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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5209_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword
- •Preface
- •Contents
- •Contributors
- •Imaging
- •Personal Preference
- •Introduction
- •Traditional Radical Therapies
- •Active Surveillance
- •Why Consider Focal Therapy?
- •Cancer Treatment Needs
- •Functional Outcomes
- •Conclusion
- •Introduction
- •Focal Therapy Candidates
- •The Index Lesion Theory
- •Further Prospective
- •Conclusions
- •References
- •Introduction
- •Renal Mass Biopsy
- •Approach
- •Cryoablation
- •Treatment Temperature
- •Radiofrequency Ablation
- •Treatment Temperature
- •Intraoperative Monitoring
- •Cryoablation
- •Radiofrequency Ablation
- •Recommended Imaging Follow-Up Protocol
- •Emerging New Ablative Modalities
- •Microwave Ablation
- •Irreversible Electroporation
- •Radiation Therapy
- •Oncological Outcomes
- •Local Recurrence-Free Survival
- •Overall Survival
- •Cryoablation Versus Radiofrequency Ablation
- •Complications
- •Conclusion
- •References
- •Introduction
- •Informed Consent
- •Why Focal Therapy?
- •References
- •References
- •Introduction
- •Conclusions
- •References
- •Introduction
- •Conclusions
- •References
- •Introduction
- •Prostate MRI
- •Robotic Surgery
- •Conclusion
- •References
- •Introduction
- •References
- •Introduction
- •Conclusions
- •References
- •Decipher
- •Oncotype DX
- •Prolaris
- •Limitations
- •Conclusion
- •References
- •Background
- •Androgen Manipulation
- •Conclusion
- •References
- •Introduction
- •Genomic Biomarkers
- •Genomic Heterogeneity
- •Targeted Biopsy Outcomes
- •Outcomes After Active Surveillance
- •Outcomes After Radical Prostatectomy
- •Conclusions
- •References
- •Introduction
- •Early Prostate MRI Consensus Meetings
- •PI-RADS v2
- •PI-RADS v2.1
- •PI-RADS Vs. Likert Score
- •MRI-Targeted Biopsies
- •Reporting Cancer Recurrence
- •MRI After Focal Therapy
- •Conclusion
- •References
- •MR Segmentation
- •US Segmentation
- •MR-US Registration/Fusion
- •Conclusion
- •References
- •Introduction
- •Ultrasound Elastography
- •Strain Elastography
- •Shear Wave Elastography
- •Patient Factors During FB
- •Discussion
- •Learning Curve
- •Core Number Optimization
- •Transrectal Versus Transperineal
- •Future Directions
- •Acoustic Radiation Force Impulse (ARFI) Imaging
- •Quantitative Ultrasound
- •Micro-Ultrasound
- •Multiparametric Ultrasound
- •Conclusions
- •References
- •Multi-Parametric Magnetic Resonance Imaging
- •References
- •Introduction
- •Cognitive Fusion
- •In-Bore MRI-Guided Biopsy
- •Software-Based Image Coregistration
- •Registration Algorithms
- •Biopsy Needle Tracking
- •Biopsy Approach
- •Commercial Systems
- •Electromagnetic Tracking
- •Mechanical Position Encoders
- •Image-Based Tracking
- •Discussion
- •Conclusion
- •References
- •Introduction
- •Complications
- •Urinary Retention
- •Bleeding
- •Conclusion
- •References
- •Introduction
- •Institutional Examples
- •Setting
- •Results
- •Discussion
- •Summary
- •References
- •Introduction
- •PET-Guided Targeted Prostate Biopsy
- •Gallium-68 (68Ga)-Radiolabeled PSMA Ligands
- •Fluorine-18 (18F)-Radiolabeled PSMA Ligands
- •Gastrin-Releasing Peptide Receptor (GRPR)
- •Future Outlook
- •Conclusion
- •References
- •Introduction
- •Approach
- •Sampling
- •Core Length
- •Histologic Submission
- •BxChip™
- •Reporting Results
- •References
- •Introduction
- •Location: Treatment Factors
- •References
- •Introduction
- •Focal Therapy Nomenclature
- •Nerve-Sparing (Unilateral or Bilateral)
- •Hemi-Ablation
- •Anterior Hockey-Stick Ablation (Anterior Three-Fourth)
- •Posterior Hockey-Stick Ablation (Posterior Three-Fourth)
- •Targeted Focal Therapy
- •Quadrant (Zonal) Ablation
- •Conclusions
- •References
- •Introduction
- •Cryotherapy
- •Irreversible Electroporation (IRE)
- •Transurethral Ultrasound Ablation (TULSA)
- •High-Intensity Focused Ultrasound (HIFU)
- •Surgery (Partial Prostatectomy)
- •Evolving Frontiers
- •Conclusion
- •References
- •Background
- •Procedure Selection
- •Patients’ Selection
- •Anesthesia
- •Perioperative Protocols
- •Procedure
- •Postoperative Period
- •Outcomes
- •Procedure Feasibility
- •Adverse Events
- •Outcomes
- •Conclusion
- •References
- •Clinical Background
- •Radiotherapy Techniques
- •Clinical Evidence About High-Dose Rate Interventional Radiotherapy (HDR IRT)
- •Clinical Evidence About Low-Dose Rate Interventional Radiotherapy (LDR IRT)
- •Clinical Evidence About Focal External Beam Radiotherapy (ERT)
- •Discussion
- •References
- •28: Focal Cryotherapy
- •Introduction
- •Focal Cryotherapy Procedure
- •Contemporary Focal Cryotherapy Series
- •Primary Focal Cryoablation
- •Salvage Focal Cryotherapy
- •Surveillance
- •Future Developments
- •Imaging
- •Cryotechnology
- •Immune Enhancer
- •References
- •Background
- •Energy Principles: Basic Science
- •Conclusion
- •References
- •Introduction
- •Early Studies
- •Phase 1 Clinical Trial (“Subtotal” Ablation)
- •Phase II (“TACT”) Clinical Trial (“Whole Gland” Ablation)
- •Patient Selection
- •Preoperative Imaging Planning
- •Intraoperative Considerations
- •Follow-Up Routine Post-Focal TULSA
- •Summary
- •References
- •Vapor 1 Study Results
- •References
- •Introduction
- •Robotic HIFU
- •Safety Features
- •Robotic HIFU Procedure
- •Intraoperative Monitoring
- •Built-in Contrast-Enhanced Transrectal Ultrasound
- •Postoperative Care
- •Follow-up
- •Oncologic Outcomes
- •Functional Outcomes
- •Complications
- •Conclusions
- •References
- •Indications
- •Contraindications
- •Preprocedure Workup
- •Technique
- •Outcomes
- •Complications
- •Controversies
- •Conclusion
- •References
- •Introduction
- •Posttreatment MRI Findings
- •High-Intensity Focused Ultrasound (HIFU)
- •Focal Laser Ablation (FLA)
- •Irreversible Electroporation (IRE)
- •Focal Cryotherapy (FC)
- •Photodynamic Therapy (PDT)
- •Future Perspectives
- •Conclusion
- •References
- •Introduction
- •Oncological Outcomes
- •Biochemical Recurrence
- •Functional Outcomes
- •Perioperative Complications
- •Urinary
- •Sexual
- •Bowel
- •Decision Regret
- •Conclusion
- •References
- •36: Assessing Functional Outcomes After Focal Therapy
- •High-Intensity Focused Ultrasound (HIFU)
- •Cryotherapy
- •Irreversible Electroporation (IRE)
- •Focal Brachytherapy
- •Focal Laser Ablation (FLA)
- •Photodynamic Therapy (PDT)
- •Microwave Ablation
- •Partial Prostatectomy
- •Bipolar Radiofrequency Ablation (bRFA)
- •Prostatic Artery Embolization (PAE)
- •Urinary Function
- •IPSS
- •EPIC
- •ICIQ-SF
- •Erectile Function
- •IIEF
- •EPIC
- •Safety Outcomes
- •Clavien-Dindo
- •CTCAE
- •Physical/Mental Outcomes
- •SF-12
- •Monitoring Patients After Focal Therapy
- •References
- •Introduction
- •PSA Nadir
- •PSA Density
- •Other Molecular Biomarkers
- •Follow-Up Protocols After FT
- •References
- •Introduction
- •Postbrachytherapy Treatment Changes
- •Post High-Intensity Focused Ultrasound (HIFU) Treatment Changes
- •Post Cryotherapy Treatment Changes
- •Post Laser Ablation Changes
- •Post Photodynamic Therapy Changes
- •Post Irreversible Electroporation Changes
- •Interstitial Microwave Thermal Therapy
- •Radiofrequency Ablation
- •References
- •39: Salvage Treatment Following Focal Therapy
- •Introduction
- •Salvage Treatment Modalities
- •Repeat Ablation
- •Salvage Radical Treatment
- •Salvage Radical Prostatectomy
- •Salvage Radiotherapy
- •References
- •Introduction
- •Ensuring Appropriate Quality
- •Conclusion
- •References
- •Patient Selection
- •Posttreatment Follow-Up
- •Conclusions
- •References
- •Index

xii
Part VII Transperineal Technologies for Focal Therapy
27 Focal Brachytherapy (Interventional Radiotherapy)
and IMRT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317
Luca Tagliaferri, Bruno Fionda, Jeremy Grummet,
Andrew See, and György Kovács
28 Focal Cryotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327
Kae Jack Tay, Sriram Deivasigamani, Aaron Katz,
and Thomas J. Polascik
29 Irreversible Electroporation for Partial Gland
Ablation: Clinical Application and Outcomes . . . . . . . . . . . . . . . 345
Jonathan Fainberg, Jonathan Coleman, Giancarlo Marra,
Phillip Stricker, and Nathan Lawrentschuk
Part VIII Transurethral Technologies for Focal Therapy
30 Role of Transurethral Ultrasound Ablation (TULSA)
in Prostate Cancer Focal Therapy . . . . . . . . . . . . . . . . . . . . . . . . . 355
Joseph L. Chin, Xiaosong Meng, and Emily Bochner
31 Transurethral Vapor Ablation in Prostate Cancer. . . . . . . . . . . . 373
Jamie S. Pak, Christopher M. Dixon, and Samir S. Taneja
Contents
Part IX Transrectal Technologies for Focal Therapy
32 Robotic High-Intensity Focused Ultrasound
of the Prostate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
Lorenzo Storino Ramacciotti, Massimo Valerio,
Sebastien Crouzet, and Andre Abreu
33 Transrectal Laser Focal Therapy of Prostate Cancer . . . . . . . . . 405
John F. Feller, Bernadette M. Greenwood, Aaron Harman,
and Ara Karamanian
Part X Post-treatment Assessment of Focal Therapy Outcomes
34 Role of Prostate MRI for Postfocal Treatment
Assessment and Surveillance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 419
Omer Tarik Esengur, David G. Gelikman, and Baris Turkbey
35 Measuring Patient-Based Outcomes: Setting
Realistic Expectations When Balancing Functional
Outcomes with Cancer Control . . . . . . . . . . . . . . . . . . . . . . . . . . . 431
Alexander Light, Deepika Reddy, and Srinivas Vourganti

Contents
xiii
36 Assessing Functional Outcomes After Focal Therapy . . . . . . . . . 441
Jason Jung, Matthijs J. Scheltema, and Phillip D. Stricker
37 Biochemical Assessment of Cancer Outcomes
Following Focal Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 449
Alireza Ghorei and Amir H. Lebastchi
38 Pathologic Assessment and Implications Following
Focal Therapy of Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . 455
Rafael E. Jimenez, Divyangi Paralkar, Alessia Cimadamore,
Andrew Evans, and Mahul B. Amin
39 Salvage Treatment Following Focal Therapy . . . . . . . . . . . . . . . . 469
Theo M. de Reijke and Derek Lomas
Part XI Looking Forward
40 Design of Payment and Reimbursement Strategies
for Focal Therapy for Acceptance in Value-Based
Care Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 477
Avinash Maganty, Neil Mendhiratta, Alexander P. Kenigsberg,
David Johnson, Cary N. Robertson, and Vishnukamal Golla
41 The Horizon: Future of Focal Therapy in Prostate
Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489
Alessandro Marquis and Ardeshir R. Rastinehad
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 493

Contributors
Andre Abreu Clinical Urology and Radiology, Image-Guided Surgery,
Focal Therapy and Articial Intelligence for Prostate Cancer, USC Institute
of Urology, Keck School of Medicine, University of Southern California, Los
Angeles, CA, USA
Center for Image-Guided Surgery, Focal Therapy and Articial Intelligence
for Prostate Cancer, USC Institute of Urology Catherine and Joseph Aresty
Department of Urology, Keck School of Medicine, University of Southern
California, Los Angeles, CA, USA
EricS. Adams Department of Urology, Duke University Medical Center,
Durham, NC, USA
ArdalanAhmad Division of Urology, Department of Surgery, University
Health Network Princess Margaret Cancer Center, Toronto, ON, Canada
Mahul B. Amin Pathology and Lab Medicine, University of Tennessee
Health Sciences System, Memphis, TN, USA
USC Keck School of Medicine, LabCorp, Los Angeles, CA, USA
PaulB.Arangua Department of Urologic Oncology, University of Colorado
Anschutz Medical Campus, Aurora, CO, USA
Pier Paolo Avolio Department of Surgery, Division of Urology, McGill
University, Montréal, QC, Canada
Department of Biomedical Sciences, Humanitas University, Milan, Italy
Mohannad A. Awad Department of Urology, University of Texas
Southwestern Medical Center, Dallas, TX, USA
Department of Surgery, King Abdulaziz University, Rabigh, Saudi Arabia
EzequielBecher CDU—Centro de Urologia, Buenos Aires, Argentina
FernandoJ.Bianco Urological Research Network, Miami, USA
EmilyBochner University of Texas Southwestern, Dallas, TX, USA
AlbertoBriganti Division of Oncology/Unit of Urology, Soldera Prostate
Cancer Lab, URI, IRCCS Ospedale San Raffaele, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy
xv

xvi
Giovanni Enrico Cacciamani Center for Image-Guided Surgery, Focal
Therapy and Articial Intelligence for Prostate Cancer, USC Institute of
Urology Catherine and Joseph Aresty Department of Urology, Norris
Comprehensive Cancer Center, Keck School of Medicine, University of
Southern California, Los Angeles, CA, USA
Jeffrey A. Cadeddu Department of Urology, University of Texas
Southwestern Medical Center, Dallas, TX, USA
Department of Radiology, University of Texas Southwestern Medical Center,
Dallas, TX, USA
Arie Carneiro Department of Urology, Hospital Israelita Albert Einstein,
São Paulo, Brazil
Francesco Cei Center for Image-Guided Surgery, Focal Therapy and
Articial Intelligence for Prostate Cancer, USC Institute of Urology Catherine
and Joseph Aresty Department of Urology, Norris Comprehensive Cancer
Center, Keck School of Medicine, University of Southern California, Los
Angeles, CA, USA
Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale
San Raffaele, Milan, Italy
Derek Chan Department of Biomedical Engineering, Duke University,
Durham, NC, USA
Contributors
JosephL.Chin Western University, London, ON, Canada
PeterKa-FungChiu SH Ho Urology Centre, Department of Surgery, Prince
of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong
Kong, China
Alessia Cimadamore Department of Medicine (DAME), University of
Udine, Institute of Surgical Pathology, Udine, Italy
Jonathan Coleman Department of Surgery, Memorial Sloan Kettering
Cancer Center, New York, NY, USA
E. David Crawford University of San Diego, Koman Family Outpatient
Pavilion, La Jolla, CA, USA
Sebastien Crouzet Department of Urology, Hôpital Edouard Herriot,
Hospices Civils de Lyon, Lyon, France
SriramDeivasigamani Duke Cancer Institute and Duke University Medical
Center, Durham, NC, USA
Department of Urologic Surgery, Duke University Medical Center, Durham,
NC, USA
ChristopherM.Dixon Bon Secours Urology, WMC Health Good Samaritan
Hospital, Suffern, NY, USA
Francis Medical Inc., Maple Grove, MN, USA

Contributors
xvii
Heying Duan Division of Nuclear Medicine and Molecular Imaging,
Department of Radiology, Stanford University, Stanford, CA, USA
BehfarEhdaie Urology Service, Department of Surgery, Memorial Sloan
Kettering Cancer Center, New York, NY, USA
Cameron Englman Division of Surgery and Interventional Science,
University College London, London, UK
Department of Radiology, University College London Hospital NHS
Foundation Trust, London, UK
OmerTarikEsengur Molecular Imaging Branch, National Cancer Institute,
National Institutes of Health, Bethesda, MD, USA
Andrew Evans Genitourinary Pathology, Cortellucci Vaughan Hospital,
Mackenzie Health, Vaughan, ON, Canada
Jonathan Fainberg Urology Service, Department of Surgery, Memorial
Sloan Kettering Cancer Center, New York, NY, USA
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York,
NY, USA
Fabian Falkenbach Martini-Klinik Prostate Cancer Center, University
Medical Center Hamburg-Eppendorf, Hamburg, Germany
JohnF.Feller HALO Precision Diagnostics, Indian Wells, CA, USA
Department of Radiology, Loma Linda University School of Medicine, Loma
Linda, CA, USA
Bruno Fionda U.O.C. Radioterapia Oncologica, Dipartimento di
Diagnostica per Immagini, Radioterapia Oncologica Ed Ematologia,
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Jurgen J. Fütterer Department of Medical Imaging, Radboudumc,
Nijmegen, The Netherlands
GiorgioGandaglia Division of Oncology/Unit of Urology, Soldera Prostate
Cancer Lab, URI, IRCCS Ospedale San Raffaele, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy
DavidG.Gelikman Molecular Imaging Branch, National Cancer Institute,
National Institutes of Health, Bethesda, MD, USA
Pejman Ghanouni Division of Body MRI, Department of Radiology,
Stanford University, Stanford, CA, USA
Alireza Ghorei Department of Urology, Keck School of Medicine,
University of Southern California, Los Angeles, CA, USA
Francesco Giganti Division of Surgery and Interventional Science,
University College London, London, UK
Department of Radiology, University College London Hospital NHS
Foundation Trust, London, UK

xviii
Vishnukamal Golla Department of Urology, Duke University School of
Medicine, Durham, VA, USA
Department of Surgery, Division of Urology, Durham, VA, USA
PaoloGontero Molinette Hospital, Turin, Italy
Bernadette M. Greenwood Department of Radiologie and Nuclear
Medicine, Radboud University Medical Center, Nijmegen, Gelderland, The
Netherlands
HALO Precision Diagnostics, Indian Wells, CA, USA
JeremyGrummet Department of Surgery, Central Clinical School, Monash
University, Melbourne, VIC, Australia
RajanT.Gupta Duke Cancer Institute and Duke University Medical Center,
Durham, NC, USA
AaronHarman HALO Precision Diagnostics, Indio, CA, USA
OmarHayek Department of Urology, University of Alabama at Birmingham,
Birmingham, AL, USA
JimC.Hu Department of Urology, New York-Presbyterian Hospital/Weill
Cornell Medical Center, New York, NY, USA
Contributors
Andrei Iagaru Division of Nuclear Medicine and Molecular Imaging,
Department of Radiology, Stanford University, Stanford, CA, USA
KennethA.Iczkowski Department of Pathology and Laboratory Medicine,
University of California—Davis, Sacramento, CA, USA
MichaelC.Ivey Duke Cancer Institute and Duke University Medical Center,
Durham, NC, USA
RafaelE.Jimenez Division of Anatomic Pathology, Laboratory Medicine
and Pathology, Mayo Clinic, Rochester, MN, USA
David Johnson Department of Urology, University of North Carolina
School of Medicine, Chapel Hill, NC, USA
JasonJung Garvan Institute of Medical Research & The Kinghorn Cancer
Centre, Sydney, NSW, Australia
St. Vincent’s Prostate Cancer Research Centre, Darlinghurst, Sydney, NSW,
Australia
MasatomoKaneko Center for Image-Guided Surgery, Focal Therapy and
Articial Intelligence for Prostate Cancer, USC Institute of Urology Catherine
and Joseph Aresty Department of Urology, Norris Comprehensive Cancer
Center, Keck School of Medicine, University of Southern California, Los
Angeles, CA, USA
AraKaramanian HALO Precision Diagnostics, Indio, CA, USA
AliKasraeian Kasraeian Urology, Jacksonville, FL, USA

Contributors
xix
AaronKatz Department of Urology, NYU-Langone Long Island School of
Medicine, New York, NY, USA
Alexander P. Kenigsberg Urologic Oncology Branch, National Cancer
Institute, National Institutes of Health, Bethesda, MD, USA
LaurenceKlotz Sunnybrook Chair of Prostate Cancer Research, Division
of Urology, Sunnybrook Health Sciences Centre, University of Toronto,
Toronto, ON, Canada
György Kovács Gemelli-INTERACTS, Università Cattolica del Sacro
Cuore, Rome, Italy
PilarLaguna Department of Urology, Medipol University, Istanbul, Turkey
Nathan Lawrentschuk Department of Surgery, University of Melbourne,
Parkville, VIC, Australia
Urology Unit, Royal Melbourne Hospital, Parkville, VIC, Australia
Amir H. Lebastchi Department of Urology, Keck School of Medicine,
University of Southern California, Los Angeles, CA, USA
Riccardo Leni Division of Oncology/Unit of Urology, Soldera Prostate
Cancer Lab, URI, IRCCS Ospedale San Raffaele, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy
HerbertLepor Department of Urology, NYU Langone Health, NYU School
of Medicine, New York, NY, USA
AlexanderLight Imperial Prostate, Imperial College London, London, UK
DerekLomas Department of Urology, Mayo Clinic, Rochester, MN, USA
Giovanni Lughezzani Department of Biomedical Sciences, Humanitas
University, Milan, Italy
Luca Lunelli Department of Urology, Hôpital Louis Pasteur, Chartres,
France
PetrMacek Department of Urology, Institut Montsouris, Paris, France
Avinash Maganty From the Dow Division of Health Services Research,
Department of Urology, University of Michigan, Ann Arbor, MI, USA
GiuseppeMaiolino Urological Research Network, Miami, USA
AlessandroMarquis Northwell Health System, Smith Institute for Urology
at Lenox Hill, Lake Success, NY, USA
Department of Surgical Sciences, Division of Urology, Molinette Hospital
and University of Turin, Turin, Italy
GiancarloMarra Molinette Hospital, Turin, Italy
Department of Surgical Sciences, Molinette Hospital, AOU Città della Salute
e della Scienza and University of Turin, Turin, Italy

xx
JodieMcDonald Department of Urology, St Vincents Hospital Melbourne,
Melbourne, VIC, Australia
Neil Mendhiratta Urologic Oncology Branch, National Cancer Institute,
National Institutes of Health, Bethesda, MD, USA
XiaosongMeng University of Texas Southwestern, Dallas, TX, USA
Caroline M. Moore Division of Surgery and Interventional Science,
University College London, London, UK
Department of Urology, University College London Hospital NHS Foundation
Trust, London, UK
MarcoMoschini Division of Oncology/Unit of Urology, Soldera Prostate
Cancer Lab, URI, IRCCS Ospedale San Raffaele, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy
Mahdi Mottaghi Duke Cancer Institute and Duke University Medical
Center, Durham, NC, USA
JuddW.Moul Department of Urology, NYU Langone Health, New York,
NY, USA
Department of Urology and Duke Cancer Institute, University Medical
Center, Durham, NC, USA
Contributors
Bruno Nahar Desai Sethi Urology Institute, Miller School of Medicine,
University of Miami, Miami, FL, USA
Kathryn Nightingale Department of Biomedical Engineering, Duke
University, Durham, NC, USA
Ruben Olivares Associate Professor of Urology, Glickman Urological
Institute, Cleveland Clinic, Cleveland, OH, USA
Jonathan Olivier Univ. Lille, CHU Lille, Service Urologie, Andrologie,
Transplantation Rénale, Lille, France
JamieS.Pak Division of Urologic Oncology, Department of Urology, NYU
Langone Health, New York, NY, USA
Divyangi Paralkar University of Southern California Keck School of
Medicine, Los Angeles, CA, USA
ThomasJ.Polascik Duke Cancer Institute, Duke Prostate and Urological
Cancer Center, Durham, NC, USA
SoroushRais-Bahrami Department of Urology, University of Alabama at
Birmingham, Birmingham, AL, USA
Department of Radiology, University of Alabama at Birmingham,
Birmingham, AL, USA
O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham,
Birmingham, AL, USA

Contributors
xxi
Lorenzo Storino Ramacciotti Center for Image-Guided Surgery, Focal
Therapy and Articial Intelligence for Prostate Cancer, USC Institute of
Urology Catherine and Joseph Aresty Department of Urology, Keck School
of Medicine, University of Southern California, Los Angeles, CA, USA
Ardeshir R. Rastinehad Smith Institute for Urology at Lenox Hill,
Northwell Health, Lake Success, New York, NY, USA
DeepikaReddy Imperial Prostate, Imperial College London, London, UK
TheoM.de Reijke Department of Urology, Amsterdam UMC, University
of Amsterdam, Amsterdam, The Netherlands
Cary N. Robertson Department of Urology, Duke University School of
Medicine, Durham, VA, USA
Department of Surgery, Division of Urology, Durham, VA, USA
Craig G. Rogers Vattikuti Urology Institute, Henry Ford Health, Detroit,
MI, USA
Francisco G. La Rosa Department of Pathology, University of Colorado
Anschutz Medical Campus, Aurora, CO, USA
MichaelB.Rothberg, MD Division of Urologic Oncology, Department of
Urology, Duke Cancer Institute Center for Prostate and Urologic Cancers,
Duke University School of Medicine, Durham, NC, USA
GeorgSalomon Martini-Klinik Prostate Cancer Center, University Medical
Center Hamburg-Eppendorf, Hamburg, Germany
RafaelSanchez-Salas Department of Surgery, Division of Urology, McGill
University, Montreal, QC, Canada
Matthijs J. Scheltema Garvan Institute of Medical Research & The
Kinghorn Cancer Centre, Sydney, NSW, Australia
St. Vincent’s Prostate Cancer Research Centre, Darlinghurst, Sydney, NSW,
Australia
AndrewSee Icon Cancer Centre, Richmond, VIC, Australia
Denis Seguier Univ. Lille, CHU Lille, Service Urologie, Andrologie,
Transplantation Rénale, Lille, France
GeoffreyA. Sonn Department of Urology, Stanford University, Stanford,
CA, USA
Nicolas Soputro Associate Professor of Urology, Glickman Urological
Institute, Cleveland Clinic, Cleveland, OH, USA
ArmandoStabile Division of Oncology/Unit of Urology, Soldera Prostate
Cancer Lab, URI, IRCCS Ospedale San Raffaele, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy
PhillipD.Stricker Urology Department, St. Vincent’s Hospital, St. Vincent’s
Prostate Cancer Research Centre, Darlinghurst, NSW, Australia

xxii
Garvan Institute of Medical Research and Kinghorn Cancer Centre,
Darlinghurst, NSW, Australia
St. Vincent’s Clinical School, UNSW, Sydney, NSW, Australia
Luca Tagliaferri U.O.C. Radioterapia Oncologica, Dipartimento di
Diagnostica per Immagini, Radioterapia Oncologica Ed Ematologia,
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
SamirS.Taneja Division of Urologic Oncology, Department of Urology,
NYU Langone Health, New York, NY, USA
WeiPhin Tan Department of Urology, NYU Langone Health, New York,
NY, USA
BenjaminTavya Smith Institute for Urology, Northwell Health, New York,
NY, USA
Kae Jack Tay Department of Urology, Singapore General Hospital,
Singapore, Singapore
Division of Surgery & Surgical Oncology, National Cancer Centre Singapore,
Singapore, Singapore
Singapore General Hospital, Singapore, Singapore
Department of Urology, NUS-Duke Health, Singapore, Singapore
Contributors
SauloBorborema Teles Department of Urology, Hospital Israelita Albert
Einstein, São Paulo, Brazil
Sameer Thakker Department of Urology, NYU Langone Health, New
York, NY, USA
Rafael Tourinho-Barbosa Department of Urology, Hospital Cardio
Pulmonar—Rede D’Or, Salvador, Brazil
Department of Urology, Institut Montsouris, Paris, France
Baris Turkbey Molecular Imaging Branch, National Cancer Institute,
National Institutes of Health, Bethesda, MD, USA
OsamuUkimura Department of Urology, Kyoto Prefectural University of
Medicine, Kyoto, Japan
Massimo Valerio Department of Urology, Geneva University Hospital,
Geneva, Switzerland
Arnauld Villers Univ. Lille, CHU Lille, Service Urologie, Andrologie,
Transplantation Rénale, Lille, France
SrinivasVourganti RUSH Medical College, Chicago, IL, USA
Yuzhi Wang Vattikuti Urology Institute, Henry Ford Health, Detroit, MI,
USA
JohnF.Ward Department of Urology, University of Texas, M.D. Anderson
Cancer Center, Houston, TX, USA
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