Nanotechnology and artificial intelligence (AI) have the potential to transform the existing treatment and diagnosis choices for gastrointestinal (GI) disorders. Several studies have shown that GI diseases can be early diagnosed and successfully treated using nanomaterials associated with AI applications. The GI tract has become a considerable target system for nanotechnology and AI, and it contains a wide range of substances, such as water, nutrients, or therapeutics that are absorbed in the GI tract when transported through the digestive tract. The behaviour of nanotechnol­ogy employed for GI disease diagnosis or therapy can be controlled depending on the pH, pressure, transit duration, and bacterial concentration of each specific nanomaterial. Because of their adjustable interactions with macrophages, M cells, immune cells and intestinal epithelial cells nanoparticles have demonstrated con­siderable promise in gastroenterology and may become a potential delivery system for vaccines. The use of AI-based advanced machines for GI surgery as well as in the study of medicine is expanding quickly. AI within the diagnostic process supports medical specialists to improve the level of diagnostic accuracy and efficiency, thus providing emergent digitalized healthcare services. Nanotechnology with AI is anticipated to have a significant impact on how GI disorders are diagnosed and treated. In terms of effectiveness, dependability, and practicality, several of the medicines and diagnostics based on AI described here outperform traditional materials. In the future, GI problems may be successfully treated using AI-based machines and their intricate mixes, which may include therapeutic substances. This book explains how the most recent advances in applications of novel biomaterials, nanotechnology and AI have paved the way for breakthroughs in drug delivery. This book demonstrates present and future applications in a setting where it is essential to provide effective, patient-centered, and long-lasting healthcare systems. This book provides an overview of the technological approaches mainly focused on the role of AI and their implications in GI disorders such as abdominal pain, bowel obstruc­tion, diarrhoea, pancreatitis, upper gastrointestinal bleeding (UGIB), non-alcoholic fatty liver diseases (NAFLD), intestinal tuberculosis (ITB), celiac disease, and duodenal ulcer as well as include the role of nanotechnology and AI in GI illnesses. Due to its high calibre material, the book will appeal to a wide range of readers, including academics, students, researchers and medical students as well as practi­tioners. It would be particularly interesting to readers interested in health, business, and research linked to the biomedical sciences. The main marketing and differ­entiating factors are the numerous libraries operating in numerous reputable private and governmental institutions or organizations.