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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5991_Библиотеки_им_академика_М_И_Перельмана
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Metals in Medicine, Volume 1
electrical, physical, mechanical, and optical capabilities.
91,92
Additionally,
93
PdNp-
94
Nie
in 2014.
95
steadily rising. PtNPs and PdNPs-based materials are reported to have good
therapeutic applications, such as anti-tumor, antioxidant, and antibacterial
agents. Also, their unique photothermal properties can be employed in the
studies to diagnose and treat various malignancies. Furthermore, PtNPs
drug exposure to nontarget sites, making PtNPs and PdNPs ideal drug-
delivery agents. Additionally, cisplatin drug-loaded PtNPs and PdNPs had
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resistance.
96
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human health.
PtNPs have a more potent cytotoxic impact and may be employed in cancer
therapy.
97
-
antibodies, biocompatible polymers, peptides, and other biomolecules can
-
98
Due to
other metals employed in therapy, PdNPs have superior photostability and
as a potential cancer treatment.
99
100
PdNPs are a viable
-
101
Photo-
in photothermal therapy.
102
research.
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Metals in Medicine, Volume 1
In recent years, engineered NPs attracting interest as a potential therapeutic
-
transport, less toxicity.
103,104
Nonetheless, as a nanoscale delivery vehicle,
105
Currently, gold, silver, and iron nanostructures are currently the subject
advanced them into clinical application.
106
outstanding photocatalytic activity, electrical properties, and optical quali-
ties.
107
107,108
-
109,110
PtNPs
cis
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that inhibits DNA transcription and repli-
have very much similar mechanisms to cisplatin.
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2020 to create a PtNPs-based drug-delivery system (PtNPs–DOX) that
113
co-glycolic acid) (PLGA) encapsulated PtNP drug-delivery system to
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at the target site.
114
Several PtNP-based drug-delivery systems have
PtNP-based clinical chemotherapy practices to deliver important drugs
115
-
ment across the board. Due to their excellent thermal tolerance, PdNPs
human cervical cancer cells (HeLa).
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Another study also reported a higher
permeation and retention rate in the breast cancer microenvironment and
PdNP-based drug-delivery systems have gained attention among scientists
due to their stability and lesser toxicity .
117
In a recent study , it has been proved
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Metals in Medicine, Volume 1
physical and chemical changes occurring in the human body due to various
119
energy sources, including thermal, electrical, magnetic, radiant, and chemical
energy.
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-
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time, linear range, distortion, minimum detectable signal, and reproducibility
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biosensor research. PtNPs and PdNPs are the noble metals recently coming
material to detect various chemical and physical changes due to their excel-
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trying to develop methodologies that can incorporate PtNPs and PdNPs into
as glucose, glutamic acid, and hormones. Similarly , PdNPs are being used as
-
chemical DNA biosensing, etc.
123–125
PtNPs and PtNPs both exhibit several
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success.
123
2
O
2
that can be used to create the best possible sensors. In 2012, Qiu, JianDing,
material to create biosensors and electrochemical sensors.
126
Similar to this,
polysilicon microheaters using PtNP catalyst loaded in a graphene aerogel
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antimicrobials.
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serious oxidative damage to cells.
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Staphylococcus aureus
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Hashimoto et al. in 2017.
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PdNPs have very similar properties to PtNPs.
Similar to this, Adams et al. (2014) discovered that at concentrations as
Gram-positive S. aureus than against Gram-negative E. coli.
132
pathogens, including Salmonella, Staphylococcus, E. coli, and Listeria up to
-
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Metals in Medicine, Volume 1
-
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tions. Rajendran S. et al. demonstrated in 2020 that synthetic AuNPs and
E.
coli, Klebsiella pneumonia
133,134
Lopes et al. proved that
Pt-bound polysaccharides such as porphyrins NPs are highly potent agents
thus can inhibit multi-drug resistant bacteria, namely , S. aureus.
135
Similarly ,
-
E. coli
Bacillus
substilis and Pseudomonas aeruginosa.
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against Aspergillum avus and Candida albicans, respectively.
137
As a result, researchers
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against Pseudomonas syringaea Fusarium
graminearum
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antimicrobial therapy to overcome multidrug resistance to conventional
therapy. One such recent method is photothermal therapy that generates
host cells. In this method, bacteria are killed by converting NIR light to heat
using a photothermal transducer. Recently, Pd nanostructures have become a
S.
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aureus and E. coli
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microorganisms.
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apeutic purposes.
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In modern era, metals have been used to make implants
According to “Medical Equipment
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metals, and polymers.
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strength, high ductility, high density, toughness, durability, high resis-
tance to corrosion, and biocompatibility. At present, metals make up
tools and devices such as surgical equipment, orthopedic devices,
dentistry supplies, cardiovascular devices, diabetes care devices, etc.
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Metals in Medicine, Volume 1
a bad impact on human health.
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biomedical applications. Also, the mechanical characteristics and ductility
medical treatments including stenting, angioplasty, and balloon angioplasty
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145
s AND PDNPs
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a substance that is extremely toxic, such as snake venom, has a minimum
-
etc.
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Importantly, toxicity testing helps to determine no observed adverse
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Source
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