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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5705_Библиотеки_им_академика_М_И_Перельмана.pdf
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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linking (Koosha et al., 2021).
3.3.3 COAXIAL ELECTROSPINNING
An initial burst release may be occurred in simple blending and emulsion
overcome this burst release, postprocessing treatments such as cross-linking
as reduced biocompatibility (Han et al., 2020). Coaxial electrospinning is
in vitro drug release
period (Gong et al., 2019).
3.3.4 SURFACE MODIFICATIONS
Electrospun Technology for Drug Delivery and Biomedical Applications
79
-
-
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through chemical bonding can decrease the initial burst release and maintain
3.4 ELECTROSPUN NANOFIBERS FOR TISSUE ENGINEERING
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be electrospun that can be reabsorbed by the human body. Altogether, these
3.4.1 ELECTROSPUN NANOFIBERS FOR HARD TISSUE ENGINEERING
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
al., 2021). Natural bone has unique mechanical qualities due to its unique
-
-
pore patterns and striving to emulate the three-dimensional (3D) electrospin-
-
-
Electrospun Technology for Drug Delivery and Biomedical Applications
81
et al., 2007). For instance, numerous scientists have developed electrospun
-
techniques such as electrospraying and coaxial electrospinning (Xie et al.,
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structures (Chahal et al., 2019).
3.4.2 ELECTROSPUN NANOFIBROUS SCAFFOLDS FOR SOFT TISSUE
HEALING
tooth, and cartilage. Hence, skin, musculoskeletal, adipose, cardiovascular,
vasculature, neural, lung, liver, kidney, gastrointestinal, and ocular tissues
main problem is that they can be easily absorbed and rapidly lost in the
al., 2014). In addition, donor-site allogeneic response and morbidity limit
approach, tissue engineering has been employed to develop potent substi-
angiogenesis, avoiding scarring, and consequently restoring the pristine
changing the electrospinning parameters and the collection process, various
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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provide topographical cues and tropism by modulating the gradient structure
nerves and central nerves), heart, blood vessels, gastrointestinal, and cornea
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3.5 CANCER DIAGNOSIS AND THERAPY
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Electrospun Technology for Drug Delivery and Biomedical Applications
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TABLE 3.1
Composition Tissues Cell type Outcomes Ref
Hard tissue engineering
Bone BMSCs (Liu et al., 2022)
PVP, ethylcellulose, Au NPs Bone hBMSCs
osteogenic genes and promoted bone regeneration.
(Huang et al., 2021)
Bone hASCs Improved cell adhesion and osteogenic gene expression. (Ahmad et al.,
2018)
inductive peptide H1
Bone hiPS-MSCs
(Xu et al., 2019)
sodium alginate
Periosteum
osteoblast cells
Facilitated osteoblast attachment and upregulated the early expression
Dentin hDPCs
(Anselmi et al.,
2022)
Nano-hydroxyapatite into
PCL
Dentin hDPCs (Mendes Soares et
al., 2022)
Soft tissue engineering
Cartilage hASCs
PLA into lignin Cartilage BMSCs
(Liang et al., 2022)
bone
MSC
2017)
oxide nanoparticles and CPP
tendon
Human tenocytes Improved the tendon ECM restoration and prevented bacterial
adhesion.
(Bianchi et al.,
2023)
GO-PLGA
tendon
BMSC
generation, and improved collagen arrangement and biomechanical
properties.
(Su et al., 2019)
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
Composition Tissues Cell type Outcomes Ref
GelMA Skin Human dermal
HUVECs
-
(Sun et al., 2017)
polystyrene and poly (4-VP)
Skin (Venault et al.,
2020)
Skin RBC and L929
collagen deposition, and angiogenesis.
(He et al., 2020)
Skin hMSCs
(Ahmad et al.,
2018)
Nerve PC12 cells and DRG
cells
Induced neurite alignment and extension. (Wang et al., 2019)
Neurite PC12 cells
visible-light stimulation.
Neurite Neural progenitor cell
(Chen et al., 2019)
Neurite
cells
Induced pro-angiogenic characteristics. Promoted morphological and
(Qian et al., 2018)
Keratin associated PCL Vascular -
plastin time.
(Li et al., 2016)
Vascular HUVECs Supported endothelial cell viability and adhesion.
Cardiac
deteriorated ventricular remodeling restrained by nanopatch.
(Chen et al., 2018)
TABLE 3.1 (Continued)
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Composition Tissues Cell type Outcomes Ref
Cardiac Rat cardiac cells
muscle.
(Fleischer et al.,
2017)
Liver Primary human
hepatocytes
Enhanced primary human hepatocyte synthetic activity.
PES
Liver Human endometrial
stem cells
2017)
Kidney
human conditionally
-
(Jansen et al., 2019)
Esophagus Primary human
ultimate tensile strength as the native esophagus.
(Wu et al., 2018)
Polyurethane Esophagus hAMSCs (Park et al., 2021)
PLGA Skeletal
muscle
Murine myoblast cells
(C2C12)
(Narayanan et al.,
2020)
Skeletal
muscle
Rat muscle precursor
cells
(Patel et al., 2020)
Abbreviations
-
TABLE 3.1
(Continued)
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
FIGURE 3.3
Source
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Electrospun Technology for Drug Delivery and Biomedical Applications
87
an implant into the postoperative tumor cavity, to prevent tumor recur-
Cavo et al., 2020). It has also been mentioned that these matrices have
demonstrated promising potential as transdermal drug delivery systems to
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responsive behavior enhance the drug delivery capability in the response
cancers malignant tumors. Based on this, biosensors are regarded to have a
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as a proper substrate to capture and detect cancer biomarkers and circulating