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328
P. Bachellier and P. Addeo
arterial resection with simultaneous pancreatectomy are more challenging than other. Resection of the superior mes­enteric artery could be seen as one of the most challenging arterial resection at the time of pancreatectomy because of: (1) the frequent presence of an associated venous invasion; (2) the variable degree of tumoral inltration downward through the mesentery; (3) the necessity of a mesenteric approach and complete mesenteric dissection; (4) the need for reconstructing more jejunal and ileal branches; (5) the high mortality rates (20%) reported so far [15]. In this chap­ter we will present the surgical technique of our standardized approach for SMA resection during pancreaticoduodenec­tomy (PD).
in detail [911, 1621]. Briey every patients presenting with a superior mesenteric artery involvement is considered as a locally advanced tumor independently from the presence of venous invasion and candidate for induction chemother­apy [11]. More often SMA involvement is seen (1) in patients having tumors located at the uncinated process along with a variable degree of venous invasion; (2) in tumors located at the proximal part of the pancreatic body invading the SMA, the splenoportal venous conuence and the coeliac trunk; (3) in bulky tumors of the pancreatic head associated with venous invasion and invasion of both the coeliac trunk and the SMA.When considering the presence of SMA involve­ment for surgery three factors should be considered. First the longitudinal extent of SMA invasion with three types easily recognized: (1) Type 1 invasion limited to the retro pancre-

42.1.1 Preoperative Planning

atic tract of the SMA trunk: (2) type 2 invasion extended to
the origin of the rst jejunal branches; (3) type 3 invasion Our standardized protocol for managing patients with locally advanced pancreatic cancers has been previously described
reaching the origin of the ileocolic branches and of the sec-
ondary or third jejunal branches (Fig. 42.1). Secondly it
ab
Fig. 42.1 Strasbourg’s classication of Superior mesenteric artery
invasion pattern: (a) Type 1 invasion limited to the retropancreatic tract of the SMA trunk: (b) type 2 invasion extended to the origin of the rst
jejunal branches and type 3 invasions reaching the origin of the ileoco-
lic branches and/or of the secondary or third jejunal branches
42 Pancreaticoduodenectomy withSuperior Mesenteric Resection andReconstruction forLocally Advanced Tumors
329
should be remarked: (1) the presence and the extent of an associated venous invasion (superior mesenteric vein versus splenomesentericoportal conuence) as well the presence of thrombosis (superior mesenteric vein, portal vein, splenic vein) and venous cavernoma transformation. Thirdly, the coexistence of coeliac trunk invasion should be remarked. Intuitively, the presence of CT invasion, a longitudinal inva­sion beyond the SMA trunk and the presence of venous inl­tration increases the technical difculties of SMA resection and indicate more aggressive disease. As a general sugges­tion preoperative planning is of paramount importance and all these three factors have been extensively planned before scheduling surgery. The need for autologous and /or heter­ologous graft should be planned. Usually we schedule sur­gery 4 weeks after the last chemotherapy cycle and preoperative nutrition is also encouraged to prepare patients for surgery. Rehabilitation should be the rule and regular daily physical activity is also strongly encouraged.

42.2 Surgical Technique

42.2.1 Basic Preliminary Maneuvers

A bilateral subcostal incision with midline extension up to the xiphoidal process is usually performed. The groins are also systematically included in the operative eld in case of need for saphenous grafts. Preliminary exploration included systematic search for liver metastases and peritoneal carci­nomatosis. The right colon and the mesenteric root are sec­tioned during a Cattel–Braasch maneuver. A large Kocher maneuver is then performed up to the left border of the aorta. The interaorticocaval area is cleared from lymphatic tissues which are sent for pathological examination. The origin of the SMA is cleared at the superior border of the left renal vein and isolated. Inltration of the origin of the SMA on the aorta indicates not resectable disease. The dissection is moved toward the mesentery in order to delineate the longi­tudinal extent of SMA inltration. The insertion of the transverse mesocolon is sectioned right-to-left by ligating the superior right colonic and the middle colonic pedicles. These sections are performed far from the colonic wall in order to preserve the communicating arterial and venous arcades. Now the mesentery is sectioned right-to-the-left perpendicularly to the axis of the SMA and the SMV. This dissection goes downward 1–2cm beyond the macroscopic venous/ arterial tumoral inltration. The SMV and/or its branches and the SMA and/or its branches are isolated and looped into the mesentery (Mikado’s technique). Inltration of the SMA trunk needing more than two branches distal reconstruction can be particularly challenging especially in older and obese patients and could eventually discouraged.
42.2.2 Management oftheMesenteric Venous System
In our experience management of the superior mesenteric venous system is of a paramount importance when perform­ing SMA resection for several reasons. First, frequently there is a variable degree of venous obstruction related to the tumoral inltration which goes from right to the left in can­cers of the uncinated process. Dissection of the mesentery and of the hepatic pedicle progressively interrupts all the col­lateral circulations which drains the bowel and supplies the liver in patients with venous obstruction. The section of these venous collaterals increases difculties in dissection and might cause profuse bleeding and liver hypoperfusion. We therefore systematically advocate early section of the SMV or its branches and derivation into the portal system at the beginning of the dissection. This is achieved by a transitory mesenterico-portal shunt using Gore-Tex ringed prosthesis interposed between the SMV and the right lateral side of the portal vein (Fig.42.2). Indeed, the SMV previously isolated is directly sectioned over a clamp and anastomosed on one end to a 20-cm long Gore-Tex ringed prosthesis which is then anastomosed to the lateral wall of the PV just below its bifurcation. The use of this shunt achieves immediate decom­pression of the bowel venous ow into the portal system which is of great importance in patients with cavernoma. Furthermore it provides superior dexterity for the dissection of the mesentery and provides continuous venous drainage into the portal vein though the entire operation [11, 20]. The advantages of this transitory shunt include (1) greater mobil­ity of the mesenteric root because of the extra-length pro­vided by the prosthesis which avoids completely the risk of venous disruption (2) the need for combined arterial and venous clamping; (3) provides superior exposure for the arterial resection and reconstruction (4) maintains portal venous inow to the liver which is very often damaged by the preoperative chemotherapy.
42.2.3 Dissection oftheSuperior Mesenteric Artery andoftheHepatic Pedicle
Once the transitory mesentericoportal shunt has been unclamped, attention is directed toward the different branches of the SMA which are isolated and looped. In presence of SMA inltration the section of the inferior pancreaticoduo­denal artery and the rst jejunal artery is not possible. The SMA trunk is currently only isolated on the future transec­tion point. Dissection proceeds on the hepatic pedicle which is completely dissected. The pyloric and the gastroduodenal artery are sectioned; the portal vein trunk is looped such as the common bile duct. The dissection is pursued downward
330
P. Bachellier and P. Addeo
Fig. 42.2 The management of the venous system is achieved by a transitory mesentericoportal shunt interposed between the right side of the
portal vein and the SMV as showed
on the coeliac trifurcation. The common hepatic artery, the splenic artery and the left gastric artery are looped. The coe­liac trunk is dissected circumferentially, and the diaphrag­matic arteries are sectioned.
teric artery trunk on its origin. With this exposure a clamp is positioned on the origin of the SMA and another on the trunk or the branches of the SMA.After systemic heparin admin­istration, the proximal and the distal SMA trunk and the dis­tal branches are sectioned. Arterial replacement is performed either end-to-end (resection up to 3-cm length) (Fig.42.3) or
42.2.4 Section ofthePancreas andVascular Resection
using a saphenous graft which is anatomized between the two ends using running 8/0 sutures (Figs.42.4 and 42.5). The
attention is now directed toward the venous system with A tunnel is created beyond the pancreatic body at the level of entry of the splenic artery or at the conuence of the inferior mesenteric vein into the splenic vein depending on the degree of tumoral spreading toward the left pancreas. The pancre­atic body is progressively dissected from the splenic vein and sectioned. The pancreas is then dissected over 6-cm from the splenic artery and vein. The splenic vein is then sectioned and this will provide superior view on the superior mesen-
sequential removal of the shunt and direct anastomoses
between the SMV and the Portal Vein. The management of
the splenic vein includes either a distal splenorenal shunt on
the left renal vein or preservation of the natural conuence
between the inferior mesenteric vein and the splenic vein
[16] (Fig.42.6). Digestive reconstruction is performed with
a telescoped pancreaticogastrosotmy [22], hepaticojejunos-
tomy and gastroenterostomy.
42 Pancreaticoduodenectomy withSuperior Mesenteric Resection andReconstruction forLocally Advanced Tumors
331
Fig. 42.3 Intraoperative view of a PD with SMA resection. A direct
end-to-end without graft interposition is generally possible in case of short (<3cm) SMA resection
Fig. 42.4 Intraoperative view of a PD with SMA resection. A saphe-
nous graft is interposed between the origin of the SMA on the aorta and
the stump of SMA into the mesentery
Fig. 42.5 Intraoperative view of a PD with SMA resection using the Mikado’s technique. In this case four different branches are sequentially
reconstructed by using several saphenous grafts. While feasible this type of resection remains very challenging
332
P. Bachellier and P. Addeo
ab
Fig. 42.6 Intraoperative view of splenic vein management either by a splenorenal shunt (a) or ligation of the splenic vein with preservation of its
conuence with the inferior mesenteric vein (b)

42.3 Postoperative Management

Intravenous heparin is administered during the rst 7days. A computed tomography scan is performed at postoperative days one and tenth to control vascular permeability. Long- term anti­aggregant therapy by aspirin is maintained in all patients (3months). An oral feeding is restarted beginning from postop­erative day 7. Postoperative diarrhea is frequent after such extended dissection of the SMA and is managed with codeine. Adjuvant chemotherapy administration is indicated according to the presence of prognostic factors given by pathology.

42.4 Conclusions

Herein we have described a standardized technique for resecting locally advanced pancreatic cancers invading the SMA. The technique presented entails extensive bowel mobilization, management of the venous system by tempo­rary shunting, resection of the artery and reconstruction by direct anastomosis or by interposing autologous saphenous graft according to segment resected.
The performance of PD with SMA requires extensive experience in vascular and pancreatic resection and should be reserved to high volume center.

References

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14. Truty MJ, Kendrick ML, Nagorney DM, etal. Factors predicting response, perioperative outcomes, and survival following total neo­adjuvant therapy for borderline/locally advanced pancreatic cancer. Ann Surg. 2021;273(2):341–9.
15. Jegatheeswaran S, Baltatzis M, Jamdar S, Siriwardena AK.Superior mesenteric artery (SMA) resection during pancreatectomy for
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Robotic Pancreaticoduodenectomy

ThiloHackert
43
Abstract
Robotic or robotic assisted surgery can be regarded as an advancement of minimally invasive surgery and has been implemented in various eld of surgery including pancre­atic surgery in recent years. Acceptance worldwide is increasing—also for complex surgical procedures—and nearly all types of pancreatic resections have been per­formed robotically in the meantime. Although robotic pancreas surgery is potentially burdened by a long learn­ing curve and increased procedure costs, standardized resections such as distal pancreatectomy and partial pancreatico- duodenectomy (PD) are well established in specialized centers today. The rst robotic PD has been reported by Giulianotti in 2001, yet, due to the complex reconstruction technique required, this has not been adopted in the following years before larger case series were published. The robotic technology advancements offer a three-dimensional movement of minimally­invasive instruments as well as a high-denition view, however, tissue handling and manipulation during resec­tion and especially reconstruction require a high level of training and expertise to achieve good results. During the learning curve, increased morbidity has to be accepted, including high conversion rates. Based on experiences of the pioneers of this technique, approximately 80 proce­dures are required to achieve a sufcient level of expertise and consequently surpass the learning curve. Yet, no ran­domized controlled trials (RCTs) on the perioperative and long-term outcomes of robotic PD compared to open or laparoscopic PD have been published, leaving a low level of evidence to support this technique today. Despite this situation, which is commonly observed when new tech­niques are introduced, a number of observational studies with promising results in terms of morbidity, mortality
T. Hackert (*) Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany e-mail: Thilo.Hackert@med.uni-heidelberg.de
and oncological outcomes have been published. Practically, no absolute contraindications to choose a robotic approach for standard PD exist. In addition, the robotic technique may also be suitable for challenging pancreatic anastomoses with a high risk of postoperative pancreatic stula (POPF) without the need to convert to an open procedure in such situations. Presumed advan­tages of robotic PD include faster postoperative mobiliza­tion and return to activity of the patients as well as shorter hospital stay without an increased need for readmission when compared to open PD.Considering the low method­ological quality of the currently available studies, these results have to be considered with caution due to the observational character of the published series and a potential bias of underreporting morbidity which may especially be a risk of bias during the learning curve of this procedure.

43.1 Background

Since the mid-1980s minimally-invasive surgery (MIS) has been established in various surgical elds, starting with gynecological operations and extending to other disciplines including visceral surgery in the 1990s [1]. After initial skep­ticism, “small” procedures like appendectomy or cholecys­tectomy were accepted and nally regarded as the standard of care, yet, it took several years to establish more complex procedures adopting this technique. The rst MIS-PD was performed in 1994 [2] demonstrating that this was generally feasible in highly specialized centers, however, no wide­spread acceptance occurred. Regarding MIS for PD, the debate is still ongoing today which is based on the data from non-observational studies, but RCTs that have reported con­icting results. Today, there are three RCTs available, two of them reporting favorable outcomes, one showing that MIS for PD may be potentially dangerous when brought into wide-spread practice [35]. Systematically analyzing these results, a potential thread for the patient is not reproducible
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022 M. Makuuchi et al. (eds.), The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases,
https://doi.org/10.1007/978-981-19-0063-1_43
335
336
T. Hackert
[6], however, a high level of specialization as well as case load seems to be required when offering MIS for PD and the potential problem is the generalizability of results which may limit the acceptance of MIS for PD in daily practice as only few centers will be able to overcome the learning curve and offer a MIS-PD program on a high level of expertise [5]. Considering this, MIS-PD does not seem to be a promising alternative approach to open PD today. In this situation, the application of the robotic technology may be the key to facil­itate minimally-invasive procedures and help to spread this approach in PD as especially the phase of reconstruction can be performed much more easily than in conventional MIS.
Regarding the development of robotic surgery, after its establishment as a small start-up joint-venture between aca­demic institutions and industry as well as the US army, in 1995 the company Intuitive Surgical© was founded and introduced the DaVinci® system as a robotic platform in 1999, receiving FDA approval for MIS procedures in 2000. Today, the company has achieved a nearly exclusive world­wide monopolistic market position and the DaVinci
®
system is by far the most commonly used device. In pancreatic sur­gery, robotic distal pancreatectomies and enucleations were performed as early as 2001 [7]. Giulianotti pioneered the rst robotic PD in the same year [8] but mainly due to the complex reconstruction, it took several before larger patient series were published, mainly from the Pittsburgh center [9]. With this increase of utilization, other centers intro­duced robotic PD increasing the number of procedures worldwide and establishing or adopting the standards pub­lished before. For any type of robotic surgery, there are mainly observational studies to date, yet, a large number of RCTs are planned or already recruiting with the aim to com­pare either robotic vs. conventional MIS or open procedures [10]. Consequently, more data on the safety and oncological feasibility are awaited within the next 3–5years. The pres­ent review summarizes the currently available data on robotic PD.

43.2 Robotic PD

Robotic PD is the most complex procedure among all types of robotic pancreas resections. Despite the advantages of the robotic platform compared to conventional MIS—especially the possibilities of three-dimensional instrument movement and high-denition view—tissue handling and manipulation during resection as well as reconstruction requires a high level of expertise as the tactile feedback is still lacking which limits the surgeon’s ability to adjust his technique to certain challenging situations including vascular involvement dur­ing resection or very soft tissue conditions during recon­struction. This implies that a very accurate diagnostic workup is mandatory to recognize potential venous or arterial
involvement by pancreatic tumors preoperatively and esti­mate the suitability of a patient for a robotic procedure. Vascular resection and reconstruction is well possible during robotic PD, however, it has to be planned and requires an adequate level of experience and technical kills when attempted. Otherwise, conversion to an open procedure— also in an emergency setting—is inevitable. This also implies that every surgeon doing robotic PD has to be trained not only in this procedure but also in open PD to be able to con­vert and x any occurring problem by an open approach if required—a merely robotic training seems to be inadequate in such a setting, especially as during the learning curve of robotic PD, an increased morbidity caused by intraoperative challenges may occur and high conversion rates are possible. Regarding the implementation of robotic PD, some precon­ditions have to be respected. Firstly, a center needs to have a level of experience in open pancreatic surgery and handling the potential complications; secondly, a certain case load has to be guaranteed—although there is no clear consensus on the minimal number of annal procedures, it seems to be rea­sonable to have a volume of at least 50 PDs per year to select proper patients for robotic PD and to surpass the learning curve for this procedure in a reasonable time frame. Thirdly, an environment of experienced open—an ideally—laparo­scopic surgeons has to be present, who are able and willing to go through training (including simulator skills, tissue training, visiting experienced centers), on-site proctoring and teaching of robotic PD. Presumed these preconditions are fullled, a patient selection is absolutely mandatory to start a robotic PD program. This implies to select clearly resectable cases of any type of pancreatic tumors to start and assure quality monitoring, which can be realized within a prospective database or a clinical study setting. Especially with regard to resectability of any pancreatic pathology, a certain selection bias is inherent during the learning curve of robotic PD.As it is common knowledge that during PD easy resection (small—potentially benign or borderline lesions, no duct dilation) is usually associated with rather difcult reconstruction (small pancreatic/bile duct, soft pancreatic remnant tissue), this may initially lead to an increase of post­operative morbidity, underlining the importance of compli­cation management to avoid any failure to rescue and endanger patients undergoing robotic PD.Furthermore, the standardization of all operative steps of PD is not only pos­sible but also helpful to achieve good outcomes. Giulianotti et al. published a 17-step procedure line for robotic PD including all key points of resection and reconstruction [11]. Although this is only a guide to perform the procedure and every patient may require individual adoption, a certain stan­dardization is certainly helpful and dened steps of the oper­ation can be standardized very well, i.e. positioning of the patient, trocar placement and positioning of the instruments on the respective arms of the robot [12]. A basic consideration
43 Robotic Pancreaticoduodenectomy
337
is the decision to perform robotic PD as a “one- surgeon” pro­cedure in which the console surgeon basically does all steps of the procedure himself and the table-site assistant is only helping with exposition, suction and instrument changes. Alternatively, robotic PD may be performed in a “two-sur­geon” approach if the table-site surgeon also actively partici­pated in the operative steps, i.e. by using a sealing/cutting device, dividing structures by scissor or applying clips. Both approaches have advantages, the rst guarantees a high grade of independence for the console surgeon and allows to per­form the procedure also with less qualied or changing table-site personnel. The disadvantage is a potentially high frequency of instrument changes that are required. The sec­ond approach may allow a faster procedure with less instru­ment changes if the team is well-practiced. This approach however, requires a steady team composed of two experi­enced surgeons and may be therefore difcult to realize in some centers.
Regarding technical aspects of robotic PD, the common principles of radical resection should be respected. This implies the common standard of required lymphadenectomy during PD including the lymph nodes on the right side of the superior mesenteric artery, celiac axis and the hepatoduode­nal ligament [13]. Furthermore, soft tissue in the “triangle” between superior mesenteric artery, celiac axis and portal vein should be cleared [14]. As resection is technically easier if all preparation can be done from the right side of the mes­enteric root without changing perspective and the eld of preparation to the left side of the Treitz ligament, the rst jejunal loop needs to pulled through after dividing Treitz ligament and after skeletonizing the loop, an “uncinate-rst
approach” is a very convenient procedure for resection during robotic PD [15]. Division of the pancreatic neck can be done by stapler or by monopolar cautery as well as by sealing/cutting devices.
After completion of the resection, pancreatic anastomosis reconstruction can be done by pancreatico-jejunostomy (PJ) or pancreatico-gastrostomy, however, most surgeons prefer PJ in a modied Blumgart fashion using an internal pancre­atic stent as this is technically the easiest way of reconstruc­tion (Fig.43.1) [16]. Hepatico-jejunostomy can be done by one-layer running sutures for dilated bile ducts (Fig.43.2) or by monolament single stitches in case of small bile ducts, comparably to hepato-jejunostomy in open PD.For gastro­jejunostomy, side-to side stapling with suture closure of the stapler introducing incision is the quickest possibility of reconstruction, but all other types of sutured anastomoses are possible, depending on the surgeon’s preference.
With regard to outcomes of robotic PD, these have to be weighed against open PD as the gold standard as well as con­ventional MIS-PD.No RCTs have yet compared these pro­cedures and data are mainly retrieved from a number of case series as well as mono-and multicenter comparative observa­tional studies [1721]. Overall, these studies conrm techni­cal feasibility and promising results regarding morbidity, mortality and oncological outcomes.
The largest observational study includes 500 robotic PD performed over a 10-year period and reports an improve­ment of operative performance with a reduction of operating room time during the rst 240 procedures with a plateau phase afterwards [22]. This impressively underlines the duration of the learning curve, furthermore the study shows
Fig. 43.1 Pancreatico-jejunostomy, modied Blumgart technique. Left side: preparation of the transparenchymal stitches (white arrows), pancre-
atic duct (black circle). Right side: duct-to-mucosa stitches (white arrow), inserted pancreatic duct stent (black asterisk)
338
Fig. 43.2 Hepatic-jejunostomy, running sutures. Left side: single-layer backwall suture. Right side: single-layer frontwall suture
T. Hackert
that during the last 100 cases in this series operation time remained stable although an increasing proportion of vascu­lar resections were performed and more patients undergoing neoadjuvant therapy—with presumably more difcult con­ditions during resection—were selected. A comparative series from the US includes eight centers and 211 post learning-curve robotic PD vs. 817 open PD [17]. This study shows that a high BMI or a history of previous abdominal surgery are no basic contraindications to choose a robotic approach, overall conversion rate was 4.7%. For malignant indications, surgeons tended to prefer an open approach as 55% of open vs. 33% of robotic PDs were performed for cancerous lesions. This may well be explained by basic con­cerns regarding radicality of the robotic procedures, results remain unclear in this respect. The proportion of R1 resec­tions was higher for the robotic group (50% vs. 33%) whereas the number of retrieved lymph nodes favored the robotic resection (n = 27.5 vs. n = 19 harvested lymph nodes) without results on long-term outcomes. Perioperative outcomes were comparable, especially clinically relevant POPF (robotic 13.8% vs. open 9.0%). With a similar length of hospital stay, robotic patients were readmitted more fre­quently (31% robotic PD vs. 24% open PD).
A denitive evaluation especially regarding long-term oncological outcomes is not possible from these data. A recent systematic review [19] includes 11 non-randomized studies comparing robotic and open PD. The number of robotic procedures in the underlying studies accounts to overall n=514 robotic PD vs. n=1263 open PD.The results show signicant differences in operation time (robotically +1.5h) and blood loss (robotically 200mL) with similar transfusion rate. In the subgroup of oncological patients, robotic PD showed a lower rate of R1 resections with a simi­lar number of retrieved lymph nodes. The data favor robotic
PD in terms of lower overall morbidity (especially surgical site infections) and faster postoperative mobilization of the patients, although this does not turn into shorter length of hospital stay.
Long-term oncological outcome as the potentially most important variable for pancreatic cancer surgery has recently been investigated in an analysis of the US National Cancer Database [23]. Stage I–III pancreatic cancer patients who underwent either robotic PD (n = 626) or open PD (n=17.205) showed no relevant differences in baseline data regarding tumor characteristics. In the short-term outcomes, robotic PD was superior with regard to lymph node yield whereas R0 resection status was similar in both groups. Robotic PD resulted in a shorter hospital stay (1 day) at similar readmission and 90-day mortality rates (9% vs. 8% readmission and 4% vs. 6% mortality, respectively. Median overall survival was 22.0months (robotic PD) vs. 21.8months (open PD) with 1-, 3- and 5-year survival rates of 74% vs. 73%, 33% vs. 31% and 19% vs. 19%, respectively. Based on such data, there should not be a general restrictive attitude towards robotic PD in malignant indications, even if results have to be considered with caution to the retrospective nature of this registry study.
Beyond standard PD, extended procedures, namely vas­cular resections have been performed in a few centers world­wide [2426]. Principally, such operations are possible using the robotic system for venous as well as arterial reconstruc­tions. Due to the very limited reported number of patients undergoing extended robotic PD it is not possible to give a valid estimation about potential advantages. In addition, con­siderable morbidity (up to 80%) and mortality rates (up to 14%) may burden these approaches which certainly require an even longer learning curve than that for standard robotic PD [27, 28].