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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5983_Библиотеки_им_академика_М_И_Перельмана.pdf
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
regions (3′
are stem-loop structures transcribed in the nucleus by RNA polymerase
-
2018).
6.3 NANOTECHNOLOGY IN GENE DELIVERY
6.3.1 PROPERTIES OF NANOPARTICLES FOR AN EFFICIENT GENE
DELIVERY
capacity to deliver many components at once (Wong et al., 2017). Induced
-
in Figure 6.1.
Nanotechnology in Gene Delivery
179
FIGURE 6.1
6.3.2 PRECLINICAL STUDIES OF NANOPARTICLES USED IN GENE
DELIVERY
-
-
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
-
-
FIGURE 6.2
-
area. Polyethylenimine (PEI), polyethylene glycol (PEG), polylysine (PLL),
Nanotechnology in Gene Delivery
181
TABLE 6.1 Nanoparticles-Mediated Gene Delivery.
Nanoparticles Gene delivered Applications Reference
Polymer
nanoparticles
Polyethylenimine
threonine kinase1 mRNA
apoptosis
Muthiah et al., 2015
and bone morphogenetic
protein 2
Bone regeneration Curtin et al., 2015
virus thymidine kinase and
granulocyte-macrophage
Antitumor activity Alekseenko et al.,
2015
pDNA Lee et al., 2015
Polylysine pDNA Lung gene therapy Suk et al., 2014
Poly(lactic-coglycolic acid) AntimiR-10b and
antimiR-21
Breast cancer therapy Devulapally et al.,
2015
Poly(beta-amino ester) pDNA Glioblastoma treatment
siRNA
nucleic acids
Borgheti-Cardoso,
2015
Dendrimer
nanoparticles
siRNA Cervical cancer therapy Ionov et al., 2015
pDNA Breast cancer therapy Figueroa et al., 2014
pDNA An et al., 2013
Carbosilane-Ammonium Oligonucleotides Liver gene therapy De las Cuevas et al.,
2012
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
Nanoparticles Gene delivered Applications Reference
miRNA Enhanced cell
Gray et al., 2013
pDNA Wang et al., 2015
Solid-lipid
nanoparticles
siRNA Breast cancer therapy Hu et al., 2013
Solid lipid nanoparticles -protamine pDNA
al., 2012
Carbon-based
nanoparticles
pDNA Enhanced
Qin et al., 2011
pDNA Antitumor activity Karmakar et al.,
2011
siRNA Neuroprotection Al-Jamal et al.,
2011
siRNA
pDNA
Antitumor activity Varkouhi et al.,
2011
Graphene
pDNA Vasculogenesis and
cardiac repair
Paul et al., 2014
Ceramic
nanoparticles
pDNA Enhanced
Wang et al., 2008
Mesoporous
pDNA Enhanced gene
Park et al., 2008
pDNA Enhanced gene
Choi et al., 2008
TABLE 6.1
(Continued)
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183
Nanoparticles Gene delivered Applications Reference
Gadolinium-oxide-doped silica
nanoparticles
pDNA Enhanced gene
Bhakta et al., 2011
3-(Aminopropyl)trimethoxysilane
pDNA Enhanced gene
Chen et al., 2005
pDNA Enhanced gene
Namgung et al.,
2011
Metallic
nanoparticles
miRNA Ghosh et al., 2013
pDNA Shan et al., 2012
Oligonucleotides Kim et al., 2012
siRNA Heinemann et al.,
2013
siRNA Conde et al., 2015
TABLE 6.1
(Continued)
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
poly(lactic-coglycolic acid) (PLGA), and poly(b-amino ester) (PBAE) are
2017).
Studies conducted both in vivo and in vitro have demonstrated the ability
-
-
-
blastoma-targeting gene therapy using the retro-inverso C-end rule peptide
-
Nanotechnology in Gene Delivery
185
repetitively branched nanoparticles. Convergent or divergent synthesis can
cationic dendrimers, including PAMAM, carbosilane, and phosphorus. Both
(Wang et al., 2015).
-
linking agents 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochlo-
(Han et al., 2014). Other dendrimers, including carbosilane, have proven
Cuevas et al., 2012).
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
vectors (Wong et al., 2017).
given to in vivo-
-
gated micelles containing pDNA are given to MCF-7 cells or mice carrying
the A549 human pulmonary carcinoma (Hu et al., 2013). A three-layered
DNA distribution has been examined (Nomoto et al., 2014). Another study
Delivering siRNA targeted against procollagena1(I) has been studied as
Carbon-based nanoparticles are used in gene delivery and they include carbon
p53 gene is used
-
Nanotechnology in Gene Delivery
187
-1
. Standard ethidium bromide and acridine orange
-
motor cortex caused by an endothelin-1-induced stroke model, peri-lesional
-
acid delivery have been conducted. Due to their nano-needle structure, they
are expected to pass through the plasma membrane and enter the cytoplasm