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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5991_Библиотеки_им_академика_М_И_Перельмана
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64
Metals in Medicine, Volume 1
2
, MgO, CeO
2
, Al
2
O
3
causes concurrent structural disturbances.
12
in vitro biosensing applications.
14
p-
13
As a
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65
-
15
porous materials
16
2
have been studied a lot as potential drug delivery systems because they break
17
MNPs
-
and others. Moreover, due to their promising qualities and potential uses
metallic nanoparticle carriers are biocompatible and stable, these inorganic
interactions, pH responsiveness, photothermal responses, and antibacte-
rial properties.
18,19
n
derivatives.
20
-
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Metals in Medicine, Volume 1
2+
-DOX and electrostatic interac-
-
21
22,23
24
Alendronate (Ald), indocyanine green (ICG),
dexamethasone,
25
risedronate,
26
the small-molecule medications that have been seen.
27
Zn-based MOFs have
the potential to transport both medicines and genes concurrently. In addition
RNAs such as micro-RNAs (miRNAs)
28
regeneration.
29
-
30
-
loaded by ZnO-based nanodelivery.
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67
MIL-100(Fe), MIL-88B(Fe), MIL-88A(Fe), MIL-53(Fe), and MIL-101(Fe)
antibacterial, bioimaging, biosensing, and drug delivery
31
due to their active
metabotropic properties, such as Ald.
32
Fe MOFs can thus be employed
regeneration.
-
docetaxel, DOX, lauric acid, mitoxantrone, 10-hydroxycamptothecin, arte-
-
33
34
Uio-66
35
Zr-based MOFs are made, including MOF-525, MOF-545, and NU-902.
36
37
medications or active components can be delivered via Zr MOFs to treat
various bone disorders. Additionally, PCN-222 may be used to transport a
36,37
Additionally, it has been
phosphate-guanosine (immunostimulatory oligonucleotides).
38
physical, and optical capabilities
39,40
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Metals in Medicine, Volume 1
2+
could trap electrons,
2+
dd transition.
Staphylococcus
aureusEscherichia coli
-
41
2+
+
redox potential than the conventional Fe
2+
2+
+
ion pair
to conventional iron-based kinetic reagents.
molecule medications into nanodrug delivery systems, including DOX,
42
chlorhexidine.
43
As a result, nano-Cu MOFs have lately attracted the greatest
44
but has the capability to load small molecules, includes aspirin,
45
and DOX
46
2
2
2
nano-
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69
2
nanomaterials,
medications, including curcumin, dexamethasone, valproic acid, gambogic
active proteins such as human recombinant BMP-2.
47
-
cochemical characteristics relative to the bulk material, such as electrical,
thermal, optical, and catalytic capabilities. AgNPs are employed in many
apoptosis and necrosis.
48
oxygen species (ROS), an increase in lactate dehydrogenase leakage, and
49
mitochondrial respiratory chain. According to certain studies, AgNPs cause
a cytotoxic impact on leukemic cells.
50
-
51
MCF-7 breast cancer
-2
,
-
tions to cancer cells.
52,53
is highly supported by this research.
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Metals in Medicine, Volume 1
S. aureus has been demonstrated to be diminished by the extracellular
silver ions in Ag NPs, indicating that these particles have antibacterial
potential against Gram-positive and Gram-negative bacteria.
54
-
E. coli
55
subsequent application in material development, synthetic chemistry, drug
delivery, and other domains.
56
Dox has been joined to a polymer molecule
57
58
-
rial capability, physicochemical properties, and osseointegration capacity,
peptides, pDNA, and siRNA.
59
Ginsenoside Rg3,
60
and gemcitabine have all
61
-
62,63
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71
Ca, and Mg MOFs are needed.
MNPs ARE USED TO TREAT BONE DISEASES
-
Additionally, ZIF-8 can deliver bisphosphonates (BP) to prevent osteoclast
behavior.
26
64
2
nanotubes. Notably , MNPs
-
65
Additionally , the
alkaline phosphate, osteocalcin, and extended bone remodeling. For instance,
66
remodeling. Similar to this, the nano-ZnO particles directly support bone
cause these Zn-based nanomaterials to have an osteogenic impact.
67
NPs
repair in addition to direct osteogenesis,
68
69
concluded that
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Metals in Medicine, Volume 1
Enhanced bone regeneration by metal-based nanoparticles.
70
71
Commonly used
72
Drugs
administered systemically.
73
researchers
74
iron oxide NPs and dramatically increased tumor tissue death in mice using
75
to
-
doped into Au core mesoporous silica NPs, according to a publication.
76
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2
2
77
2
by
2
by Zou et al.
78
employing ZIF-8-capped Cu
2
microenvironment, Cu
2
into Cu
+
and Cu
2+
2
-XSe
-
79
45
or antibiotic-encapsulated MNPs can be applied topically to improve osteo-
cadherin antibodies can target the osteoblast and inhibit the S. aureus-based
80
S. aureus
81
Also, compared to traditional antibiotics, MNPs can get around the
-
rial strains, researchers
82
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