CST 2015 / AMPK
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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AMPK Signaling
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Leptin |
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Brain |
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α-Adrenergic |
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Adiponectin |
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Glucose |
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Receptor |
Receptor |
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Glut4 |
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PLCβ |
Gαq |
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[Ca2+] |
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Glut4 |
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Translocation |
CaMKK |
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Glut4 |
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Glut4 |
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vesicle |
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Trafficking |
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Low Glucose,
Hypoxia, Ischemia,
Heat Shock
AICAR
Histamine Exercise
Thrombin
AMP + ADP |
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[cAMP] |
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ATP |
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PKA |
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STRAD |
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MO25α |
LKB1 |
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Insulin |
Other RTKs |
Receptor |
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Insulin |
Ras
PI3K
Raf
Erk Akt
Glycogen |
GS |
TBC1D1 |
Synthesis |
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Glycolysis |
PFKFB3 |
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A |
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c |
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HMG-CoA |
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u |
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Reductase |
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R Sterol/Isoprenoid |
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t |
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g |
Synthesis |
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Malonyl |
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CoA |
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CPT1 |
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Fatty |
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M |
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o |
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f |
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a Oxidation |
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HSL |
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b |
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m |
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ATGL |
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Lipolysis |
Tau |
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CLIP170 |
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Microtubules |
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ACC 
MYPT1 
MBS85
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Myosin |
C |
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Light |
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Chain2 |
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y |
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t |
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o |
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s |
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Actin |
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k |
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Dynamics |
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S |
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g |
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n |
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a |
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li |
CRY1 |
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ng |
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β γ
AMPKα
p300
HNF4α
HDAC4
HDAC5
HDAC7 Torc2
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p90RSK |
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TSC2 |
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a |
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TSC1 Rheb |
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y |
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g |
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h |
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Raptor |
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p |
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mTOR GβL |
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A |
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4E-BP1 |
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m |
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l |
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ULK1 |
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p70 |
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S6K |
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FIP200 ATG13 |
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Autophagy |
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e |
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SREBP-1 |
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r |
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P |
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SirT1 |
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Fatty Acid |
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Synthase |
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Lipogenesis |
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PGC1α |
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lism |
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CREB |
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FoxO |
Gluconeogenesis |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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© 2008 – 2014 Cell Signaling Technology, Inc.