Traditional methods for diagnosis of GIDs based on classical methods include x-ray, computed tomography scan (CT scan), magnetic resonance imaging (MRI), ultra­sound and endoscopy depend on laboratory tests that may have long procedure from taking samples to receiving results [10]. A lot of work has gone into creating breakthrough diagnostic and treatment techniques to extend patient survival and improve quality of life. In order to substantially improve patient outcomes, advance­ments in image-based detection, personalized medicine distribution, and metastases ablation could be pursued. Traditional procedures sometimes fail to meet patients’ expectations due to a lack of precision and insufficient patient categorization. There is a need for more specialized, highly targeted treatments. Nanotechnologies and nano­devices have been researched for their potential applications in advancing tailored therapy strategies in order to achieve this. A number of methods for various fabricated biosensors are reported as electrochemical (amperometric, potentiometric, conducto­metric), optical (fluorescence, refractive index, luminescence), capacitive biosensors, piezoelectric or calorimetric and field-effect transistor for quantification of various biomarkers. Biosensors may play a key responsibility as a substitute to classical methods of GIDs detection. They offer many advantages such as being rapid, robust, cost effective, user-friendly and having the ability for multi-analyte testing [11]. They do not require costly and time-consuming laboratory tests. Hence, the healthcare services cost can be reduced. The recent trend is to make use of nanomaterials having different morphology, size and composition of materials for biosensors owing to their unique properties including conductivity, high surface-to-volume ratio as well as good biocompatibility that leads to enhanced performance [12]. A number of nanomaterials such as those based on carbon (carbon nanotubes, graphene), metal nanoparticles (silver, gold, platinum, and copper), quantum dots of semiconductors (Cd, Ge, Te, Se), metal oxides (ZnO, SnO have been incorporated into biosensors for detection of various biomarkers [13]. Nanomaterials based on gold have been exploited for designing of different biosensors due to their exceptional electrical, optical as well as mechanical properties, however, high cost limits their use [14].