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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5471_Библиотеки_им_академика_М_И_Перельмана
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104
Metals in Medicine, Volume 1
dependent.
17–19
out.
20–23
-
NH
3
, H
2
S, NO
2
, and so on.
20–23
Ship” (BAS).
24
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105
-
-
25
Although SIB techniques are
26
-
the cages. Precursors to those composing elements are typically injected
25
Despite the
26
their study
(POM) and soluble salts onto these materials.
27,28
oxidation state. Metal oxide MOFs, such as Cu
2
O, have been prepared using
this technique.
29
30
A controlled encapsulation technique involving
31
Post-synthesis techniques can be used to carry out the composing process
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106
Metals in Medicine, Volume 1
and modulating agents, the macroscopic order can be tailored by controlled
synthesis.
13,15
6
at high pressures or above the boiling point.
requiring numerous techniques.
32
solvothermal synthesis is typically done at high temperatures or above
is typically conducted under circumstances that encourage nucleation. For
medication distribution uses, unconventional synthesis techniques, such as
33,34
Numerous
-
tion” process.
Synthesis techniques have been created in aqueous circumstances and
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107
uses.
35–39
have been researched.
40,41
42
42
2
cm
3
42
Molecular simulation
3
revealed by molecular modeling.
42
43
result in chemically variable porous designs that have attracted extensive
research. Recently, catalytic uses based on their chemical tunability have
thermal expansion have increased interest in the area.
44,45
-
-
amorphous MOF reported structures amounting to under 30).
46
While there
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108
Metals in Medicine, Volume 1
47
-
-
48,49
50 years and include amorphous silicon and germanium.
50,51
ZIF-4 (Zn(C
3
H
3
N
2
)
2
-
-
silica.
52
-
to create amorphous ZIF-4 atomistic models, or mechanistic understanding
51,53
diameter (dynamic light scattering, nanoparticle tracking analysis), MOF
-
microscopy) etc.
54
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109
-
55
55
3
2
·12H
2
-
55
55
temperature in addition to solvent–reagent ratio, reaction kinetics, equilib-
54
to prepare stable, monodispersed, and homogenous nanoparticles. It is
synthesis technique used. Controlling composition and process conditions,
adding additives, using nanoscale templates, and shrinking the particles via
this goal.
55
2
uptake capability drasti-
2
2
escaped the amine due to the greater sorption temperature. Furthermore,
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110
Metals in Medicine, Volume 1
CO
2
2
capture
CO
2
supported-amine system to capture CO
2
56
s
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111
57–59
bioim-
aging,
60
2
S, the EAUC (Eu
3+
+
@UiO-66- (COOH)
2
+
and H
2
S and output as the inten-
2
S detection in both PC12 cells and diluted blood samples,
57
Nucleic acid sensing because DNA
H
2
58
Research that intracellular
59
5
Posi-
61
ascorbic acid colorimetric sensing.
62
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112
Metals in Medicine, Volume 1
drug delivery , bioimaging or diagnostic agents, and therapeutic agents. Lipo-
include a high drug load, control over matrix degradation and drug release,
noncovalent encapsulation into the MOF via physisorption, post-synthetic
medications as catalysts.
60
TABLE 5.2
MOF Organic linker Metal node Therapeutic agent
MIL-53 (Fe) FeCl
3
.6H
2
O
MIL-100 (Fe)
acid
Fe
3
O (trimer) Doxorubicin
Mi-UiO-68 Maleimide-attached H
2
L ligand ZrCl
4
Doxorubicin
Folic acid
ZIF-8 Zn(NO
3
)
2
.6H
2
O 5-Flurouracil
UiO-66-NH
2
Amino terephthalic acid Zr
6
O
8
cluster 5-Flurouracil
MIL-88A (Fe) Fumaric acid FeCl
3
.6H
2
O
-
carriers. It has been suggested that both organic and inorganic nanocarriers
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113
equivalents and has become the ideal drug delivery system. Formerly , MOFs
3–5
-
applications, MOFs have several other biomedical uses, such as targeted
drug delivery, molecular imaging, and biological sensing, and have also
conventional nanometric carrier systems such as quantum dots, liposomes,
complications, and toxicity.
3–5
bigger cargos, such as cells and vaccines, have been investigated. In biolog-
thermal alterations have also been used. Mechanical grinding and ball
retention, or biocompatibility.
3–5
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