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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5705_Библиотеки_им_академика_М_И_Перельмана.pdf
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
brain barrier permeability as investigated by in vitro permeability assay in
bEnd.3 cells (Pradhan et al., 2019).
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al. prepared doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles
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cells. In addition, the hybrid nanocarriers revealed good stability , biocompat-
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to entrap high drug amounts and sustain their release. When compared to
untreated control cells, both andrographolide and andrographolide nanopar-
In the recognition test, neither treated nor untreated animals demonstrated
Natural Biocarriers for Brain Targeting
119
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pholide nanoparticles have exceptional versatility , nontoxicity, nonimmuno-
genicity, high biodegradability, and astounding drug-loading capacity (Bilia
et al., 2019).
In another study, Gregory et al. designed a human serum albumin-based
mammals. Its main role is to support connective tissues such as the bones,
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treat several conditions, including cerebral ischemia and neurodegenerative
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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nanoparticles, even in small doses (Rathore et al., 2020b).
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tion restrict its medical use. Glutathione-coated collagen nanoparticles,
termed nanoresveratrol, had been developed to improve resveratrol delivery
cognitive impairment test and biochemical and histopathological investiga-
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curcumin–collagen nanocomposites (Rathore et al., 2020a).
Natural Biocarriers for Brain Targeting
121
a good antioxidant property as studied using the DPPH radical scavenging
an acetylcholinesterase inhibitor (Bashir et al., 2022). A more recent study
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acetylcholinesterase, malondialdehyde, superoxide dismutase, and catalase
(Bashir et al., 2023).
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mine the gelatin type (Ucar, 2021). Depending on the preparation method,
et al., 2017). Gelatin provides several advantages as a drug carrier, including
biomedical and pharmaceutical applications (Shamarekh et al., 2020).
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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tive reliability as a magnetic resonance imaging contrast agent. Gadolinium-
tumors (Kimura et al., 2021).
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presented paclitaxel encapsulated in dual stimuli-responsive in situ hydro-
Joachim et al. developed 17-estradiol-loaded gelatin nanoparticles to be
Natural Biocarriers for Brain Targeting
123
delivered intranasally to the brain to enhance neuroprotection and decrease
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ticles resulted in 5-times increase in E2 brain concentration and 2.5-times
is a hydrophobic protein secreted by some insects, such as spiders and silk-
by being biocompatible, biodegradable, nontoxic, and nonimmunogenic
prepared matrix in the rodent brain revealed good biocompatibility and toler-
to prolong the circulation time and enhance the blood–brain barrier trans-
99m
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
et al., 2020b).
loaded nanoparticles demonstrated spherical, negatively charged particles
investigated carrier (Xu et al., 2018).
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2022b).
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125
Aiming to overcome this obstacle, Moreno et al. encapsulated quercetin into
in vivo
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distinguished by their ability to highly penetrate the cell membrane like
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cellular uptake by BCEC and C6 cell lines than casein-based nanoparticles.
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
nanoparticles to penetrate in vitro
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on serum iron concentration and serum pituitary hormones. In addition,
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4.2.3 EXOSOMES
Exosomes, or extracellular nanovesicles, are biological cell-derived lipid
astrocytes, neuronal, oligodendrocytes, microglia, and endothelial-derived
more stable than their parent cells and can cross the blood–brain barrier.
exosomes in addition to the exosomes content particularly microRNAs that
have a vital role in gene regulation (Xiong et al., 2017).
Natural Biocarriers for Brain Targeting
127
TABLE 4.3
Protein
type
Disease Drug Special comment References
Albumin
endocytosis-mediated and CD44 receptor targeting.
2021)
Glioblastoma Doxorubicin Doxorubicin-loaded poly(lactic-co-glycolic acid)nanoparticles
2019)
siRNA
(iRGD).
(Gregory et al., 2020)
Stroke Citicoline
(Pradhan et al., 2019)
Albumin nanoparticles encapsulating iron oxide nanoparticles
disease
Andrographolide
(Bilia et al., 2019)
Curcumin
circulation time.
(Gao et al., 2020)
Rh-erythropoietin (Xue et al., 2020)
Epilepsy Levetiracetam (Wilson et al., 2020)
Collagen Cerebral ischemia Silymarin
biochemical, histopathological, and immunohistochemical
(Rathore et al., 2020b)
Curcumin
(Rathore et al., 2020a)
Epilepsy Resveratrol Glutathione-coated collagen nanoparticles. (Siddiqui et al., 2022)