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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5277_Библиотеки_им_академика_М_И_Перельмана.pdf
Bioactive Glass Materials for
Biological Applications
Bioactive Glass Materials for Biological Applications envelopes the complexities,
challenges, and advancement in developing a new class of bioactive materials for
versatile applications. It outlines the materials involved, bioactivity against bioin-
ert materials, phase change materials, biomolecular nature, synthetic biodegradable
polymers, and bioactive glasses. The processing techniques of the bioactive glasses
for versatile applications are also covered. A comprehensive focus is on the review of
additive manufacturing routes suitable for biological applications with the ability to
print various bioactive materials whilst carrying living cells.
Features:
• Introduces bioactive glass materials and their nature aimed towards biologi-
cal applications.
• Covers how biological materials behave in vivo and in vitro for tailoring
materials and sensitivity to the biological environment.
• Explores relevant additive manufacturing platforms.
• Reviews new chemistry and molecules for therapeutic and drug delivery
applications alongside bone tissue and regenerative medicine.
• Spotlights the future scope of bioactive glass nanoparticles, their limita-
tions, and research focus areas.
This book is aimed at graduate students and researchers in glasses and ceramics and
biomaterials.
Bioactive Glass Materials
for Biological Applications
Edited by Gujjala Raghavendra,
P. Syam Prasad and Dheeraj Kumar Gara
First edition published 2026
by CRC Press
2385 NW Executive Center Drive, Suite 320, Boca Raton FL 33431
and by CRC Press
4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN
CRC Press is an imprint of Taylor & Francis Group, LLC
© 2026 selection and editorial matter, Gujjala Raghavendra, P. Syam Prasad and Dheeraj Kumar
Gara; individual chapters, the contributors
Reasonable eorts have been made to publish reliable data and information, but the author and pub‑
lisher cannot assume responsibility for the validity of all materials or the consequences of their use.
e authors and publishers have attempted to trace the copyright holders of all material reproduced
in this publication and apologize to copyright holders if permission to publish in this form has not
been obtained. If any copyright material has not been acknowledged please write and let us know so
we may rectify in any future reprint.
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced,
transmitted, or utilized in any form by any electronic, mechanical, or other means, now known
or hereafter invented, including photocopying, microlming, and recording, or in any information
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For permission to photocopy or use material electronically from this work, access www.copyright.
com or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA
01923, 978‑750‑84 00. For works th at are not avail able on CCC please contac t mpkbooksperm issions@
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Trademark notice: Product or corporate names may be trademarks or registered trademarks and are
used only for identication and explanation without intent to infringe.
ISBN: 9781032689852 (hbk)
ISBN: 978104111606 6 (pbk)
ISBN: 97810 0366 0781 (ebk)
DOI: 10.1201/9781003660781
Typeset in Times
by codeMantra
v
Contents
Preface......................................................................................................................vii
About the Editors ...................................................................................................... ix
List of Contributors ................................................................................................... xi
Chapter 1 Introduction to Bioactive Materials: Metals to non-metals .................. 1
Dheeraj K. Gara, Raghavendra Gujjala, P. Syam Prasad,
Madaboosi. Srinivasan. Narayanan and Mutlu Özcan
Chapter 2 Bioactive Glasses for Biological Applications ....................................21
Ramu Inala, Raghavendra Gujjala, Shanmukha Raju,
Rakesh Kanakam, and Marcin Środa
Chapter 3 Role of Nanomaterials in Bioactive Glasses .......................................37
Manuela Reben, S. Indran, Somaiah Chowdary,
Shakuntala Ojha, and Nadeem Siddiqui
Chapter 4 Nature, Processing, and Characterization of Glass-Ceramics for
Biological Applications ...................................................................... 48
Ishika Singh Solanki, Dheeraj Kumar Gara,
V. N. Radha Manohar Aepuru, Aswani Kumar Bandaru, and
Akanksha Mohanty
Chapter 5 In Vivo and In Vitro Behaviours of Bioactive Glass Materials ......... 64
Che Azurahanim Binti Che Abdullah, H. Jeevan Rao,
Krina Goda, Kondaiah Gudimetla, Shakuntala Ojha
and Teegala Divya
Chapter 6 Mechanosensing Interactions of Bioactive Glasses...........................103
Y. B. Sudhir Sastry, Gebru Kiros Berhe, Riessom Weldegiorgis,
Satish Jain, K. G. Prashanth, and Parthiban Ramaswamy
vi Contents
Chapter 7 Recent Advances in Additive Manufacturing for Printing
Biological Tissues ������������������������������������������������������������������������������136
Vishnu Vijay Kumar, S. Shiva, R. G. Asuwin Prabu,
P. Navaneetha krishnan, Shrishail B. Sollappur,
M. Sharan Chandran and Muhammad Akhsin Muikhun
Chapter 8 Biodegradable Polymers‑Based Bioactive Glasses
Nanocomposite ����������������������������������������������������������������������������������153
Yugesh A. Kharche and Santosh R. Shekokar
Chapter 9 Bioinspired Synthesis‑Based Bioactive Glasses ��������������������������������166
Laxmikanth Cherupally, Dheeraj Kumar Gara,
Shakuntala Ojha, Satish Jain, Locherla Daloji,
and P. Phani Prasanthi
Chapter 10 Challenges for Industrial Compliance and Life Cycle Analysis
of Bioactive Glasses ��������������������������������������������������������������������������181
P. Venkateswara Rao, P. Abdul Azeem,
Shakuntala Ojha, Rakesh Kanakam,
P. Gopinath Chowdary and Tan Fırat Eyüboğlu
Index ���������������������������������������������������������������������������������������������������������������������� 215
vii
Preface
Drug delivery, regenerative medicine, and other niche areas such as bone tissue engi‑
neering have received signicant attention in the scientic community, and more
than ve decades of work have been dedicated to the global research. Despite being,
still there are challenges appraising these new areas due to the nature of the biologi‑
cal environment that makes them sophisticated to accept a new foreign material. To
realize this, materials scientists have come up with practical solutions that display
some possibilities towards meeting the golden standards of human environment. In
lieu of this, materials referred to as bioactive glass materials have been found to
be potential materials since they show up an intriguing characteristic of interacting
with the host environment and thus enabling the growth factors to perform various
growth‑induced activities in the physiological environment.
However, they are backed by a few complexities to use them in a more poten‑
tial way due to their nature and characteristics that are required to tailor or mimic
the bioactivity at various scales. This book envelopes the various complexities and
challenges, advancement in developing new class of bioactive materials for versatile
applications that developed over a phase of last ve decades, and a potential for
the future towards developing these materials. This book technically outlines the
materials involved with human environment and discussion on bioactivity against
bioinert materials, phase change materials, biomolecules nature and synthetic biode‑
gradable polymers, and bioactive glasses. The processing techniques of the bioactive
glasses for versatile applications will be covered, and novel approaches that can actu‑
ally allow integration of live cells for clinical in vivo will be discussed. This book
also discusses the recent post‑processing techniques such as additive manufacturing
routes.
A comprehensive focus on the review of additive manufacturing routes that are
suitable for biological applications will be put forth. At the same time, an emphasis
will be made on 3D and 4D bioprinting that has the ability to print various bioactive
materials whilst carrying living cells. Finally, a foresee on the outlook of the poten‑
tial for developing these materials will be included that give readers to understand,
identify, and investigate towards contribution to the development of bioactive glass
materials for regenerative, bone tissue, drug delivery, and orthodontic applications.
ix
About the Editors
Gujjala Raghavendra is currently working
as an Assistant Professor in the Department of
Mechanical Engineering at the National Institute
of Technology, Warangal, Telangana, India. He
obtained his M.Tech and Ph.D. degrees from NIT
Rourkela. His research interests include composite
materials, functionally graded materials (FGMs),
nanomaterials, and bioglasses. Under his supervi‑
sion, seven Ph.D. degrees have been awarded, and
twelve more are currently in progress. He has pub‑
lished over 130 articles in international and national
journals and conferences, along with more than
12 book chapters. He has also edited books in the
Lecture Notes in Mechanical Engineering series
(Springer) and with CRC Press. Dr. Raghavendra serves as a reviewer for several
national and international journals and currently manages three sponsored research
projects. He has taught courses on composites, tribology, and material characteriza‑
tion at both undergraduate and postgraduate levels.
P. Syam Prasad is working as a Professor in
the Department of Physics, National Institute of
Technology, Warangal, Telangana, INDIA. He has
received his MSc (Physics), MPhil (Glass Science),
and PhD (Material Sciences and Engineering),
respectively. He possesses more than 18 years of
combined teaching and research experience in
the eld of physical sciences and glass science, in
particular. His current research theme focuses on
the development and characterization of glasses
and glass ceramics for photonic, electronic, and
biomedical applications. He has published nearly
50 articles in various reputed international and
national journals and conferences. He has com‑
pleted six and two ongoing R&D projects sanctioned by the Government of India.
Currently, six PhD students are working under his supervision, and three students
have completed their PhDs under his guidance. He has reviewed many papers in
reputed research journals like Scientic Reports, Spectroscopy Letters, Physics B:
Condensed Matter Physics, the Journal of Alloys and Compounds, the Journal of
American Ceramic Society, the Journal of Molecular Liquids, Ceramic International,
Optical Materials, and Bioactive Materials. He has presented his research in the
USA, Portugal, Hungary, Egypt, Slovakia, Switzerland, Austria, and other countries
x About the Editors
in the world. His research interests include glasses and glass‑ceramics for electronic,
optical, and biomedical applications, nanostructured magnetic and semiconductor
materials, magnetic and semiconductor thin lms and devices.
Dheeraj Kumar Gara is an Assistant Professor
in the Department of Aerospace Engineering at
Jain University and PhD scholar in Mechanical
Engineering, National Institute of Technology,
Warangal. His areas of interest lie in composite
materials for aerospace and biomedical applica‑
tions, energy storage devices, bioactive materi‑
als, functionally graded materials, shape memory
alloys, and nanoparticles. He has published a decent
number of journals in aerospace and biomedical
domains and currently heads his lab on Biostimulus
Materials Laboratory at Jain University, Bengaluru,
India, dedicated for the development of 3D and 4D
bioprinting platforms for printing tissues.
xi
Contributors
Che Azurahanim Binti Che Abdullah
Faculty of Science, Department of
Physics
Universiti Putra Malaysia
Seri Kembangan, Malaysia
V.N. Radha Manohar Aepuru
Department of Mechanical Engineering
Advanced Materials Laboratory
Universidad de Chile
Santiago, Chile
P. Abdul Azeem
Department of Physics
NIT Warangal
Telangana, India
Aswani Kumar Bandaru
Department of Mechanical/Biomedical
Engineering
Munster Technological University
Cork, Ireland
Gebru Kiros Berhe
Professor, Department of Aerospace
Engineering
College of Engineering
Ethiopian Defence University
Bishoftu, Ethiopia
M. Sharan Chandran
School of Mechanical Engineering
Vellore Institute of Technology
Vellore, India
Laxmikanth Cherupally
Energy and Materials Research Lab,
Department of Physics
College of Natural and Mathematical
Sciences
The University of Dodoma, Tanzania
P. Gopinath Chowdary
Department of Mechanical Engineering
NIT Warangal
Telangana, India
Somaiah Chowdary
Department of Mechanical Engineering
IIT Guwahati, Guwahati
Assam, India
Locherla Daloji
Department of Mechanical Engineering
NIT Warangal
Telangana, India
Teegala Divya
Faculty of Science and Technology
(IcfaiTech), Department of
Mathematics
ICFAI Foundation for Higher Education
Hyderabad, Telangana, India
Tan Fırat Eyüboğlu
Faculty of Dentistry, Department of
Endodontics
Istanbul Medipol University
Istanbul, Türkiye
Dheeraj Kumar Gara
Department of Aerospace Engineering
Jain University
Bangalore, Karnataka, India
Department of Mechanical Engineering
NITWarangal
Telangana, India
Krina Goda
Scholar, Department of Aerospace
Engineering
Jain University
Bangalore, Karnataka, India