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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5447_Библиотеки_им_академика_М_И_Перельмана
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297
Supporting area, 198
Surface active agents, 71, 76, 183
amphoteric surfactants, 73, 74
anionic surfactants, 72, 73
cationic surfactants, 73
nonionic surfactants, 74, 75
Surfactant(s), 69, 81, 87, 126, 183, 184
Suspending agent(s), 81
Suspensions
advantages, 82
disadvantages, 82
dispersed particles, 82–84
formulation (see Formulation of suspensions)
manufacturing, 89–90
properties, 82
stability, 91–93
Sustained-release DDS
advantages, 219
biological factor affecting design
strategy, 220
absorption property of drugs, 221
half-life of drug, 220, 221
metabolism of drug, 221
components, 223
conventional peroral dosage forms, 218
formulation, 223
hydrophilic polymeric matrix, 223, 224
IES, 225, 226
insoluble polymeric matrix, 224
limitations, 220
monolithic/matrix systems, 223
osmotic pump systems, 225
physicochemical factor affecting design
strategy, 220
dose size, 221
ionization, 222
partition coefcient, 222
solubility and permeability, 222
reservoir drug delivery systems, 224, 225
types, 223
Synthetic biodegradable polymers, 254–256
biocompatible synthetic polymers, 254
cross-linked polyesters, 256
polyanhydrides, 256
polyesters
PCL, 256
PGA, 255
PLA, 255
PLGA, 255
Syrup (smoothing/color) coating, 110
T
Tablet coating
defects, 114, 115
equipment
conventional coating pan, 112
uidized bed coaters, 114
perforated drum coater, 112, 114
lm coating, 110–112
friability, 106
gold and silver, 106
hot air, 106
polymer, 106
purposes, 106, 109
in rotating pan, 106
sugar coating, 109, 110
Tablet compression process
compaction, 102, 103
consolidation, 103–105
direct compression, 99
dry granulation, 101, 102
rotary tablet press, 105, 106
wet granulation, 99–101
Tablet formulation
excipients and role, 96, 98–99
Tablet press, 104
Tablets
advantages, 96
compression process (see Tablet
compression process)
defects, 105, 107–109
dosage form, 95
limitations, 96
physical and chemical attributes, 96
types, 96, 97
Takeoff blade, 105
Tamping device, 118, 119
Temperature, 75, 193
Terminally sterilized products, 198, 199
Tertiary packaging, 57
Testosterone, 186
The immersion sword system, 112
Thermally induced phase separation
(TIPS), 257
Thermoplastics, 60
Thermosensitive gelation, 191
Thermosets, 60
Through Skin Appendages, 155
Tin, 58
Topical ophthalmic products
classes
eye drops, 190
gel formation, 190, 191
solutions, 190
Topical ophthalmic products (cont.)
formulations considerations, 189, 190
ocular insert, 191, 192
reconstitution powders, 191
suspensions, 191
Index
https://t.me/medicina_free
298
Topically applied products, 154
Toxic mechanism, 131
TPX asymmetric membrane, 168
Transappendageal route, 155
Transcellular pathway, 155
Transdermal drug delivery (TDD)
denition, 165
skin patches (see Transdermal patches)
systemic circulation, 153
systemic effect, 165
Transdermal medications, 152
Transdermal microneedles
easy penetration, 171
insoluble metal alloys, 171
manufacturing methods, 172
measurements, 171
types
coated, 172
dissolving, 172
hollow, 172
solid, 171
Transdermal patches
advantages, 167
components, 165
manufacturing methods, 168
quality control parameters
drug content uniformity, 170
folding endurance, 170
percent moisture uptake, 170
physical appearance, 169
thickness, 169
weight variation, 169
scopolamine, 165
therapeutic applications, 171
types
multilayer drug in adhesive, 167
single-layer drug in adhesive, 166
Transferrin receptor (TfR), 239
Translation, 265
Tray dryer, 8
Triple roller mill, 41–43
Trituration, 22
Tumbling, 22, 23
Tunnel dryers, 8
Turbine impeller, 18
Types of dryers
direct dryers, 6
FBD, 9–10
indirect dryers, 6
moving-bed dryers, 8
pneumatic systems, 10–11
static bed dryers, 7–8
Typical Fitz mill, 38
U
Ultrasonic nebulizer, 142
Ultrasonic vibration, 42
Ultrasound attenuation (UA), 91
Uniformity of Dosage Units, 163
V
Vaccines, 281
Vacuum emulsifying mixer, 43
Valrelease
®
, 229
van der Waals forces, 76, 140
Vapor patch, 167
Vegetable oils, 157
Verbal violence, 213
Vertical FBD, 10
Vertical ow room, 195
Vertical uidized bed dryer, 10
Vibration absorbent material, 204
Violence, 213
Viscoplastic uids, 87
Viscosity, 70, 71, 86, 87, 92
Viscosity theory, 69
W
Water in oil (W/O) emulsions, 68
Wet granulation, 99
advantages, 101, 102
die cavity, 101
dry mixing, 100
dry sieving, 100, 101
limitations, 101, 102
lubrication, 101
wet mixing, 100
wet sifting, 100
Wet mixing, 100
Wet sifting, 100
Wetting, 87, 88
X
Xanthan gum, 191
Y
Yield stress, 87
Yield value, 87
Z
Zeta potential, 82, 83
Index
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