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136
Figs. 8.28, 8.29, 8.30, 8.31, and 8.32 (continued)
E.K. Johnson
Fig. 8.33 The “pinch” test that can be done to assess readiness for reconstructive surgery
to attempted reconstruction of 311 days [ 65 ], 184 days [ 66 ], and 585 days [ 67 ]. Due to the retrospective nature of these studies, it is diffi cult to relate the success of a reconstructive effort with the timing of surgery. What is clear, though, is that a waiting period of 6 months or longer is common. Contrary to these reports, another author suggests that a delay of longer than 12 months may be associated with increased loss of domain, thereby making a tension-free repair more diffi cult leading to an increased recurrence [ 64 ]. It must be noted that these studies included many patients
that did not have EAFs and simply required abdominal wall reconstruction after management with a planned ventral her­nia strategy after an open abdomen. Regardless, any recon­structive attempt must be well planned, and the optimal timing will be intimately related to resolution of infl amma­tion, softening of the surrounding tissues, improvement in nutritional status, and overall fi tness of the patient. Surgical judgment based on these multiple factors is likely the key to success.
Optimization: Preparation for Surgery
Optimization of these factors prior to surgery can be achieved through utilization of an appropriate delay, aggressive nutri­tional strategy, overall medical and physical re-conditioning, and detailed planning. No matter what nutritional strategy is employed, the patient’s overall nutritional status should be assessed. This is likely best accomplished through the mea­surement of serum prealbumin levels, albumin and protein levels. It is best to see a sustained achievement of normal levels to ensure adequate nutritional status over time. Any sudden decrease in the serum level of prealbumin should be followed by measurement of serum C-reactive protein (CRP), as any secondary infection or infl ammatory process will lead to an acute phase response with a decrease in syn­thesis of prealbumin accompanied by an increase in CRP. Sometimes this may be an early sign of line sepsis, pneumo­nia, or recurrent intra-abdominal abscess and should prompt further investigation and avoidance of any extensive surgical procedure. Any reconstructive procedure performed on a
8 Enteroatmospheric Fistula
137
malnourished patient is doomed to failure. This may be the single most important factor to optimize prior to surgery.
Medical and physical optimization will require support from a multidisciplinary team of providers including inter­nists, medical subspecialists, physical therapists, and social workers. Diligent preparation in these areas will ease recovery from major reconstructive procedures and must be empha­sized. Detailed planning for reconstruction starts fi rst with obtaining an abdominopelvic CT scan utilizing IV and enteral contrast. Imaging will assist in defi ning areas of potential ongoing infl ammation and obstruction, as well as provide detailed information about abdominal wall musculature and its relation to underlying structures. The distance of rectus diasta­sis can be accurately measured, and a safe site of entry can potentially be chosen. This information will assist the surgeon in determining potential sizes and types of reinforcing materi­als that will have to be on hand and may in fact determine the best approach to abdominal wall closure and reconstruction.
Staged vs. Non-staged Approaches
Key Concept : One or more extensive operations may be required to achieve EAF and abdominal wall closure . Planning for this involves setting well - defi ned goals , com­municating these with the patient and their family , avoid­ance of overaggressive surgery , and knowledge of “ bail - out ”
strategies .
As previously stated, an individual that has been patiently awaiting corrective surgery for an EAF will often push their surgeon to achieve a quick single-stage solution to their problem. The prospect of undergoing two or more major sur­gical procedures to correct all existing problems may not be palatable to patient or family. Advocates of a single-stage approach to this problem cite this advantage, as well as a potential decrease in overall morbidity by avoiding multiple procedures. A second approach to the problems of gastroin­testinal tract fi stulae and coexisting abdominal wall defects is to handle these issues remotely from one another at sepa­rate surgeries in order to improve the outcomes associated with the abdominal wall reconstruction.
When using complex reconstructive techniques such as component separation, [ 68 ] (Fig. 8.34 ) or fl aps, the fi rst attempt will be the easiest and most likely to achieve success. Proponents of the staged procedure cite several advantages. Given the contaminated nature of these cases performed in patients with fi stulae and/or intestinal stomas, infectious complications may be decreased, as well as improving over­all closure rates, and decreasing the rates of recurrent hernia by performing the abdominal wall reconstruction after the EAF has been addressed. Aside from the risk of infection, the nutritional status of these patients may be far superior after repair of their fi stula and complete reliance on enteral feeding utilizing the entire GI tract.
There are no prospective studies that have randomized patients to a staged vs. non-staged approach to these prob-
Fig. 8.34 A unilateral traditional “Ramirez” component separation. Unilateral fascial release may be all that is needed in some cases to get approximation of the rectus fascia at the midline
lems. There are several small retrospective analyses of patients that required surgical management of both fi stulae (not all EAF) and large abdominal wall defects, some of which took a staged approach [ 66 ] and some of which did not [ 69 , 70 ]. One retrospective review of 19 patients with high-output EAFs associated with large abdominal wall defects revealed a 31.5 % re-fi stulization rate after the initial procedure performed to repair the digestive tract fi stula [ 66 ]. The investigators used a staged approach to abdominal wall reconstruction employing the use of fl ap procedures, but unfortunately did not report the results of the reconstruction in their manuscript. It is certainly reasonable to assume that the cases where re-fi stulization occurred would have likely failed any abdominal wall reconstructive attempt had the procedures been performed concomitantly.
A retrospective study of 32 patients that had either intes­tinal stomas or enterocutaneous fi stulae in the presence of large abdominal wall defects who subsequently underwent single-stage closure of the gastrointestinal tract and their abdominal wall defect using a component separation tech­nique reported a 28 % rate of wound complications, 21 % recurrence of hernia, and 26 % recurrence of fi stulae with a median follow-up of 20 months [ 69 ]. The authors concluded that the rates of hernia recurrence and re-fi stulization were acceptable, although the defi nition of acceptable is certainly open for debate. Because of the diffi culty associated with the care of these patients, the United Kingdom has established specialized intestinal failure units to assist in, and potentially improve the care of these diffi cult cases [ 70 ]. The standard management in one of these units has been to perform repair of the fi stula with concomitant abdominal wall closure/ reconstruction after initial optimization of the patient’s over­all condition—focusing mainly on nutritional support and control of sepsis. Sixty-one patients underwent 63 operations
138
E.K. Johnson
to close digestive tract fi stulae associated with open abdomi­nal wounds. They used primary suture repair, with and with­out component separation, or suture repair in combination with absorbable or nonabsorbable prosthetic mesh to recon­struct the abdominal wall in these individuals. The observed postoperative mortality rate was 4.8 %, with respiratory or surgical site infections occurring in 82.5 %. Re-fi stulization occurred in 11.1 % of the group but was more common when prosthetic mesh was used (24.1 %). Porcine collagen mesh was associated with a particularly high rate of re-fi stulization at 41.7 %. These authors discourage the concomitant repair of fi stulas with abdominal wall reconstruction and suggest avoiding the use of prosthetic mesh [
70 ].
Jernigan and colleagues [ 64 ] reviewed their experience with a 3-stage approach to complex abdominal wall defects in 274 patients over 8 years. They did not specifi cally address individuals with fi stulae, but all patients were critically ill and were managed with open abdomens. Their management scheme was as follows: stage 1, absorbable mesh insertion for temporary closure (with mesh pleating and delayed clo­sure if edema resolved within 3–5 days); stage 2, mesh removal after 2–3 weeks and formation of a planned ventral hernia through placement of a split-thickness skin graft over granulation tissue or a full-thickness skin closure over vis­cera; and stage 3, defi nitive abdominal wall reconstruction after 6–12 months using the modifi ed component separation technique. Of note, 39 % of the patients died during stage 1 secondary to shock. Of the 166 patients who lived and had absorbable mesh placed, 22 % underwent delayed fascial closure. In the stage 2 group, there were nine deaths from multisystem organ failure, with 96 % of the remaining 120 patients having a skin graft placed over the viscera. A total of 14 fi stulae occurred (8 % of survivors). To date, 73 of the 120 have undergone defi nitive abdominal wall reconstruction with no deaths and a 5 % rate of recurrent hernia at a mean follow-up of 24 months. This large, retrospective study dem­onstrates nicely how a well thought-out and staged recon­structive plan can result in low mortality with good long-term results. Application of these results to the patient with an EAF must be done cautiously, however, as these patients were not analyzed separately as a specifi c group.
Abdominal Wall Reconstruction (AWR)
Key Concept : Reconstruction of the abdominal wall may be the most diffi cult aspect of the case , fraught with high com­plication rates . Expertise is crucial to successful results and may require a multidisciplinary approach along with use of mesh , fl a p , or tissue transfer techniques .
Reconstruction of the abdominal wall can be a complex and high-risk procedure. When performing defi nitive surgery for EAF, one immediate goal is to obtain closure of the abdo­men over the visceral repair (Fig. 8.35 ). Exposure of bowel to the environment is one factor that likely led to formation of an
EAF to begin with and must be avoided at this stage at all costs. The approach to closure of the abdominal wall will be dictated in part by the decision to stage the repair or not. There is no ideal technique or simple approach to AWR. Component separation techniques (CST) and fl ap reconstruc­tions tend to be technically demanding and can be associated with an increased incidence of wound problems depending on the approach used; however, they can provide a functional abdominal wall reconstruction. Simple mesh underlay closure of fascial defects will result in an acceptable hernia repair, but often leaves the patient with a large area of laxity on the ante­rior abdominal wall. The lack of a functional anterior abdomi­nal wall may limit their physical activity in the future, and the fi nished appearance may be cosmetically inferior. It is impor­tant to consider a patient’s functional status and expectations when determining which approach to use for abdominal wall reconstruction and hernia repair (Figs.
The CST originally popularized by Ramirez in 1990 [
8.36 and 8.37 ). 68 ]
involves separating the rectus muscle from the posterior rec­tus sheath and the external oblique muscle from the internal oblique, thereby resulting in medial advancement of approxi­mately 5 cm at the epigastrium, 10 cm at the waistline, and 3 cm in the suprapubic region unilaterally (Fig. 8.38 ). This can be coupled with mesh reinforcement and restores a dynamic and functional abdominal wall. There are several reports in the literature on the success of CST in the management of large ventral hernias, revealing rates of hernia recurrence from 6 to 52 % [ 68 , 7183 ]. It may seem intuitive, but it is worth stating that larger hernia defects are more likely to recur and they are more likely to require mesh-bridging techniques whether or not CST is used. Ideally, CST is used to facilitate full re-approxi­mation of the rectus complex in the midline with some sort of mesh buttress. Some defects are so large that bridging will still be required even after performance of component separation. One can expect higher recurrence rates in these scenarios.
A randomized comparison of CST to prosthetic mesh clo­sure with an expanded PTFE patch in 39 patients [ 78 ] showed that wound complications were more frequent in the pros­thetic group and 38 % of the patients closed with mesh required its removal later because of infectious complica­tions. Recurrent hernia was noted in 52 % of those undergo­ing CST and in 36 % of those with prosthetic repair. While it is diffi cult to draw defi nitive conclusions from this small study, the two methods were statistically equivalent in this group. Several minor modifi cations of the CST technique have been reported in the literature with varying success rates [ 74 , 75 , 81 , 84 ]. All of these reports involved either single cases or very small groups of patients. More recently there has been a surge of interest in the use of the posterior CST,
81 ] likely related to the ability to exploit the retro-rectus
[ space for placement of mesh reinforcement. Many of those who were major proponents of the classic anterior CST have shifted to the posterior approach.
8 Enteroatmospheric Fistula
Yes
EAF and AW
defect, cannot
get midline
closed
139
No
EAF takedown
Visceral
coverage
Absorbable
mesh
Adequate skin
coverage
No
NPWT
keep moist
Fig. 8.35 Algorithm illustrating a strategy for abdominal wall reconstruction in EAF patients. EAF enteroatmospheric fi stula, AW abdominal wall, AWR abdominal wall reconstruction, CST component separation technique, NPWT negative-pressure wound therapy
Biological
mesh
Yes
Close skin
over drains
Staged repair?
No
EAF takedown
with biologic
bridge
Candidate
for AWR?
Yes
EAF takedown
and CST
Reinforce CST, primary closure
with biologic
mesh
Utilization of CST may assist in AWR by increasing abdominal domain. Comparisons of preoperative and post­operative CT scans of the abdomen and pelvis after CST repair of large abdominal wall hernias with associated loss of domain have shown signifi cant increases in the intra­abdominal volume without any signifi cant change in dia­phragmatic height [ 85 ]. It may be possible to restore lost domain without the unfavorable result of pulmonary com­promise secondary to a loss of thoracic volume.
One of the major criticisms of the anterior CST approach is the large bilateral skin fl aps that result from the dissection necessary for exposure during the procedure. Flap compli­cations comprise the majority of wound occurrences noted with this procedure. Several approaches have been devised to avoid the seroma and potential infections that can be com­mon. The use of fi brin sealant has been shown to reduce seroma and wound infection rates in patients undergoing traditional anterior CST [ 82 ]. Placing numerous “quilting” mattress sutures has been described to eliminate dead space with the potential decrease in seroma formation but has not been studied prospectively. Rosen et al. [ 83 ] described
the use of a laparoscopic component separation technique in seven patients that altogether eliminates the large fl aps created using the open technique. The technique is similar to that used in TEPP laparoscopic inguinal hernia repair. Release of Scarpa’s fascia should also be performed with this approach, although care must be taken not to divide the linea semilunaris itself. After performance of the CST portion of the case laparoscopically, the midline may be reconstructed using either a laparoscopic or open approach—a requirement in all EAF patients treated with a single-stage procedure. Short- term follow-up of patients treated with this technique has shown acceptable outcomes. Laparoscopic CST has been shown to be inferior with regard to mobility in a porcine model, as it yielded only 86 % of the medial mobilization of the rectus that was achieved with the open technique [ 86 ]. In cadaveric testing the two have been shown to be equiva­lent [ 87 ]. Another minimally invasive method of achieving a lateral release has been described by creating small tunnels from the midline incision instead of large fl aps [
88 ]. While
this technique is approached through a large midline inci­sion, it avoids the creation of large fl aps with their attendant
140
E.K. Johnson
Figs. 8.36 and 8.37 These images show a young patient after a func­tional abdominal wall reconstruction. Note the obvious positioning of the rectus back in the midline as well as his ability to perform a sit-up
wound morbidity, potentially making it ideal in the case of single-stage repair of EAF. Laparoscopic and other mini­mally invasive approaches to component separation are rela­tively new, and to date, no randomized comparisons of these techniques with traditional techniques have been undertaken.
Biologic or Synthetic Mesh
Key Concept : Choice of mesh involves factors ranging from the risk of infection , strength and durability to incorporation , to personal preference . Regardless of choice , primary myo­fascial apposition along with the mesh vs . using a mesh
bridge ” results in decreased hernia formation .
AWR performed at the time of EAF repair will occur in a contaminated or potentially grossly infected environment. This precludes the placement of a permanent prosthetic or
alloplastic mesh as a bridge or reinforcement secondary to risk of infection requiring prosthetic removal. The advent of biologic prosthetic meshes has provided one more tool for the care of these complex patients. While these materials can still get infected in 0–40 % of cases [ 29 , 30 , 89106 ], they appear to be more suitable for placement in contaminated operative fi elds than do permanent synthetic prosthetics.
There are currently numerous biologic mesh products available on the market, the discussion of which is beyond the scope of this chapter. The majority of products are collagen­based, and this collagen can be either cross-linked or non­cross-linked. They are all somewhat different in the way they are processed, and all products claim to support normal host fi broblast and vascular ingrowth. Each manufacturer claims that their product is either integrated into or replaced by host tissue. There is a paucity of high-quality data to sup­port any of these claims, but what appears certain is that these materials can be used safely in complicated scenarios to assist in the achievement of abdominal wall closure and visceral coverage when permanent synthetic options cannot be used. Cross-linked biologic prosthetics tend to be stronger and have higher bursting strengths, while non-cross- linked biologic prosthetics allow for more host cellular ingrowth and “resorb” faster in vivo. It is the author’s experience that cross-linked prosthetics become encapsulated as opposed to incorporated into host tissues. This may or may not be desir­able to the operating surgeon. It is important to note that a completely cross-linked prosthetic will not incorporate into host tissues at all, while partially cross-linked prosthetics will incorporate to some degree.
The majority of data available for biologic mesh use in AWR involves three products: AlloDerm ® (LifeCell Corporation, Branchburg, NJ) [ 29 , 30 , 96106 ], Surgisis ® (Cook Biotech, West Lafayette, IN) [ 9395 ], and Permacol™ (Covidien Surgical, Mansfi eld, MA) [ 8992 ]. AlloDerm studies included between 10 and 144 patients revealing her­nia recurrence rates between 0 and 100 % with variable fol­low- up. There is unfortunately a fair amount of heterogeneity in the approach to reconstruction within each study, making it diffi cult to draw defi nitive conclusion from the data. Reports of Permacol™ use include between 1 and 28 patients with hernia recurrence rates of 0–15 % with variable length of follow-up [ 8992 ]. Several studies on the use of Surgisis ® to repair both ventral and inguinal hernia defects in con­taminated environments have been published [ 9395 ]. These studies have included between 20 and 53 patients with mean follow-up periods of 14–19 months and showed hernia recur­rence rates of 0–30 %. All ventral repairs completed in these studies were performed using a fascial-bridging technique. One study of the use of a non-cross-linked porcine dermal scaffold in the abdominal wall reconstruction of 16 patients reported a 7 % hernia recurrence rate after 16.5 months of follow -up [
105 ]. Importantly, the majority of these patients
8 Enteroatmospheric Fistula
ab
cd
ef
141
Fig. 8.38 These drawings depict the anatomy of the rectus and oblique muscles on one side of the anterior abdominal wall. The traditional “Ramirez” anterior component separation is shown. Release of the external oblique is performed and the space between the external and
underwent CST, and they achieved complete apposition and closure of the rectus muscles in 88 %. The porcine matrix was used as a reinforcing underlay in the majority of these patients but was used as a bridge graft in those where rectus apposition could not be achieved. The only recurrence was noted in a patient who was “bridged” (Fig. 8.39 ).
There is some controversy as to whether or not bridg­ing a fascial defect with a biologic prosthetic is an ade­quate hernia repair. A retrospective review of 11 patients that had large complex hernias bridged with human acel­lular dermal matrix found an 80 % hernia recurrence rate at a mean follow-up of 24 months and a cost of $5,100 per patient [ 29 ]. The manuscript title asserts that bridging with a biologic may simply result in an expensive hernia sac. Another study showed that a biologic mesh-reinforced primary repair (involving CST in most) had only a 20 % recurrence, while 80 % of patients who were bridged with the same biologic mesh-reinforced primary repair had hernia recurrence [ 96 ]. The obvious confounder in this study is that patients who were bridged had larger defects that were more likely to recur in any case. Comparison of biologic reinforcement of CST with historical controls
internal obliques is developed out to the fl ank. The posterior rectus fas­cia is also released. Arrows indicate the direction of dissection, ( a – f ) indicate the order of dissection, 1 – 4 indicate the layers of the abdominal wall and muscles
Fig. 8.39 A bridge repair with a biologic mesh
who were not reinforced shows a decreased recurrence rate in hernias that did not require bridging [
97 ]. There
have been other reports that surgical site infection is more common with larger biologic implants [
103 ] and that
142
E.K. Johnson
hernia recurrence in those treated with biologic implants is more common in women, increased body mass index, prior failed repair [
104 ], and with use of the ultra-thick
form of human acellular dermal matrix as opposed to the thick variety [ 100 ].
Another controversy that exists regarding the use of bio­logics in abdominal wall reconstruction is the issue of what defi nes a recurrent hernia vs. simple abdominal wall lax­ity. Unfortunately, the difference between these two, if one exists, is often not addressed in manuscripts that discuss her­nia recurrence rates. In one study that does address this issue [ 101 ], the authors comment that bridging was performed in 9 of the 27 patients in their study group who underwent repair of large abdominal hernias using AlloDerm as an underlay in combination with CST. Two of the 9 patients also had a poly­propylene mesh onlay constructed over the biologic. Laxity was seen at 1-year follow-up in 7 of the 9 that did not have a polypropylene mesh onlay performed. Others report laxity or hernia recurrence in 100 % of those bridged with AlloDerm ® at 1 year follow-up [ 30 ]. AlloDerm ® in particular has been associated with abdominal wall laxity with long-term follow­ up, and this is believed to be related to the elastin content in the graft. The manufacturer suggests pre-stretching the graft and placing it under some tension to minimize this compli­cation. LifeCell Corporation also now markets Strattice™, a non-cross-linked porcine dermal product, specifi cally for the purpose of AWR given its lack of elastin content.
In the situation of a staged abdominal wall reconstruction in a patient that has previously undergone EAF repair with simple visceral coverage, a synthetic prosthetic mesh may be appropriate to use (for a clean wound class I). The issue of bridging vs. complete myofascial re-approximation is perti­nent in the select patient population with complex abdominal wall defects. While the idea of tension-free hernia repair has made its way from use in the inguinal region to use in ventral hernia repair; it may be that this concept is fundamentally fl awed. It is obvious that bringing a patient’s fascia together in the midline under extreme tension increases the risk of failure; however, a certain amount of tension on a repair is desired. When surgeons place a piece of prosthetic mesh as an underlay to bridge a fascial defect, a degree of tension is intentionally placed upon the underlay mesh to fascia inter­face. A prosthetic placed with no tension at all results in a palpable bulge or soft spot at the location of the fascial defect. This is undesirable to patients both physically and cosmeti­cally. Either the mesh should likely be placed under some ten­sion to fl atten abdominal contour or a component separation should be performed to achieve complete myofascial approx­imation and a functional abdominal wall reconstruction. This issue is controversial and is not strongly supported by data; however, a 2005 review of 188 patients with large abdominal hernias showed a recurrence rate of 31 % in patients treated with a fascial-bridging synthetic prosthetic vs. 9 % in those that had complete restoration of myofascial continuity of
the abdominal wall [ 106 ]. It is the author’s recommendation that primary fascial closure be performed whenever possible while using a prosthetic underlay to reduce hernia recurrence. This applies to both synthetics and biologics but is certainly more important when using a biologic with the intention of performing a durable hernia repair.

Summary Pearls

EAF patients will present a multitude of challenges to the surgeon. In a typical case, the surgeon will be confronted with a complex fi stula, a hostile peritoneal cavity, a complex and large abdominal wound, the possible presence of or need for a stoma, a diffi cult abdominal contour, and the presence of old contaminated prosthetic mesh—all potentially in an initially septic patient. Each of these elements must be fac­tored into the operative plan to optimize the chance for suc­cess. Something as simple as gaining entrance to the peritoneal cavity must be given thoughtful consideration. Fortunately, many of these patients are quite remote from the index procedure and have developed adjacent incisional her­nias that may facilitate ease of entry into the abdomen. Preoperative CT scan may show this and physical examina­tion will be confi rmatory. The presence of adjacent hernia sac provides a site of entrance that will be free of adhesions. Take advantage of this if it is present. If not, one may be forced to enter in the midline where dense adhesions between the bowel and anterior abdominal wall will create diffi culty and potentially enterotomies. Lateral entry into the abdomen should be avoided as it may limit the options for CST during the reconstructive portion of the procedure.
Performing a complete adhesiolysis during laparotomy is tempting and can certainly be achieved in some circum­stances. Yet, if there are no signs of bowel obstruction either clinically or radiographically, it is likely best to limit adhe­siolysis to areas of necessity. The risk of enterotomy is high, and the likelihood of re-fi stulization increases with every enterotomy created. Fistulas should be resected and the remaining bowel re-anastomosed. The temptation to free an area of fi stulized bowel followed by primary closure should be reserved for situations where it is the only possibility. These repairs tend to break down and are discouraged.
The patient with an ostomy presents an additional chal­lenge. The surgeon must fi rst consider if the stoma should be closed or left in place. The length of remaining bowel, conti­nence status, presence of a parastomal hernia, and potential for the need to perform a high-risk distal anastomosis must all be considered. If the need for a stoma remains, it is easiest to leave the existing stoma in place. If AWR is performed at the time of EAF closure, it is likely that the abdominal wall con­tour will change to some degree. A stoma site that was prime preoperatively may be completely unsuitable after AWR. This is especially important with high-output stomas and
8 Enteroatmospheric Fistula
143
Fig. 8.40 A patient previously operated upon where “incorporated” polypropylene mesh was left in place. She suffered midline wound breakdown and bowel fi stulization through the mesh. Ultimately this mesh was excised and she underwent AWR with a good result
ileostomies. If this situation is encountered, the best course of action is to re-site the stoma. You won’t have the luxury of selecting an appropriate site preoperatively, so familiarity with the concepts of selecting an optimal stoma site is criti­cal. The stoma can be delivered through a keyhole in any mesh used as reinforcement, and should be located through the rectus muscle. Parastomal hernias can be repaired using the Sugarbaker technique or can also be addressed via reloca­tion of the stoma and primary closure with mesh reinforce­ment. High-risk or distal colorectal/coloanal anastomoses should be covered with a proximal stoma. You have one good shot at helping these patients, and clinical sequelae of a leak­ing anastomosis will destroy any chance of success. If any previous mesh is encountered during the procedure, remove it completely (Fig. 8.40 ). The old adage that “incorporated mesh” is fi ne to leave behind is a terrible pitfall. While con­troversial, it is this author’s opinion that leaving old and potentially infected mesh behind is a recipe for failure.
Finally, often in the profession of surgery, true wisdom involves knowing when to say when. There are some EAF patients that, despite our best efforts and intentions, simply cannot be helped with surgery. Unfortunately there is no sur­gical “crystal ball” that will allow us to reliably make this assessment. Though it may sound obvious, these procedures are extremely stressful on the patient, and those in poor med­ical condition with severe cardiopulmonary disease may not tolerate this stress. Some patients will learn to live harmoni­ously with an EAF over time. In some, the fi stula simply becomes a poorly sited stoma that can be effectively con­trolled with an appliance and wound care products. An elderly patient with signifi cant comorbidities and a well­controlled EAF may be best left alone. Give this consider­able thought and ensure adequate counseling of the patient prior to making the commitment to surgical repair.

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