Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_890_Библиотеки_им_академика_М_И_Перельмана.pdf
Скачиваний:
0
Добавлен:
31.08.2026
Размер:
33 Мб
Скачать
18 The Failed Anastomosis
293
Proximal diversion has improved mortality (15 % vs. 37 %) compared to anastomotic takedown and end colostomy (Hartmann’s) [
132 ]. Patients with proximal diversion are
more likely to have their stomas reversed (100 % vs. 57 %) and with decreased morbidity (17.6 % vs. 71 % ) compared to Hartmann’s [
132 ]. Proximal diversion can improve anas-
tomotic healing and allow for the use of other interventions needed to repair the anastomosis [
133 , 134 ]. Local drainage
alone without diversion risks prolonged pelvic sepsis causing fi brosis of the neorectum resulting in very poor function [ 135 ].
Diversion, Resection, and Revision
Key Concept : Unstable patients or those with low rectal anastomoses have better early and future outcomes if the anastomosis is left alone and only diversion and drainage is performed .
During the laparotomy, high-volume lavage with warm fl uid and drainage of the infected material is the basis for suc­cessful infectious source control. In addition the surgeon can perform proximal diversion, anastomotic revision with or without proximal diversion, or resection of the anastomosis with Hartmann’s stump and end ostomy. Several factors are against both you and the patient at this stage. Reoperations for anastomotic leaks take place in a hostile abdomen in the setting of a severe infl ammatory response to the infection and usually encumbered by the dense adhesions of the postopera­tive period. Patients with septic shock are also not likely to tolerate the long operation needed for any formal revision. Additionally, the infl ammatory mass around the anastomotic leak prevents any safe surgical dissection [ 91 ]. Many outside factors also infl uence your options (i.e., age, shock, immune status). Treatment of anastomotic leak accompanied by septic shock may benefi t from a diverting colostomy or ileostomy, such as in the case of trauma or diverticulitis, as these ade­quately control the source of contamination and infection [ 115 , 132 , 136 ]. Diversion is particularly benefi cial in patients with septic shock who might not tolerate a longer procedure or those cases where the peri- anastomotic infl ammatory pro­cess does not permit a safe dissection of the anastomosis.
Resection of the low-lying rectal anastomosis and end colostomy can negatively impact a patient’s ability to undergo future ostomy closure [ 132 ]. The literature confi rms that an end colostomy with a Hartmann pouch causes increased morbidity and increases the permanent stoma rate without actually providing any signifi cant benefi t over a diverting ostomy [ 132 ]. Anastomotic revision under severe infl ammatory conditions may adversely affect the blood sup­ply at the anastomosis that could result in continued sepsis from the ensuing bowel necrosis. For this reason many advo­cate the use of diversion alone [ 113 , 131 ].
In situations where there is necrosis or a greater than 50 % dehiscence of the anastomosis, a diverting ostomy
may be inadequate in controlling the source of infection. Resection and reanastomosis with proximal diversion are recommended, if technically feasible, in a stable patient. However, if the blood supply still appears to be insuffi cient following resection or in any circumstance where a reanas­tomosis would be inappropriate, an end ostomy should be created. The exception to this is the circumstance where an extremely low rectal anastomosis has been constructed with proximal diversion. The addition of rectal lavage has been shown to be effective even in cases with >50 % dehiscence [
74 ]. It is benefi cial in the long term to preserve the anasto-
mosis, but ongoing pelvic contamination or chronic infec­tion can likewise have devastating consequences for future bowel function and quality of life [ 137 ]. In circumstances where that is likely, another approach may be considered. The Turnbull- Cutait pull-through of the left colon can elimi­nate the risk of poor blood supply or tension causing another anastomotic leak (Fig. 18.5a–d ). This technique often requires extensive mobilization of the left and transverse colon to allow the bowel to be pulled though the short rectal stump. The mucosa is stripped to the dentate line, and the bowel is pulled through the anus to leave 7–10 cm hanging from the anus. A 34-French mushroom catheter is placed in the left colon to hang out of the anus and the bowel tied to the catheter to prevent slippage. The catheter is placed to closed drainage, and the externalized bowel is wrapped with Betadine soaked Kerlix and kept moist with fresh Betadine for 7 days. The patient returns to the OR on day 7 to amputate the external segment and suture the coloanal anastomosis.

Suture Repair

Key Concept : Do not give in to the allure of performing a simple suture repair .
Since many anastomotic dehiscences are small, it seems logical that they would be amenable to simple suture repair. Unfortunately sutures can decrease the blood supply to nearby tissues in an area of dehiscence that may already have a questionable blood supply, thus potentially making matters worse. Some surgeons are advocates of suture repair in minor defects (1 cm or less); however, there is lim­ited evidence to support this recommendation. In fact, at least one study has questioned whether suture repair should be an option at all [ 112 ]. This study found that patients with a positive leak test during an elective colorectal resection had a much higher incidence of postoperative leaks with suture repair compared to revision [ 113 ]. If you do decide to perform a suture repair, you should consider performing a proximal diversion. In fact, with any positive leak test, the decision tree should almost always include a diverting stoma [
138 ].
294
N. Smallwood et al.
Fig. 18.5 Turnbull-Cutait pull-through. ( a ) The end of the colon is grasped from below and pulled through the anal verge. ( b ) Excess length is pulled through to the desired level and wrapped in dressing.

Management Unique to the Crohn’s Patient

Key Concept : Crohn ’ s patients with an ileocolic anastomotic leak behave differently and require different treatment than those with a colocolic anastomosis .
Anastomotic leaks can have a severe impact on the long­term outcome in patients with Crohn’s disease. Only one study specifi cally focuses on the management of ileocolic and colocolic anastomotic leaks. The only apparent differ­ence in Crohn’s patients was seen in ileocolic leaks [ 139 ]. It was readily apparent in this study that resection with end ileostomy had far superior results in mortality (0 % vs. 21 %) and disease recurrence (0 % vs. 57 %) compared to methods which attempted to preserve or revise the
( c ) After time, the excess length is resected. ( d ) Final hand-sewn colo- anal anastomosis. (Reprinted with permission. © Cleveland Clinic Foundation, Cleveland, OH)
anastomosis. Colo- colonic anastomotic-related complica­tions were treated with methods of anastomotic preservation or takedown with end ostomies. Anastomotic-preserving methods included combined antibiotics, percutaneous drain­age, and laparoscopic lavage or laparotomy with suturing of the leak site or resection and revision with or without proxi­mal diversion. There was no difference in mortality, entero­cutaneous fi stula, or disease recurrence. Colo-colonic anastomotic leaks appeared to be a more localized process, with a much higher rate of spontaneous healing of enterocu­taneous fi stula. These results should be given consideration when faced with ileocolic anastomotic complications and warrant further studies. Most often, though, a conservative approach to managing the leak should be considered.
18 The Failed Anastomosis
295
Establishment of drainage by percutaneous placement of pigtail catheters allows the sepsis to be treated and bowel rest to be applied in an attempt to close the leak without operating. This approach can successfully manage up to two-thirds of abscesses and fi stulas [
140 ].

Management After the Acute Setting

Key Concept : You are not fi nished treating a leak until after ostomy closure . Treating the area of dehiscence early on may allow for higher rates of ostomy closure and improved func­tional outcomes .
After the successful management of an anastomotic leak, the focus should shift to planning for the eventual res­toration of intestinal continuity. This is an issue of equal importance, especially to the patient, and is best addressed early. Anastomotic defects, whether they are simple fi stulas or large sinuses, can often spontaneously heal on their own if the patient is diverted [ 124 , 130 ]. Unfortunately, not all defects will heal completely. Some will require additional months of diversion before they completely heal. The cav­ity around the leak must be completely healed before ostomy closure in order to prevent recurrent pelvic sepsis [ 134 ]. During this “healing period,” chronic infl ammation, and even low-grade infection, is allowed to persist while the defect undergoes secondary healing. The resulting fi brosis and scar formation can lead to persistent larger sinuses or ultimately to stenotic areas [ 141 ]. New methods of treating the local area of disrupted anastomosis may speed healing and reduce contamination to improve func­tional outcome.
Endoscopic Vacuum-Assisted Closure (Endoluminal VAC) or Endo-Sponge™
Key Concept : This negative pressure system may be useful for select low - lying anastomotic leaks ; however , it should be applied within 6 weeks and will require several endoscopic changes .
Modifi cation of the vacuum-assisted dressing to achieve endoluminal and endocavitary suction has been useful in closing low colorectal anastomotic leaks [ (Fig. 18.6 ). The actual manufactured device currently available for use in treating gastrointestinal complications is the Endo-Sponge™ (B Braun Melsungen AG, Melsungen, Germany) [ 145 ], which has been available in Europe for more than a decade (Fig. 18.6 ). As of 2012 the FDA has approved it in the USA. Surgeons have adapted the current Wound V.A.C™ (Lifecell, Bridgewater, NJ) for use as an internal Wound V.A.C™ dressing. The amount of negative pressure to use when adapting the Wound V.A.C™
141144 ]
for anastomotic leaks is unknown. For the Endo-Sponge™ the negative pressure is set at a much lower negative pres­sure than the traditional Wound V.A.C™, but it appears that even −125 mmHg is well tolerated [ ported advantage is the endoluminal VAC can drain intes­tinal contents before they are able to leak out into the adjoining abscess cavity. On the contrary, percutaneous drainage is unable to prevent this extravasation. Effective drainage and removal of necrotic material reduces the bac­terial burden facilitating an increase in granulation tissue and a decrease in the size of the cavity [ minal VAC can at times even prevent the need for proximal diversion [ 142 ]. However, the endoluminal VAC is more effective at shrinking cavities if applied within 6 weeks after the anastomotic leak [ 143 ]. This is likely attributable to the increase in collagen deposition and scarring within the adjoining cavity which takes place over time. Once secondary healing occurs, the cavity is far less likely to undergo any signifi cant cavity contraction [ 143 ]. Closure of presacral sinuses, abscess cavities, and fi stulas occurs in 75–97 % of patients who began treatment within 6 weeks compared to 38 % in patients who began treatment after 6 weeks. Total number of VAC changes (endoscopic ses­sions) needed for successful closure was a median of 11–13 over a median time period of 34–40 days [ 142 , 143 ]. At times patients may have very small fi stula open- ings that feed larger sinuses. Endoluminal VAC placement into the abscess cavity is diffi cult or impossible through small fi stula openings. For these small fi stulae orifi ces that lead to larger sinuses, the endoluminal VAC can be applied over the fi stula orifi ce within the rectum with or without percutaneous drainage of the sinus. The other option would be to expand the fi stula orifi ce to allow sponge placement. Endoluminal VAC therapy is promising and seems to be very useful in the early setting—allowing for both healing and drainage, and even complete closure of anastomotic fi stulas or sinuses. Even if the endoluminal VAC is unable to completely close a defect, it will still have resolved any infection and provided healthier tissue for use in other methods of repair.
141 ]. One pur-
142 ]. The endolu-
Fibrin Glue
Key Concept : Fibrin glue is probably best used in the chronic setting to close small fi stula openings before trying other more invasive options — so long as there is limited purulent material and a minimal amount of fecal or bacterial contamination .
Fibrin glue (combined thrombin and fi brinogen) or other types of nonbiologic glues have been used during anastomo­sis creation and for leaks and fi stulas. Despite the early suc­cess showing an 85 % healing rate of anal fi stulae, recent
296
N. Smallwood et al.
Fig. 18.6 Adaptation of KCI’s proprietary V.A.C.® Therapy System for use as a type of endoluminal VAC. Images A – D are a pictorial guide in creating an endoluminal VAC. Step A : Cut the tubing close to the suction application pad to provide adequate length without requiring extra tub­ing. The KCI attached to a smaller diameter drain for smaller fi stulas. Cut the sponge to the size of sinus or fi stula tract keeping in mind the amount of magni-
TM
tubing can be directly applied to the sponge or if needed
studies have failed to replicate these numbers. It also has been shown that fi brin glues are less effective in treating rectal complications compared to other areas like the esopha­gus. During the acute setting tissues have a signifi cant amount of bacterial content and infl ammation [
146 ].
Currently, fi brin glue has a 25–33 % success rate as a single agent for treating rectal anastomotic complications [ 146 , 147 ]. It is diffi cult to discern from the literature the exact role for fi brin glue. The two benefi ts in using fi brin glue are that it is fairly quick and easy to apply and it will not prevent the use of any other method if it fails. Fibrin glue is most useful in a chronic setting, especially with the low-volume small bowel fi stula that is due to an anastomotic leak at an ileocolic staple line or strictureplasty. After removal of the percutane­ous drain from the collapsed tract, the tract can be fi lled with fi brin glue to fi nish the healing.
fi cation when viewed through the endoscope. Make sure the base is broader to allow a securer attachment of the tubing. Step B : Cut a circu- lar area out of the base of the sponge extending about half the length of the sponge. Steps C , D : Secure the sponge with through and through bites of sponge and tubing. Three different horizontal mattress stitches using a Keith needle is a fairly easy and secure method. The remainder of the procedure is similar to placing the Endo-Sponge™
Covered Stents
Key Concept : While the emerging use of covered stents may dramatically change the way we treat certain leaks , for now they are relegated to treating those patients with a severe or complete disunion of their anastomosis , typically along with a proximal diverting ostomy , or in patients that have both a fi stula and an adjacent stenotic area .
Stents are beginning to be used in cases of malignant colorectal obstructions, with a very limited amount of use in colorectal anastomotic leaks. Much of what we know about the use of stents for anastomotic complications comes from treating esophageal anastomotic leaks. Covered stents, when used to treat esophageal anastomotic leaks, have been able to achieve complete resolution, in a minimally invasive fashion, within days to weeks. Studies show that esophageal stents
18 The Failed Anastomosis
297
allow much earlier resumption of oral intake, signifi cant shorter hospital stays, and an 87–94 % success rate [
148 ,
149 ]. The overall therapeutic principle behind stents is that they are able to effectively “bridge the breach” [
150 ] and in
doing so provide a scaffold which allows for reapproxima­tion of the two ends, mucosal regeneration, and prevention of further drainage through the anastomotic defect and infec­tious complications.
Only a small number of studies, mainly composed of case
series, include colorectal anastomotic leaks (Fig.
18.7 ).
Studies show varying degrees of success in treating acute leaks, sometimes with almost complete anastomotic disunion as well as chronic fi stulas [ 150 , 151 ]. This is level IV evi- dence, at best, but we can draw some general conclusions.
1. Additional procedures, like percutaneous drainage, are
very often still needed [ 150 , 151 ].
2. The use of covered stents to cover the opening in the
colorectal anastomosis may allow the fi stula to heal with­out a diverting ostomy in up to 80 % of patients [ 151 ].
3. There is a high incidence of rectal pain if the distal aspect
of the stent is within 5 cm of anal verge [ 152 ].
4. Migration is the #1 problem:
• Full-thickness sutures or clips can help prevent migration.
• Biodegradable and fully covered stents are more likely to migrate.
• Patients who have stenosis in addition to a leak are less likely to have migration problems.
• Due to these migration issues, using the stent to avoid proximal diversion could be technically challenging and may expose the patient to further infectious­related complications if migration does occur.
5. Partially covered stents migrate less, but allow for tissue in-growth, and the eventual removal can at times be very diffi cult.
Solution : Stent Within a Stent Technique
Some gastroenterologists prefer to place a fully cov­ered stent within the previously placed stent a few days before the stent will be removed. This will cause necrosis and sloughing of the mucosal in-growth and easier removal [ 153 ].
6. “Stent-guided regeneration and epithelialization” [ 150 ]— This is an interesting concept where stents, in cases of near-complete anastomotic disunion, act like scaffolds, allowing for approximation of the two bowel ends and reepithelialization.
Transanal Repair
Key Concept : Different methods of transanal repair have been used in an attempt to close the unhealed fi stula or sinus near the anal verge and allow for future ostomy closure .
Fig. 18.7 Covered stent use for a colorectal anastomotic leak (Courtesy of Elisa Birnbaum, MD)
These include simple suturing , curettage , clips , marsupial-
ization , plugs ( for RVF ,) and mucosal advancement — all with variable results and experience .
Transanal methods are technically more diffi cult to use for leaks higher up in the rectum and are prone to fail in patients who are not diverted. Simple suturing should only be attempted for small defects in tissues with minimal infl ammation, and even then it is prone to fail. Some chronic small fi stula tracts may be allowed to heal by performing local curettage to remove the epithelialized tract but more often is used as an adjunct to other procedures such as fi stula plugs and endomucosal fl aps [ 154 ]. Patients with chronic, large presacral sinuses, associated with small openings, may benefi t from expanding the small opening in a procedure known as marsupialization where the rectal wall overlying the abscess cavity is incised and abscess cavity laid open. Marsupialization allows for better drainage and healing that can result in complete resolution of the sinus in a few months through reepithelialization. Marsupialization can be done endoscopically using an Olympus Triple Lumen Needle Knife [ 155 ], as well as with proctoscope or anoscope and the laparoscopic electrocautery scissors. Currently, this author, and others [ 156 ], uses a laparoscopic EndoGIA stapling device placed through the anus with the thin anvil in the fi s­tula and the staple cartridge in the rectal lumen with good results, but it is conceivable that radiofrequency tissue seal­ing devices could work just as well. Flap advancement tech­niques more often have been used to treat rectovaginal fi stulas, but can also be applied to any anastomotic fi stula in close proximity to the anal verge [
154 , 157 ]. Flap advance-
ment is akin to simple suturing but appears to have better results because it involves excising the fi stula opening and
298
N. Smallwood et al.
Fig. 18.8 Endoscopic clip placement for an anastomotic leak (Courtesy of Elisa Birnbaum, MD)
mobilizing the adjacent tissues, allowing for the approxima­tion of healthy tissues without tension. Finally, there are lim­ited reports of successful use of endoscopic clips to close the opening (Fig. 18.8 ).
Redo Surgery
Key Concept : Reoperative surgery should not be undertaken lightly , although it is sometimes the only way in which bowel continuity can be restored after other methods have failed .
Redo surgery is an elective surgery to restore intestinal continuity. It is associated with an approximately 20 % failure rate due to intraoperative failures or postoperative complica­tions that ultimately result in a permanent stoma [ 158 ]. Anastomotic leaks occur with at least equal frequency as the initial operation; therefore, it is highly recommended to pro­tect the new anastomosis with a diverting ostomy. This unfor­tunately will require an additional procedure, at a later date, for ostomy closure. Mortality is typically low with the appro­priate patient selection, while morbidity is still typically high (32–55 %) [ 158 , 159 ]. Some patients, even after a successful redo surgery, will have signifi cant functional issues, such as increased frequency, incontinence, constipation, and diffi cult evacuation, following ostomy closure. Ureteral stent place­ment is recommended in the previously operated pelvis [ 159 ].
As a general rule of thumb, redo surgery is appropriate in patients:
• When other methods have failed
• Who have a minimal risk of perioperative mortality
• Who are not currently undergoing chemotherapy or
radiation
• Nutritionally optimized
• Highly motivated for ostomy reversal
• Fully understand the risks involved and the possibility of failure

Anastomotic Stenosis

Key Concept : Anastomotic stenosis may be as signifi cant as leaks because of the impact on a patient ’ s quality of life , potential need for multiple revision attempts , and risk of per­manent stoma .
Unfortunately for the colon and rectal surgeon, there are
multiple ways an anastomosis can fail, with stenosis being a prominent one. It is a relatively common complication fol­lowing colorectal surgery, reported in up to 20 % of patients
160 ]. Due to the wide variety of defi nitions used, the nor-
[ mally quoted incidence ranges from 3 to 30 % [
161163 ].
Using a single defi nition for “stenosis” as the inability to pass an 18- or 19 mm-diameter rigid rectoscope through an observed narrowing regardless of symptoms resulted in an incidence of 13–20 % [ 160 , 161 ]. This number is likely to vary per surgeon and, in our own experience, does not seem to be as common. Many patients will have a fi brous stricture or web at the site of the anastomosis, sometimes appearing to be totally occluding the lumen. These are almost always eas­ily broken up digitally or with the passage of the rigid proc­toscope, and ultimately do not recur. Regardless of its true incidence, anastomotic stenosis is a challenge for the surgeon.

Pathophysiology

Key Concept : Several risk factors , including stapling devices , correlate with higher stenosis rates , while an intact mucosa may lead to lower rates of development .
Use of stapling devices, but not the size of stapler, is a risk factor for stenosis [ 161 ]. Necrotic tissue within the staple line and the small gap that is created between adjacent mucosa leads to an increased infl ammatory response, collagen depo­sition, and secondary healing [ 101 ]. The signifi cance of hav- ing an intact mucosa can further be derived from esophageal endomucosal resections where signifi cant stenosis can occur in 75–80 % of patients who undergo more than 75 % circum­ferential resections of the mucosa [ 164 ]. An iatrogenically created mucosal defect in the esophagogastrostomy model in a dog resulted in higher degrees of stenosis and more scarring at the site of the anastomosis than those with an intact mucosa
164 ]. An intact mucosa and mucosa-to- mucosa apposition
[ appear to be important in preventing stenosis. Other identifi ed risk factors include anastomotic leaks, pelvic sepsis, long­term diversion, and radiotherapy [ 163 , 165 ].
18 The Failed Anastomosis
299
Symptoms and Clinical Course
Key Concept : Symptoms of anastomotic stenosis include bloating , constipation , and incomplete defecation . You should realize that the severity of symptoms will often not correlate with the degree of stenosis .
A clinical scoring system combines both the severity of symptoms with the necessary therapeutic intervention [ 160 , 161 ]. Severe cases of stenosis in diverted patients will not be apparent until the patient undergoes hypaque enema evalua­tion for ostomy closure. Regardless of the absence of symp­toms, the stenosis will need to be treated before ostomy closure. In general, though, patients should only be treated if they are symptomatic [ 160 ].
Treatment
Key Concept : Treatment for stenosis is accomplished using fi nger dilation , endoscopic balloon dilation , or stent placement .
Many stenoses will be amenable to fi nger fracture or endoscopic dilation alone; however, repeat procedures are commonly needed [ 161 ]. In some patients no method of treatment will work other than surgical revision. Most treat­ments are more effective if performed within the fi rst few months postoperatively and seem to be much more refrac­tory if performed later [ 161 ]. Some patients, despite prob- lematic symptoms, will wait months to years before seeking help. Informing patients of the expected symptoms and changes in bowel function will speed diagnosis and treat­ment [ 161 ].
Balloon Dilation
Endoscopic balloon dilation, whether performed under fl uo­roscopy or through the scope, has up to a 90 % success rate with minimal associated morbidity. Patients should realize that multiple dilating procedures may be required before symptom resolution. This may be related to inadequate ini­tial balloon dilatation [ 162 ]. Kim et al. [ 162 ] used a balloon dilation treatment algorithm that involved dilating a single 20 mm balloon followed by adding a second 10 mm balloon if no pain or blood was seen on the catheter. The 10 mm bal­loon was then changed out to a 15 mm and fi nally a 20 mm balloon as long as the patient did not experience pain or blood is not seen on the catheter. This method resulted in an 86 % success rate at long-term follow-up; however, there was no control group for comparison [ 162 ]. There is cur- rently no consensus as to how many different dilation treat­ments are warranted before moving on to some other modality. A general rule is that after three endoscopic dila­tions, any symptomatic recurrent stenosis should be treated with a different method.
S t e n t s
Stents were fi rst used to treat cancer-related esophageal obstructions. Obstructive colorectal cancers are now being treated with soft expanding metal stents. The absolute effec­tiveness of this treatment modality is unknown at this time. It has been shown to be effective in the cases where both stenosis and a fi stula or sinus exist as previously discussed. Successful stenting of anastomotic stricture has been reported [ 166 ]. Migration and in-growth of tissue are likely complications.
Complete Obstruction
There are other alternatives besides surgical revision that can potentially treat the totally occluded anastomosis. In addition to the circular stapled revision, which will be described later, one other alternative remains. This method explained by Curcio et al. [ access the proximal lumen from the distal lumen under both endoscopic and fl uoroscopic control. Placement of a 0.025 in. wire through the 18 gauge catheter allowed for progressive balloon dilation of the area up to a 20 mm balloon with good results. In circumstances where the ostomy proximal to the obliterated anastomosis is available to introduce an endo­scope, the light of the proximally placed endoscope can guide recanalization using cautery or sharp dissection. Resection of the central scar and complete dilation are then possible.
167 ] uses a suprapapillary puncture catheter to
Surgical Revision
Surgical revision should be considered should other less inva­sive modalities fail. The operation will be diffi cult with blood supply to the anastomosis tenuous, and similar to revision of anastomotic leaks, should not be taken lightly. There are two techniques that allow for surgical correction of the stenosis without formal resection and revision. These are stricturo­plasty and circular stapled revision without resection. The stricturoplasty is similar to the Heineke-Mikulicz pyloro­plasty on the anterior aspect of the anastomosis. The stapled revision requires a longitudinal incision on the anterior border of the proximal limb with insertion of the anvil, and under direct vision, the pin of the circular stapler is deployed through the stenotic or obstructed area and the anvil attached. McKee and colleagues described this method [ 168 ] by using a 29 mm circular stapler in a 51-year-old female. Success with these two methods needs to be further explored. However, they should remain in the surgeon’s armamentar­ium, especially in cases where the complete dissection of the low rectal anastomoses is diffi cult. Anastomotic resection and reconstruction is preferred if soft tissue is not available or revision increases the likelihood of further complications due to poor blood supply. A low rectal anastomosis is an extremely diffi cult procedure in the reoperative pelvis and requires patience and experience to achieve success.
300
Fig. 18.9 Algorithm to treat an anastomotic stricture
N. Smallwood et al.

Anastomotic Stenosis Summary

The severity of the problem with anastomotic stenosis in rela­tion to its incidence is extremely variable. Since staplers appear
future preventive measures will need to address the design of stapled anastomoses. There is no consensus that outlines man­agement or treatment of stenosis. A treatment algorithm is pre­sented in Fig. 18.9 . Finally, anastomotic stenosis or recurrence of stenosis months to years after successful treatment may be due to cancer recurrence. It is therefore important to take biop­sies upon the fi rst identifi cation of stenosis along with addi­tional biopsies and/or imaging in cases of recurrent stenosis that follows a prolonged asymptomatic period.

References

1. Dietz UA, Debus ES. Intestinal anastomoses prior to 1882; a leg-
acy of ingenuity, persistence, and research form a foundation for modern gastrointestinal surgery. World J Surg. 2005;29:396–401.
2. Munireddy S, Kavalukas SL, Barbul A. Intra-abdominal healing: gastrointestinal tract and adhesions. Surg Clin North Am. 2010;90(6):1227–36.
3. Brian WA. The pathology of diverticulosis: classical concepts and mucosal changes in diverticula. J Clin Gastroenterol. 2006;40 Suppl 3:S126–31.
4. Halsted WS. Circular suture of the intestine: an experimental study. Am J Med Sci. 1887;94:436–61.
5. Thompson SK, Chang EY, Jobe BA. Clinical review: healing in gas­trointestinal anastomoses, part I. Microsurgery. 2006;26:131–6.
6. Kologlu M, Yorganci K, Renda N, et al. Effect of local and remote ischemia-reperfusion injury on healing of colonic anastomoses. Surgery. 2000;128(1):99–104.
7. Mast BA. Healing in other tissues. Surg Clin North Am. 1997;77:529–47.
8. Whiteway J, Morson BC. Elastosis in diverticular disease of the sigmoid colon. Gut. 1985;26:258–66.
9. Thornton FJ, Barbul A. Healing in the gastrointestinal tract. Surg Clin North Am. 1997;77:549–73.
10. Baker RS, Foote J, Kemmeter P, Brady R, Vroegop T, Serveld M. The science of stapling and leaks. Obes Surg. 2004;14: 1290–8.
11. Hyman N. Anastomotic leaks after intestinal anastomosis: it’s later than you think. Ann Surg. 2007;245:254–8.
12. Stewart D, Hunt S, Pierce R, et al. Validation of the NITI endolu­minal compression anastomosis ring (EndoCAR) device and
18 The Failed Anastomosis
301
comparison to the traditional circular stapled colorectal anastomo­sis in a porcine model. Surg Innov. 2007;14:252–60.
13. Dubay DA, Franz MG. Acute wound healing: the biology of acute wound failure. Surg Clin North Am. 2003;83:463–81.
14. Wiesner W, Khurana B, Ji H, Ros PR. CT of acute bowel isch­emia. Radiology. 2003;226:635–50.
15. Allison AS, Bloor C, Faux W, et al. The angiographic anatomy of the small arteries and their collaterals in colorectal resections: some insights into anastomotic perfusion. Ann Surg. 2010;251(6): 1092–109.
16. Meyers MA. Griffi ths’ point: critical anastomosis at the splenic fl exure. Signifi cance in ischemia of the colon. AJR Am J Roentgenol. 1976;126:77–94.
17. Trencheva K, Morrissey KP, Wells M. Identifying important pre­dictors for anastomotic leak after colon and rectal resection: pro­spective study on 616 patients. Ann Surg. 2013;257(1):108–13.
18. Vignali A, Gianotti L, Braga M, Radaelli G, Malvezzi L, Di Carlo V. Altered microperfusion at the rectal stump is predictive for rec­tal anastomotic leak. Dis Colon Rectum. 2000;43(1):76–82.
19. Marino PL. The ICU, book. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 26–7.
20. Davis BD, Rivadeneira DE. Complications of colorectal anasto­moses: leaks, strictures, and bleeding. Surg Clin North Am. 2013; 93(1):61–87.
21. Veyrie N, Ata T, Muscari F. Anastomotic leakage after elective right versus left colectomy for cancer: prevalence and indepen­dent risk factors. J Am Coll Surg. 2007;205:785–93.
22. Wexner S. Invited critique to article of Alves et al. Postoperative mortality and morbidity in French patients undergoing colorectal surgery. Arch Surg. 2005;140:284.
23. Benoist S, Panis Y, Alves A, Valleur P. Impact of obesity on surgi­cal outcomes after colorectal resection. Am J Surg. 2000;179: 275–81.
24. Dana A, Edward H, Celia M. Risk factors for anastomotic leak following colorectal surgery. Arch Surg. 2010;145:371–6.
25. Mäkelä JT, Kiviniemi H. Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum. 2003;46(5):653–60.
26. Garcia-Botello SA, Garcia-Armengol J, Garcia-Granero E, et al. A prospective audit of the complications of loop ileostomy con­struction and takedown. Dig Surg. 2004;21(5–6):440–6.
27. Clinical Outcomes of Surgical Therapy Study Group. A compari­son of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med. 2004;350(20):2050–9.
28. Jie B, Jiang Z, Nolan M, Zhu S. Impact of preoperative nutritional support on clinical outcome in abdominal surgical patients at nutritional risk. Nutrition. 2012;28:1022–7.
29. Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002;96(1): 23–43.
30. Shental O, Tulchinsky H, Greenberg R, Klausner JM, Avital S. Positive histological infl ammatory margins are associated with increased risk for intra-abdominal septic complications in patients undergoing ileocolic resection for Crohn’s disease. Dis Colon Rectum. 2012;55(11):1125–30.
31. Mascarenhas C, Nunoo R, Asgeirsson T, et al. Outcomes of ileo­colic resection and right hemicolectomies for Crohn’s patients in comparison with non-Crohn’s patients and the impact of periop­erative immunosuppressive therapy with biologics and steroids on inpatient complications. Am J Surg. 2012;203(3):375–8.
32. Bafford AC, Powers S, Ha C, et al. Immunosuppressive therapy does not increase operative morbidity in patients with Crohn’s dis­ease. J Clin Gastroenterol. 2012;47(6):491–5.
33. Colombel JF, Loftus Jr EV, Tremaine WJ, et al. Early postopera­tive complications are not increased in patients with Crohn’s dis­ease treated perioperatively with infl iximab or immunosuppressive therapy. Am J Gastroenterol. 2004;99(5):878–83.
34. Fazio VW, Marchetti F, Church M, et al. Effect of resection mar­gins on the recurrence of Crohn’s disease in the small bowel. A randomized controlled trial. Ann Surg. 1996;224(4):563–71; dis­cussion 571–3.
35. Slieker JC, Komen N, Mannaerts GH. Long-term and perioperative corticosteroids in anastomotic leakage: a prospective study of 259 left-sided colorectal anastomoses. Arch Surg. 2012;147(5):447–52.
36. Yamamoto T, Allan RN, Keighley MR. Risk factors for intra­abdominal sepsis after surgery in Crohn’s disease. Dis Colon Rectum. 2000;43:1141–5.
37. Post S, Betzler M, von Ditfurth B, et al. Risks of intestinal anasto­moses in Crohn’s disease. Ann Surg. 1991;213:37–42.
38. Selvasekar CR, Cima RR, Larson DW, et al. Effect of infl iximab on short-term complications in patients undergoing operation for chronic ulcerative colitis. J Am Coll Surg. 2007;204(5):956–62.
39. Subramanian V, Pollok RC, Kang JY, Kumar D. Systematic review of postoperative complications in patients with infl amma­tory bowel disease treated with immunomodulators. Br J Surg. 2006;93(7):793–9.
40. Alves A, Panis Y, Bouhnik Y, Pocard M, Vicaut E, Valleur P. Risk factors for intra-abdominal septic complications after a fi rst ileo­cecal resection for Crohn’s disease: a multivariate analysis in 161 consecutive patients. Dis Colon Rectum. 2007;50(3):331–6.
41. Heuman R, Boeryd B, Bolin T, Sjodahl R. The infl uence of dis­ease at the margin of resection on the outcome of Crohn’s disease. Br J Surg. 1983;70(9):519–21.
42. Nisar PJ, Lavery IC, Kiran RP. Infl uence of neoadjuvant radio­therapy on anastomotic leak after restorative resection for rectal cancer. J Gastrointest Surg. 2012;16(9):1750–7.
43. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351(17):1731–40.
44. Kim J, Mittal R, Konyalian V, King J, Stamos MJ, Kumar RR. Outcome analysis of patients undergoing colorectal resection for emergent and elective indications. Am Surg. 2007;73(10):991–3.
45. Alves A, Panis Y, Trancart D, et al. Factors associated with clini­cally signifi cant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients. World J Surg. 2002; 26(4):499–502.
46. Choi HK, Law WL, Ho JW. Leakage after section and intraperito­neal anastomosis for colorectal malignancy: analysis of risk fac­tors. Dis Colon Rectum. 2006;49(11):1719–25.
47. Biondo S, Pares D, Kreisler E, et al. Anastomotic dehiscence after resection and primary anastomosis in left-sided colonic emergen­cies. Dis Colon Rectum. 2005;48(12):2272–80.
48. Gooszen AW, Tollenaar RA, Geelkerken RH, et al. Prospective study of primary anastomosis following sigmoid resection for sus­pected acute complicated diverticular disease. Br J Surg. 2001; 88(5):693–7.
49. Forloni B, Reduzzi R, Paludetti A, Colpani L, Cavallari G, Frosali D. Intraoperative colonic lavage in emergency surgical treatment of left-sided colonic obstruction. Dis Colon Rectum. 1998;41(1):23–7.
50. Biondo S, Perea MT, Ragué JM, Parés D, Jaurrieta E. One-stage procedure in non-elective surgery for diverticular disease compli­cations. Colorectal Dis. 2001;3:42–5.
51. Ravo B, Metwally N, Castera P, Polansky PJ, Ger R. The impor­tance of intraluminal anastomotic fecal contact and peritonitis in colonic anastomotic leakages. An experimental study. Dis Colon Rectum. 1988;31(11):868–71.
52. Ravo B, Metwall N, Yeh J, Polansky P, Frattaroli FM. Effect of fecal loading with/without peritonitis on the healing of a colonic anastomosis: an experimental study. Eur Surg Res. 1991;23(2): 100–7.
53. Salem L, Flum DR. Primary anastomosis or Hartmann’s proce­dure for patients with diverticular peritonitis? A systematic review. Dis Colon Rectum. 2004;47(11):1953–64.
302
N. Smallwood et al.
54. Chiappa A, Zbar A, Biella F, Staudacher C. One-stage resection and primary anastomosis following acute obstruction of the left colon for cancer. Am Surg. 2000;66(7):619–22.
55. Demetriades D, Murray JA, Chan L, et al. Penetrating colon injuries requiring resection: diversion or primary anastomosis? An AAST prospective multicenter study. J Trauma. 2001;50(5):765–75.
56. Boccola MA, Buettnr PG, Rozen WM, et al. Risk factors and out­comes for anastomotic leakage in colorectal surgery: a single­institution analysis of 1576 patients. World J Surg. 2011; 35(1):186–95.
57. Gendall KA, Raniga S, Kennedy R, Frizelle FA. The impact of obesity on outcome after major colorectal surgery. Dis Colon Rectum. 2007;50(12):2223–37.
58. Jung SH, Yu CS, Choi PW, et al. Risk factors and oncologic impact of anastomotic leakage after rectal cancer surgery. Dis Colon Rectum. 2008;51(6):902–8.
59. Nesbakken A, Nygaard K, Westerheim O, et al. Audit of intraop­erative and early postoperative complications after introduction of mesorectal excision for rectal cancer. Eur J Surg. 2002; 168(4):229–35.
60. Law WL, Chu KW, Ho J, Chan CW. Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision. Am J Surg. 2000;179:92–6.
61. Yeh CY, Changchien CR, Wang JY, et al. Pelvic drainage and other risk factors for leakage after elective anterior resection in rectal cancer patients: a prospective study of 978 patients. Ann Surg. 2005;241(1):9–13.
62. Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M. Risk factors for anastomotic leakage after resection of rectal can­cer. Br J Surg. 1998;85(3):355–8.
63. Ba ZF, Yokoyama Y, Toth B, Rue 3rd LW, Bland KI, Chaudry IH. Gender differences in small intestinal endothelial function: inhibi­tory role of androgens. Am J Physiol Gastrointest Liver Physiol. 2004;286(3):G452–7.
64. Telem DA, Chin EH, Nguyen SQ, et al. Risk factors for anasto­motic leak following colorectal surgery: a case–control study. Arch Surg. 2010;145(4):371–6.
65. Lee MR, Hong CW, Yoon SN, et al. Risk factors for anastomotic leakage after resection for rectal cancer. Hepatogastroenterology. 2006;53(71):682–6.
66. Lipska MA, Bissett IP, Parry BR, Merrie AE. Anastomotic leak­age after lower gastrointestinal anastomosis: men are at a higher risk. ANZ J Surg. 2006;76(7):579–85.
67. Choi DH, Hwang JK, Ko YT, et al. Risk factors for anastomotic leakage after laparoscopic rectal resection. J Korean Soc Coloproctol. 2010;26(4):265–73.
68. Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hos­pitalization. Study of wound infection and temperature group. N Engl J Med. 1996;334(19):1209–15.
69. Karliczek A, Jesus EC, Matos D, Castro AA, Atallah AN, Wiggers T. Drainage or nondrainage in elective colorectal anastomosis: a system­atic review and meta-analysis. Colorectal Dis. 2006;8(4):259–65.
70. Matthiessen P, Hallbook O, Andersson M, et al. Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis. 2004;6:462–9.
71. Mansson P, Zhang XW, Jeppsson B, Thorlacius H. Anastomotic healing in the rat colon: comparison between a radiological method, breaking strength and bursting pressure. Int J Colorectal Dis. 2002;17(6):420–5.
72. Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from sta­pled low anastomosis after total mesorectal excision for carci­noma of the rectum. Br J Surg. 1994;81(8):1224–6.
73. Tsujinaka S, Kawamura YJ, Konishi F, Maeda T, Mizokami K. Pelvic drainage for anterior resection revisited: use of drains in anastomotic leaks. ANZ J Surg. 2008;78(6):461–5.
74. Urbach DR, Kennedy ED, Cohen MM. Colon and rectal anasto­moses do not require routine drainage: a systematic review and meta-analysis. Ann Surg. 1999;229(2):174–80.
75. Eckmann C, Kujath P, Schiedeck TH, Shekarriz H, Bruch HP. Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approach. Int J Colorectal Dis. 2004;19(2):128–33.
76. Kang CY, Chaudhry OO, Halabi WJ, et al. Outcomes of laparo­scopic colorectal surgery: data from the nationwide inpatient sample 2009. Am J Surg. 2012;204(6):952–7.
77. Krarup PM, Jorgensen LN, Andreasen AH, Harling H, Danish Colorectal Cancer Group. A nationwide study on anastomotic leakage after colonic cancer surgery. Colorectal Dis. 2012;14(10):e661–7.
78. Moreaux J, Horiot A, Barrat F, Mabille J. Obliteration of the pel­vic space with pedicled omentum after excision of the rectum for cancer. Am J Surg. 1984;148:640–4.
79. Merad F, Hay JM, Fingerhut A, Flamant Y, Molkhou JM, Laborde Y. Omentoplasty in the prevention of anastomotic leakage after colonic or rectal resection. A prospective randomized study in 712 patients. Ann Surg. 1998;227:179–86.
80. Tocchi A, Mazzoni G, Lepre L, et al. Prospective evaluation of omentoplasty in preventing leakage of colorectal anastomosis. Dis Colon Rectum. 2000;43(7):951–5.
81. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58(2):71–96.
82. Nakajima K, Takahashi S, Saito N, et al. Predictive factors for anastomotic leakage after simultaneous resection of synchronous colorectal liver metastasis. J Gastrointest Surg. 2012;16(4):821–7.
83. Martin 2nd RC, Augenstein V, Reuter NP, Scoggins CR, McMasters KM. Simultaneous versus staged resection for syn­chronous colorectal cancer liver metastases. J Am Coll Surg. 2009;208(5):842–50; discussion 850–2.
84. Roxburgh CS, Richards CH, Moug SJ, Foulis AK, McMillan DC, Horgan PG. Determinants of short- and long-term outcome in patients undergoing simultaneous resection of colorectal cancer and synchronous colorectal liver metastases. Int J Colorectal Dis. 2012;27(3):363–9.
85. Wong NY, Eu KW. A defunctioning ileostomy does not prevent clinical anastomotic leak after a low anterior resection: a prospec­tive, comparative study. Dis Colon Rectum. 2005;48(11):2076–9.
86. Montedori A, Cirocchi R, Farinella E, Sciannameo F, Abraha I. Covering ileo- or colostomy in anterior resection for rectal carci­noma. Cochrane Database Syst Rev. 2010;5, CD006878.
87. Messaris E, Sehgal R, Deiling S, et al. Dehydration is the most common indication for readmission after diverting ileostomy creation. Dis Colon Rectum. 2012;55(2):175–80.
88. Bakx R, Busch OR, Bemelman WA, Veldink GJ, Slors JF, van Lanschot JJ. Morbidity of temporary loop ileostomies. Dig Surg. 2004;21:277–81.
89. Williams NS, Nasmyth DG, Jones D, Smith AH. Defunctioning stomas: a prospective controlled trial comparing loop ileostomy with loop transverse colostomy. Br J Surg. 1986;73:566–70.
90. Matthiessen P, Hallbook O, Rutegard J, Simert G, Sjodahl R. Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg. 2007;246(2):207–14.
91. Cao F, Li J, Li F. Mechanical bowel preparation for elective colorectal surgery: updated systematic review and meta-analysis. Int J Colorectal Dis. 2012;27(6):803–10.
92. Bretagnol F, Alves A, Ricci A, Valleur P, Panis Y. Rectal cancer surgery without mechanical bowel preparation. Br J Surg. 2007;94:1266–71.
93. Vlot EA, Zeebregts CJ, Gerritsen JJ, Mulder HJ, Mastboom WJ, Klaase JM. Anterior resection of rectal cancer without bowel preparation and diverting stoma. Surg Today. 2005;35:629–33.