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25 Considerations in the Elderly
399
a
b
“bird’s beak”
a preoperative colonoscopy should be performed since a dis­tal obstructing lesion may precipitate volvulus. Additionally, colonoscopy may allow for transient detorsion of the volvu­lized segment.
Key Concept : The incidence of colonic pseudo - obstruction is
increased in the elderly and may complicate the postopera­tive course of elective or urgent orthopedic procedures . However , the need for surgical intervention should be rare with appropriate management .
When the diagnosis of Ogilvie’s syndrome is suspected, initial management is aimed at correcting all metabolic dis­turbances and discontinuation of narcotic use. Distal mechanical obstruction MUST be ruled out. This is best accomplished by colonoscopy that can be both diagnostic and therapeutic in terms of colonic decompression. Other approaches are Gastrografi n enema or as third-line option, CT scan (Fig. 25.6 ). Once mechanical obstruction is ruled out, several highly effective options exist. The most com­monly used one is a peripherally acting acetylcholinester­ase inhibitor such as neostigmine. Intravenous administration must be performed in a monitored setting
because of the arrhythmogenic risk, but resolution of the pseudo- obstruction is usually immediate and dramatic. If this option isn’t available or deemed too high a risk, then a spinal anesthetic and the resulting sympathetic blockade is almost as effective. Operative intervention is almost never needed.
Key Concept : Unlike other patient cohorts , there is often a
signifi cant rate of associated cognitive , family , and psycho­social issues that may complicate the management of elderly patients and must be taken into consideration prior to pro­ceeding with care .
When considering any surgical intervention in the elderly, consideration must be given to the issues of informed con­sent. Concomitant with the elderly is a signifi cant rate of associated cognitive and psychosocial issues that complicate the issue of informed consent. It is important to determine the competency of the elderly patient in the setting of poten­tially life-altering and high-risk surgery. Issues such as the ability of an elderly person to care for themselves after sur­gery and the potential ramifi cations of a signifi cant period of postoperative debilitation must be taken into account. Ultimately, the physician’s responsibility is to inform the
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J.I.S. Bleier and R.D. Fry
decompression and large proximal dilation
Yet, age is still a consideration when determining therapeu­tic options in other scenarios. With respect to colonoscopic screening guidelines, in the 1995 version of the US Preventive Services Task Force (USPSTF) recommendations in the Guide to Clinical Preventive Services, second edition, screening was recommended for all adults age 50 or older. Interestingly, at that time, screening modalities included primarily fecal occult blood testing (FOBT) and fl exible sigmoidoscopy. There was insuffi cient evidence to recommend for or against routine colonoscopic screening at that time. In the 2002 update to the USPSTSF recommendations, the recommendations for screening all adults above age 50 were reaffi rmed, but now with colonoscopy as a primary screening modality [
17 ]. By
2008, and now the most current version, the USPSTF “recom­mends against routine screening for colorectal cancer in adults 76–85 years of age.” However, a caveat is given that colorectal cancer screening is supported in individual cases, usually based on a past history of colonic polyps or cancer, or a strong family history [ 17 ]. However, in people above 85 years of age, no screening is recommended. The recommendation for screening in higher-risk individuals, those with a family his­tory or personal history of polyps or cancer, or infl ammatory disease are varied and beyond the scope of this chapter. In general, there is no formal recommendation for screening after age 85 in any circumstance or if the patient is believed to have less than a 10-year life expectancy [ 18 , 19 ].
competent patient of the various options and advocate for what is in the patient’s best interest. However, the competent elderly adult has the right to choose, even if the choice may be against the recommendation of the surgeon. Whenever possible, the surgeon should make sure the patient’s family or signifi cant supporters are involved whenever there is a question of competence or the signifi cant likelihood of dis­ability in the postoperative period.
Key Concept : Recommendations regarding traditional screening modalities in the elderly may not apply .
Historically, surgeons assumed a strong “parental” role in decision making for their patients, serving a caretaker role. Traditionally, age alone was considered as a signifi cant fac­tor in the decision-making process. With the advent of newer, less morbid surgical techniques, advances in the effective­ness of critical care management, and with increasing life span, we have shifted away for this “age-ist” perspective. Chronologic age is no longer considered in isolation; rather, physiologic age and functional capacity are the signifi cant determinants in surgical management.
Key Concept : Minimally invasive approaches to colorectal
surgery have resulted in a paradigm shift in the management of patients and expectations , as well as improved outcomes .
It has been well established that laparoscopic approaches to benign abdominal disease result in decreased pain, shorter hospital stays, and improved cosmesis. In its use for colon cancer, we know that oncologic outcomes are equivalent. As such, laparoscopy has been established as fi rst-line treat­ment, in general, in the absence of other contraindications. The defi nition of what a contraindication to laparoscopic sur­gery has undergone evolution, with signifi cant comorbidity, obesity, and prior operations being absolute contraindica­tions. Ironically, as our experience has grown, and we have seen the advantages of the minimally invasive approach, these original contraindications have now become primary indications for the MIS approach and can accentuate the advantages of laparoscopy. The use of laparoscopy in the elderly is no exception; multiple studies have validated the specifi c benefi t of laparoscopy in this group. Frasson et al. looked a cohort of 535 patients undergoing elective laparoscopic or open colorectal surgery, 37.6 % of whom were over 70 years of age. A laparoscopic approach in the elderly group reduced the rate of postoperative morbidity
25 Considerations in the Elderly
401
a
b
(20.2 vs. 37.5 %) as well as length of stay (LOS) (9.5 vs. 13 days). When compared to the younger cohort, these advan­tages were more pronounced in the elderly [ 20 ]. Stocchi et al. reported on 42 elderly patients undergoing laparoscopic colorectal surgery versus a case-matched set undergoing open colectomy. The laparoscopy group was associated with decreased postoperative morbidity, faster return of bowel function, decreased length of stay, and less pain [ 21 ]. The literature is replete with such studies, with the overall con­clusion that laparoscopy is not only safe in the elderly but most likely associated with the same benefi ts enjoyed by the younger patients [ 22 ]. One important point you should remember, however, is that due to the frailty in older patients’ skin and loss of subcutaneous fat, additional padding should be placed over bony prominences (Fig. 25.7a, b ).
Management of the elderly patient with colorectal problems can be complex and may affect every aspect of your care: from diagnosis, informed consent, and considerations of cure versus function to the methods of operative technique and pre- and post-op surveillance. It is your job as a surgeon to do try to do what is best for your patients, treating them as individuals rather than as diagnoses. You must use our expe­rience and judgment to inform your elderly patients and help them make the best decision possible, hopefully with the input of their loved ones and caretakers. Remember, in the
modern surgical practice, chronologic age alone no longer is an absolute factor, rather you must determine the patient’s physiologic age, which is really a proxy for their fi tness for surgery. Maximizing successful and compassionate out­comes is an exercise in both technique and wisdom.
1. Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL,
Fleischmann KE, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: execu­tive summary: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol. 2007;50(17):1707–32.
2. American College of Cardiology/American Heart Association Task
Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery), American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the
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2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Anesth Analg. 2008;106(3):685–712.
3. American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, et al. 2009 ACCF/AHA focused update on perioperative beta blockade incorporated into the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery. J Am Coll Cardiol. 2009;54(22):e13–118.
4. Causey MW, Maykel JA, Hatch Q, Miller S, Steele SR. Identifying risk factors for renal failure and myocardial infarction following colorectal surgery. J Surg Res. 2011;170(1):32–7.
5. Laurberg S, Swash M. Effects of aging on the anorectal sphincters and their innervation. Dis Colon Rectum. 1989;32(9):737–42.
6. Fox JC, Fletcher JG, Zinsmeister AR, Seide B, Riederer SJ, Bharucha AE. Effect of aging on anorectal and pelvic fl oor func­tions in females. Dis Colon Rectum. 2006;49(11):1726–35.
7. Shah BJ, Chokhavatia S, Rose S. Fecal incontinence in the elderly: FAQ. Am J Gastroenterol. 2012;107(11):1635–46.
8. Mellgren A, Wexner SD, Coller JA, Devroede G, Lerew DR, Madoff RD, et al. Long-term effi cacy and safety of sacral nerve stimulation for fecal incontinence. Dis Colon Rectum. 2011; 54(9):1065–75.
9. Hinchey EJ, Schaal PG, Richards GK. Treatment of perforated diverticular disease of the colon. Adv Surg. 1978;12:85–109.
10. Eglinton T, Nguyen T, Raniga S, Dixon L, Dobbs B, Frizelle FA. Patterns of recurrence in patients with acute diverticulitis. Br J Surg. 2010;97(6):952–7.
11. Modini C, Romagnoli F, De Milito R, Romeo V, Petroni R, La Torre F, et al. Octogenarians: an increasing challenge for acute care and colorectal surgeons. An outcomes analysis of emergency colorectal surgery in the elderly. Colorectal Dis. 2012;14(6): e312–8.
12. Mamidanna R, Eid-Arimoku L, Almoudaris AM, Burns EM, Bottle A, Aylin P, et al. Poor 1-year survival in elderly patients undergoing
nonelective colorectal resection. Dis Colon Rectum. 2012;55(7): 788–96.
13. Birnbaum EH, Myerson RJ, Fry RD, Kodner IJ, Fleshman JW. Chronic effects of pelvic radiation therapy on anorectal function. Dis Colon Rectum. 1994;37(9):909–15.
14. Tsai BM, Finne CO, Nordenstam JF, Christoforidis D, Madoff RD, Mellgren A. Transanal endoscopic microsurgery resection of rectal tumors: outcomes and recommendations. Dis Colon Rectum. 2010;53(1):16–23.
15. Habr-Gama A, Perez RO, Sao Juliao GP, Proscurshim I, Gama­Rodrigues J. Nonoperative approaches to rectal cancer: a critical evaluation. Semin Radiat Oncol. 2011;21(3):234–9.
16. Garcia-Aguilar J, Shi Q, Thomas Jr CR, Chan E, Cataldo P, Marcet J, et al. A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trial. Ann Surg Oncol. 2012;19(2):384–91.
17. U.S. Preventive Services Task Force. Screening for colorectal can­cer: recommendation and rationale. Ann Intern Med. 2002;137(2): 129–31.
18. Lieberman DA, Rex DK, Winawer SJ, Giardiello FM, Johnson DA, Levin TR. Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2012;143(3): 844–57.
19. U.S. Preventive Services Task Force. Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation state­ment. Ann Intern Med. 2008;149(9):627–37.
20. Frasson M, Braga M, Vignali A, Zuliani W, Di Carlo V. Benefi ts of laparoscopic colorectal resection are more pronounced in elderly patients. Dis Colon Rectum. 2008;51(3):296–300.
21. Stocchi L, Nelson H, Young-Fadok TM, Larson DR, Ilstrup DM. Safety and advantages of laparoscopic vs. open colectomy in the elderly: matched-control study. Dis Colon Rectum. 2000;43(3): 326–32.
22. Mutch MG. Laparoscopic colectomy in the elderly: when is too old? Clin Colon Rectal Surg. 2006;19(1):33–9.

The Morbidly Obese Patient

Jonathan E. Efron and H. David Vargas
2 6
Key Points
• Obesity-related issues in surgery extend well beyond the operating room—prepare well ahead and have a plan for each phase.
• While BMI is helpful for stratifying patients, there are multiple ways to measure obesity.
• Even “easy” laparoscopic cases in the morbidly obese present technical challenges.
• Recognize the impact that obesity has on individual colorectal procedures and how you will approach them.

Introduction

Key concept : Obesity is quickly emerging as one of the larg­est healthcare issues facing all surgeons .
The obesity epidemic represents one of the greatest healthcare challenges of our generation. Obesity in America is now adding an astounding $190 billion to the annual national healthcare price tag, exceeding smoking as public health enemy number one when it comes to cost [ 1 ]. These patients comprise approximately one-third of our surgical practice requiring operative intervention for colorectal disease. Unfortunately in many cases, we still fail to grasp the extent of its reach. For example, obesity
J. E. Efron , MD (*) Ravitch Division, Department of Surgery , Johns Hopkins University , 1800 Orleans St , Baltimore , MD 21287 , USA e-mail: jefron1@jhmi.edu
H. D. Vargas , MD Department of Colon and Rectal Surgery , Ochsner Clinic Foundation , 1514 Jefferson Highway , New Orleans , LA 70121 , USA e-mail: dvargas@ochsner.org
has not only been linked to the complications occurring in colorectal surgery but also has been shown to be a risk fac­tor for colorectal cancer [ 2 ]. Furthermore, the novice sur- geon may underestimate the complexity of the obese patient by simply focusing on the technical challenges imposed by physical characteristics. In contrast, the more mature and experienced surgeon hopefully will identify the increased risk posed by the comorbid conditions often associated with obesity, the ramifi cations for perioperative decision-making, and the impact on clinical outcomes. This chapter attempts to explore these issues and identify rational strategies for enhancing perioperative care and outcomes.
D e fi ning Obesity and Limitations of BMI
Key concept : Understand the utility as well as the limitations of BMI as it pertains to various categories of patients .
Many defi nitions exist for obesity. These include abso­lute weight, anthropometric measures, and, the most com­monly used defi nition, the body mass index (BMI), which is a calculation based on weight and height. Currently, patients are considered obese if their BMI is greater than 30 and morbidly obese with a BMI greater than 40. While BMI serves as a useful snapshot to stratify patients, and correlate with estimated risk, it does not always give the complete picture. Body mass index as a metric alone possesses inher­ent limitations based on differences in adipose distribution, muscle mass, and differences across races and gender. For example, weight lifters and body builders have increased muscle mass and weight with little body fat; yet, calcula­tions of BMI may classify such individuals as obese. With aging, loss of mean muscle mass and increases in adipose will render BMI inaccurate. Furthermore, racial disparities exist with BMI, as best exemplifi ed in Asian Pacifi c races where BMI again fails to account for decreased lean muscle mass.
S.R. Steele et al. (eds.), Complexities in Colorectal Surgery, DOI 10.1007/978-1-4614-9022-7_26, © Springer Science+Business Media New York 2014
403
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J.E. Efron and H.D. Vargas

Abdominal Obesity: Not All Obesity Is the Same

Key concept : Central obesity is more problematic as it relates to overall health than other types of obesity .
Central adipose distribution has been described by several different names—“abdominal obesity,” “mesenteric obesity,” “male pattern,” or “android obesity.” What is becoming appar­ent is that this central distribution best predicts comorbid con­ditions associated with obesity such as the metabolic syndrome. This syndrome is hallmarked by a cluster of condi­tions (not all need to be present depending on the defi nition) that include hypertension, hypertriglyceridemia, hyperglyce­mia (i.e., insulin resistance), hypercholesterolemia, microal­buminuria, and central obesity. Risk factors for metabolic syndrome include stress, obesity, endocrine disorders, seden­tary lifestyle, older age, and select mental health and rheuma­tological disorders (i.e., schizophrenia, psoriasis). The syndrome, for which central obesity is a key component, increases the overall risk of cardiovascular morbidity and dia­betes, though the clinical utility has been debated. Most important to colorectal surgeons, abdominal obesity may bet­ter determine the relative risk for postoperative morbidity.
From a technical standpoint, experienced surgeons often use the “eyeball test” and can subjectively distinguish the potential differences in degrees of diffi culty when compar­ing a normal-sized patient with a morbidly obese one. If that is the case, then what is the ideal index for defi ning obesity? Anthropometric measurements such as waist circumference or waist-to-height ratios often represent a more pragmatic and clinically relevant method of defi ning obesity. There are, however, challenges in the task of consistently measuring abdominal girth. Furthermore, for surgeons, what is on the outside may or may not accurately refl ect what is on the inside. CT scan imaging provides a novel alternative to mea­sure adipose tissue. In fact, several authors have identifi ed CT as a useful method to defi ne mesenteric or central obesity and correlate it with outcomes and morbidity [ 3 , 4 ].
This is not to say that BMI does not have value. Most of the current literature certainly relies primarily on this stan­dard defi nition. Clearly, at a minimum this serves as a “screening” measure stratifying patients. However, how we defi ne obesity and our tendency to focus on the “morbidly obese” underestimates the true challenge facing surgeons. Consider, for example, gender differences. A female with distribution of adipose primarily in the hips, buttocks, and thighs may, in fact, be easier to perform an abdominal opera­tion than a male whose adipose is located primarily abdomi­nally, even though her absolute BMI is higher. As a result, you must be cautious to avoid relying too heavily on BMI as a potential predictor of postoperative outcomes. Rather, choose to “screen” with BMI initially, and then identify spe­cifi c distribution characteristics of the individual (i.e., fat distribution) when considering implications for surgery.

Preoperative Evaluation

Key concept : Identifying and managing the associated the medical morbidities commonly associated with obese patients helps prevent intraoperative and postoperative complications .
One of the fi rst things to recognize is that obesity never occurs alone, and nearly every organ system can be affected. One or more comorbid medical conditions, including type 2 diabetes, coronary artery diseases, hypertension, joint prob­lems, pulmonary issues, and stroke, are nearly always present or may manifest under stress [ 5 ]. Therefore, it is extremely important you take the time ahead of the operation to per­form a thorough evaluation to deal with these in the elective setting (if possible). For those who present emergently, the degree of urgency will take precedence, but you can still institute preventative measures by identifying the scale of your patient’s issues.
While Chap. 2 of this textbook provides a more compre- hensive risk assessment for all patients, it is worth highlight­ing a few things as it pertains to the obese population. As with any patient, initial work-up includes a general history and physical examination. Your goals should be to both identify how to manage the disease you are presented with and also implement an appropriate time line. A perforated obstructing cancer requires immediate intervention, but identifying that the patient has pulmonary issues, underlying cardiac disease, or adrenal insuffi ciency may alter the way you manage them perioperatively. For elective operations, a standardized approach through a preoperative evaluation clinic is a mean­ingful method of assessing all high-risk surgical candidates. Obese, and particularly morbidly obese, patients should always be considered higher risk and evaluated through a standardized setting when possible [ 6 ]. Preoperative educa- tion and counseling helps to defi ne goals of postoperative outcomes and expectations to minimize complications. In this arena you can discuss several things that may arise that are more common in obese patients. For example, it is imper­ative to inform the obese patient that they have a higher likeli­hood of needing to open the wound for a wound infection and will need to pack the wound postoperatively. For those with pulmonary issues, you should discuss the increased chance of needing to stay intubated for longer cases or the need for pro­longed DVT chemoprophylaxis—even after discharge. It is also an opportunity to ensure that you have special wheel­chairs, beds, and trapeze available to help your get out of bed, ambulate, and move around the hospital.
Systems-Based Evaluation and Prevention Tips
Pulmonary : Preoperative pulmonary evaluation should include an assessment of undiagnosed obstructive sleep apnea, for which the risk factor most closely associated is
26 The Morbidly Obese Patient
405
obesity [ 7 ]. Identifying these patients preoperatively is essential so that adequate postoperative management of the patient for the fi rst 24 h is achieved. This postoperative care includes oxygenation monitoring and the use of continuous positive airway pressure (CPAP) management when sleep­ing or in the recovery unit, if required. While incentive spi­rometry and early ambulation are needed in all patients, it is critical in the obese, as atelectasis, pneumonia, and mucus plugging are all more common.
Cardiac : A thorough assessment of the obese patient’s overall cardiac function is also mandatory. Hypertensive status, myocardial function, angina, and infarction history are some of the important factors to address. Diagnosing hypertension is based on the patient having elevated read­ings at two or more offi ce visits and requires the patient to be seated for approximately 5 min with their feet on the ground. Remember, an appropriately sized arm cuff must be used, more applicable when measuring the pressure in an obese individual. A general physical examination is recom­mended for any operative candidate, but care should be taken in the obese to identify a nodular thyroid, identify a heart murmur or click, and listen for wheezing or rales on pulmonary examination. Look for signs of peripheral edema, venous stasis, or vascular insuffi ciency. These are all indications of congestive heart failure or poorly con­trolled cardiac function and require a more thorough cardiac examination.
When identifi ed, hypertension requires correction prior to surgery with a goal of reaching a pressure less than 140/90 mmHg and even lower in those with concomitant renal disease or diabetes [
8 ]. This goal may be achieved
through lifestyle modifi cations or pharmacotherapy. Often there is no time to employ lifestyle modifi cations, but if pos­sible, smoking cessation, weight loss, dietary changes, and increased physical exercise are all encouraged. In general, single drug therapy should be started and titrated; however, when the patient’s pressure exceeds 160/100 mmHg, then combined drug therapy (typically utilizing a thiazide diuretic) is recommended [ 8 ]. When required, the patient’s primary medical physician best manages initiation or manipulation of these medications.
Obesity and cardiovascular disease go hand in hand. The Framingham Heart Study identifi ed obesity as an independent risk factor for sudden death, congestive heart failure, and coronary disease [ 9 ]. Central obesity, more commonly found in men, carries the highest cardiac risk in the obese population and carries the risk of the aforemen­tioned metabolic syndrome [ 10 ]. The American College of Cardiology, in conjunction with the American Heart Association, has published specifi c guidelines on the pre­operative cardiac evaluation of obese patients [ 11 ]. These are summarized in Table 26.1 and should be employed when planning elective surgery on an obese individual. If patients fall into the intermediate or high-risk category
Table 26.1 Preoperative risk stratifi cation [ 10 ]
1. Identify those with active cardiac conditions/comorbidities suggestive of high risk and take steps to correct these conditions prior to elective surgery. They include:
Stable or unstable angina Decompensated heart failure Recent MI (within 6 months) Decompensated heart failure Signifi cant arrhythmia Severe valvular disease (specifi cally aortic or mitral stenosis)
2. Determine the severity of the surgery (inherent risk of the procedure)
Low risk (<1 %) Endoscopic Superfi cial Intermediate risk (1–5 %) Peritoneal Thoracic Orthopedic High risk (>5 %) Major vascular Cytoreduction and HIPEC Select pelvic cases
3. For those undergoing intermediate- or high-risk surgery, proceed with assessment of their functional capacity:
Assessment of metabolic equivalents (METs): based on treadmill
test or patients ability to ambulate 4 blocks or two fl ights of stairs without symptoms.
(a) >4 METs = those with adequate functional capacity as seen
on treadmill or asymptomatic may proceed with surgery
(b) For all others requiring further work-up (< 4METs): see
2 on perioperative risk assessment
Chap.
with respect to their cardiac risk, and are undergoing a laparotomy, further evaluation by a cardiologist is recommended.
Thromboembolic Disease : Obesity is also an indepen­dent risk factor for increasing the risk of deep vein thrombo­sis (DVT) or pulmonary embolism (PE) in patients undergoing abdominal surgery [ 12 ]. Many colorectal disor- ders such as cancer and infl ammatory bowel disease also increase the risk of thromboembolic disease and are inde­pendent risk factors that are additive to an obese patient’s risk of having a thromboembolic complications with colorectal surgery. Therefore, preoperative administration of subcutaneous heparin with the use of sequential stockings as per SCIP and ASCRS guidelines is highly recommended [ 13 ]. Care must be taken to ensure appropriate timing of the heparin and also of the adequate dose. Obese patients may require a higher dose of unfractionated heparin, depending on their weight. A Cochrane review comparing various strategies for preventing DVTs in colorectal surgery demon­strated no difference in outcomes when low molecular weight heparin was compared to unfractionated heparin; however, the addition of compression stockings to heparin
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J.E. Efron and H.D. Vargas
appeared to provide greater protection from DVTs [ 14 ]. Currently, we recommend pneumatic compression stock­ings with an appropriate dose of unfractionated heparin pre­operatively, during the hospital stay, and in some patients (i.e., prior DVT or excessive BMI), postoperatively for up to 30 days. Postoperative prophylaxis after discharge is contro­versial, but several large reviews have demonstrated a sig­nifi cant reduction in the incidence of DVTs and PE in those treated after discharge [
Diabetes : Diabetes is an independent risk factor predict- ing postoperative morbidity [ 17 ]. While hemoglobin A1c levels provide a global assessment of a patient’s overall glu­cose control, as it provides an indicator of the extent of hyperglycemia that has occurred during the life of a red blood cell (120 days), the perioperative stress may make even borderline insulin- resistant patients problematic to control. To facilitate adequate glucose control on the day of surgery, diabetic patients should be scheduled in the morn­ing and the use half of their daily dose of insulin that morn­ing. The patient also requires intraoperative monitoring and in some cases constant glucose monitoring with initiation of an insulin drip is required. Inadequate intraoperative glu­cose control (even in nondiabetics) has been shown to be associated with increased wound infections, operative re­interventions, and death [ 18 ]. However, correction of this proper insulin therapy lowers this risk to that of patients with normal blood glucose and is an important quality metric.
15 , 16 ].

Laparoscopic Colectomy in the Obese Patient

Key concept : Even the straightforward laparoscopic cases in the obese patient present technical challenges that you need to prepare for and well versed with the technical nuisances to overcome them .
Laparoscopic colectomy offers improved postoperative outcomes compared to open in essentially every patient population, and this in no different in the obese patient. However, application of this technique in an obese patient clearly should be considered one of the most technically challenging laparoscopic operations, even for experienced surgeons. There are numerous reasons why this is diffi cult. Increased adipose of the retroperitoneum, mesentery, and omentum reduces peritoneal space and diminishes the “doming effect” of pneumoperitoneum, thus compromising video-scopic perspective. Additionally, mesenteric fat increases the volume of small bowel and mesentery to be retracted for exposure, while the overall thickness of the mesentery and its foreshortening makes vessel identifi ca­tion and division challenging. The omentum also poses a specifi c challenge for retraction due to its greater volume,
weight, and adhesions. Unfortunately, the instrumentation that we use often adds to the complexity. The long thin min­iature shaft and narrow end effectors used for grasping and dissection prove mechanically disadvantaged when attempt­ing to manipulate the increased volume and weight of organs involved. Lastly, the use of gravity as the additional retractor in laparoscopic surgery poses signifi cant issues in the morbidly obese. In order to adequately expose the oper­ative fi eld, extremes of body positioning with steep Trendelenburg and “reverse T” along with lateral tilt are needed. In reality, some of these are nearly impossible with the extremes of weight and poses hazards to peripheral nerves and even dislodgement of the patient (Fig. 26.1 ). Not surprisingly, the initial reports of laparoscopic colectomy often cited severe obesity as a relative contraindication to this technique.
As in any other operation, preparation for a laparoscopic colectomy in the obese patient remains paramount. First, you must mentally prepare and comprehend that these cases possess unique challenges that increase in complexity as BMI increases. Also, you must be realistic by consider­ing your own laparoscopic experience and where you are on the learning curve. Identifying a complex operation involves consideration of patient characteristics such as obesity, severity of pathologic condition, urgency, prior abdominal operations, and type of colectomy planned. Conversion serves as a surrogate marker for the degree of technical diffi culty of a procedure but also may be a marker for good judgment on your part. In a study of nearly 1,000 laparoscopic colectomies, the authors identifi ed surgeon experience, left-sided resection, fi stula and abscess, and obesity as risk factors for conversion. Furthermore, there is an exponentially greater risk of conversion (vs. simply cumulative) when multiple factors are present. For exam­ple, an obese patient requiring sigmoidectomy for divertic­ulitis complicated by colovesical fi stula will be a daunting task for any surgeon but especially for the surgeon with limited laparoscopic experience. This is not to say that you should not attempt a diagnostic laparoscopy, proceed with initial dissection, and perform the operation laparoscopi­cally to the extent you feel safe and comfortable. This is often a great objective, at any point along your learning curve. One effective strategy is to set a time limit and deter­mine ahead of time that if you are not making progress by the end that you will convert. Another operative approach in the patient described above or other complicated left­sided resections is to focus on the splenic fl exure and colon mobilization. After that is performed, the fi stula and resec­tion can be approached through a low midline or Pfannenstiel incision under direct vision. Remember, a splenic fl exure takedown in a morbidly obese patient with a heavy, thick body wall that has to be retracted in the open setting is not easy either.
26 The Morbidly Obese Patient
Fig. 26.1 Positioning a patient with massive obesity (BMI 80) for laparoscopic surgery (Courtesy of Justin A. Maykel, MD)
407
Lesion Localization
Key concept : Have a plan and backup plan in place with obese patients to ensure the proper identifi cation of the pathology and corresponding boundaries of resection .
As highlighted above, scheduling the case early in the day, budgeting appropriate operative time, and ensuring you have adequate surgical assistance and technical support will reduce the burden of these complex cases. A clear operative plan must also be in order. It may seem intuitive, but the fi rst specifi c task is the proper identifi cation of the colonic pathol­ogy requiring resection. You have likely already heard the basics—check your CT, review the scope report, and tattoo the site of the pathology. However, in the obese patient it is not always that simple. Identifying a serosal tattoo can be a challenge, as a large omentum, enlarged appendices epiplo­ica, and abundant retroperitoneal and mesenteric fat often obscure the mark. By now you recognize that any lesion described as being in the region of the hepatic fl exure and proximal to the rectum should be expected to be particularly concerning in this regard. To preoperatively localize the lesion for operative planning, we place an endoscopic clip (Fig. 26.2 ) at the lesion as a backup plan (especially in obese patients) and perform plain radiography for segment local­ization. Alternatively, the metallic clip can be identifi ed on CT. Admittedly, overlapping segments of colon, especially with a fl oppy transverse colon, could occur on plain radiog­raphy, although this has yet to have occurred in our experi­ence. One helpful tip is that if the KUB is performed
immediately after colonoscopy, the residual gas in the bowel provides a well-delineated outline of distinct bowel seg­ments effectively and easier identifi cation of the metallic clip. This enables you to go to the operating room with con­fi dence in a clear operative plan.
This simple maneuver may allow you to position the patient supine for a right colectomy and avoid lithotomy positioning and the potential risks of DVT and peripheral nerve injury. Remember, positioning is a major component of operating on the morbidly obese, something we will address shortly. If nothing else, you can avoid searching for the tattoo prior to initiating dissection and mobilization, potentially reducing operative time. This is not to say we avoid a tattoo. Rather, the clip serves as a backup, and tattoo identifi cation provides the ultimate intraoperative confi rma­tion; therefore, we still fi nd the tattoo of benefi t. This also obviates the need for on-table colonoscopy to localize the lesion—another often discussed, but in practice, time­consuming and more diffi cult maneuver.
We routinely ask our institution’s gastroenterologists to perform both a three-quadrant tattoo and endoscopic clip for lesions in the vicinity of the transverse colon, either fl exure, or the descending colon. The difference in diffi culty of a splenic fl exure resection as opposed to sigmoid colectomy cannot be overstated in normal-sized patients. When you are dealing with the morbidly obese, this becomes magnifi ed. Mid- or distal transverse colon lesions may be approached as an extended right colectomy versus variations of a left colec­tomy. Descending colon lesions pose similar challenges in
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J.E. Efron and H.D. Vargas
Fig. 26.2 Endoscopic photo of metal clip, useful to radiologically localize the polyp or tumor
terms of the extent of resection. Should you perform an extended left colectomy and potentially require consider­ation of transverse colon to rectal anastomosis? An ileal mes­enteric window may be necessary to facilitate tension-free anastomosis, especially given the foreshortening of a thick mesentery in an obese patient. Another alternative to reach the pelvis with the mid-transverse colon is to fully mobilize the right colon and turn the right colon mesentery counter­clockwise into the pelvis as a straight line. How often have you done that and what is the orientation of the right colon you are going use to bring down to avoid twisting or cutting off blood supply? These are often things we bring up on boards or in conference, but many of you may have never seen or tried these technical steps. The benefi t of being able to think through this decision process prior to going to the operating room cannot be overstated. Thus, in the obese patient who already poses signifi cant technical diffi culties, being able to anticipate such operative decision-making prior to surgery enhances surgical performance.
The Value of Your Assistant
Key concept : Approaching your more complex cases in the obese patient with someone not facile in laparoscopic sur­gery , using the camera , or providing adequate exposure is a setup for failure from the beginning .
A standard laparoscopic resection in the obese patient will
require a skilled surgical assistance. If you are at an institu-
tion with senior surgical residents or colorectal/minimally invasive fellows available, such an issue may not be ger­mane. However, in a private institution, another attending or highly experienced surgical assistant should be present. Certainly, the feasibility of laparoscopic colectomy in the obese patient has been demonstrated. Delaney and col­leagues compared laparoscopic colectomy in an obese cohort compared to a matched control group and found a similar length of stay and no increase in overall complications. However, not unexpectedly, they did show an increased operative time and higher conversion to open rate in the obese cohort [
19 ]. Leroy and associates also reported on
laparoscopic sigmoid colectomy in the obese patient where they described their consecutive series of 29 patients without conversion [ 20 ]. Utilizing a 5- or 6-port technique with excellent results, however, more pointedly illustrates the need for a team approach, with multiple skilled assistants, to achieve technical profi ciency.
Patient Setup, Port Placement, and Exposure
Key concept : Your setup is the initial key to your success in the OR . While you may still struggle , problems at this stage will almost assuredly make things much more diffi cult .
By now you realize that the extremes of rotation allow you to maximize gravity’s effect for providing exposure in laparoscopic colectomy (Fig. 26.3 ). This is much more dif- fi cult in the morbidly obese patient. The fi rst step you need to focus on is properly positioning, padding, and securing the patient to the operating room table. Depending on your table, once your patient’s weight approaches over 400 lb, you must ensure that the table meets the requirements for supporting them. To secure the patient, there are several systems avail­able and different surgeons have their own preferences; yet all focus on avoiding slipping and causing any traction or pressure-related injury. We prefer to use 3-in. wide silk tape over a barrier towel across the patient’s chest wrapped three times around the table. Others describe using beanbags, foam securing systems, IV bags at the shoulders (not recom­mended), arm sleds, and gel pads on the operating room table. Some even secure the bed sheet to the lowered foot of the bed. While it is important for you to fi nd what works for you, consider this word of caution if you are a beanbag user. Because we rely on a fulcrum of downward movement of your graspers to raise the colon (especially with a medial approach), having your beanbag infl ated high up on the patient’s side will cause you to hit the beanbag and lose this ability. Curling it slightly back or avoiding this tight “high­riding cocoon” will avoid this common mistake. We also recommend a “dry run” before prepping and draping by hav­ing anesthesia put the patient in all 4 extremes of position and ensuring the patient is adequately secured. That way,