Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5362_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Carbon Based Nanomaterials for Drug Delivery
- •Preface
- •Acknowledgements
- •Contents
- •Editor and Contributors
- •Abbreviations
- •1.2 Market Statistics
- •Carbon-Based Nanomaterials: An Overview
- •1. Introduction
- •1.1 Evolution of Carbon-Based Nanomaterials
- •2. Carbon-Based Nanostructures
- •2.1 Fullerene
- •2.2 Carbon Nanotubes (CNTs)
- •2.4 Graphene
- •2.5 Nanodiamonds (NDs)
- •2.6 Nano-Onions (CNOs)
- •2.7 Nanohorns (CNHs)
- •2.8 Carbon Dots (CDs)
- •2.9 Nanoporous Activated Carbon
- •3. Synthesis Techniques
- •4. Properties of Carbon-Based Nanomaterials
- •4.1 Physicochemical Properties
- •4.2 Thermal Properties
- •4.3 Mechanical Properties
- •4.4 Optoelectronic Properties
- •4.5 Antimicrobial Properties
- •4.6 Biological Properties
- •5. Applications of Carbon-Based Nanomaterials
- •5.1 Environmental Remediation
- •5.2 Agriculture
- •5.3 Biofuel
- •5.4 Energy Storage
- •5.5 Biomedical Applications
- •6. Challenges and Future Perspectives
- •7. Concluding Remarks
- •References
- •Carbon-Based Nanostructured Materials: Designing, Properties and Applications
- •1. Introduction
- •2.1 Zero-Dimensional Carbon-Based Nanostructures (0D)
- •2.2 One-Dimensional Carbon-Based Nanostructures
- •2.3 Two-Dimensional (2D) Carbon-Based Nanostructures
- •2.4 Three-Dimensional (3D) Carbon-Based Nanostructures
- •3.1 Chemical Vapor Deposition
- •3.2 Hydrothermal and Solvothermal Techniques
- •3.3 Microwave-Assisted Technique
- •3.4 Chemical Oxidation Synthesis
- •4. Properties of Carbon-Based Nanostructured Materials
- •4.1 Thermal Properties
- •4.2 Mechanical Properties
- •4.3 Optoelectronic Properties
- •4.4 Antimicrobial Properties
- •4.5 Biological Properties
- •5. Applications of Carbon-Based Nanostructured Materials
- •5.2 Antibacterial and Antiviral Applications
- •5.3 Theragnostic
- •5.4 Wound Healing
- •5.5 Tissue Engineering
- •5.6 Drug Delivery
- •5.7 Biosensing
- •6. Challenges and Future Perspectives
- •7. Concluding Remarks
- •References
- •Drug Delivery System and Technologies
- •1. Introduction
- •2. Drug Delivery System
- •2.1 Conventional Drug Delivery System
- •2.2 Advanced Drug Delivery System
- •2.3 Controlled and Sustainable Drug Delivery System
- •3. Drug Delivery Technologies
- •3.1 Active and Passive Drug Delivery
- •3.2 Smart Drug Delivery
- •3.3 Intravenous and Extravaneous Drug Delivery
- •3.4 Various Types of Delivery Technologies
- •4. Challenges and Future Perspectives
- •5. Conclusion
- •References
- •Carbon-Based Nanomaterials for Drug Delivery: Past, Present, Future Directions
- •1. Introduction
- •3. Current Status in Drug Delivery by CNMs
- •3.1 Graphene-Based Nanomaterials in Drug Delivery
- •3.4 Nanodiamond Based Drug Delivery Systems
- •3.5 Nano-Onions in Drug Delivery
- •3.6 Nanohorns in Drug Delivery
- •3.7 Fullerene in Drug Delivery
- •4. Challenges and Future Perspective
- •5. Conclusions
- •References
- •Carbon Nanomaterial-Incorporated Supramolecular Drug Delivery
- •1. Introduction
- •2. Different Carbon Nanomaterials in Drug Delivery
- •2.1 Carbon Nanotubes (CNTs)
- •2.3 Graphene
- •2.4 Carbon Quantum Dots
- •2.5 Fullerene
- •2.6 Carbon Nanohorns
- •2.7 Carbon Nano-Onions
- •2.8 Nano-Diamond
- •3. Supramolecular Chemistry in Drug Delivery
- •3.1 Principles of Supramolecular Chemistry
- •3.3 Applications of Supramolecular Biomaterials
- •4. Carbon Nanomaterial-Incorporated Supramolecular Drug Delivery
- •5.1 Cyclodextrins
- •5.2 Calixarenes
- •5.3 Cucurbituril
- •5.4 Pillarenes
- •5.5 Crown Ether
- •6. Toxicity Concerns of Carbon Nanomaterials
- •7. Improving the Effectiveness of Nanoparticle Systems
- •8. Future of Nanomedicine
- •9.1 Challenges
- •9.2 Future Perspectives and Opportunities
- •9.3 Conclusions
- •References
- •Carbon Nanomaterial-Based Polymeric Nanocomposites for Drug Delivery
- •1. Introduction
- •2.1 Carbon Quantum Dot-Based Polymer Nanocomposite
- •2.2 Carbon Nanotube-Based Polymer Nanocomposite
- •2.3 Graphene Quantum Dot-Based Polymer Nanocomposite
- •2.5 Fullerene-Based Polymer Nanocomposite
- •2.6 Nanodiamond-Based Polymer Nanocomposite
- •3. Drug Delivery Systems Using Carbon Nanomaterial
- •3.1 Anticancer Drug Delivery
- •3.3 Infectious Disease Drug Delivery
- •3.4 Topical Drug Delivery
- •3.5 Brain Drug Delivery
- •3.6 Oral Drug Delivery
- •4. Challenge and Future Perspectives
- •5. Conclusion
- •References
- •Carbon Nanomaterial-Incorporated Polysaccharide-Based Nanocomposite for Drug Delivery
- •1. Introduction
- •1.1 Drug Delivery
- •1.2 Carbon Nanomaterials
- •1.3 Polysaccharide-Based Nanocomposite
- •2.1 CN-Incorporated Alginate-Based Nanocomposite
- •2.2 CN-Incorporated Cellulose-Based Nanocomposite
- •2.3 CN-Incorporated Chitosan-Based Nanocomposite
- •2.4 CN-Incorporated Dextran-Based Nanocomposite
- •2.5 CN-Incorporated Hyaluronic Acid-Based Nanocomposite
- •2.6 CN-Incorporated Starch-Based Nanocomposite
- •2.7 CN-Incorporated Pectin-Based Nanocomposite
- •2.8 CN-Incorporated Guar Gum-Based Nanocomposite
- •2.9 CN-Incorporated Agarose-Based Nanocomposite
- •2.10 CN-Incorporated Carrageenan-Based Nanocomposite
- •2.11 CN-Incorporated Glucomannan-Based Nanocomposite
- •3. Challenges and Future Prospective
- •4. Concluding Remarks
- •References
- •Graphene-Based Nanomaterials for Drug Delivery
- •1. Introduction
- •1.1 Challenges in Conventional Drug Delivery Systems
- •1.2 Overview of Nanomaterials for Drug Delivery
- •1.3 Role of Graphene-Based Nanomaterials in Drug Delivery
- •2. Synthesis of Graphene
- •2.1 Chemical Reduction Method
- •2.2 Thermal Reduction
- •2.3 Electrochemical Reduction
- •2.4 Chemical Vapor Deposition Method
- •2.5 Mechanical Exfoliation
- •2.6 Epitaxial Growth Method
- •2.7 Growth in Solvothermal and Hydrothermal Systems
- •2.8 Electrochemical Deposition
- •3. Types of Graphene-Based Materials
- •3.1 Graphene Quantum Dots, (GQDs)
- •3.2 Graphene Oxide (GO)
- •3.3 Graphene Nanoribbons (GNRs)
- •3.4 Oxidized Graphene Nanoribbons
- •4. Graphene Functionalized Materials for Drug Delivery
- •4.1 In Bone Tissue Regeneration
- •4.2 In Neural Regeneration
- •4.3 In Photodynamic and Photothermal Therapy
- •4.4 In Enhancing Cellular and Humoral Immunity
- •4.6 Miscellaneous
- •5. Challenges and Future Perspective
- •6. Conclusion
- •References
- •Carbon Quantum Dots Based Materials for Drug Delivery
- •1. Introduction
- •2. Synthesis Process of Carbon Quantum Dots
- •2.1 Top-Down Approaches
- •2.2 Bottom-Up Approaches
- •2.3 Microwave-Assisted Method
- •2.4 Electrochemical Method
- •2.5 Laser Ablation Method
- •2.6 Pyrolysis Method
- •2.7 Template-Assisted Method
- •4. Challenges and Future Perspective
- •5. Concluding Remarks
- •References
- •Carbon-based Nanocarriers for Sustained Drug Release in Dentistry
- •1. Introduction
- •2.1 Oral Mucosa Structure
- •2.2 Sites for Drug Delivery
- •2.3 Permeability
- •3. Local Drug Delivery for Dental Diseases
- •3.1 Odontogenic Infection
- •3.2 Non-odontogenic Infection
- •4. Bio-adhesive Nanoparticles: Novel Treatment Modality
- •4.1 Bio-adhesive Nanoparticles
- •4.2 Mechanism of Bioadhesion
- •5.1 Carbon Nanotubes
- •5.2 Graphene
- •5.3 Nanodiamonds
- •5.4 Fullerenes
- •5.5 Porous Carbon
- •5.6 Carbon Dots
- •6. Drug Delivery Systems Based on CBNs
- •6.2 Immediate Drug Delivery System (IDDS)
- •6.3 Sustained-release Drug Delivery Systems
- •6.4 Controlled Drug Delivery System (CDDs)
- •8. Conclusion
- •References
- •Fullerene Based Materials for Drug Delivery
- •1. Introduction
- •2. Types of Fullerene Derivatives
- •2.1 Exohedral Fullerene Derivatives
- •2.2 Endohedral Fullerene Derivatives
- •2.3 Surface Derivatized Fullerenes
- •3. Interaction of Fullerene Derivatives for Drug Delivery
- •4. Fullerene Based Materials for Drug Delivery
- •4.1 Nucleic Acid Delivery
- •4.2 Peptide Delivery
- •4.3 Topical Drug Delivery
- •4.4 Infectious Diseases Drug Delivery
- •4.5 Anticancer Drug Delivery
- •4.7 Brain Drug Delivery
- •4.8 Ocular Drug Delivery
- •5. Challenges and Future Perspectives
- •6. Concluding Remarks
- •6.1 Abbreviations
- •References
- •Graphene Quantum Dots-based Nanomaterials for Drug Delivery
- •1. Introduction
- •2. Synthesis of GQDs
- •3. GQD’s Properties for Drug Delivery
- •3.1 Optical Properties
- •3.2 Physicochemical Properties
- •3.3 Mechanical Properties
- •3.4 Biocompatibility and Cytotoxicity
- •4. Characterization of GQDs-Based Nanomaterials
- •4.1 Characterization of Multifunctional GQDs-Based Nanomaterials
- •5.1 Strategies for Developing Medication Delivery Systems Based on GQD
- •5.2 PH-responsive Drug Delivery Systems (GQD-DDSs)
- •5.3 Targeted Drug Delivery Using Ligand-Based GQDs as a Mediator
- •5.4 Improvement of Medicines’ Pharmacological Properties Using GQDs
- •5.5 Enhancing Cytotoxicity with GQD-DDS
- •7. Applications of Chiral GQDs
- •10. Challenges and Future Perspectives
- •11. Conclusions
- •References
- •Carbon Nano-onions for Drug Delivery
- •1. Introduction
- •2. Carbon Nano-Onion: A Multi-Layered Nanocarrier
- •3. Synthesis of Carbon Nano-Onions
- •3.1 Annealing Method
- •3.2 Carbon Ion Implantation Method
- •3.3 Arc Discharge Method
- •3.4 Carbon Vapour Deposition Method
- •3.5 Pyrolysis Method
- •6. Carbon Nano-Onions in Drug Delivery
- •6.1 Delivery of Therapeutic Agents
- •6.2 Delivery of Targeting Agents
- •6.3 Delivery of Imaging Agents
- •7. Challenges and Future Perspectives
- •8. Concluding Remarks
- •References
- •Chitosan/Carbon Nanocomposites in Drug Delivery and Cardiovascular Diseases
- •1. Introduction
- •1.1 Drug Delivery
- •1.2 Cardiovascular Diseases
- •1.3 Chitosan and Its Properties
- •1.4 Chitosan/Carbon Nanocomposites
- •2. Chitosan/Carbon Nanocomposites in Drug Delivery
- •3. Chitosan/Carbon Nanocomposites in CVDs
- •3.1 Chitosan-Based Scaffolds
- •3.2 Chitosan in Cardiac Tissue Engineering
- •3.3 Chitosan-Based Cell Therapy
- •3.4 Chitosan-Based Gene Delivery
- •3.5 Chitosan-Protein Interaction
- •4. Challenges and Future Perspective
- •5. Concluding Remarks
- •References
- •Graphene Reinforced Chitosan Nanocomposites for Drug Delivery
- •1. Introduction
- •2. Chitosan: Structure and Properties
- •3. Graphene: Structure, Types and Properties
- •4.1 Electrospinning Method
- •4.2 Sol–gel Method
- •4.3 Solution Mixing Method
- •4.4 In-situ Polymerization Method
- •5.2 Chitosan/Graphene Aerogels
- •5.3 Chitosan/Graphene Hydrogels
- •5.4 Chitosan/Graphene Thin Films
- •6.1 Oral Drug Delivery
- •6.2 Mucosal Drug Delivery
- •6.3 Transdermal Drug Delivery
- •6.4 Parenteral Drug Delivery
- •7. Challenges and Future Perspectives
- •8. Concluding Remarks
- •References
- •1. Introduction
- •2. Functionalization of CNFs
- •2.1 The Need for Functionalization


Carbon Based Nanomaterials for Drug Delivery

Smart Nanomaterials Technology
Series Editors
Azamal Husen
Mohammad Jawaid, Chemical and Petroleum Engineering, United Arab Emirates
University, Al Ain, United Arab Emirates
, Wolaita Sodo University, Wolaita, Ethiopia

Nanotechnology isa rapidly growing scientific field and has attracted a great interest
over the last few years because of its abundant applications in different fields like
biology, physics and chemistry. This science deals with the production of minute
particles called nanomaterials having dimensions between 1 and 100 nm which may
serve as building blocks for various physical and biological systems. On the other
hand, there is the class of smart materials where the material that can stimuli by
external factors and results a new kind of functional properties. The combination of
these two classes forms a new class of smart nanomaterials, which produces unique
functional material properties and a great opportunity to larger span of application. Smart nanomaterials have been employed by researchers to use it effectively in
agricultural production, soil improvement, disease management, energy and environment, medical science, pharmaceuticals, engineering, food, animal husbandry and
forestry sectors.
This book series in Smart Nanomaterials Technology aims to comprehensively
cover topics in the fabrication, synthesis and application of these materials for
applications in the following fields:
•
Energy Systems—Renewable energy, energy storage (supercapacitors and elec-
trochemical cells), hydrogen storage, photocatalytic water splitting for hydrogen
production
•
Biomedical—controlled release of drugs, treatment of various diseases, biosen-
sors,
•
Agricultural—agricultural production, soil improvement, disease management,
animal feed, egg, milk and meat production/processing,
•
Forestry—wood preservation, protection, disease management
•
Environment—wastewater treatment, separation of hazardous contaminants from
wastewater, indoor air filters.

Sarat Kumar Swain
Editor
Carbon Based Nanomaterials for Drug Delivery

Editor
Sarat Kumar Swain
Department of Chemistry
Veer Surendra Sai University of Technology
Burla, Sambalpur, Odisha, India
ISSN 3004-8273 ISSN 3004-8281 (electronic)
Smart Nanomaterials Technology
ISBN 978-981-97-8085-3 ISBN 978-981-97-8086-0 (eBook)
https://doi.org/10.1007/978-981-97-8086-0
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature
Singapore Pte Ltd. 2025
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether
the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse
of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and
transmission or information storage and retrieval, electronic adaptation, computer software, or by similar
or dissimilar methodology now known or hereafter developed.
The use of general descriptivenames,registerednames,trademarks,service marks, etc. in this publication
does not imply, even in the absence of a specific statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book
are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or
the editors give a warranty, expressed or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional
claims in published maps and institutional affiliations.
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.
The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721,
Singapore
If disposing of this product, please recycle the paper.

The editor dedicates this book to…
Lord Jagannath, Lord Balabhadra and Devi
Subhadra

Preface
Carbon (roots from Latin word carbo; coal), most primitive element ever known
to mankind, is also the most abundant element on earth and is known as the “element of life”. Its unique properties keep on fascinating us, which allows it to form
numerous allotropic forms via sp, sp
structural characterization of graphite by John D. Bernal in the Twentieth Century,
carbon became the focus of an extensive line of research. The detailed study related
to carbon and its properties, “carbon chemistry” formed the backbone of organic
chemistry. With due course of time, the motivation of miniaturizing devices gave
birth to an extremely robust class of nanomaterials known as “Carbon-Based Nanomaterials”. The history of nanotechnology and carbon-based nanomaterials is highly
intertwined. Following the invention of electron microscope and introduction of the
term “nanotechnology”, the miraculous discovery of fullerenes or “Bucky ball” in
1985 laid the first stepping stone in the history of nanomaterials. It became the first
structurally investigated nanomaterial to be reported and it is the biggest milestone
in the journey of nanotechnology. Science then, several forms of nano-dimensional
carbonaceous matters have been discovered and reported which have revolutionized the field of material science. In the past decades, the remarkable mechanical,
electrical, and optical properties of carbon-based nanomaterials havemade them the
center of attraction for academicians and industrialists for their applicability in a
plethora of applications ranging from aeronautics to biomedical science. These tiny
miracles have proved to be a boon in the field of therapeutics. Sustained encapsulation and release of optimized dosages of therapeutics in their hollow cavities make
them the most promising candidates for drug delivery applications. Various forms
of carbonaceous nanomaterials like fullerenes, carbon nanotubes, carbon nanofibers,
nanodiamonds, graphene, carbon quantum dots, nanohorns, and nano-onions have
found the way toward success in the field of drug delivery. The book mainly focuses
ontheeffectivenessofdifferentnanomaterials toward targeteddeliveryof therapeutic
compounds to different parts of the body.
The key objective of this book entitled Carbon Based Nanocomposites for Drug
Delivery is to bring forward the journey of carbon nanomaterials right from prehistoric times to Indian mothers preparing kohl using wick lamps to the advanced
2
, and sp3hybridization. Immediately after the
vii

viii Preface
research in material science, specifically in the field of biomedical application in
particular to drug delivery. The book dives into the evolution of carbon-based nanomaterials,shedding light into variouscarbonaceous nanoforms as well as theirbiological aspects and highlights the utilization of these nanomaterials in different facets
of drug delivery applications. The book is divided into 18 chapters contributed by
eminent authors from more than 10 countries; each addressing different aspects of
carbon-based nanomaterials, their nanocomposites and potency of these functional
materials in different forms of drug delivery. The detailed introduction regarding
carbon-based nanomaterials, their roles in drug delivery, drug encapsulation, and
release efficacies in isolated or hybrid states as well as illuminates the noteworthy
achievements of academicians and researchers in the concerned field. The present
book brings together the functionalities of carbon-based nanomaterials in different
types of drug delivery under one roof for providing a better reading experience to
the readers.
It would be a matter of great pleasure, if our united efforts will be an addition to
the existing literature regarding nanotechnology in drug delivery.
Burla, Sambalpur, Odisha, India
January 2024
Prof. Sarat Kumar Swain

Acknowledgements
With heartfelt appreciation, I extend my sincere gratitude to the Springer Nature,
Singapore Pte. Ltd. for publishing this book entitled Carbon Based Nanomaterials
for Drug Delivery. With due regards, I express my thanks and respect to the eminent
Series Editor, Prof. Mohammad Jawaid and Dr. Ramesh Nath Premnath, Publishing
Editor of Springer for their invaluable opportunity to present my ideas through this
bookas part of thebook series Smart Nanomaterials Technology.Specialappreciation
goes to Dr. Karthik Raj, Project Coordinator, for his unwavering support during the
editing process.
I would like to express my deep sense of gratitude to the research groups
of Prof. Martínez-Vargas, Prof. Lei Nie, Prof. Guin, Prof. Hoque, Prof. Li,
Dr. Noor An’amt, Dr. Pourmadadi, Dr. Biswal, Prof. Sarkar, Prof. Wiwanitkit,
Dr. Yasri, Prof. Mahmoud, Prof. Maruthupandy, Prof. Cho, Prof. Nam, Dr. Chatterji, Prof. Palanisamy, Prof. Sharma, and Prof. Roushani for contributing their valuable works to make this complete one. I am equally indebted to the tireless efforts
of the dedicated members of my research group, namely, Dr. Anuradha Biswal,
Ms. Swapnita Patra, Mr. Shuvendu Shuvankar Purohit, and Mr. Susobhan Swain for
their timely help. However, effort of Ms. Krishna Manjari Sahu, my Ph.D. Scholar
is highly appreciated for her active involvement during entire editing process. At
the outset, I also acknowledge the support to the Vice-Chancellor of my University,
“Veer Surendra Sai University of Technology” for his encouragement. The last but
not least, I express my gratitude to my beloved parents for their inspirations and
blessings.
It is my sincere hope that, in collaboration with the contributing authors and
publishers, this work will meet the needs of academics, researchers, and students in
industrial, biomedical, and pharmaceutical domains.
Prof. Sarat Kumar Swain
ix
Соседние файлы в папке Библиотека им академика М.И. Перельмана
