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24 Clinical Applications 327

24.6 Conclusion

EEG is a versat ile and accessible tool in clinical neuroscience research. It provides a cost-effective approach for capturing brain dynamics noninvasively in clinical and emerging home-based contexts. EEG has been well established in clinical applica­tions such as sleep and epilepsy, where distinct EEG characteristics have been classied and are used for diagnostic or therapeutic outcome evaluations. Wearable EEG technologies and brain-computer interfaces further provi de potential for clin­ical applications. Yet, despite the advances in EEG technology and research, chal­lenges remain. Particularly, in psychiatric applications, in which heterogeneity and methodological inconsistencies limit clinical translation. Further efforts toward standardized recording and analysis procedures, as well as the integration of EEG with other neuroimaging techniques, may help to address these challenges and make the use of EEG more widespread in clinical applications.

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Chapter 25
From Brain Signals to Neuroadaptive Technology: BCIs for Human-Computer Interaction
Marius Klug, Diana E. Gherman-Nagy, and Thorsten O. Zander
Abstract This chapter introduces brain-computer interfaces (BCIs) with a focus on
their
role in human-computer interaction and neuroadaptive technology. We rst dene BCIs and distinguish active, reactive, and passive systems, emphasizing how EEG-based BCIs transform neural activity into real-time system behavior. We then review the main neural signals and sensing modalities used in BCIs, with an emphasis on wearable EEG and emerging form factors for everyday use. The core BCI pipeline is outlined from experimental desig n and labeling through preprocessing, feature extraction, machine learning, and validation, providing readers with a practical overview of how decoding models are built and assessed. Using motor imagery, P300/SSVEP, and a range of passive paradigms as examples, we illustrate how BCIs can decode intention, workload, error perception, vigilance, and related mental states. Building on this, we describe how passive BCIs enable neuroadaptive systems, from mental state assessment and open-loop feedback to closed-loop and autonomous adaptations. Finally, we discuss key practical chal­lenges, including artifacts, non-stationarity, and cross-user generalization, as well as ethical issues around privacy and neurorights. The chapter concludes by outlining future trajector ies for BCIs as a core component of human-centered, adaptive AI systems.
Keywords Brain-computer interface · BCI · Passive BCI · Neuroadaptive systems · Human-co
mputer interaction · Mental state decoding

25.1 Introduction

Imagine you are studying for an important exam, scrolling through an online tuto rial late at night. The material is dense, the examples feel rushed, and you catch yourself rereading the same paragraph without taking in a word. Your eyes stay on the page,
M. Klug (*) · D. E. Gherman-Nagy · T. O. Zander Neuroadaptive Human-Computer Interaction, Brandenburg University of Technology Cottbus­Senftenberg, Cottbus, Germany e-mail:
marius.klug@b-tu.de
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2026 T.
Warbrick (ed.), The EEG Handbook,
https://doi.org/10.1007/978-3-032-20450-9_25
331
332 M. Klug et al.
your mouse hardly moves, yet inside your head, workload and fatigue are rising, and your attention is drifting.
As you continue, the layout on the screen qu ietly changes. The video pauses and is replaced by a short multiple-choice quiz that checks a single key concept. The pace slows, and a brief recap appears in the margin. A few minutes later, after you answer condently and your brain activity settles back into a lower workload pattern, the system resumes the normal speed and hides the extra scaffolding. You never told it you were confused. You never clicked a helpbutton. The adaptation was triggered by a small EEG headset resting behind your ear that continuously tracks your mental state.
What makes this possible is a passive brain-computer interface: a system that does
not wait for explicit commands but instead monitors ongoing brain activity to infer states such as effort, fatigue, and engagement. In this chapter, you will get an overview of how BCIs work, from EEG acquisition through the full processing pipeline, with a special focus on passive BCIs and how they can be integrated into everyday technology to create interfaces that respond not only to what you do, but also to how you think and feel while you are doing it.

25.1.1 Why Connect Brains and Computers?

When humans interact with machines, systems usually infer goals and internal states from behavior: button presses, cursor movements, speech, or gaze patterns. These cues are useful but indirect and often arrive only after critical decisions have been made. Brain-computer interfaces (BCIs) add a complementary information channel by decoding neural activity itself. In clinical settings, BCIs can restore communica­tion and basic control to people with severe motor impairm ents by translating brain signals into selections or movements (Farwell & Donchin,
2002). Beyond rehabilitation, BCIs can reveal workload, attention, or error percep-
tion
during ongoing interaction (Parasuraman & Rizzo, 2007; Zander & Kothe,
2011), enabling adaptive systems that respond not only to what users do, but also
to
how they currently think and feel.
1988; Wolpaw et al.,

25.1.2 What Is a BCI?

A brain-computer interface is a system that measures neural activity, extracts informative features, and translates them into outputs that inuence an external device or software process (Wolpaw & Wolpaw, acquis
ition, processing, decoding, and system actiondistinguishes BCIs from general neuroimaging, where brain signals are recorded for analysis rather than real-time interaction. BCIs can rely on various modalities, but EEG remains the dominant choice because it is safe, portable, inexpensive, and capable of
2012). This canonical loop
25 From Brain Signals to Neuroadaptive Technology: BCIs for Human-Computer... 333
millisecond-level temporal resolution (Mehta & Parasuraman, 2013). In a BCI, the dening property is the real-time transformation of actual brain activity into mean­ingful system behavior.

25.1.3 Types of BCIs: Active, Reactive, Passive

A widely used taxonomy distinguishes BCIs by the origin and purpose of the neural activity they decode (Zander & Kothe, 2011). Active BCIs rely on intentionally generated brain signals that are independent of external stimulati on. Users deliber­ately modulate neural activity to convey commands, as in motor imagery (MI) systems where imagined hand movements control cursors or prostheses (Daly & Wolpaw,
re substantial training, and are most commonl y used in clinical settings.
requi
Reactive BCIs decode brain responses that are elicited by external stimuli. Here,
the
control signal is tied to events in the environment but still shaped by the users attention. Classic examples include P300-based spellers, where rare or attended items evoke a characteri stic potent ial (Farw ell & Donchin, 1988), and steady-state systems in stimulus-locked responses.
contr load, engagement, fatigue, or error perception (Zander & Kothe, 2011). Rather than repla by adding implicit information about user state, enabling systems to adapt to them continuously during complex tasks.
that use frequency-tagged ickering targets (Norcia et al., 2015). Users
uence the interface by focusing attention on specic stimuli, producing reliable,
Passive BCIs (pBCIs) interpret neural activity that arises without intentional
ol. They infer naturally occurring cognitive and affective states such as work-
cing explicit input, passive BCIs augment human-computer interaction (HCI)
2008). These interfaces emphasize volitional control, often

25.1.4 BCIs in Neuroscience and HCI

BCIs occupy a dual position in research and application. In neuroscience, they enable real-time access to cognitive processes during naturalistic behavior, supporting studies that investigate perception, prediction, and action outside con­trolled laboratory settings (Gramann et al., tant
in this context because many states relevant for interactionsuch as workload, attention, or prediction errorsmanifest differently in realistic environments. Study­ing these states during movement, navigation, or immersive tasks increases ecolog­ical validity and reveals how neural dynamics behave under conditions that more closely resemble everyday interaction. This also aligns BCI research with the broader shift in HCI toward examining users in real-world contexts rather than exclusively in seated, constrained setups.
2011). Mobile EEG is especially impor-
334 M. Klug et al.
Within HCI, BCIs contribute to user modeling by providing direct markers of internal states that are difcult to infer from behavior alone, allowing interfaces to respond to cognitive or affective changes as they occur (Schmidt,
2001). The focus on passive BCIs follows natur ally from this intersection. Because
e BCIs decode spontaneously occurring neural activity without requiring
passiv intentional control, they add an implicit information channel that complements traditional input modalities (Zander & Kothe, time
brain state decoding (RBSD) enables systems to detect elevated workload, lapses of attention, or perceived errors and adapt accordingly, supporting applica­tions in driving, aviation, and learning technologies. Passive BCIs thus form a foundation for neuroadapti ve systems that adjust their behavior to suppor t perfor­mance, maintain safety, or personalize user experience (Krol et al.,
to supply continuous, ne-grained information about the users internal state
ability positions them as a central component in future adaptive HCI and human–AI systems.
2011; Zander et al., 2014). Real-
2000; Fischer,
2018b). Their

25.2 Signals and Sensors

25.2.1 Neural Signals for BCIs

BCIs rely on neural signals that differ in temporal resolution, spatial specicity, and practicality for real-time decoding. Electrophysiological methods such as EEG (see also Chap. tials makin shifts, or oscillatory markers of workload (Mehta & Parasuraman, 2013). Their spatial of EEGmake them the backbone of most BCI systems. Hemodynamic methods such as fNIRS and fMRI instead indirectly measure activity by blood-oxygenation changes and thus offer better spatial localization at the cost of several-second delays. These slower dynamics restrict real-time use to gradual cognitive states rather than fast perceptual or decision-related events. As a result, electrophysiology is favored when BCIs must operate continuously and respond within behaviorally relevant timescales.
Outside of restorative research, such as speech reconstruction (Willett et al.,
2023), EEG is particularly prevalent in BCI research because it strikes a practical
balanc tively inexpensive, portable, and compatible with mobile or immersive setups, enabling studies and applications beyond traditional laboratory environments. EEG also offers the high temporal resolution that is essential for decoding fast neural phenomena in real time. At the same time, EEG data suffer from low signal­to-noise ratio, sensitivity to artifacts, and limited spatial precision due to volume conduction. These constraints require careful preprocessing and feature extraction,
2) and MEG measure voltage changes generated by postsynaptic poten-
and capture neural dynamics on the millisecond scale (Biasiucci et al., 2019),
g them suitable for detect ing rapid processes like error responses, attention
resolution is limited, but their speed and portabilityespecially in the case
e between safety, usability, and information content. EEG systems are rela-
25 From Brain Signals to Neuroadaptive Technology: BCIs for Human-Computer... 335
and they shape which mental states can be decoded reliably. Despite these limita­tions, EEG remains the most versatile modality for BCIs because it supports rapid, continuous, and minimally intrusive monitoring of brain activity in real-world contexts.
EEG signals relevant for BCIs fall broadly into two categories: event-related responses and ongoing oscillatory activity. Event-related potentials (ERPs) are time­locked amplitude deections in the EEG that occur in response to discrete sensory, cognitive, or action-related events (see also Chap. ture
allows precise identication of components such as the P300, error-related negativity, or xation-related potentials, each reecting specic stages of informa­tion processing (Farwell & Donchin, Voytek, 2022). ERPs form the basis of many reactive BCIs because they offer reliable uctuations in synchronized neural activity, typically quantied through power in frequency bands such as theta, alpha, beta, or gamma (see also Chap. these ery, or vigilance (Klimesch, 1999; Gevins & Smith, 2003; Gherman et al., 2025). Together BCI design.
markers tied to stimulus timing. Oscillatory rhythms reect continuous
rhythms index sustained processes including workload, attention, motor imag-
, ERPs and oscillations constitute the primary signal families exploited in
1988; Falkenstein et al., 2000; Donoghue &
19). Their temporo-spatial struc-
18). Changes in

25.2.2 Wearable EEG and Form Factors

EEG systems vary widely in how electrodes make contact with the scalp, how portable they are, and how well they balance signal quality with user comfort. Gel-based caps provide the highest signal quality and remain the standard in research and clinical environments, but they require time-consuming preparation and restrict mobility. Dry electrodes reduce setup time and improve comfort, enabling faster deployment in applied settings, though they often trade off signal­to-noise ratio and can be more sensitive to motion artifacts (Zander et al.,
Semi-dry
quality and setup time, but require saline solution to be re-applied over time.
stable recordings suitable for long-term use and emerging everyday BCI applications (Debener et al., Interaxon Muse, further emphasize ease of use and accessibility, integrating light­weight materials and wireless transmission. They can still be used to detect oscilla­tions, as well as limited event-related responses (Krigolson et al., 2017), lower channel counts and variable t limit the complexity of signals that can be decoded reliably (R atti et al., such displays, supporting BCIs in extended reality scenarios while introducing new constraints related to weight, ergonomics, and mechanical coupling during move­ment. These diverse form factors reect ongoing efforts to reconcile signal delity with practicality and user comfort.
solutions refer to saline sponge electrodes that have an intermediate signal
Ear-EEG syst
as the OpenBCI Galea, combines neural sensing with immersive head-mounted
ems position electrodes in or around the ear canal, offering discrete,
2015; Mirkovic et al., 2016). Consumer headsets, such as the
2017). Finally, Virtual Reality (VR)-integrated EEG,
2017).
but their
336 M. Klug et al.

25.3 The BCI Pipeline: From Raw Signals to Decisions

25.3.1 Overvie w

A BCI transforms neural activity into meaningful system outputs through a series of coordinated stages. The pipeline begins with experimental design, where tasks and labeling strategies determine what neural phenomena can be decoded. Data acqui­sition and preprocessing follow, addressing arti facts and preparing the signals for reliable analysis. Feature extraction converts continuous EEG into informative representations, which are then passed to machine learning models that learn map­pings between neural activity and target states. Finally, trained models are validated and deployed in real time for online interaction.

25.3.2 Experimental Design and Labeling

The structure of a BCI experiment determines the information available for decoding and the quality of the labels used for training. Event-based paradigms rely on well­dened, time-locked events such as the presentation of images and sounds, system errors, or xation onsets. These designs allow the precise stimulus-locked segmen­tation of EEG and thus enable the subsequent decoding of ERPs. In contrast, continuous-state elicitation involves tasks that manipulate cognitive variables over longer periods, such as workload, vigilance, or affect. Here, labels often reect gradual changes, derived from task difculty, behavioral markers, or continuous ratings.
Regardless of the paradigm type, having properly labeled data is critical. Noisy
labels
from ambiguous or imprecise instructions or temporal jitter in the apparatus can erode classier performance severely and make a proper interpretation of the results impossible. Ensuring a well-dened mental stat e elicitation, minimizing confounds (e.g., from co-occurring eye movements), and aligning labels precisely with the actual neural events is thus vital in ensuring the validity of the experimental design.

25.3.3 Preprocessing and Artifacts

Raw EEG is susceptible to noise from environmental sources, hardware, and phys­iological processes (see also Chap. 17). Preprocessing aims to attenuate these disturbanc include band-pass ltering to remove slow drifts and high-frequency, notch-ltering or other tools to remove line noise, the removal of bad channels, and re-referencing to the common average. Artifacts from eye blinks and muscle activity, too, can pose
es while preserving neural signals relevant for decoding. Standard steps