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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5471_Библиотеки_им_академика_М_И_Перельмана
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134
Metals in Medicine, Volume 1
corresponding MOFs.
75,76
acids.
77,78
-
sition in order to accurately diagnose the diseased condition in a patient.
an electrochemical, electrical, optical, gravimetric, or acoustic signal (via
77
-
Finally, the display unit includes a user interpretation system that presents
77
ability to detect not only the intracellular molecules but also intracellular pH.
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Metal–Organic Framework in Bioimaging and Biosensing Application
135
-
77
2. small biomolecules such as the highly-reactive oxygen species,
3. the pH in and around a cell and its organelles.
-
late gene expression by cleaving or repressing mRNA. While some diseased
their complementary segments in the endogenous DNA or miRNA. Conju-
target recognition, and good biocompatibility including but not limited to
cell permeability and photostability.
79
Fluorophore-labeled DNA probes
Source
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136
Metals in Medicine, Volume 1
80
oxygen releasing reactions (ORR) has been extensively carried out using
platinum and carbon metals. Mao et al. developed a strategy to replace
-
81
Chen et al. developed three-
electronic devices.
82
biosensors.
80
-
-
-
47
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Metal–Organic Framework in Bioimaging and Biosensing Application
137
Source
47
-
3
3
+ core-shell increased the
83
-
2
2
S is a poisonous gas that is
-
2
S, the third
83,84
2
S in cancer patients correctly
85
2
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138
Metals in Medicine, Volume 1
2
S made gas chromatography,
2
2
S is
2
S
sensing inaccurate and unreliable.
86
2
S
87
Cu
2+
ions are used as central metal ligands, that H
2
S can bind to in
NO donors. UiO-66-N
3
, on the other hand, is used to monitor the mediation
2
-
trin) also used to detect intracellular H
2
S.
Since, proteins are sensitive to pH and must maintain their structural integrity
-
88
sense O
2
in living cells. O
2
-
sion tomography, immunohistological staining or O
2
needle electrodes
88
O
2
2
insensitive probe and an O
2
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Metal–Organic Framework in Bioimaging and Biosensing Application
139
2
concentrations in a cell.
O
2
and provide the most stable O
2
88
body among many others.
95
resonance spectroscopy.
Magnetic resonance imaging (MRI) is a commonly used diagnostic procedure
96,97
98,99
-
tional metal ions, such as Gd3+ or Mn
2+
100
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TABLE 6.2 MOFs Application in Bioimaging.
140
Ligand structures Ligand Metal MOF formula Preparation MOF particle Imaging References
abbreviation approach size applications
C
4
Mn
2+
6
H
10
O
6
H
8
O
4
) (H
2
Ultrasonic
(MnDMS)
BDC Zr
4+
6
O
4
(OH)
4
Solvothermal 125 nm RNA
(UiO-66) method
1.5
(H
2
O)
2
Reverse 155 ± 30 nm
Microemulsion
Process
NH2-BDC
4
O (H
2
-BDC)
3
250 nm MRI
IRMOF
-3
H
2
L Solvothermal 50–200 nm
method
Zr+4 Zr- UiO Solvothermal 50–200 nm
method
Metals in Medicine, Volume 1
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Metal–Organic Framework in Bioimaging and Biosensing Application
141
°
-
body.
81
-
X-ray attenuation than healthy cells and thus guarantee accurate and sensi-
100,101
ability to enhance the longitudinal relaxation rate and their ability to emit red
-
mice as models.
97
Mn
2+
-based nanoparticles have also been used more
enhancement.
102
2+
becomes imperative.
103
3
O
4
nanopar-
3
O
4
on the Fe
3
O
4
-
ibility and degradability.
102
Fe
3
O
4
@IRMOF-3,
104,105
Fe
3
O
4
@ZIF8 and Fe
3
O
4
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142
Metals in Medicine, Volume 1
high-contrast MRI. Fortunately, the Fe
3
O
4
to improve its applications.
106
-
GdMOF-PAA-Au hybrid system to enhance contrast in scans obtained on
100
107–109
(a) phosphate-terminal DNA aptamer to a Zr–MOF nanoparticle quencher can
Source
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Metal–Organic Framework in Bioimaging and Biosensing Application
143
nanoparticle quencher that not only provides target-based bioimaging but
-
methylrhodamine) dyes and provides target-based imaging (Fig. 6.7c and d).
-
and other everyday settings. MOFs have also been used as transducers to
-
-
•
• biosensing
• bioimaging
• aptamer
• nanocomposite
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