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NEUROPHYSIOLOGY

Olfactory System: Pathway

Efferent fibers

Afferent fibers

Granule cell (excited by and inhibiting to mitral and tufted cells)

Mitral cell

Recurrent process

Tufted cell

Periglomerular cell

Glomerulus

Olfactory nerve fibers

Olfactory epithelium

Olfactory tract

Olfactory nerves

Anterior olfactory nucleus

Olfactory bulb

Cribriform plate of ethmoid bone

FIGURE 2.41 OLFACTORY PATHWAY

Fibers from contralateral olfactory bulb

Fibers to contralateral olfactory bulb

Anterior commissure

Medial olfactory stria

Olfactory trigone and olfactory tubercle

Anterior perforated substance

Lateral olfactory stria

Lateral olfactory tract nucleus

Piriform lobe

Uncus

Amygdala (in phantom)

Entorhinal area

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Olfactory stimuli are detected by the nerve fibers of the olfactory epithelium and conveyed to the olfactory bulb (detailed local circuitry shown in upper left panel). Integrated signals pass along the olfactory tract and centrally diverge to pass to the anterior commis-

sure (some efferent projections course to the contralateral olfactory bulb, blue lines) or terminate in the ipsilateral olfactory trigone (olfactory tubercle). Axons then project to the primary olfactory cortex (piriform cortex), entorhinal cortex, and amygdala.

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