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Contents

Carbon-Based Nanomaterials: An Overview ......................... 1
Sarat Kumar Swain, Anuradha Biswal, Swapnita Patra, and Krishna Manjari Sahu
Carbon-Based Nanostructured Materials: Designing, Properties
and Applications .................................................. 39
Verónica Esparza-Cordero, Camila Castanedo-Carrillo, Alain R. Picos-Benítez, and Blanca L. Martínez-Vargas
Drug Delivery System and Technologies ............................. 73
Wei Guo, Peng Ding, Oseweuba Valentine Okoro, Yanfang Sun, Guohua Jiang, Amin Shavandi, and Lei Nie
Carbon-Based Nanomaterials for Drug Delivery: Past, Present,
Future Directions .................................................. 99
N. B. Singh, Tanaya Kundu, and Mridula Guin
Carbon Nanomaterial-Incorporated Supramolecular Drug
Delivery .......................................................... 129
Noshin Tasnim Tuli, Nuzhat Aqila Tushe, Adib Bin Rashid, and Md Enamul Hoque
Carbon Nanomaterial-Based Polymeric Nanocomposites for Drug
Delivery .......................................................... 169
Danyang Song and Hongbin Li
Carbon Nanomaterial-Incorporated Polysaccharide-Based
Nanocomposite for Drug Delivery ................................... 189
Krishna Manjari Sahu, Kumar Panchajanya Nayak, and Sarat Kumar Swain
Graphene-Based Nanomaterials for Drug Delivery ................... 229
An’amt Mohamed Noor, Farah Amanina Mohd Zin, Nasrun Hasenan, and Lee Seong Wei
xi
xii Contents
Carbon Quantum Dots Based Materials for Drug Delivery ............ 261
Mehrab Pourmadadi, Bahareh Farasati Far, Mohamad Mahdi Khajeh, and Amin Shamsabadipour
Carbon-based Nanocarriers for Sustained Drug Release
in Dentistry ....................................................... 293
Abhisikta Biswal
Fullerene Based Materials for Drug Delivery ......................... 323
Mitali Sarkar and Dhiman Santra
Graphene Quantum Dots-based Nanomaterials for Drug Delivery ..... 357
Md Emamul Kabir, Adib Bin Rashid, and Md Enamul Hoque
Carbon Nano-onions for Drug Delivery .............................. 385
Sora Yasri and Viroj Wiwanitkit
Chitosan/Carbon Nanocomposites in Drug Delivery
and Cardiovascular Diseases ....................................... 413
Ayman M. Mahmoud, Ahmed M. Sayed, Emad H. M. Hassanein, Krishna Manjari Sahu, and Sarat Kumar Swain
Graphene Reinforced Chitosan Nanocomposites for Drug Delivery ..... 443
Ranganathan Priya, Seung Yun Nam, Wan-Seob Cho, and Muthuchamy Maruthupandy
Carbon Nanofiber-Based Materials for Drug Delivery ................. 469
Namrata Khanna, Tanushri Chatterji, and Tanya Bhagat
Metallic Nanoparticles, Carbon-Based Nanocomposites for Drug
Delivery System ................................................... 495
Shruti Sharma, Mukesh Kumar, Anurag Gautam, Sivasubramanian Palanisamy, and Ashutosh Sharma
Carbon based Nanomaterials are Multifunctional Drug Carriers
Opportunity: Challenges ........................................... 523
Neda Zalpour, Reza Samsami, and Mahmoud Roushani

Editor and Contributors

About the Editor
Prof. Sarat Kumar Swain is currently working as a
Professor of Chemistry at Veer Surendra Sai University of Technology (VSSUT), Burla, Sambalpur, Odisha, India. Professor Swain was a Post-doctoral Fellow in the Department of Polymer Engineering, University of Akron, OH, USA, after receiving his doctoral degree from Utkal University, Bhubaneswar, India. He has also worked as a visiting scientist at the Indian Asso­ciation for the Cultivation of Science, Kolkata with INSA SR Fellowship and at the Jawaharlal Nehru Centre for Advanced and Scientific Research, Banga­lore with JNCASR Fellowship. He has more than 25 years of experiencein teaching and research in the areas of Organic Chemistry, Materials Chemistry, Nanotech­nology and Polymer Chemistry at UG, PG and Ph.D. levels. Professor Swain has successfully supervised 19 Ph.D. scholars and three Post-doctoral fellows along with more than 50 Master dissertations as the output of his research. His research interests include rein­forced polymer nanocomposites, hybrid nanomaterials, advanced materials like nanoclay, graphene, CNF, CNT and CQD for improving the fire-retardant, gas barrier, thermal, chemical and mechanical resistance proper­ties of materials. He has designed various kinds of nanostructured materials for waste water treatment, packaging, anti-corrosion performance, superconductor properties, sensing behaviours, drugs delivery and biomedical applications. Professor Swain has published
xiii
xiv Editor and Contributors
morethan 150 research articlesindifferent reputed inter­national SCI/Scopus indexed journals and contributed chapters to several edited books. He has also published seven books with different international publishers and has invented two patents (one USA and one Indian) to his credit. He has received several awards such as a BOYSCAST Fellowship and DAE-Young Scien­tist Research Award from the Government of India, along with the prestigious “Samanta Chandra Sekhar Award” from the Government of Odisha as a recognition of his scientific and academicachievements.Besides his academic credits, he has also taken on various admin­istrative responsibilities such as Director (IQAC), Dean (Academic Affairs), Dean (PG Studies and Research), Head of the Department of Chemistry, etc. during his professional career.
Contributors
Farah Amanina Mohd Zin Advanced Materials Research Cluster, Faculty of
Bioengineering and Technology, Universiti Malaysia Kelantan, Jeli Campus, Jeli Kelantan, Malaysia
Tanya Bhagat Department of Biosciences, Institute of Management Studies Ghaziabad (University Courses Campus), Ghaziabad, Uttar Pradesh, India; Department of Biochemistry, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
Abhisikta Biswal Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India
Anuradha Biswal Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur, Odisha, India
Camila Castanedo-Carrillo Centro de Estudios Científicos y Tecnológicos, Instituto Politécnico Nacional, Zacatecas, México
Tanushri Chatterji Department of Biosciences, Institute of Management Studies Ghaziabad (University Courses Campus), Ghaziabad, Uttar Pradesh, India
Wan-Seob Cho Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan, Republic of Korea
Peng Ding College of Life Sciences, Xinyang Normal University, Xinyang, China Md Emamul Kabir Mechanical Engineering Department, Military Institute of
Science and Technology (MIST), Dhaka, Bangladesh
Editor and Contributors xv
Verónica Esparza-Cordero Unidad Profesional Interdisciplinaria de Ingeniería Campus Zacatecas, Instituto Politécnico Nacional, Zacatecas, México
Bahareh Farasati Far Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Anurag Gautam School of Sciences, Malla Reddy University, Hyderabad, Telangana, India
Mridula Guin Department of Chemistry and Biochemistry, Sharda University, Greater Noida, India
Wei Guo College of Life Sciences, Xinyang Normal University, Xinyang, China Nasrun Hasenan Pathologi Department, Hospital Raja Perempuan Zainab ll,
Kota Bharu, Kelantan, Malaysia Emad H. M. Hassanein Department of Pharmacology and Toxicology, Faculty of
Pharmacy, Al-Azhar University, Assiut, Egypt Md Enamul Hoque Department of Biomedical Engineering, Military Institute of
Science & Technology (MIST), Dhaka, Bangladesh Guohua Jiang School of Materials Science and Engineering, Zhejiang Sci-Tech
University, Hangzhou, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, China
Namrata Khanna Department of Biochemistry, M. A. Rangoonwala College of Dental Sciences and Research Centre, Pune, Maharashtra, India
Mukesh Kumar Department of Physics, Faculty of Applied and Basic Sciences, Shree Guru Gobind Singh Tricentenary University, Gurugram, Delhi-NCR, India
Tanaya Kundu Undergraduate Programmes, Indian Institute of Science, Bangalore, India
Hongbin Li College of Light Industry and Textile, Qiqihar University, Qiqihar, Heilongjiang, P. R. China; Engineering Research Center for Hemp and Product in Cold Region of Ministry of Education, Qiqihar University, Qiqihar, P. R. China
Mohamad Mahdi Khajeh Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
Ayman M. Mahmoud Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK
Blanca L. Martínez-Vargas Centro de Estudios Científicos y Tecnológicos, Instituto Politécnico Nacional, Zacatecas, México
xvi Editor and Contributors
Muthuchamy Maruthupandy Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan, Republic of Korea
An’amt Mohamed Noor Advanced Materials Research Cluster, Faculty of Bioengineering and Technology, Universiti Malaysia Kelantan, Jeli Campus, Jeli Kelantan, Malaysia
Lei Nie College of Life Sciences, Xinyang Normal University, Xinyang, China Sivasubramanian Palanisamy Department of Mechanical Engineering, PTR
College of Engineering & Technology, Madurai, Tamil Nadu, India Kumar Panchajanya Nayak Veer Surendra Sai University of Technology, Burla,
Sambalpur, India Swapnita Patra Department of Chemistry, Veer Surendra Sai University of
Technology, Burla, Sambalpur, Odisha, India Alain R. Picos-Benítez Centro de Estudios Científicos y Tecnológicos, Instituto
Politécnico Nacional, Zacatecas, México Mehrab Pourmadadi Protein Research Center, Shahid Beheshti University,
Tehran, GC, Iran Ranganathan Priya Industry 4.0 Convergence Bionic Engineering, Pukyong
National University, Busan, Republic of Korea Adib Bin Rashid Department of Industrial and Production Engineering, Military
Institute of Science and Technology (MIST), Dhaka, Bangladesh Mahmoud Roushani Department of Chemistry, Faculty of Sciences, Ilam
University, Ilam, Iran Krishna Manjari Sahu Department of Chemistry, Veer Surendra Sai University
of Technology, Burla, Sambalpur, Odisha, India Reza Samsami Department of Chemistry, Dezful Branch, Islamic Azad
University, Dezful, Iran Dhiman Santra Department of Chemistry, University of Kalyani, Kalyani, West
Bengal, India Mitali Sarkar Department of Chemistry, University of Kalyani, Kalyani, West
Bengal, India Ahmed M. Sayed Biochemistry Laboratory, Chemistry Department, Faculty of
Science, Assiut University, Assiut, Egypt Lee Seong Wei Department of Agricultural Science, Faculty of Agro-Based
Industry, Universiti Malaysia Kelantan, Jeli Campus, Jeli Kelantan, Malaysia Amin Shamsabadipour Department of Chemical and Petroleum Engineering,
Sharif University of Technology, Tehran, Iran
Editor and Contributors xvii
Ashutosh Sharma Department of Materials Science and Engineering, Suwon, Gyeonggi-Do, Republic of Korea; Amity Institute of Applied Sciences, Amity University Jharkhand, Ranchi ­834002, India
Shruti Sharma Department of Electrical and Computer Engineering, Ajou University, Suwon, Gyeonggi-Do, Republic of Korea
Amin Shavandi Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, Brussels, Belgium
N. B. Singh Department of Chemistry and Biochemistry, Sharda University, Greater Noida, India
Danyang Song College of Light Industry and Textile, Qiqihar University, Qiqihar, Heilongjiang, P. R. China
Yanfang Sun College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China
Sarat Kumar Swain Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur, Odisha, India
Noshin Tasnim Tuli Department of Industrial and Production Engineering, Military Institute of Science and Technology (MIST), Dhaka, Bangladesh
Nuzhat Aqila Tushe Department of Mechanical Engineering, Military Institute of Science and Technology (MIST), Dhaka, Bangladesh
Oseweuba Valentine Okoro Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, Brussels, Belgium
Viroj Wiwanitkit Chandigarh University, Punjab, India; Dr. D. Y. Patil Medical College, Hospital and Research Centre, D. Y. Patil Vidyapeeth, Pune, India; Department of Eastern Medicine, Government College University Faisalabad, Faisalabad, Pakistan; Hainan Medical University, Haikou, China; Faculty of Medicine, University of Nis, Niš, Serbia; Joseph Ayobalola University, Ikeji-Arakeji, Nigeria
Sora Yasri KM Center, Bangkok, Thailand Seung Yun Nam Industry 4.0 Convergence Bionic Engineering, Pukyong
National University, Busan, Republic of Korea; Major of Biomedical Engineering, Division of Smart Healthcare, Pukyong National University, Busan, Republic of Korea
Neda Zalpour Department of Chemistry, Faculty of Sciences, Ilam University, Ilam, Iran

Abbreviations

β-TC Tetracycline Associated with β-cyclodextrin μs Microseconds
1
H NMR Proton nuclear magnetic resonance
1G First Generation
1
O
2
2G Second Generation 3G Third Generation 3T3 3-day transfer, inoculum 3×10 5-FU 5-Fluorouracil AC Aceclofenac ACV Acyclovir AD Alzheimer’s Disease AFM Atomic Force Microscope Ag Silver AGO Amine functionalized Graphene Oxide A-GQDs Aminated GQDs AIDS Acquired Immunodeficiency Syndrome ALG/al Alginate ALS Amyotrophic Lateral Sclerosis AMB Amphotericin B AMOX Amoxicillin APA Acetaminophen APIs Active Pharmaceutical Ingredients Apt Aptamer APTES (3-Aminopropyl)triethoxysilane Arg-Gly-Asp Arginylglycylaspartic ASK1 Apoptosis Signal-Regulating Kinase 1 ATP Adenosine Triphosphate ATR-IR Attenuated Total Reflection-Infrared Radiation Baa Bucky amino acid BBB Blood–Brain Barrier
Singlet Oxygen
5
cell
xix
xx Abbreviations
BET Brunauer–Emmett–Teller B-GQDs Boron-Doped GQDs bGQDs Gum Arabic-Based Graphene Quantum Dots BHC Benzene Hexachloride BTB Blood–Tumor Barrier C
60
Fullerene CA Calcium Alginate CA-CD Carbon-Dot-Coated Alginate Beads CAF Caffeine CAGR Compound Annual Growth Rate CAP Cellulose Acetate Phthalate CB Cucurbituril CBN Carbon-Based Nanomaterials CC8 Cell Counting Kit-8 CD/CDs Carbon Dots CF Carbon Fiber CG MD Coarse-Grained Molecular Dynamics cGQDs Carboxylated Graphene Quantum Dots C CH
h
4
Chiral vector
Methane CHS Chitosan CIPRO Ciprofloxacin CLSM Confocal Laser Scanning Microscopy CMC/CMC CMC
2
1
Carboxymethyl Cellulose
Carboxymethyl Chitosan CMCS Chemically Modified Chitosan CMS Carboxymethyl Starch CNF Carbon Nanofiber CNH Carbon Nanohorn CNHs Carbon-Nitrogen Hybrid Materials CNM Carbon Nanomaterials CNMs Carbon-Based Nanomaterials CNOs Carbon Nano-onions CNPCP Carbon Dot-Chitosan-PEG CNS Central Nervous System CNT Carbon Nanotube CPO Chronic Post-traumatic Osteomyelitis CPP Cell Penetrating Peptides CPT Camptothecin CQD Carbon Quantum Dot cRGD Cyclic Arginylglycylaspartic Acid CrGO Chemically Reduced Graphene Oxide CS/CTS Chitosan CS-DA-LAG Dihydrocaffeic Acid and L-arginine-cografted Chitosan CS-SWCNTs Chitosan Modified Single-Walled Carbon Nanotubes
Abbreviations xxi
Cu Copper
O Cuprous Oxide
Cu
2
CuO Cupric Oxide Cur/CUR Curcumin CV Cyclic Voltammetry CVD Chemical Vapor Deposition CVD
1
Carbon Vapor Deposition Cyt Cytarabine DBU 1,8-diazabicyclo [5.4.0] undec-7-ene DCA Deoxycholic Acid DCA-HPCHS Mphiphilic Deoxycholic Acid-Modified Hydropropyl
Chitosan DDS Drug Delivery System DFT Density Functional Therapy DHA Dihydroartemisinin DLPC Dilauroylphosphatidylcholine DLS Dynamic Light Scanning/Dynamic Light Scattering DMA Dimethyl Maleic Acid DMAc Dimethylacetamide DMSNs Dendrimer-Like Mesoporous Silica Nanospheres DNA Deoxyribonucleic Acid DNDs Detonation Nanodiamonds DOC Docetaxel DOS Density of States DOX/DOXO Doxorubicin DPH Diphenhydramine DPP-4 Dipeptidyl Peptidase-4 DPPH 2,2-Diphenyl-1-Picryhydrazyl Radical DSC Differential Scanning Calorimetry dsDNA Double-Stranded DNA DSPE Distearoylphosphatidylethanolamine DTC
2+
60
N,N-Dimethyl-2-(4-N,N,N-Trimethylamino
phenyl)fulleropyrrolidinium Iodide DWCNTs Double-Walled Carbon Nanotubes EC Ethyl Cellulose EDC-NHS 1-Ethyl-3-(3-Dimethylaminopropyl)carbodiimide/
N-Hydroxysuccinimide EDS Energy-Dispersive Spectroscopy EDX Energy-Dispersive X-ray EMF Endohedral Metallofullerene EPI Epirubicin EPR Enhanced Permeability and Retention ESR Electron Spin Resonance EYFP Enhanced Yellow Fluorescent Protein FA Folic Acid