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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3715_Библиотеки_им_академика_М_И_Перельмана
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8 Imaging Studies andHaemodynamics inChronic Constrictive Pericarditis
In this study, extensive pericardial calcication were present in 5 (41.7%)
patients, spreading over the anterior and inferior surfaces of ventricles. Despite
extensive calcication, total pericardiectomy could be achieved in all patients of the
study group. However these patients required higher inotropic support in the immediate postoperative period to tide over low cardiac output syndrome. This may be
explained by underlying myocardial damage or atrophy, secondary to long standing
encasement and penetration of the myocardium by calcium spurs, and persistent
inammation. In addition, other investigators have suggested possibility of residual
constriction, brous invasion of the myocardium and myocardial altercation leading
to abnormal ventricular compliance.
The utility of speckle tracking echocardiography and tissue Doppler imaging in
identifying residual constrictive pericarditis needs investigation on larger population and should be correlated with clinical outcomes [204]. In chronic constrictive
pericarditis, the epicardial dysfunction leads to depressed global circumferential
strain and left ventricular torsion (LVT), whereas global longitudinal strain and
global radial strain are preserved (Figs.8.10, 8.11, 8.12, and 8.13).
Studies assessing the extent of myocardial damage with two-dimensional speckle
tracking echocardiography in constrictive pericarditis are limited. In a study by
Sengupta and associates, longitudinal, radial, and circumferential mechanics of the
left ventricle were quantied by two-dimensional speckle tracking echocardiography on 26 patients with constrictive pericarditis and 19 patients with restrictive
Fig. 8.10 Two-dimensional speckle echocardiography showing global longitudinal strain (GLS
pattern)– Preoperative

8.2 Echocardiography
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Fig. 8.11 Two-dimensional speckle echocardiography showing global circumferential strain
(GCS pattern)– Postoperative
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Fig. 8.12 Two-dimensional speckle echocardiography showing global longitudinal strain (GLS
pattern)– Postoperative

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Fig. 8.13 Two-Dimensional speckle echocardiography showing global radial strain (GRS
pattern)– Postoperative
8 Imaging Studies andHaemodynamics inChronic Constrictive Pericarditis
cardiomyopathy. Compared to controls, individuals with constrictive pericarditis
had impaired left ventricle circumferential strain (ε) (base; −16± 6 vs −9± 6%;
p<0.01) [194–196, 202]. Amaki and associates validated the usefulness of twodimensional speckle tracking echocardiography and cardiac magnetic resonance
imaging on 30 patients with restrictive cardiomyopathy and 28 patients with constrictive pericarditis [3].
8.3 Computed Tomography
In addition to cardiac structures, computed tomography and magnetic resonance
imaging allows examination of the entire mediastinum and lungs. Computed tomography and magnetic resonance images provide excellent anatomic delineation, and
are superior to echocardiography in evaluation of pericardial calcication, localized
pericardial effusion, pericardial mass, and asymmetric pericardial thickening [8,
18–25, 161, 164, 165, 167, 180, 234, 235].
Both computed tomography and magnetic resonance imaging are not operator
dependent like echocardiography. Multidetector computed tomography enables
motion-free pericardial imaging as well as multiplanar visualization of any pericardial disease. Computed tomographic attenuation measurements may provide tissue

8.3 Computed Tomography
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characterization of some pericardial masses. Cardiac computed tomography has
good spatial and temporal resolution, a wide eld of view, and multiplanar reconstruction abilities.
The limitations of computed tomography include the use of intravenously administered iodinated contrast agents, ionizing radiations, and cardiac motion artifacts in
non-ECG gated computed tomographic scans.
Although expert consensus guidelines on the diagnosis and management of pericardial diseases have been published, the role of multimodality imaging has not
been clearly dened [118]. Clinically, routine application of these guidelines can be
difcult because (a) exposure to iodinated contrast agent or ionizing radiation, (b)
non-gated computed tomography possibly limiting the evaluation of the pericardium because of motion artifacts, (c) questionable cost effectiveness, and d) imaging that can be challenging in patients with arrhythmia or poor breath holders and in
patients with unstable hemodynamics.
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8.3.1 Pericardial Structural Evaluation
The normal pericardium on computed tomography ranges between 0.7 mm and
3mm; the ability to measure accurately is dependent on reconstructed slide thickness. Computed tomography is highly accurate in estimating the thickness of the
pericardium and dening the distribution of thickening [54, 72, 73, 85–92, 188].
The normal pericardium is identied as a curvilinear line of soft tissue density,
whereas in chronic constrictive pericarditis the parietal pericardium may be
4–30mm thick. Although cardiac computed tomography is not a rst-line investigation in patients with suspected constrictive pericarditis, it is useful in conrmation
of diagnosis and preoperative planning for pericardiectomy including redo cases
[85]. Pericardial thickness of 4 mm or more indicates abnormal thickening and,
when accompanied by clinical ndings of congestive cardiac failure, is highly suggestive of chronic constrictive pericarditis [234, 235]. The distribution of pericardial
thickening may be asymmetric located over the right heart or over the atrioventricular groove [19, 22–24].
Multidetector computed tomography offers additional information including
location of cardiac and vascular structures relative to midline retro-sternum as well
as associated aortic atherosclerosis, if any. In addition to features of pericardial
disease, computerized tomographic scans of the chest may show typical mediastinal
lymphadenopathy (i.e. enlargement >10mm with matting and hypodense centres)
in almost 100% of cases in the acute phase that resolve on treatment [29]. In patients
with abnormal symptoms, there may be ndings suggestive of diagnosis of constrictive pericarditis with an abdominal computed tomography [80–83].
However, there exists a cohort of patients with constrictive physiology and normally appearing pericardium on imaging studies [214]. Despite normal thickness,
these patients exhibit histologic evidence of inammation and calcication; there

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8 Imaging Studies andHaemodynamics inChronic Constrictive Pericarditis
are distorted ventricular contours on magnetic resonance imaging. This subset of
patients constituted 18% of patients with chronic constrictive pericarditis in the
Mayo Clinic Series [214].
The incidence of pericardial calcication in tubercular chronic constrictive pericarditis in the published literature ranges from 5% to 76% [18–25, 30, 31, 58, 59,
62, 91, 114, 163–165]. Several investigators have demonstrated that pericardial cal-
cication is predominantly located over the right atrium, right ventricle, diaphragmatic surface and atrioventricular grooves [18–25, 30, 31, 58, 59, 62, 91, 114,
163–165]. Fluid displaced by the vigorous contraction of the left ventricle during
resorption of the primary pericardial effusion preferentially gravitates toward the
right side of the heart. The inspissated uid over the right side forms the base for
dystrophic calcication including bone formation in some cases. The apex and anterior wall of the left ventricle is often spared [163, 186]. Failure to visualize the
posterolateral wall of the left ventricle on dynamic computed tomography suggests
myocardial brosis or atrophy and is associated with poor surgical outcome
[163, 186].
Since pericardial constriction can occur in patients with histologically normal
pericardial thickness, other ancillary ndings need documentation, including biatrial
enlargement, dilatation of the inferior caval vein, pleural effusions, and distorted
ventricular contours (Figs.8.14, 8.15, 8.16, 8.17, 8.18, 8.19, 8.20, 8.21, 8.22, 8.23,
8.24, 8.25, 8.26, 8.27, 8.28).
a
b c
Fig. 8.14 Short axis non-contrast CT images (a and b) show presence of near circumferential
pericardial calcication (arrowheads). Volume rendered image (c) of CT angiography depicts
extensive pericardial calcication extending from the atrioventricular groove over the ventricular
surfaces. (LA- Left atrium, LV-Left ventricle, MPA-Main pulmonary artery, RV-Right ventricle)

b
8.3 Computed Tomography
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111
a
Fig. 8.15 Four chamber image (a) and volume rendered image (b) of CT angiography shows
pericardial calcication (arrowhead) with a thick calcic spur inltrating into the left ventricular
myocardium (large black arrow). (LA- Left atrium, LV-Left ventricle, MPA-Main pulmonary
artery, RA-Right atrium, RV-Right ventricle)
b
a
c
Fig. 8.16 Sagittal (a) and axial (b) images show presence of thick sheet-like pericardial calcication (arrowhead) along the diaphragmatic surface of the heart. Volume rendered image (c) viewed
from below shows the sheet-like pericardial calcication (asterisk) along the diaphragmatic surface of the heart. (DTA-Descending thoracic aorta, IVC-Inferior caval vein, LA- Left atrium,
LV-Left ventricle, RA-Right atrium, RV-Right ventricle)

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8 Imaging Studies andHaemodynamics inChronic Constrictive Pericarditis
a
Fig. 8.17 Axial (a) and four-chamber image (b) shows patchy pericardial calcication (arrowhead) anterior to right ventricular outow tract and in the region of atrioventricular groove. Volume
rendered images (c and d) show the patchy pericardial calcication (asterisk). (LA- Left atrium,
LV-Left ventricle, RA-Right atrium, RV-Right ventricle)
c
8.3.2 Cardiac Magnetic Resonance Imaging inChronic
Constrictive Pericarditis
Cardiac magnetic resonance is a second-line imaging modality for both structural
and haemodynamic evaluation in chronic constrictive pericarditis [4–6, 85, 97, 100,
167, 215, 218, 235]. Cardiac magnetic resonance has high spatiotemporal resolu-
tion; it enables excellent anatomic delineation of the pericardium and also effectively characterizes features of constrictive,physiology [5, 6, 45, 46, 56, 69–75, 98,
99, 155, 156, 164, 165, 167, 215, 216, 218, 234, 235] Its unrestricted imaging eld

8.3 Computed Tomography
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113
a
Fig. 8.18 Short axis image (a) and volume rendered image (b) viewed from below shows a pericardial collection (asterisk) with patchy calcication of both the parietal (white arrowheads) and
visceral pericardium (black arrowheads). (LA- Left atrium, LV-Left ventricle, RA-Right atrium,
RV-Right ventricle)
Fig. 8.19 Four-chambered
gated computed
tomographic image
showing thickened,
calcied pericardium
(shown by arrow) along the
anterior right ventricular
wall, biatrial enlargement
and tubular right and left
ventricles. (LA- Left
atrium, LV-Left ventricle,
RA-Right atrium,
RV-Right ventricle)
b
enables assessment of mediastinal lymphadenopathy (enlargement >10mm), pericardial inammation, associated myocardial involvement, if any, and associated
haemodynamic effects on the cardiac chambers. It has superior tissue contrast and
spatial resolution compared with echocardiography [119, 235]. These characteristics are useful in evaluation of the pericardium, for tissue characterization,

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8 Imaging Studies andHaemodynamics inChronic Constrictive Pericarditis
a
c
b
d
Fig. 8.20 Non-contrast CT images– Axial (a) and coronal (b) showing pericardial thickening and
calcication (white arrows); and post-contrast images– four– chamber image (c) showing tubular
conguration of both ventricles and biatrial dilation, coronal imaging (d) showing dilated superior
and inferior caval veins and hepatic veins (Black arrows)
assessment of inammation, and delineation of the extent of spread of pericardial
masses. Although computed tomography may provide better spatial resolution, and
detects pericardial calcication accurately, cardiac magnetic resonance avoids the
need for iodinated contrast agents, ionizing radiation, or additional image processing.
However, cardiac magnetic resonance cannot be performed in patients with
claustrophobia, in presence of contraindications to magnetic resonance imaging
such as patients with devices or cardiac implants, metallic coils, severe renal dysfunction, and in haemodynamically unstable patients [11–15].
(a) Introduction to various imaging sequences
A standard MRI protocol used at All India Institute of Medical Sciences, New
Delhi, for pericardial imaging is shown in Table8.1. The procedure takes around
30–40minutes; sequences can be added or removed depending on the requirement
and patient’s clinical condition e.g. presence of arrhythmia, and breath-holding
capacity.

8.3 Computed Tomography
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a
b
c
de
Fig. 8.21 Four-chamber images (a–c: T1, T2 and LGE respectively)-showing thickened and
enhancing pericardium predominantly along right atrium and ventricle, tubular conguration of
both ventricles and biatrial dilation; (d) dilated inferior caval vein and hepatic veins; (e) necrotic
mediastinal lymph nodes
a
d
Fig. 8.22 Frontal chest radiograph (a) shows plaque-like calcication along the diaphragmatic
(white arrowhead) and left border (black arrowhead) areas of the heart. Note is made of right pleural effusion. Four-chamber (b), two-chamber (c) and short axis (d) reconstructions of CT angiography and volume rendered images (e and f) show extensive pericardial calcication along the
diaphragmatic surface and free walls of both ventricles. Note is made of biatrial dilation and tubular ventricles. (LA- Left atrium, LV-Left ventricle, RA-Right atrium, RV-Right ventricle)
b
e
c
f
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