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23 Global Medicine Perspectives
Fig. 23.2 Marker=Collaborating site for POC US education and training in resource-limited set­ting. From http://www.globalsono.org/AllSites.aspx
377
training guidelines to assist LMICs in ultrasound program development [8], however the literature suggests that the major barrier to adoption of ultrasound worldwide is lack of training in its use [9].
Despite the challenges of ultrasound program development in LMICs, successful implementation of sustainable ultrasound services has been undertaken by several organizations. Their models have helped to guide many other programs to begin needs assessments and edgling training programs worldwide and the leadership of each of these listed organizations are receptive to collaboration.
• PURE: Point-of-care Ultrasound in Resource Limited Environments (www.
pureultrasound.org). This nonprot organization is dedicated to enhancing ultra-
sound education and use in the developing world, with current focus in Africa.
PURE has created sustainable ultrasound programs at the district hospital level
in Rwanda and has developed a Training of Trainers Course to promote long-
term partnership.
• Partners In Health: (www.pih.org) This nonprot has ultrasound programs in
nearly all of its locations including Mexico, Haiti, Rwanda, Lesotho, Malawi,
Liberia, and Sierra Leone including over 40 machines in use and hundreds of
clinicians trained in ultrasound [10].
• Global Emergency Care Collaborative: (www.globalemergencycare.org) This
unique nonprot focuses on development of Emergency care training programs
for nurses practicing in East Africa. It has a novel published ultrasound curricu-
lum for nonphysician clinicians [11].
• WINFOCUS: This multinational organization leads training and educational
programs in many middle-income countries worldwide including Brazil, India,
and within Eastern Europe, with the mission of enhancing education in POC US
for treatment of “critical” patients, from the out-of-hospital realm to emergency
departments to intensive care units [12].
378
S.P. Shah

Ultrasound Management in Global Medicine: Key Concepts

Equipment

Procurement of ultrasound equipment that will function well and last for years in limited resource settings can be a challenge. When seeking ultrasound machines for use in a district hospital or health center, consider these features:
Portability: Hand-carried machines have the advantage of extreme portability
making them invaluable for use on home visits and also between hospital build-
ings. Perhaps more importantly, hand-carried machines can be easily transported
back to the manufacturer for service. However, extremely portable machines
have a risk of theft or loss if not properly secured, therefore a mechanism for
signing out the machine from a secure location within the hospital is
recommended.
Durability: How much heat can the machine withstand? How much mois-
ture? How much dust? What if the machine or probes get dropped or jostled?
What is the battery life? We suggest purchase of a service contract for ongo-
ing machine maintenance as well as loaner machine options. Consider asking
the manufacturer to provide in-service training to the regional site biomedi-
cal engineer in commonly encountered equipment problems and their
solutions.
Electrical concerns: Long battery life and short boot-up time are ideal. Consider
adding extra batteries and power cords at the time of original purchase, as some
power cords are sensitive to the frequent power surges and non-grounded electri-
cal outlets found in many developing countries.
Options for remote QA: Even with adequate training, clinician sonographers in
any program sometimes require image interpretation assistance, and should be
encouraged to maintain quality assurance image review procedures. Ease of
image upload via PACS or ash disc should be considered with ultrasound
machine procurement.
Probes: Studies demonstrate that obstetric and abdominal ultrasound exams are
the most frequent application in many LMICs, and thus a low frequency curved
abdominal probe is a must [13, 14]. In addition, the WHO and United Nations
have recently recognized noncommunicable diseases (NCDs) such as hyperten-
sion and diabetes mellitus as a major challenge for sustainable development,
therefore a phased array probe is suggested for diagnosis of NCD complications
including heart and renal failure [15]. If there is ability to secure multiple
probes, a linear, high frequency probe can be quite useful for procedural guid-
ance and deep venous thrombosis assessment in areas with high prevalence of
tuberculosis (e.g., Tuberculous pericardial and pleural effusions and ascites
requiring drainage) and HIV (which increases the risk of deep venous
thrombosis).
Many of the major ultrasound manufacturers produce ultra-mobile equipment for use in LMIC settings (See Chap. 12 – Ultrasound Equipment and Purchase).
23 Global Medicine Perspectives
Table 23.1 Example options for sonography equipment geared for LMIC use
Company Product
Sonosite Inc. (Fujilm) Soundcaring program (refurbished): Nanomaxx
and M turbo
New release 2016: iViz (handheld tablet) Phillips VISIQ, Lumify (tablet-based with lease option) Terason t3200, t3300 (PC laptop based machines) Mindray M5, M7, M9 Siemans Acuson P300, freestyle (wireless probes) GE Vscan (portable, handheld)
379
While not exhaustive, the table below provides an example of the different types of options currently in use internationally or newly available (Table23.1).
Financial constraints often preclude purchase of new ultrasound equipment for use in LMICs. However, refurbished or slightly older equipment is often of high enough quality to be useful and is more affordable. If procuring a machine to leave or donate in an LMIC, many of the major manufacturers have charitable arms (e.g., Soundcaring program, Sonosite Inc.) [16] which may accept applications for low cost or free machines. Another option is to ask for donation of refurbished machines from your local hospitals. Most major companies will loan extra equipment for training pur­poses for periods of up to a few months with enough lead time, and this can often be arranged by your local representative. Careful reading of loan agreements is recom­mended, and consideration of additional insurance for loaned equipment by your hospital’s underwriter is sometimes necessary. When traveling with loaned equip­ment, a letter stating the value of the equipment and that it is for use on loan should be hand-carried from the international host hospital in case of customs interrogation.

Maintenance

Implementation of ultrasound programs should include plans for maintenance before equipment fails. In LMICs, if local biomedical engineering is available, con­sider requesting the equipment manufacturer to host a training for the engineer to learn more about their machine, or providing a service contract for repair with the equipment. Consider paper and electronic copies of the user manuals on site, as well as extra cords/batteries on hand.
Despite thoughtful consideration in the procurement of ultrasound equipment, there are known points of weakness even in the most durable machines. Hand- carried machines stored in bags with probe cords curled will suffer fraying of cords at the junction of cord and probe as well as cord and connector plate over time. Consider establishing a safe area to hang probes while they are not in use to avoid this prob­lem. Another common issue arises from the sensitivity of the equipment to voltage surges which can burn the power boxes and cords, which is completely avoidable by use of voltage stabilizers and grounding of outlets used to charge equipment.
380
S.P. Shah

Program Implementation

Ultrasound services will only ourish if they address the immediate patient care needs of the clinicians and impact patient care substantially to offset time and human resources needed for training/implementation. To create this scenario, the program must include attention to the question of what happens when a surgical or medical emergency is diagnosed with ultrasound. Ultrasound programs are often most impactful when plans for rapid transfer to higher level of care, or to operative or transfusion services are arranged simultaneously or otherwise established. Therefore, we recommend beginning with a needs-assessment to discern which ultrasound applications will be most useful for each specic setting (Table 23.2: Needs Assessment sample questions) [17]. Once a needs-assessment has been per­formed, development and delivery of a tailored curriculum can begin.

Education Strategies

Even the best ultrasound equipment will collect dust in storage or be quickly ren­dered medical waste by misuse without proper training. Ultrasound technology implementation without training is, to borrow a Haitian proverb, like washing your hands and drying them in the dirt. To manage a successful ultrasound program in an under-resourced setting, we suggest the following key considerations:
Table 23.2 Needs Assessment sample questions
Ultrasound Machine Available? Type? Probes?
Current use of ultrasound? Indications? Background training of users? Logging scans?
Hospital characteristics: OR? L&D?Xray? Electricity? Internet?
Top 10 causes of death in this region, top causes of in-hospital mortality
Hospital politics? Will trainers need a medical license?
Yes or no questionnaire for diseases present: Heart failure, renal failure, sepsis, pneumonia, ascites/effusions, TB, HIV, trauma, unexplained Dyspnea
Contact list: Obtain names/emails for medical director, clinical director, head of nursing, radiographers, prior US trained clinicians
Henwood P, Mackenzie D, Rempell J, Murray A, Leo M, Dean AJ, Liteplo A, Noble V.A Practical Guide to Self-Sustaining Point-of-Care Ultrasound Education Programs in Resource-Limited Settings. Annals of Emerg Med 2014 Sept;64 (3):277–85 [17]
Establish plan for Maintenance, Service, Bring loaner/update probes
Create log system, expand indications of current use, use established experts to help train (if any)
Establish communication for sending images for review if needed, establish protocols for how to transfer patients based on ultrasound ndings to OR if needed
Use this to build your curriculum for life-saving POC US exams rst
Consider training administrators/MD’s rst, obtain local licenses, permission from ministries of health
Use this to create your curriculum tailored to what clinicians will encounter on their wards
Begin contact well before introducing ultrasound and training to establish rapport and enthusiasm
23 Global Medicine Perspectives
381
Train an ultrasound champion: Choose an enthusiastic clinician with leadership
skills to be your local ultrasound coordinator in charge of arranging trainings, keep-
ing equipment safe and functioning, and establishing a quality assurance program.
Sustainability: Training programs should include both initial trainings, refresher
courses within 6months, ongoing email contact for case discussion and quality
assurance, and eventual training of local trainers through mentorship and sepa-
rate coursework. Establish ability for image upload and distance learning options,
such as webinars or image based case reviews at timely intervals, as early as
possible after initial training.
• Consider an interdisciplinary approach to use the clinical skills of physicians
from varied specialties and other health professionals who will be able to offer
different training perspectives and assist with integration of the newfound ultra-
sound knowledge into clinical care.
Train administrators and publicize: Train not only the clinicians who interface
directly with patients whether they are physicians, nurses, or clinical ofcers, but
also physician/nurse administrators so they understand the scope and importance
of POC US and will advocate for continuation of the services once they are
established. Consider widely publicizing the training and presence of ultrasound
services once established, to draw patients to services and alert referral hospitals
of the new diagnostic option.
Sample Curricula: Sample curricula exist and learning resources for training
courses do not need to be reinvented. While published data suggest training
length varies substantially, consider building a curriculum to address the main
causes of mortality (Table23.3: PIH Ultrasound Curriculum).
Table 23.3 PIH ultrasound curriculum
Ultrasound exam topic Focus
Safety, physics ALARA principle, cleaning/sanitation, common artifacts, machine
Cardiac/volume assessment
Trauma Hemothorax, hemopericardium, Hemoperitoneum (eFAST exam),
Thoracic Pleural effusion, PTX, pneumonia Abdominal Liver cirrhosis/cysts/abscess, ascites, hydronephrosis, chronic renal
Obstetrics Ectopic and intrauterine pregnancy, molar pregnancy, estimation of
Procedural guidance Thoracentesis, paracentesis, pericardiocentesis Soft tissue/bone Cellulitis, abscess, pyomyositis, fracture Deep venous
thrombosis
Advanced topics: Testicular torsion/masses, thyroid, biopsy guidance, regional Anesthesia
Adapted from Partners In Health Ultrasound Curriculum (copyright 2011), http://www.pih.org/
library/manual-of-ultrasound-for-resource-limited-settings
knobs and modes of scanning, quality assurance process Pericardial effusion, chamber size, heart failure, endocarditis,
rheumatic valvular disease, inferior vena cava collapsibility and IVC: Aorta ratio
pneumothorax (PTX)
failure, gallstones, cholecystitis
gestational age, multiple gestation, placenta previa, amniotic uid index, abnormal fetal presentation, fetal heart rate
2 point exam for DVT in femoral or popliteal vein
382
S.P. Shah

Politics: Funding, Billing, Infrastructure

Despite good will and intentions, it can be a struggle to nd funding for develop­ment of ultrasound services in LMIC countries. Potential donated equipment should be thoroughly inspected before acceptance to ensure it is within the required speci­cations with respect to durability and functionality, and should always be deployed with a training plan in place which will likely require its own funding. Research in POC US use for specic indications in LMICs is an area rich for exploration [18]. Funded research studies can help to build local capacity both by engaging local providers in academic pursuits and by nancing general ultrasound training and equipment. The knowledge gained by local practitioners along with the ultrasound equipment remains long after the study period.
While still uncommon, some developing countries (e.g., Rwanda, Uganda) have established POC US billing which when paired with national insurance, can estab­lish a steady revenue stream for the hospital to ensure continuation of services.
Sanitation, Storage, andSafety
Providing sanitary medical care and ultrasound services can be a challenge in areas of the world where medical waste is burned or dumped near water supplies, and chemical agents such as Cidex and sterilization options are limited. For sanitation of probes, alcohol should be avoided, however diluted bleach solutions can be used for sanitation of most probes. Intracavitary probes consistently used with probe covers and bleach water and sterilized between uses should ideally not transmit disease. Nevertheless, local customs for sanitation of sensitive equipment should be followed [19, 20]. To encourage safe and responsible use of ultrasound, training should begin with the ALARA (as low as reasonably achievable) principle. Trainers should also be familiar with local ultrasound laws and regulations, including cultural and social issues, before embarking on ultrasound training missions. For example, teaching gender identication is illegal and punishable in areas of the world known for sex­selective abortion and female infanticide (e.g., China and India) [21, 22]. Archiving options are uncommon in LMICs, limited currently to PACS wireless upload and cumbersome mechanical downloading, however secure, cloud-based options are on the horizon. For example, Sonosite Inc. has partnered with Trice Imaging for Sonosite’s newly released iViz, which has embedded software to allow rapid, secure, cloud-based image transfer from remote locations using WiFi or cellular service.

Discussion

The eld of POC US in resource-limited settings is ever-changing, and clinicians from many disciplines of medicine are nding leadership in this eld to be both rewarding and challenging. While the equipment is rapidly evolving to meeting the
23 Global Medicine Perspectives
technological needs of worldwide users, best practices with regard to training and program management are quickly being established. Leaders in POC US with inter­est in developing ultrasound services in LMICs can successfully overcome com­monly encountered challenges with advanced planning discussed in this chapter and further details from other sections in this book. While unanticipated obstacles often crop up when working in LMIC’s, creative solutions are generated in discussion with the small but growing community of clinicians with expertise in this eld.
383

Pitfalls

Unfortunately, many potential pitfalls exist when implementing any program in a LMIC in addition to the ultrasound-specic challenges. Potential pitfalls and tech­niques for avoiding them include:
• Administrators do not understand scope or importance of POC US and can feel
ashamed that less experienced clinicians have skills they do not: Train the admin-
istrators rst, publicize the training, and suggest billing for services once
established.
• Ultrasound training is completed, but then adoption is slow: Train high impact
exam types rst (e.g., saving lives through rapid diagnosis of life-threatening
diseases such as ruptured ectopic and traumatic hemoperitoneum), integrate time
scanning on the clinical wards to discuss ways that ultrasound could be used to
explore almost every chief complaint and emphasize how the ndings change
patient management.
• Ultrasound services begin, but then referrals don’t increase and practice contin-
ues in a silo: Consider public outreach to make referral centers and tertiary care
centers aware of the training and new ultrasound programs.
• Staff turnover leaves no one trained after implementation of the ultrasound pro-
gram: Timely refresher courses can ensure knowledge transfer even with staff
turnover. Establishing a cadre of local trainers who can easily return to the site
for future training sessions will reduce need for foreign trainers.

Key Recommendations

• Ultrasound should be introduced as part of an overall health systems strengthen-
ing package, including training and human resources for improvement of clinical
care.
• Highest impact of ultrasound is attained when POC US is paired with improve-
ment of surgical services and ability for emergency transport of critical patients.
• Introducing ultrasound services means more than just choosing an ideal machine;
it involves ongoing partnership for training and education and a curriculum tai-
lored to meet the needs of the resource-limited setting.
384
S.P. Shah

References

1. http://www.who.int/diagnostic_imaging/imaging_modalities/dim_ultrasound/en/.
2. http://www.pih.org/blog/a-new-resource-for-using-ultrasound-in-developing-countries.
3. http://www.doctorswithoutborders.org/news-stories/eld-blog-doctor-what-about-my-brother.
4. http://internationalmedicalcorps.org/page.aspx?pid=1906.
5. http://www.rmdc.rw/spip.php?article159.
6. Kawooya M.Training for rural radiology and imaging in sub-Saharan Africa: a mismatch
between services and population. JClin Imaging Sci. 2012;2:37.
7. http://www.diagnosticimaging.com/articles/radiologist-sightings-drop-around-world.
8. Training in diagnostic ultrasound: essentials, principles and standards. Report of a WHO Study
Group. World Health Organ Tech Rep Ser. 1998;875:i-46.
9. LaGrone LN, Sadasivam V, Kushner AL, Groen RS.A review of training opportunities for ultra-
sonography in low and middle income countries. Tropical Med Int Health. 2012;17(7):808–19.
10. Shah S, Epino H, Bukhman G, Dushimiyimana JMV, Umulisa I, Reichman A, Noble V.Impact
of the introduction of ultrasound services in a limited resource setting: rural Rwanda 2008. BMC Int Health Hum Rights. 2009;9:4.
11. Stolz L, Muruganandan KM, Bisanzo M, Dreifuss B, Hammerstedt H, Nelson S, Nayabale I,
Shah S.Point-of-care ultrasound education for non-physician clinicians in a resource-limited emergency department. Trop Med Int Health. 2015;20(8):1067–72.
12. www.winfocus.org.
13. Steinmetz JP, Berger JP.Ultrasonography as an aid to diagnosis and treatment in a rural African
hospital: a prospective study of 1,119 cases. Am JTrop Med Hyg. 1999;60(1):119–23.
14. Sippel S, Muruganandan K, Levine A, Shah S.Review article: use of ultrasound in the devel-
oping world. Int JEmerg Med. 2011;4:72.
15. http://www.who.int/global-coordination-mechanism/ncd-themes/sustainable-development-goals/en/.
16. http://www.sonosite.com/about/global-health/soundcaring.
17. Henwood P, Mackenzie D, Rempell J, Murray A, Leo M, Dean AJ, Liteplo A, Noble V.A prac-
tical guide to self-sustaining point-of-care ultrasound education programs in resource-limited settings. Ann Emerg Med. 2014;64(3):277–85.
18. Moresky R, Bisanzo M, Rubenstein B, Hubbard S, Cohen H, Ouyang H, Marsh RH. A
research agenda for acute care services delivery in low- and middle-income countries. Acad Emerg Med. 2013;20(12):1264–71.
19. Talan D, Partida CN.Emergency department ultrasound infection control: do unto (and into)
others. Ann Emerg Med. 2011;58(1):64–6.
20. Frazee BW, Fahimi J, Lambert L, Nagdev A. Emergency department ultrasonographic
probe contamination and experimental model of probe disinfection. Ann Emerg Med. 2011;58(1):56–63.
21. Oomman N, Ganatra BR.Sex selection: the systematic elimination of girls. Reprod Health
Matters. 2002;10(19):184–8.
22. Complilation and Analysis of Case-Laws on Pre-conception and Pre-natal Diagnostics
Techniques (Prohibition of Sex Selection) Act, 1994. www.countryofce.unfpa.org/india/
drive/Compilation_and_Analysis_of_Case_Laws_on_Pre_Conception.pdf.
Chapter 24
Pediatric-Specic Point of Care US Management
JenniferR.Marin

Objectives

• Discuss reasons why ultrasound is favorable in pediatric patients
• Highlight specic point-of-care ultrasound exams in pediatric patients and the
limitations of each
• Describe strategies to reduce anxiety and pain associated with particular point-
of- care ultrasound examinations
• Describe how to demonstrate need and obtain funding for ultrasound equipment
in the pediatric setting

Introduction

Point-of-care ultrasound in pediatric patients has several unique and important con­siderations, beyond the typical advantages of ultrasound (rapid, bedside, non­invasive, less costly), making it a favorable imaging modality. First, children have higher water content and smaller body habitus relative to adult patients resulting in high quality images. Second, ultrasound can be performed without the child being completely still, and thus requires less cooperation than with other imaging modali­ties. Third, when considering diagnostic imaging in pediatric patients, ultrasound, compared with computed tomography (CT), is often the preferred modality, given the lack of radiation and in keeping with the As Low As Reasonably Achievable (ALARA) principle. Radiation exposure from medical imaging is particularly
J.R. Marin, MD, MSc Departments of Pediatrics and Emergency Medicine, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA e-mail: jennifer.marin@chp.edu
V. S. Tayal et al. (eds.), Ultrasound Program Management,
https://doi.org/10.1007/978-3-319-63143-1_24
385© Springer International Publishing AG 2018
386
J.R. Marin
relevant in pediatric patients, as they are more sensitive to radiation compared to adults [1]. Recent epidemiological studies support the increased relative risk of future malignancies from childhood exposures to CT [2].
Pediatric-Specic US Examinations andConsiderations
Many of the point-of-care ultrasound examinations performed in adult patients can be translated to use in pediatric patients. For example, torso trauma, pregnancy, cardiac instability, and appendicitis are also seen in pediatric patients. Therefore, many core emergency ultrasound applications should be learned for use for the pediatric population [3]. However, there are several exams that are particularly rel­evant and in some cases, unique, to children and worthy of discussion (Table24.1).
Most pediatric emergency visits are to general EDs [4] that may not have around­the- clock radiology ultrasound. Further, if ultrasound examinations are available, ultrasound technicians may not be skilled in pediatric-specic exams. For some exam­inations, point-of-care ultrasound may obviate the need for other imaging modalities, such as computed tomography and radiography. These point-of-care ultrasound examinations may also be important to guide further evaluation and management strategies as well as decrease emergency department lengths of stay. Therefore, it behooves the emergency physician to become adept at performing these exams. It should be noted that the overall incidence of disease and pathology in children pre­senting to the emergency department is much less than that of adults, therefore, physi­cians should be conscientious about getting enough experience with “positive” studies in order to be competent in a particular application.
Table 24.1 Key point-of-care ultrasound exams in pediatric patients
a
Exam
Bladder volume Pre-urethral catheterization Soft tissue Distinguishing abscess from cellulitis; evaluating
Hip effusion Limp, leg pain, refusal to bear weight Elbow fracture Fall on outstretched arm Skull fracture Closed head trauma Ultrasound-guided venous access Need for vascular access Pneumonia/parapneumonic effusion Symptoms concerning for pneumonia; lower lobe
Intussusception Colicky abdominal pain; bilious emesis,
Pyloric stenosis Non-bilious emesis in a 1-month old Appendicitis Right-sided abdominal pain, fever, vomiting
Exams ordered by increasing difculty
a
A linear array transducer is appropriate for all exams listed
Indications
for foreign body
consolidation
hematochezia