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- •Preface
- •Acknowledgments
- •About This Book
- •Contents
- •List of Figures
- •List of Tables
- •Editor and Contributors
- •1.3 EEG and Other Neuroscience Methods
- •1.4 The Future of EEG
- •1.1 EEG Technology: Past to Present
- •1.2 What Do We Know About the EEG Signal?
- •1.5 Conclusions
- •References
- •2.1 Physiological Origins of the EEG
- •2.2 Signals of the EEG
- •2.3 Concluding Summary
- •References
- •3.1 Introduction
- •3.2 General Organization
- •3.3 Finding Your Way Around: Brain Atlases
- •3.3.2 Talairach Atlas and MNI Coordinates
- •3.3.4 Accessing and Using Atlases
- •3.4 Putting into All Together
- •3.5 Conclusion
- •References
- •4.1 Introduction
- •4.2 Overview of the Peripheral Nervous System
- •4.3 Basic Anatomical Unit of the PNS: Ganglia and Nerves
- •4.4 Anatomy of Somatic Nervous System
- •4.4.1 Receptors
- •4.4.1.1 Vision
- •4.4.1.2 Audition
- •4.4.1.3 Vestibular System and Balance
- •4.4.1.4 General Sensory Modalities
- •4.4.2 Somatic Sensory System
- •4.5 Anatomy of the Autonomic Nervous System
- •4.5.1 Sympathetic Nervous System
- •4.5.2 Parasympathetic Nervous System
- •4.6 Cranial Nerves
- •4.7 Function of the PNS and CNS as a Unit
- •4.8 Concluding Remarks
- •References
- •5.1 Introduction
- •5.2 Head Anatomy and Signal Propagation
- •5.3.1 The Eyes and Ocular Potentials
- •5.3.2 Facial Muscles and EMG
- •5.3.3 Sweat Glands and Skin Potentials
- •5.3.4 Blood Vessels and Heartbeat
- •5.4 Conclusion
- •References
- •6.1 Introduction
- •6.2.1 What Is a Brain State?
- •6.2.2 Brain States Measured with EEG
- •6.3 Examples of Brain States
- •6.3.1 Awake State Sleep State
- •6.3.2 Consciousness States: Presence Loss (Anesthesia)
- •6.4 Pathological Brain States
- •6.4.1 Traumatic Brain Injury
- •6.4.2 ADHD
- •6.5 Framework of Brain States
- •6.6 Concluding Summary
- •References
- •7.1 Introduction
- •7.3 Identifying Task Processes Within a Trial Segment
- •7.3.2 Cross-Trial Comparability and Flexible Time-Locking
- •7.4 What Does Activity Look Like on the Timeline?
- •7.5 Conclusion
- •References
- •8.1 Introduction
- •8.2 Setting a Research Question
- •8.3 Setting a Hypothesis
- •8.3.2 Testing the Hypothesis
- •8.4 Design of the Study
- •8.4.1 Contextualization of the Hypothesis
- •8.4.1.1 Experimental Paradigm
- •8.4.1.2 EEG Index
- •8.4.1.3 Group/Sample
- •8.4.2 Implementation of the Study
- •8.4.2.1 Paradigm/Task Implementation
- •8.4.2.2 Measurement Precision
- •8.4.2.3 Experimental Protocol
- •8.4.2.4 Pilot Testing
- •8.5 Concluding Summary
- •References
- •9.1 Introduction
- •9.2 Why Is Statistics Needed in EEG Research?
- •9.3 When Is Statistics Applied During EEG Data Analysis?
- •9.3.1 Raw EEG Data
- •9.3.2 Individual-Level (First-Level) Analysis
- •9.3.3 Group-Level (Second-Level) Analysis
- •9.3.3.1 Statistical Hypotheses
- •9.3.4 Application of Statistical Inference
- •9.3.5 Interpretation and Inference
- •9.4.1 Hypotheses (Upper Plane of Fig. 9.2)
- •9.4.2 Population and Sample Data (Bottom Plane of Fig. 9.2)
- •9.4.3 Sample Statistic (Middle Plane of Fig. 9.2)
- •9.5 Conclusion
- •References
- •10.1.1 Why Pilot Testing Matters
- •10.2 How to Prepare and Run the Pilot Testing
- •10.2.1.1 Signal Quality
- •10.2.1.2 Task Parameters
- •10.2.1.3 Instructions
- •10.2.1.4 Participant Experience
- •10.2.1.5 Equipment Setup
- •10.2.1.6 Procedures
- •10.2.1.7 Questionnaires
- •10.1 What Pilot Testing Is
- •10.3 Concluding Summary
- •References
- •11.1 Introduction
- •11.2 Lab Management
- •11.2.1 Admin and Organisation
- •11.2.2 Hardware and Software Maintenance
- •11.2.3 Lab Logbook
- •11.3 Keep Your Own Lab Notebook
- •11.4.1 Pre-measurement
- •11.4.2 Measurement
- •11.4.3 Post Measurement
- •11.5 Conclusion
- •References
- •12.1 Introduction
- •12.2 Components of the System
- •12.2.1 Detecting the Signal: EEG Electrode Technology
- •12.2.1.1 Passive Electrode Plus Gel
- •12.2.1.2 Active Electrodes Plus Gel
- •12.2.1.3 Passive Electrode and Saline Soaked Sponges
- •12.2.1.4 Dry Electrodes
- •12.2.1.5 Electrode Positions
- •12.2.2 Detecting the Signal: Sensors for Other Measures
- •12.2.2.1 Bipolar Peripheral Electrophysiology
- •12.2.2.2 Peripheral Physiological Sensors
- •12.2.2.3 GSR
- •12.2.2.4 Respiration
- •12.2.2.5 Photoplethysmography (PPG)
- •12.3 Conclusion
- •References
- •13.1 Purpose and Features
- •13.2 Before Starting Your Study
- •13.2.1 General Parameters
- •13.2.2 Special Applications
- •13.2.3 Real-Time Processing
- •13.3 During a Measurement Session
- •13.4 Troubleshooting
- •13.5 Conclusion
- •References
- •14.1 Introduction
- •14.2 Importance of Triggers
- •14.3 Advantages of Triggers
- •14.4 Disadvantages of Triggers
- •14.5 Alternatives to Triggers
- •14.6 Good Practice for Using Triggers
- •14.7.1 Setup
- •14.7.2 Analysis
- •14.7.3 Interpretation
- •14.8 Conclusion
- •References
- •15.1 Introduction
- •15.2 The Idea of Signal-to-Noise Ratio (SNR)
- •15.3 Sources of Artifact
- •15.4 Common Physiological Artifacts
- •15.4.1 Eye Artifacts
- •15.4.2 ECG Artifacts
- •15.4.4 Other Physiological Artifacts
- •15.5 Common Technical Artifacts
- •15.5.1 Technical Artifacts
- •15.5.2 Electrode Artifacts
- •15.5.3 Gel-Related Artifacts
- •15.5.4 Movement Artifacts
- •15.5.5 Body/Head Movements
- •15.5.6 Cable Movement Artifacts
- •15.6 Artifacts in Advanced Applications and Multi-modal Recordings
- •15.6.1 EEG and Functional MRI
- •15.6.2 EEG and Non-invasive Brain Stimulation
- •15.7 Optimizing the EEG Recording Quality
- •15.7.1 Focus on the Cap Preparation
- •15.7.2 Optimize the Recording Environment
- •15.7.3 During the Recording
- •15.7.4 Post Recordings
- •15.8 Conclusion
- •References
- •16.1 Introduction
- •16.2 Lab Infrastructure
- •16.2.1 Signal Quality
- •16.2.2 Control Over the Experimental Environment
- •16.2.4 Safety
- •16.3 Position of the Equipment and Accessories
- •16.4 Lab Procedures
- •16.5.1 Mobile Setups
- •16.5.2 Electrode Types
- •16.5.2.1 Passive Sponge-Based Electrodes
- •16.5.2.3 Dry Electrodes
- •16.5.3 Special Populations
- •16.5.3.1 Children
- •16.6 Concluding Summary
- •References
- •17.1 Introduction
- •17.2 Common Preprocessing Steps: Data Transformation
- •17.2.1 Inspecting Data
- •17.2.2 Changing the Sampling Frequency
- •17.2.3 Re-referencing
- •17.2.4 Interpolating Channels or Data Portions
- •17.2.5 Segmenting Data
- •17.3 Common Preprocessing Steps: Artifact Handling
- •17.3.1 Filtering
- •17.3.2 Attenuating Artifacts
- •17.3.2.1 Independent Component Analysis (ICA)
- •17.3.2.2 Regression Techniques
- •17.3.2.3 Template Subtraction Methods
- •17.3.3 Rejecting Artifacts
- •17.5 Tools for Processing and Analyzing EEG
- •17.6 Concluding Remarks
- •References
- •18.1 Introduction
- •18.2 Characterizing an Oscillatory Process
- •18.2.1 Fundamental Characteristics of an Oscillatory Process
- •18.2.2 From Time to Frequency and Back
- •18.3 Foundation for Spectral Analysis: The Dot Product
- •18.4 Fourier Analysis
- •18.4.1 From Vectors to Sinusoids: The Fourier Connection
- •18.4.2 The Fourier Family
- •18.4.3 Discrete Fourier Transform
- •18.4.4 Power Spectrum
- •Further Readings
- •References
- •19.1 Introduction
- •19.2 How to Get from EEG to ERPs
- •19.2.1 How to Process Your ERP Data
- •19.2.1.1 Pre-processing
- •19.2.1.2 Trial Selection
- •19.2.1.3 Baseline Correction
- •19.2.1.4 Averaging
- •19.2.2 Interpreting ERPs
- •19.2.3 Group Analysis
- •19.2.4 Single-Trial Analysis
- •19.3 Characteristics of the ERP and Its Components
- •19.4 Commonly Investigated ERP Components
- •19.4.1 Early Sensory Components
- •19.4.2 Long-Latency Sensory Components
- •19.4.3 Later Cognitive Components
- •19.4.4 ERP Components in Multimodal Recording Scenarios
- •19.5 Extraction of ERP Features
- •19.6 Conclusion
- •References
- •20.1 Introduction
- •20.2 Fundamentals of EEG Source Imaging
- •20.3 Forward Problem
- •20.4 Source Estimation
- •20.5 Statistical Inference in the Source Space
- •20.6 Source Connectivity
- •20.7 Conclusion
- •References
- •21.1 Introduction
- •21.2 Raw Data Access
- •21.2.1 How to Get Raw Data
- •21.2.2 How to Work with Raw Data Online
- •21.2.3 What Factors to Consider for Online Processing
- •21.3 Designing an Online Processing Experiment, an Example
- •21.4 Conclusion
- •References
- •22.1 Introduction
- •22.1.2 Chapter Overview
- •22.2.2 Exactly What the SME Means
- •22.2.5 Why the Scoring Method Matters
- •22.2.8 Other Potential Uses of the SME
- •22.4 Metrics of Reliability
- •22.5 Final Thoughts
- •References
- •23.1 Cognitive Neuroscience
- •23.1.1 Neuropsychology and EEG
- •23.1.2 Mental Chronometry and EEG
- •23.2 Research on the EEG Signals
- •23.3 Conclusions
- •References
- •24.1 Introduction
- •24.2.1 Clinical Research
- •24.2.2 EEG in Research for Clinical Applications
- •24.2.3 EEG as a Biomarker
- •24.3 Examples of Clinical Applications of EEG
- •24.3.1 Epilepsy
- •24.3.2 Sleep and Sleep Disorders
- •24.3.3 Anesthesia
- •24.4.2 Brain-Computer Interfaces and Movement Disorders
- •24.5 Future of EEG in Clinical Applications
- •24.6 Conclusion
- •References
- •25.1 Introduction
- •25.1.1 Why Connect Brains and Computers?
- •25.1.2 What Is a BCI?
- •25.1.3 Types of BCIs: Active, Reactive, Passive
- •25.1.4 BCIs in Neuroscience and HCI
- •25.2 Signals and Sensors
- •25.2.1 Neural Signals for BCIs
- •25.2.2 Wearable EEG and Form Factors
- •25.3 The BCI Pipeline: From Raw Signals to Decisions
- •25.3.1 Overview
- •25.3.2 Experimental Design and Labeling
- •25.3.3 Preprocessing and Artifacts
- •25.3.4 Feature Extraction
- •25.4 BCI Types Illustrated
- •25.4.1 Motor Imagery as an Active BCI Paradigm
- •25.4.2 P300 and SSVEPs as Reactive BCI Paradigms
- •25.4.3 Workload, Error, and Other Passive BCI Paradigms
- •25.5.1 Mental State Assessment as a First Stage
- •25.5.2 Open- and Closed-Loop Adaptation
- •25.6 Practical Challenges
- •25.6.1 Mobility, Artifacts, and Non-stationarity
- •25.6.2 Cross-User and Cross-Session Generalization
- •25.6.3 Evaluation in Real Settings
- •25.6.4 Ethics, Privacy, and Neurorights
- •25.7 Conclusions and Outlook
- •25.7.1 Key Takeaways
- •25.7.2 Future Trajectories
- •References
- •26.1 Focal Epilepsy
- •26.2 EEG Manifestations of Focal Epilepsy
- •26.2.1 Ictal EEG Patterns
- •26.2.2 Interictal EEG Patterns
- •26.3 Localization of Ictal and Interictal EEG Events
- •26.4 Intracranial EEG in Presurgical Planning
- •26.5 AI in EEG Interpretation
- •26.6 Conclusion
- •References
- •27.1 Introduction
- •27.2 Neonatal EEG Applications
- •27.2.2 Somatosensory States Monitoring in Neonates
- •27.3 Paediatric EEG Applications
- •27.3.1 Sleep Monitoring in Children and Adolescents
- •27.4 Future Directions and Conclusion
- •References
- •28.1 What Is Sleep?
- •28.1.1 Stages of Sleep
- •28.1.2 How Sleep Changes with Age
- •28.2 Measuring Human Sleep
- •28.2.1 The Various Forms of Sleep
- •28.2.2 Unihemispheric Sleep
- •28.3.1 NREM Sleep and Learning
- •28.3.2 REM Sleep and Learning
- •28.4.1 Active Brain Networks During Sleep
- •28.4.2 Measuring the Balance of Excitation and Inhibition in the Human Brain
- •28.4.3 The Cerebrospinal Fluid Dynamics in Human Sleep
- •28.5 Conclusions
- •References
- •29.1 What Is Mobile EEG?
- •29.2 Range of mEEG Systems
- •29.3 Technical Considerations
- •29.4 Validation
- •29.5 Application
- •29.6 Mild Cognitive Impairment
- •29.7 mEEG and Health and Exercise
- •29.8 mEEG in Sports
- •29.9 Conclusions
- •References
- •30.1 Introduction
- •30.2 General Framework and System Overview
- •30.3 Spectrum of Studies
- •30.4 MoBI+ Framework
- •30.5 Processing Multimodal MoBI Data
- •30.6 Challenges and Limitations
- •30.7 Conclusion
- •Appendix
- •List: Traveling with MoBI Equipment
- •References
- •31.1 Introduction
- •31.2 Types of Electric Brain Stimulation
- •31.3 Online Effects
- •31.3.1 Conventional Artifact Removal Strategies
- •31.3.1.1 Transcranial Direct Current Stimulation (tDCS)
- •31.3.1.2 Transcranial Random Noise Stimulation (tRNS)
- •31.3.1.3 Transcranial Alternating Current Stimulation (tACS)
- •31.3.3 Innovative Approaches to Minimize Artifacts
- •31.3.3.1 Non-Sinusoidal Waveforms
- •31.3.3.2 Amplitude-Modulated tACS (AM-tACS)
- •31.3.3.3 Transcranial Temporal Interference Stimulation (tTIS)
- •31.3.3.4 Summary of Advantages and Limitations
- •31.4.1 Spectral Power
- •31.4.2 Phase Locking/Phase Coherence
- •31.4.3 ERPs
- •31.4.4 Further Measures
- •31.5.1 Rationale
- •31.5.2 Procedure
- •31.6 Closed-Loop Systems
- •31.7 Technical Requirements
- •31.8 Conclusion
- •References
- •32.1 Introduction
- •32.2.1 Equipment

24 Clinical Applications 327
24.6 Conclusion
EEG is a versat ile and accessible tool in clinical neuroscience research. It provides a
cost-effective approach for capturing brain dynamics noninvasively in clinical and
emerging home-based contexts. EEG has been well established in clinical applications such as sleep and epilepsy, where distinct EEG characteristics have been
classified and are used for diagnostic or therapeutic outcome evaluations. Wearable
EEG technologies and brain-computer interfaces further provi de potential for clinical applications. Yet, despite the advances in EEG technology and research, challenges remain. Particularly, in psychiatric applications, in which heterogeneity and
methodological inconsistencies limit clinical translation. Further efforts toward
standardized recording and analysis procedures, as well as the integration of EEG
with other neuroimaging techniques, may help to address these challenges and make
the use of EEG more widespread in clinical applications.
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Chapter 25
From Brain Signals to Neuroadaptive
Technology: BCIs for Human-Computer
Interaction
Marius Klug, Diana E. Gherman-Nagy, and Thorsten O. Zander
Abstract This chapter introduces brain-computer interfaces (BCIs) with a focus on
their
role in human-computer interaction and neuroadaptive technology. We first
define BCIs and distinguish active, reactive, and passive systems, emphasizing how
EEG-based BCIs transform neural activity into real-time system behavior. We then
review the main neural signals and sensing modalities used in BCIs, with an
emphasis on wearable EEG and emerging form factors for everyday use. The core
BCI pipeline is outlined from experimental desig n and labeling through
preprocessing, feature extraction, machine learning, and validation, providing
readers with a practical overview of how decoding models are built and assessed.
Using motor imagery, P300/SSVEP, and a range of passive paradigms as examples,
we illustrate how BCIs can decode intention, workload, error perception, vigilance,
and related mental states. Building on this, we describe how passive BCIs enable
neuroadaptive systems, from mental state assessment and open-loop feedback to
closed-loop and autonomous adaptations. Finally, we discuss key practical challenges, including artifacts, non-stationarity, and cross-user generalization, as well as
ethical issues around privacy and neurorights. The chapter concludes by outlining
future trajector ies for BCIs as a core component of human-centered, adaptive AI
systems.
Keywords Brain-computer interface · BCI · Passive BCI · Neuroadaptive systems ·
Human-co
mputer interaction · Mental state decoding
25.1 Introduction
Imagine you are studying for an important exam, scrolling through an online tuto rial
late at night. The material is dense, the examples feel rushed, and you catch yourself
rereading the same paragraph without taking in a word. Your eyes stay on the page,
M. Klug (*) · D. E. Gherman-Nagy · T. O. Zander
Neuroadaptive Human-Computer Interaction, Brandenburg University of Technology CottbusSenftenberg, Cottbus, Germany
e-mail:
marius.klug@b-tu.de
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2026
T.
Warbrick (ed.), The EEG Handbook,
https://doi.org/10.1007/978-3-032-20450-9_25
331

332 M. Klug et al.
your mouse hardly moves, yet inside your head, workload and fatigue are rising, and
your attention is drifting.
As you continue, the layout on the screen qu ietly changes. The video pauses and
is replaced by a short multiple-choice quiz that checks a single key concept. The pace
slows, and a brief recap appears in the margin. A few minutes later, after you answer
confidently and your brain activity settles back into a lower workload pattern, the
system resumes the normal speed and hides the extra scaffolding. You never told it
you were confused. You never clicked a “help” button. The adaptation was triggered
by a small EEG headset resting behind your ear that continuously tracks your mental
state.
What makes this possible is a passive brain-computer interface: a system that
does
not wait for explicit commands but instead monitors ongoing brain activity to
infer states such as effort, fatigue, and engagement. In this chapter, you will get an
overview of how BCIs work, from EEG acquisition through the full processing
pipeline, with a special focus on passive BCIs and how they can be integrated into
everyday technology to create interfaces that respond not only to what you do, but
also to how you think and feel while you are doing it.
25.1.1 Why Connect Brains and Computers?
When humans interact with machines, systems usually infer goals and internal states
from behavior: button presses, cursor movements, speech, or gaze patterns. These
cues are useful but indirect and often arrive only after critical decisions have been
made. Brain-computer interfaces (BCIs) add a complementary information channel
by decoding neural activity itself. In clinical settings, BCIs can restore communication and basic control to people with severe motor impairm ents by translating brain
signals into selections or movements (Farwell & Donchin,
2002). Beyond rehabilitation, BCIs can reveal workload, attention, or error percep-
tion
during ongoing interaction (Parasuraman & Rizzo, 2007; Zander & Kothe,
2011), enabling adaptive systems that respond not only to what users do, but also
to
how they currently think and feel.
1988; Wolpaw et al.,
25.1.2 What Is a BCI?
A brain-computer interface is a system that measures neural activity, extracts
informative features, and translates them into outputs that influence an external
device or software process (Wolpaw & Wolpaw,
acquis
ition, processing, decoding, and system action—distinguishes BCIs from
general neuroimaging, where brain signals are recorded for analysis rather than
real-time interaction. BCIs can rely on various modalities, but EEG remains the
dominant choice because it is safe, portable, inexpensive, and capable of
2012). This canonical loop—

25 From Brain Signals to Neuroadaptive Technology: BCIs for Human-Computer... 333
millisecond-level temporal resolution (Mehta & Parasuraman, 2013). In a BCI, the
defining property is the real-time transformation of actual brain activity into meaningful system behavior.
25.1.3 Types of BCIs: Active, Reactive, Passive
A widely used taxonomy distinguishes BCIs by the origin and purpose of the neural
activity they decode (Zander & Kothe, 2011). Active BCIs rely on intentionally
generated brain signals that are independent of external stimulati on. Users deliberately modulate neural activity to convey commands, as in motor imagery
(MI) systems where imagined hand movements control cursors or prostheses
(Daly & Wolpaw,
re substantial training, and are most commonl y used in clinical settings.
requi
Reactive BCIs decode brain responses that are elicited by external stimuli. Here,
the
control signal is tied to events in the environment but still shaped by the user’s
attention. Classic examples include P300-based spellers, where rare or attended
items evoke a characteri stic potent ial (Farw ell & Donchin, 1988), and steady-state
systems
in
stimulus-locked responses.
contr
load, engagement, fatigue, or error perception (Zander & Kothe, 2011). Rather than
repla
by adding implicit information about user state, enabling systems to adapt to them
continuously during complex tasks.
that use frequency-tagged flickering targets (Norcia et al., 2015). Users
fluence the interface by focusing attention on specific stimuli, producing reliable,
Passive BCIs (pBCIs) interpret neural activity that arises without intentional
ol. They infer naturally occurring cognitive and affective states such as work-
cing explicit input, passive BCIs augment human-computer interaction (HCI)
2008). These interfaces emphasize volitional control, often
25.1.4 BCIs in Neuroscience and HCI
BCIs occupy a dual position in research and application. In neuroscience, they
enable real-time access to cognitive processes during naturalistic behavior,
supporting studies that investigate perception, prediction, and action outside controlled laboratory settings (Gramann et al.,
tant
in this context because many states relevant for interaction—such as workload,
attention, or prediction errors—manifest differently in realistic environments. Studying these states during movement, navigation, or immersive tasks increases ecological validity and reveals how neural dynamics behave under conditions that more
closely resemble everyday interaction. This also aligns BCI research with the
broader shift in HCI toward examining users in real-world contexts rather than
exclusively in seated, constrained setups.
2011). Mobile EEG is especially impor-

334 M. Klug et al.
Within HCI, BCIs contribute to user modeling by providing direct markers of
internal states that are difficult to infer from behavior alone, allowing interfaces to
respond to cognitive or affective changes as they occur (Schmidt,
2001). The focus on passive BCIs follows natur ally from this intersection. Because
e BCIs decode spontaneously occurring neural activity without requiring
passiv
intentional control, they add an implicit information channel that complements
traditional input modalities (Zander & Kothe,
time
brain state decoding (RBSD) enables systems to detect elevated workload,
lapses of attention, or perceived errors and adapt accordingly, supporting applications in driving, aviation, and learning technologies. Passive BCIs thus form a
foundation for neuroadapti ve systems that adjust their behavior to suppor t performance, maintain safety, or personalize user experience (Krol et al.,
to supply continuous, fine-grained information about the user’s internal state
ability
positions them as a central component in future adaptive HCI and human–AI
systems.
2011; Zander et al., 2014). Real-
2000; Fischer,
2018b). Their
25.2 Signals and Sensors
25.2.1 Neural Signals for BCIs
BCIs rely on neural signals that differ in temporal resolution, spatial specificity, and
practicality for real-time decoding. Electrophysiological methods such as EEG (see
also Chap.
tials
makin
shifts, or oscillatory markers of workload (Mehta & Parasuraman, 2013). Their
spatial
of EEG—make them the backbone of most BCI systems. Hemodynamic methods
such as fNIRS and fMRI instead indirectly measure activity by blood-oxygenation
changes and thus offer better spatial localization at the cost of several-second delays.
These slower dynamics restrict real-time use to gradual cognitive states rather than
fast perceptual or decision-related events. As a result, electrophysiology is favored
when BCIs must operate continuously and respond within behaviorally relevant
timescales.
Outside of restorative research, such as speech reconstruction (Willett et al.,
2023), EEG is particularly prevalent in BCI research because it strikes a practical
balanc
tively inexpensive, portable, and compatible with mobile or immersive setups,
enabling studies and applications beyond traditional laboratory environments.
EEG also offers the high temporal resolution that is essential for decoding fast
neural phenomena in real time. At the same time, EEG data suffer from low signalto-noise ratio, sensitivity to artifacts, and limited spatial precision due to volume
conduction. These constraints require careful preprocessing and feature extraction,
2) and MEG measure voltage changes generated by postsynaptic poten-
and capture neural dynamics on the millisecond scale (Biasiucci et al., 2019),
g them suitable for detect ing rapid processes like error responses, attention
resolution is limited, but their speed and portability—especially in the case
e between safety, usability, and information content. EEG systems are rela-

25 From Brain Signals to Neuroadaptive Technology: BCIs for Human-Computer... 335
and they shape which mental states can be decoded reliably. Despite these limitations, EEG remains the most versatile modality for BCIs because it supports rapid,
continuous, and minimally intrusive monitoring of brain activity in real-world
contexts.
EEG signals relevant for BCIs fall broadly into two categories: event-related
responses and ongoing oscillatory activity. Event-related potentials (ERPs) are timelocked amplitude deflections in the EEG that occur in response to discrete sensory,
cognitive, or action-related events (see also Chap.
ture
allows precise identification of components such as the P300, error-related
negativity, or fixation-related potentials, each reflecting specific stages of information processing (Farwell & Donchin,
Voytek, 2022). ERPs form the basis of many reactive BCIs because they offer
reliable
fluctuations in synchronized neural activity, typically quantified through power in
frequency bands such as theta, alpha, beta, or gamma (see also Chap.
these
ery, or vigilance (Klimesch, 1999; Gevins & Smith, 2003; Gherman et al., 2025).
Together
BCI design.
markers tied to stimulus timing. Oscillatory rhythms reflect continuous
rhythms index sustained processes including workload, attention, motor imag-
, ERPs and oscillations constitute the primary signal families exploited in
1988; Falkenstein et al., 2000; Donoghue &
19). Their temporo-spatial struc-
18). Changes in
25.2.2 Wearable EEG and Form Factors
EEG systems vary widely in how electrodes make contact with the scalp, how
portable they are, and how well they balance signal quality with user comfort.
Gel-based caps provide the highest signal quality and remain the standard in
research and clinical environments, but they require time-consuming preparation
and restrict mobility. Dry electrodes reduce setup time and improve comfort,
enabling faster deployment in applied settings, though they often trade off signalto-noise ratio and can be more sensitive to motion artifacts (Zander et al.,
Semi-dry
quality and setup time, but require saline solution to be re-applied over time.
stable recordings suitable for long-term use and emerging everyday BCI applications
(Debener et al.,
Interaxon Muse, further emphasize ease of use and accessibility, integrating lightweight materials and wireless transmission. They can still be used to detect oscillations, as well as limited event-related responses (Krigolson et al., 2017),
lower channel counts and variable fit limit the complexity of signals that can be
decoded reliably (R atti et al.,
such
displays, supporting BCIs in extended reality scenarios while introducing new
constraints related to weight, ergonomics, and mechanical coupling during movement. These diverse form factors reflect ongoing efforts to reconcile signal fidelity
with practicality and user comfort.
solutions refer to saline sponge electrodes that have an intermediate signal
Ear-EEG syst
as the OpenBCI Galea, combines neural sensing with immersive head-mounted
ems position electrodes in or around the ear canal, offering discrete,
2015; Mirkovic et al., 2016). Consumer headsets, such as the
2017). Finally, Virtual Reality (VR)-integrated EEG,
2017).
but their

336 M. Klug et al.
25.3 The BCI Pipeline: From Raw Signals to Decisions
25.3.1 Overvie w
A BCI transforms neural activity into meaningful system outputs through a series of
coordinated stages. The pipeline begins with experimental design, where tasks and
labeling strategies determine what neural phenomena can be decoded. Data acquisition and preprocessing follow, addressing arti facts and preparing the signals for
reliable analysis. Feature extraction converts continuous EEG into informative
representations, which are then passed to machine learning models that learn mappings between neural activity and target states. Finally, trained models are validated
and deployed in real time for online interaction.
25.3.2 Experimental Design and Labeling
The structure of a BCI experiment determines the information available for decoding
and the quality of the labels used for training. Event-based paradigms rely on welldefined, time-locked events such as the presentation of images and sounds, system
errors, or fixation onsets. These designs allow the precise stimulus-locked segmentation of EEG and thus enable the subsequent decoding of ERPs. In contrast,
continuous-state elicitation involves tasks that manipulate cognitive variables over
longer periods, such as workload, vigilance, or affect. Here, labels often reflect
gradual changes, derived from task difficulty, behavioral markers, or continuous
ratings.
Regardless of the paradigm type, having properly labeled data is critical. Noisy
labels
from ambiguous or imprecise instructions or temporal jitter in the apparatus
can erode classifier performance severely and make a proper interpretation of the
results impossible. Ensuring a well-defined mental stat e elicitation, minimizing
confounds (e.g., from co-occurring eye movements), and aligning labels precisely
with the actual neural events is thus vital in ensuring the validity of the experimental
design.
25.3.3 Preprocessing and Artifacts
Raw EEG is susceptible to noise from environmental sources, hardware, and physiological processes (see also Chap. 17). Preprocessing aims to attenuate these
disturbanc
include band-pass filtering to remove slow drifts and high-frequency, notch-filtering
or other tools to remove line noise, the removal of bad channels, and re-referencing
to the common average. Artifacts from eye blinks and muscle activity, too, can pose
es while preserving neural signals relevant for decoding. Standard steps
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