting the blood–brain
barrier integrity.
2021)
Macrophages
derived
exosomes
Baicalin ischemic
stroke
Baicalin-loaded exosomes
revealed better targeting
Baicalin-loaded exosomes
reactive oxygen species.
(Huang et
al., 2021)
Plasma
exosomes
Quercetin
disease
Enhanced brain delivery
quercetin using drug-loaded
symptoms
(Qi et al.,
2020)
Macrophage-
derived
exosomes
Curcumin Ischemia-
Inhibiting reactive oxygen
species-mediated mitochon-
drial apoptosis in a transient
cerebral ischemia rat model.
(He et al.,
2020)
132
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
4.3 CONCLUSIONS AND PERSPECTIVES
carbohydrate and protein-based carriers tailored to target the brain have
KEYWORDS
• biocarriers
• targeting
• Alzheimer's disease
• Parkinson's disease
• exosomes
• polysaccharides based carriers
• protein based carriers
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