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12 Decision-Making on the Timings of Pericardiectomy, Selection of the Optimal…
little hemodynamic sequence in the great majority of patients undergoing pericar­dial resection.
Additionally, it is literally an impossible task to excise the portion of pericardium posterior to the phrenic nerves through median sternotomy without utilizing cardio­pulmonary bypass [5, 1423, 30, 35, 6062, 77, 7981, 100].
In a South African study as 113 patients undergoing pericardiectomy for tuber­cular chronic constrictive pericarditis, 97% were discharged from hospital. Although hepatomegaly and pedal oedema quickly resolved in the great majority of patients, regression of ascites and venous congestion occurred over 2–3months [33].
At author’s institute, in a study on 395 patients undergoing pericardiectomy being followed-up for 17.9±0.3years, 96.3% of pericardiectomy survivors of the sternotomy group and 79.1% of survivors of the thoracotomy group were in func­tional class I/II (p<0.001). The time taken for normalization of hemodynamics and improved functional classes I and II in the sternotomy and thoracotomy groups was 34±12 and 70±22days respectively (p<0.001).
Diastolic lling characteristics remained abnormal in 15.9% (n= 54) patients undergoing total pericardiectomy and 61.4% (n=35) patients undergoing partial pericardiectomy (p<0.001) in the immediate postoperative period. At the time of reporting, 3.7% (n= 11) of sternotomy survivors and 20.9% (n=9) of the thora­cotomy survivors exhibited persistent abnormal diastolic lling pattern on Doppler echocardiogram (p=0.004) [19].
Despite total pericardiectomy, the perioperative mortality was 7.6% in our series and 6–19% in several large series published after 1985; the reported incidence of low cardiac output syndrome ranges from 50% to 69% [4, 5, 1227, 5053, 60, 62,
80, 100].
In order to further decrease the perioperative mortality rates of 7.6% and postop­erative low cardiac output syndrome, the author proceeded to perform several tech­nical modications of the conventional left anterolateral thoracotomy to achieve radical excision of the pericardium posterior to the phrenic nerve and diaphragmatic pericardium and published the preliminary experience with step-by-step surgical illustrations on 25 patients in Operative Techniques in Thoracic and Cardiovascular Surgery [26].
The surgical approach for pericardiectomy, although mostly based on surgeon’s preference, median sternotomy was the preferred approach in the following subset of patients:
(i) atrioventricular annular constrictive pericarditis, (ii) “cocoon” pericardial calcication encompassing all cardiac chambers, (iii) calcic pericardial patch compressing the right atrium and right ventricular
outow tract, (iv) extracardiac intrapericardial mass mostly comprising of caseous material, (v) presence of a 2 mm or greater gradient in the superior or inferior cavoatrial
junctions, (vi) constrictive pericarditis following open heart surgery, (vii) postradiation constrictive pericarditis, and
12.2 Criteria for Decision-Making on the Indications and Timings for Pericardiectomy…
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(viii) recurrent constrictive pericarditis following partial pericardiectomy.
Median sternotomy was preferred for the above clinical circumstances for improved surgical exposure without compromising the hemodynamics, and easy institution of cardiopulmonary bypass in the event of inadvertent surgical injury and bleeding [1927].
Till 2020, a series of 127 consecutive patients underwent total pericardiectomy via modied left anterolateral thoracotomy without utilizing cardiopulmonary bypass (UKC’s modication) at the author’s institution [27]. By employing these modications, the author succeeded to reduce the perioperative mortality from
7.6% (previous series) to 3.1% (present series), and postoperative low cardiac out­put syndrome from 69% (previous series) to 24.4% (present series) [27]. Our over­all perioperative mortality is 3.1%, which is in accordance with the 6% to 19% perioperative mortality rate of large series published after 1985 [1, 2, 4, 5, 1527,
50, 52, 5860, 6264, 67, 69, 79, 8284, 109]. At a mean follow-up of
97.3±50.8months, 93.4% (n=113) were in functional class I/II and 6.6% (n=8) were in functional class III.The time taken to achieve normal hemodynamics and improved functional class was 39± 10days. Although hepatomegaly and ascites resolved promptly in the majority of patients, overall venous body congestion improved over a period of 30–40days in some patients [27].
The timing of pericardiectomy in patients diagnosed with chronic constrictive pericarditis remains ill dened. Based on the evidence enunciated above and in the published literature, we conclude that the natural course of constrictive pericarditis is permanent and often progressive in the majority unless the constriction is surgi­cally relieved. It is indeed difcult to ascertain the degree of myocardial involve­ment in a case of constrictive pericarditis. Analysis of the published literature substantiate poor results of pericardiectomy in patients dominant myocardial involvement and superior results with dominant constrictive element which is reli­ably assessed by cardiac magnetic resonance imaging and speckle tracking echocar­diography [1927, 109].
Following successful pericardiectomy in patients with mixed constrictive restric­tive disease, there may not be improvement of symptoms due to impaired myocar­dial compliance [1, 2, 4, 5, 1527, 50, 52, 5860, 6264, 67, 69, 71, 79, 8284,
109]. Although limited evidence-based data are available, an useful guideline is: the
more signicant inspiratory ow variations noted on Doppler echocardiography and cardiac catheterization, the more likelihood of the presence of a dominant constric­tive element and the better is the surgical result.
Since the degree of enhanced ventricular interaction is proportional to the sever­ity of pericardial restraint, it is indeed important to ascertain the relationship between the right and left ventricular pressure curves to determine the degree of predominant pericardial or myocardial involvement of the disease process. In gen­eral, patients with constrictive pericarditis with a greater degree of ventricular dis­cordance during respiratory cycles, benet maximum from pericardiectomy [1927].
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12 Decision-Making on the Timings of Pericardiectomy, Selection of the Optimal…
Conversely, some patients have a mild degree of ventricular discordance; the rise of the diastolic pressure is disproportionate to the discordance. In these patients, the major pathophysiological process is an abnormal myocardial compliance. These patients exhibit persistent signs and symptoms of right heart failure despite pericar­diectomy [69, 70]. The presence of advanced disease with myocardial involvement, signs of severe congestive cardiac failure and hepatorenal involvement have been identied as an incremental risk factors for death [1927].
Analysis of the published literature substantiates that early pericardiectomy appears benecial in patients with right atrial pressure between 12 to 15mmHg, early signs of hepatorenal dysfunction, and massive ascites [8, 19, 24, 27, 33, 72,
8793]. Thus, patients with markers of prolonged chronic constriction e.g. cachexia,
higher right atrial pressure, hepatorenal dysfunction, signs of progressive systemic congestion like massive pleural effusion and ascites, a lesser degree of ventricular discordance during respiratory cycle, brocalcic involvement of the myocardium on cardiac magnetic resonance are suitable candidates for urgent pericardial exci­sion [68, 1927, 50, 57, 85, 8792].
It has been further demonstrated that patients with ‘end-stage’ constrictive peri­carditis derive little or no benet from pericardiectomy. Literature documents higher operative risk in patients undergoing pericardiectomy for advanced calcic con­strictive pericarditis [3133, 37, 54, 55, 73]. Despite high operative risk, the survival rate of patients with chronic constrictive pericarditis following pericardiectomy is higher in this group than without surgery [35, 8, 11, 12, 31, 32, 42, 5053, 57, 66,
74, 8792, 100]. The indicators of end-stage constrictive pericarditis include car-
diac cachexia, reduced cardiac output (CI <1.2 LPM/m2), hepatic dysfunction due to congestive hepatomegaly or cardiogenic cirrhosis, hypoalbuminemia due to protein- losing enteropathy and liver cirrhosis [1927].
Patients with cardiac tamponade or a large pericardial effusion as echocardio­gram, usually undergo initial echo guided percutaneous pericardiocentesis using a pigtail catheter. Early pericardiectomy may be desirable if pericardiocentesis fails to drain loculated effusions, in cases of recurrent effusions, or if echocardiographic/ integrated imaging studies are suggestive of effusive-constrictive disease or early constrictive pericarditis after 4 to 6weeks of anti-tubercular drug therapy [42, 57,
74, 87, 93, 95, 96, 102104].
The therapeutic strategy in patients with tuberculous non-calcic constrictive pericarditis involves a trial of anti-tubercular medication for 6–8weeks and referral for pericardiectomy for patients with no improvement or worsening clinical signs and symptoms of pericardial constriction with supportive structural and haemody­namic criteria [8, 19, 24, 27, 33, 72, 8793].
Calcic constrictive pericarditis whenever detected is, however, an absolute indi­cation of pericardiectomy. Calcic pericardium signies late presentation with myocardial brosis. Calcied spicules may penetrate the myocardium, causing left ventricular dysfunction that may preclude surgical options [40]. However, we have been able to remove the calcic spurs in all patients undergoing pericardiectomy for calcic constrictive pericarditis in our institution [19, 23, 24, 26, 27].
12.3 Should Cardiopulmonary Bypass Be Used Routinely while Performing…
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12.3 Should Cardiopulmonary Bypass BeUsed Routinely
while Performing Pericardiectomy?
Published literature including our observations does not provide any conclusive answer. Although it is easy to perform pericardiectomy for effusive-constrictive and pyogenic pericarditis, it may indeed be difcult in cases of calcic and post­irradiation constrictive pericarditis. The latter group of patents may not tolerate car­diac manipulation, while excising the pericardium.
Studies in which cardiopulmonary bypass was associated with higher periopera­tive mortality including the Stanford series reects an advanced disease process in whom cardiopulmonary bypass was required [1113]. Thus, one should not be reluctant to use cardiopulmonary bypass, if required, to facilitate complete pericar­dial excision, since it improves long-term patient outcomes. Additionally, cardio­pulmonary bypass allows one to ultraltrate some ascitic uid and tissue uids from the third space. Thus, employment of cardiopulmonary bypass may prevent auto­transfusion following pericardial resection, a concept thus far not well appreciated and well-explored [5, 1927, 3436, 50, 52, 57, 59, 74, 100].
Cardiopulmonary bypass empties the cardiac chambers, thereby denes exact dissection plane and facilitates management of inadvertent injury to cardiac cham­bers and great vessels. Tokuda and associates in the Japan Adult Cardiovascular Surgery Database observed cardiopulmonary bypass as an incremental risk factor of a worse outcome [100]. Cox regression analysis of the database indicated that employment of cardiopulmonary bypass was not a surrogate of the severity of dis­ease process but that the use of cardiopulmonary bypass itself was an incremental risk factor for adverse outcome. Database analysis further demonstrated that use of cardiopulmonary bypass was associated with bleeding and other bypass related complications [101]. The Japanese study further observed that an increased inci­dence of reoperation for perioperative bleeding and an ICU stay exceeding 8days among patients undergoing pericardiectomy using cardiopulmonary bypass than those without cardiopulmonary bypass [100].
While performing pericardiectomy via left anterolateral thoracotomy, it is essen­tial to prepare the left groin for emergent institution of cardiopulmonary bypass, if deemed necessary. It is equally important to assess the respiratory function, and exclude the presence of signicant right-sided pleural effusion preoperatively due to the positional negative effect of thoracotomy [9].
Based on the available evidence in the literature, we conclude that cardiopulmo­nary bypass is useful in performing pericardiectomy in the following circumstances: (i) inadvertent intraoperative injury to the cardiac chambers and great vessels, (ii) constriction after previous open heart surgery, (iii) post irradiation constrictive peri­carditis, (iv) recurrent constrictive pericarditis following partial pericardiectomy, (v) calcied pericardial “Cocoon” compressing the cardiac chambers and great ves­sels, and (vi) co-existing cardiac lesion requiring open heart surgery [1927]. In addition, cardiopulmonary bypass facilitates ultraltration of ascitic uids, thus pre­venting autotransfusion and postoperative cardiac distension.
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12 Decision-Making on the Timings of Pericardiectomy, Selection of the Optimal…
Cardiac transplantation with constrictive pericarditis generally presents with symptoms and signs of right-sided cardiac failure, with peripheral oedema and asci­tes mimicking cardiac rejection and restrictive cardiomyopathy. An integration of clinical picture and multimodality imaging studies including M and Doppler echo­cardiography, cardiac computed tomography, cardiac magnetic resonance imaging, invasive cardiac catheterization is essential to establish an early diagnosis of post­transplant constrictive pericarditis. For early diagnosis, nuclear magnetic resonance is the best imaging technique to document pericardial thickening, mediastinal hematoma, and right atrial/right ventricular compression. A subxiphoid pericardio­stomy for pericardial effusion followed by total pericardiectomy is treatment of choice for these patients [10, 11, 28, 4446, 49, 56, 105, 106].
The European society of Cardiology, American Heart Association, and Japanese Cardiovascular Society acknowledges the role of medical management in a subset of patients with constrictive pericarditis [3, 42, 49, 57, 65, 71, 72, 106]. However, analysis of the published literature suggests timely institution of total pericardiec­tomy with epicardial decortication is essential for superior short- and long-term outcomes [1827].
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