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NEUROPHYSIOLOGY

Hypothalamus

 

Septum

 

 

 

Corpus callosum

 

 

 

 

Fornix

 

 

 

 

pellucidum

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Lateral

 

 

 

 

 

 

 

 

ventricle

 

 

 

 

 

 

 

 

Thalamus

 

 

From

 

 

 

hippocampal

 

 

 

 

Interthalamic

formation

 

Lateral

 

 

 

 

 

 

 

 

adhesion

 

 

 

 

hypothalamic area

 

 

 

 

 

Medial

Paraventricular nucleus

 

 

 

Anterior

Anterior hypothalamic area

 

 

 

forebrain

commissure

Dorsal hypothalamic area

 

 

 

bundle

 

 

 

 

 

Dorsomedial nucleus

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Mamillothalamic tract

 

 

 

 

 

Posterior area

Lateral

 

 

 

 

Periventricular

preoptic

Medial

 

 

 

nucleus

nucleus

preoptic

 

 

 

Nucleus

 

nucleus

 

 

 

intercalatus

Olfactory

 

 

 

 

 

 

 

 

tract

 

 

 

 

 

 

 

 

 

 

 

Fornix

Red nucleus

Cerebral

 

 

 

 

 

peduncle

 

 

Ventromedial

 

 

 

 

 

nucleus

 

Mamillary

 

 

 

Optic (II)

 

 

 

 

complex

Dorsal

nerve

 

Tuberohypophyseal tract

Optic chiasm

 

 

 

 

longitudinal

 

Oculomotor (III) nerve

fasciculus

 

 

 

 

 

Supraoptic nucleus

Descending

 

 

Supraopticohypophyseal

hypothalamic

 

 

connections

 

 

tract

 

 

Pons

 

 

Posterior lobe of pituitary

Anterior

 

Reticular

 

 

 

 

 

 

 

 

 

lobe of

 

 

 

 

 

formation

 

 

pituitary

 

 

 

 

 

 

©

 

CHART 2.3 MAJOR FUNCTIONS OF THE HYPOTHALAMUS

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hypothalamic Area

 

 

 

Major Functions*

 

 

 

Preoptic and anterior

 

 

 

Heat loss center: cutaneous vasodilation and sweating

Posterior

 

 

 

Heat conservation center: cutaneous vasoconstriction and shivering

Lateral

 

 

 

Feeding center: eating behavior

Ventromedial

 

 

 

Satiety center: inhibits eating behavior

Supraoptic (subfornical organ and organum vasculosum)

 

ADH and oxytocin secretion (sensation of thirst)

Paraventricular

 

 

 

ADH and oxytocin secretion

Periventricular

 

 

 

Releasing hormones for the anterior pituitary

 

 

 

 

 

 

 

 

*Stimulation of the center causes the responses listed.

 

 

 

 

 

 

 

FIGURE 2.17 SCHEMATIC RECONSTRUCTION OF THE HYPOTHALAMUS

The hypothalamus, part of the diencephalon, controls a number of important homeostatic systems within the body, including temperature regulation, food intake, water intake, many of the endocrine systems (see Chapter 8), motivation, and emotional behavior. It receives inputs from the reticular formation (sleep/wake cycle

information), the thalamus (pain), the limbic system (emotion, fear, anger, smell), the medulla oblongata (blood pressure and heart rate), and the optic system, and it integrates these inputs for regulation of the functions listed.

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Limbic System

NEUROPHYSIOLOGY

Columns of fornix

Genu of corpus callosum

Head of caudate nucleus

Columns of fornix

Body of fornix

Thalamus

Uncus

Crura of fornix

Fimbria of hippocampus

Hippocampus

Commissure of fornix

Splenium of corpus callosum

Lateral ventricle

Body of fornix

Commissure of fornix

Crura of fornix

Mamillary bodies

 

Hippocampus

 

Amygdaloid bodies

with fimbria

©

FIGURE 2.18 HIPPOCAMPUS AND FORNIX

The limbic system includes the hypothalamus and a collection of interconnected structures in the telencephalon (cingulate, parahippocampal, and subcallosal gyri), as well as the amygdala and hip-

pocampal formation. The limbic system functions in linking emotion and motivation (amygdala), learning and memory (hippocampal formation), and sexual behavior (hypothalamus).

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NEUROPHYSIOLOGY

The Cerebral Cortex

Ms I

Motor Premotor; orientation; Ms II

eye and head movements

Prefrontal; inhibitory control of behavior; higher intelligence

Motor control of speech

Motor

Premotor

Prefrontal; inhibitory control of behavior; higher intelligence

Cingulate gyrus (emotional behavior) and cingulum

Olfactory

Ms I

Ms II

Sm I

Sm II Sensory

Sensory analysis

Visual III

Visual II

Visual I

Language; reading; speech

Auditory I

Auditory II

Sm I

Sm III Sensory

?

Visual III

Visual II

Visual I

©

Corpus callosum

Hippocampal commissure

Anterior commissure

FIGURE 2.19 CEREBRAL CORTEX: LOCALIZATION OF FUNCTION AND ASSOCIATION PATHWAYS

The cerebral cortex is organized into functional regions. In addition to specific areas devoted to sensory and motor functions, there are areas that integrate information from multiple sources. The cerebral cortex participates in advanced intellectual functions,

including aspects of memory storage and recall, language, higher cognitive functions, conscious perception, sensory integration, and planning/execution of complex motor activity. General cortical areas associated with these functions are illustrated.

70

Descending Motor Pathways

NEUROPHYSIOLOGY

Motor cortex

Internal capsule

Midbrain

Pons

Medulla

Medulla

Above midthoracic level

Spinal

cord Below midthoracic

level

Hip

Knee

Ankle

Toes

Trunk

Shoulder

Elbow

W rist Fingers Thumb Neck

Brow

Eyelid

Nares

Lips

Tongue

Larynx

Lateral aspect of cerebral cortex to show topographic projection of motor centers on precentral gyrus

Basis

Motor system

Fibers originate in motor cortex and

pedunculi

 

descend via posterior limb of internal

 

capsule to basis pedunculi of midbrain

 

Longitudinal bundles branch upon

 

entering basis pontis and rejoin to

Basis

enter pyramids of medulla

pontis

At lower medulla, bulk of fibers cross

 

 

median plane to form lateral

 

corticospinal tract; some fibers

 

continue downward in ipsilateral

 

lateral corticospinal tract; others

Pyramids

descending ipsilateral anterior

corticospinal tract

 

Synapse occurs at spinal level: Lateral

 

corticospinal fibers synapse on

 

ipsilateral anterior horn cells; anterior

 

corticospinal fibers synapse on

Decussation

contralateral anterior horn cells

 

of pyramids

 

Motor endplate

Anterior corticospinal tract

Lateral corticospinal tract

Motor

endplate

©

FIGURE 2.20 CORTICOSPINAL TRACTS

The corticospinal, or pyramidal, tract is the major motor tract that controls voluntary movement of the skeletal muscles, especially skilled movements of distal muscles of the limbs. All structures from the cerebral cortex to the anterior horn cells in the spinal

cord constitute the upper portion of the system (upper motor neuron). The anterior horn cells and their associated axons constitute the lower portion of the system (lower motor neuron).

71