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Metals in Medicine, Volume 1: Metals for Tissue Engineering and Pharmaceutical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
and
Shobhaben Pratapbhai Patel School of Pharmacy & Technology
Management, SVKM’s NMIMS, Vile Parle, Mumbai, Maharashtra, India
CHAPTER 8
ABSTRACT
drug-delivery systems (DDSs) to carry out a requested therapeutic response.
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responsive smart MOFs and their applications are suggested.
disease condition.
1
current problems in nanomedicine.
2
Nanomaterials, such as biochemicals,
10
m
3
4
delivery, such as biomaterials, medical imaging, diagnostics, and therapy.
5
diseases, majorly in cancer.
6,7
Overall, many nanomedicine preparations are
currently in clinical trials, covering major diseases, such as neurological,
8,9
Nanomedi-
conditions, chronic pain, multiple sclerosis, asthma, and emphysema.
10
11,12
s
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and metal atoms attached to them via coordinate bonds. Due to its adjust-
13–15
delivery and have gained prominence in recent years. When MOF materials
diagnostic imaging, chemotherapy , photothermal or photodynamic therapy .
16
Liposomes, micelles, dendrimers, microbubbles, and solid lipid nanopar-
ticles have been explored as nanoparticle-based drug-delivery methods.
17
Applications in Drug Delivery
-
18
drug release.
19,20
-
uronic acid, and antibodies), and delivery due to the increased permeability
and retention phenomena (e.g., temperature, pH, photoirradiation, and
endocytosis, and sometimes independent endocytosis.
21,22
-
23
the loaded drug molecules, subsequently reducing its therapeutic outcome.
24
On the contrary, endocytosis mediated by caveolin results in the develop-
25
Nanoparticles that have
26
is premature drug release. Recent studies have demonstrated that several
could be used to address this issue.
27,28
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examples.
30,31
-
supercapacitors.
32,33
-
ucts such as doxorubicin, topotecan, and camptothecin have been integrated
into MOFs.
19,34
20
For photodynamic treatment, MOFs
biological operations.
35
36
in these contexts.
37
38
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some action or external input.
39, 40
drug-delivery types (Fig. 8.1)
41,42
:
1. Physical stimuli such as thermal, ultrasound, osmotic pressure
2. Chemical stimuli such as pH changes, ionic capacity, and presence
macromolecules.
Drug-delivery types.
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It is possible to apply stimuli-responsive drug-delivery techniques by using an
properties under particular external physical stimuli applied to the tumor.
43–45
21st century , the current cancer treatment used in clinics has both severe side
46
cancer therapy approaches.
47
Particularly , various DDSs activated by stimuli
48
Internally Regulated systems
the delivery system is brought on by a change in the biocomposition at the
altered externally.
49
Enzyme Responsive Systems
metalloproteinases (MMPs), urokinase plasminogen activators (uPAs), and
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50
evidence that they are overexpressed in many malignancies. In line to induce
peptide.
51
stimulated vectors.
52
peptide CGLDD.
53
-
54
Since
in line to initiate the delivery.
52
the protease-cleavable peptide CGLDD.
53
Externally Regulated system
be accurately regulated.
55
Here it is discussed that existing research carried
stimuli-responsive DDS is nontoxic to cells, escaping the disadvantage drug
56,57
In contrast
to the conventional DDS, smart stimuli-responsive DDS can be developed
thanks to nanomaterial chemistry.
Stimuli-responsive DDS guarantees on-demand medication delivery to the
intended target cancer cells in either a spatial or temporal manner. Inorganic
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