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- •Biomedical Engineering in Gastrointestinal Surgery
- •Copyright
- •Contents
- •Foreword
- •Acknowledgments
- •2.1.3 Attrition and Erosion
- •2.2 Esophagus
- •2.2.1 Anatomical Description
- •2.2.2 Functional Task
- •2.2.3 Disorders and Diseases
- •2.2.4 Cancer
- •2.2.5 Biomedical Engineering Aspects
- •2.2.5.1 Internal (Endoscopic) Reinforcement
- •Reference
- •2.1 The Gastrointestinal Tract: an Overview
- •2.1.1 Structural Defects
- •2.1.2 Functional Defects
- •2.2.5.2 Implants
- •2.2.5.3 Electrical Stimulation
- •2.3 Stomach
- •2.3.1 Anatomical Description
- •2.3.2 Functional Task
- •2.3.3 Disorders and Diseases
- •2.3.4 Biomedical Engineering Aspects
- •2.4 Duodenum and Small Intestine
- •2.4.1 Anatomical Description
- •2.4.2 Functional Task
- •2.4.3 Disorders and Diseases
- •2.4.4 Biomedical Engineering Aspects
- •2.5 Colon and Rectum
- •2.5.1 Anatomical Description
- •2.5.2 Functional Task
- •2.5.3 Disorders and Diseases
- •2.5.4 Biomedical Engineering Aspects
- •2.6 Liver/Gallbladder
- •2.6.1 Anatomical Description
- •2.6.2 Functional Task
- •2.6.3 Disorders and Diseases
- •2.6.4 Biomedical Engineering Aspects
- •2.7 Pancreas
- •2.7.1 Anatomical Description
- •2.7.2 Functional Task
- •2.7.3 Disorders and Diseases
- •2.7.4 Biomedical Engineering Aspects
- •References
- •3.1 Definition
- •3.2 Basic Surgical Principles
- •3.2.1 Wound Healing, Wound Treatment
- •3.2.2 Indications for Surgery
- •3.2.2.1 Emergency Surgery
- •3.2.2.2 Urgent Surgery
- •3.2.2.3 Semielective Surgery
- •3.2.2.4 Elective Surgery
- •3.2.3 Steps of the Operation
- •3.2.3.1 Positioning on the OR Table
- •3.2.3.2 Incision
- •3.2.3.3 Exposure
- •3.2.3.4 Dissection
- •3.2.3.5 Resection
- •3.2.3.6 Specimen Retrieval
- •3.2.3.7 Viscerosynthesis/Reconstruction
- •3.2.3.8 Wound Closure
- •3.3 Structure and Organization of Surgical Care
- •3.3.1 Outpatient Surgical Care
- •3.3.2 In-Hospital Surgical Care
- •3.3.2.1 Emergencies in Visceral Surgery
- •3.3.2.2 Elective Surgery
- •3.3.2.3 Hospital Beds
- •4.1 Asepsis
- •4.1.1 The Detection of Antisepsis
- •4.1.2 Reprocessing of Surgical Instruments
- •4.1.3 Sterilization
- •4.2 Anesthesia
- •4.2.1 Sedation
- •4.3 Dedicated Workplace: The Operating Room
- •4.3.1 The Surgical Workplace
- •4.3.2 Core Elements of the Surgical Site
- •4.3.3 Stationary Systems
- •4.3.4 Typical Surgical Positions in Visceral Surgery
- •4.3.5 Maximum Load
- •4.3.6 Cleaning and Disinfection
- •4.3.7 Operating Lights
- •4.3.8 Peripheral Devices
- •4.3.9 Structural Preconditions
- •References
- •5.1 Conventional Radiology
- •5.1.1 Technical Aspects
- •5.1.2 Generation and Detection of X-Rays
- •5.1.3 Projection Radiography
- •5.1.4 Real-Time Radiography
- •5.2 Computed Tomography
- •5.2.1 Principle of Computed Tomography
- •5.2.2 Multislice Computed Tomography
- •5.2.3 Cone Beam Computed Tomography
- •5.2.4 Dual-Energy Computed Tomography
- •5.3 Magnetic Resonance Imaging
- •5.3.1 General Considerations
- •5.3.2 Technical Insights
- •5.3.3 Contrast Agents for Magnetic Resonance Imaging
- •5.3.4 Magnets
- •5.3.5 Real-Time Magnetic Resonance Imaging
- •5.3.6 Magnetic Particle Imaging
- •5.2.5 Dual-Source Computed Tomography
- •5.2.6 Phase-Contrast Computed Tomography
- •5.2.7 X-Ray Microtomography
- •5.2.8 Electron-Beam Computed Tomography
- •5.4 Diagnostic Ultrasound
- •5.4.1 History
- •5.4.2 Transducer Arrays
- •5.4.3 US Application in Visceral Medicine
- •5.4.4 Doppler Imaging
- •5.4.5 US Elastography
- •5.4.5.1 Acoustic Radiation Force Impulse Imaging
- •5.4.5.2 Shear Wave Elastography
- •5.4.5.3 Shear Wave Dispersion Ultrasound Vibrometry
- •5.4.6 3D/4D Ultrasound
- •5.4.7 Ultrasound Computed Tomography
- •5.5 Nuclear Imaging Systems
- •5.5.1 Gamma Camera
- •5.5.2 Positron Emission Tomography
- •5.5.3 Single-Photon Emission Computed Tomography
- •5.5.4 Conclusion
- •5.6 Advanced Optical Systems
- •5.6.1 Photodetectors
- •5.6.2 Optical Coherence Tomography
- •5.6.2.1 Time-Domain Optical Coherence Tomography
- •5.6.2.2 Fourier-Domain Optical Coherence Tomography
- •5.6.2.3 Fourier-Domain Doppler Optical Coherence Tomography
- •5.6.3 Optical Fluorescence Imaging
- •5.6.4 Hyperspectral Imaging
- •5.6.5 Diffuse Optical Imaging (Near-Infrared Optical Tomography)
- •5.6.6 Confocal Laser Scanning
- •5.6.7 Photoacoustic Imaging
- •5.6.8 Conclusion
- •5.7 Endoscopy
- •5.7.1 Rigid Endoscopes
- •5.7.2 Flexible Diagnostic Endoscopy
- •5.7.2.1 Flexible Scopes
- •5.7.2.1.1 The Handle
- •5.7.2.1.2 Connection to the Control/Supply Unit
- •5.7.2.2 Control/Support Unit
- •5.7.2.2.1 Imaging/Illumination
- •5.7.2.2.2 Suction/Irrigation/Insufflation
- •5.7.2.3 Instruments
- •5.7.2.4 The Endoscopic Trolley
- •5.7.2.5 Instrument Reprocessing
- •5.7.2.6 Clinical Applications
- •5.7.2.6.1 Colonoscopy
- •5.7.2.6.2 Enteroscopy, “Deep Endoscopy”
- •5.7.3 Autofluorescence Imaging Endoscopy
- •5.7.4 Computed Virtual Chromoendoscopy/Narrow Band Imaging (NBI)
- •5.7.5 Confocal Endomicroscopy
- •5.7.6 Endoscopic Optical Coherence Tomography
- •5.7.7 Endoscopic Ultrasound
- •5.7.8 Wireless Capsule Endoscopy
- •5.7.9 Conclusion
- •5.8 Hybrid Systems
- •5.8.1 Real-Time Virtual Sonography
- •5.8.2 Positron Emission Tomography/Computed Tomography
- •5.8.3 Single-Photon Emission Computed Tomography/Computed Tomography
- •5.8.4 Positron Emission Tomography/Magnetic Resonance Imaging
- •5.8.5 Single-Photon Emission Computed Tomography/Magnetic Resonance Imaging
- •5.8.6 X-Ray/MRI
- •5.8.7 Integrated Optical Coherence Tomography Ultrasound Imaging System
- •5.8.8 Integrated Optical Coherence Tomography and Positron Detection
- •5.8.9 Microscope Integrated Optical Coherence Tomography and Optical Coherence Microscope
- •5.9 Intraoperative Diagnostic Procedures
- •5.9.1 Ultrasound
- •5.9.2 Conventional Radiography (C-Arm)
- •5.9.3 Isocentric Radiography
- •5.9.4 Intraoperative Volume Data Acquisition
- •5.9.5 Intraoperative Computed Tomography/Magnetic Resonance Imaging
- •References
- •6.1 “Classical” Surgical Instruments for Conventional Surgery
- •6.1.1 Surgical Knives/Scalpels
- •6.1.2 Forceps/Tweezers
- •6.1.2.1 Basic Forceps Designs
- •6.1.3 Scissors
- •6.1.4 Fixation Instruments/Locking Forceps
- •6.1.4.1 Hemostats
- •6.1.4.2 Vascular Clamps
- •6.1.5 Retractors
- •6.1.6 Self-Retaining Retractors
- •6.1.7 Needle Holders
- •6.1.8 Others
- •6.2 Electrosurgery
- •6.2.1 Thermal Low-Temperature Effects
- •6.2.2 Hyperthermia and Devitalization
- •6.2.3 Thermal Coagulation
- •6.2.4 Thermal Desiccation
- •6.2.5 Thermal High-Temperature Effects
- •6.2.6 Carbonization
- •6.2.7 Vaporization
- •6.2.8 Principles of Electrosurgery
- •6.2.9 Physical Theories of Electrosurgery
- •6.2.10 Electrosurgical Techniques
- •6.2.11 Monopolar Technique
- •6.2.12 Electrosurgical Coagulation and Desiccation (Hemostasis)
- •6.2.12.1 Impedance-Controlled Electrocoagulation
- •6.2.12.2 Argon Plasma Coagulation
- •6.2.13 Electrosurgical Cutting
- •6.2.14 Electrosurgical Unit
- •6.2.15 Clinical Aspects of Electrosurgery
- •6.3 Ultrasound Dissection
- •6.4 Water Jet
- •6.5 Stapling Devices
- •6.5.1 Linear staplers
- •6.5.2 Linear Cutting Devices
- •6.5.3 Circular Staplers
- •6.6 Biomaterials
- •6.6.1 Surgical Suture Materials
- •6.6.1.1 Absorbability
- •6.6.1.2 Internal Structure
- •6.6.2 Surgical Mesh
- •References
- •7.1 Basics
- •7.1.1 Pneumoperitoneum
- •7.1.1.1 Creation of the Necessary Space
- •7.1.2 The Veress Needle
- •7.1.2.1 Insertion of the Veress Needle
- •7.1.3 Gas Insufflators
- •7.1.3.1 Insufflation Device
- •7.1.3.2 Creation of the Pneumoperitoneum
- •7.1.4 Trocars
- •7.1.4.1 Reusable Trocars
- •7.1.4.2 Disposable Trocars
- •7.1.4.3 Hybrid Systems
- •7.1.5 Visualization
- •7.1.5.1 Laparoscopes (Laparoscopic Telescopes)
- •7.1.5.1.1 Advanced Laparoscopes
- •7.1.5.1.2 Future Developments
- •7.1.5.2 Laparoscopic Cameras
- •7.1.5.3 Laparoscopic Image Processors (Camera Control Unit)
- •7.1.5.4 Monitors
- •7.1.5.5 3D Endoscopy
- •7.1.6 Light Source and Transmission
- •7.1.6.1 Halogen Lamps
- •7.1.6.2 Xenon
- •7.1.6.3 Halide Lamps
- •7.1.6.4 Condensing Lens
- •7.1.6.5 Illumination Control
- •7.1.6.6 Light Cables
- •7.1.7 Suction/Irrigation Device
- •7.1.8 Documentation
- •7.1.9 Equipment Cart
- •7.2 Hand Instruments
- •7.2.1 Forceps/Graspers
- •7.2.2 Dissectors
- •7.2.3 Scissors
- •7.2.4 Needle Drivers
- •7.2.5 Retractors
- •7.2.6 Laparoscopic Electrosurgery
- •7.2.7 Clips and Clip Appliers
- •7.2.8 Laparoscopic Stapling Devices
- •7.2.9 Laparoscopic Ultrasound Dissection
- •7.2.10 Impedance-Guided Dissection
- •7.3 Minilaparoscopic Procedures
- •7.4 Mono-Port (Single Port) Surgery
- •7.4.1 Trocars
- •7.4.2 Hand Instruments
- •7.4.2.1 The SPIDER Surgical System
- •7.4.2.2 Critical Comments and Outlook
- •References
- •8.1 “Operative” Endoscopes
- •8.1.1 Upper Gastrointestinal Scopes, Colonoscopes
- •8.1.2 Side-Viewing Duodenoscopes
- •8.2 Instruments
- •8.2.1 Knives
- •8.2.2 Hooks
- •8.2.3 Snares
- •8.2.4 Injection Needles
- •8.2.5 Forceps/Graspers
- •8.3 Clips
- •8.3.1 Standard endoscopic clips
- •8.3.2 Over-the-Scope-Clip
- •8.4 Clinical Applications
- •8.4.1 Gastrointestinal Bleeding
- •8.4.1.1 Injection Therapy
- •8.4.1.2 Thermal Hemostasis
- •8.4.1.2.1 Contact Methods
- •8.4.1.2.2 Noncontact Methods
- •8.4.1.3 Mechanical Methods
- •8.4.2 Percutaneous Endoscopic Gastrostomy
- •8.4.3 Endoscopic Resection of Neoplastic Tissue
- •8.4.3.1 Snare Polypectomy
- •8.4.3.2 Endoscopic Mucosal Resection
- •8.4.3.3 Endoscopic Submucosal Dissection
- •8.4.4 Endoscopic Interventions on the Bile Duct (ERCP)
- •8.4.5 Gastrointestinal Stenting
- •8.4.5.1 Bougienage and Balloon Dilatation
- •8.4.6 Outlook
- •References
- •9.1 Combined Laparoscopic-Endoscopic Procedures (CLEP)
- •9.1.1 Indications
- •9.1.2 Esophagus
- •9.1.3 Stomach
- •9.1.4 Duodenum
- •9.1.5 Colon
- •9.1.6 Contraindications
- •9.1.7 Tumor Localization
- •9.1.8 Defining the Line of Section (Margin)
- •9.1.9 Selection of the Appropriate Technique for Tumor Resection
- •9.1.10 Specimen Retrieval
- •9.1.11 Leak Test
- •9.1.12 Technical Considerations
- •9.2 Natural Orifice Transluminal Endoscopic Surgery—Surgery Without Visible Scars
- •9.2.1 Access into the Abdominal Cavity
- •9.2.1.1 Transgastric Approach
- •9.2.1.2 Transurethral Approach
- •9.2.1.3 Transvaginal Approach
- •9.2.1.4 Transcolonic Approach
- •9.2.2 Intestinal Closure
- •9.2.2.1 Clips
- •9.2.2.2 Suturing Devices
- •9.2.3 Flexible Staplers
- •9.2.4 Plicator-Like Devices
- •9.2.5 Rivets
- •9.3 Spatial Orientation
- •9.4 Illumination
- •9.5 Fog/Mist Elimination
- •9.6 Stabilization of the Horizon
- •9.7 View Extension
- •9.8 Three-Dimensional Stereoscopy
- •9.9 Multifunctional Endoscopes and Mechanical Platforms
- •9.9.1 Endosamurai
- •9.9.2 Anubis
- •9.9.3 SPOT (Single Port Overtube System), Technische Universität München
- •9.10 Outlook
- •References
- •10.1 Computerized Systems
- •10.1.1 Active Camera Holders
- •10.1.1.1 Automated Endoscope System for Optimal Positioning
- •10.1.1.2 Currently Available Active Camera Holders
- •10.1.1.3 Conclusion and Further Development
- •10.1.2.1 Zeus
- •10.1.2.2 DaVinci
- •10.1.2.3 New Developments
- •10.1.2.3.1 Titan SPORT
- •10.1.2.3.2 Senhance Surgical Robot System
- •10.1.2.3.3 MiroSurge
- •10.1.3 Computerized Platforms for NOTES
- •10.1.3.1 Electromechanically Controlled Conventional Endoscopes
- •10.1.3.2 Systems With Elements of Autonomous Locomotion
- •10.1.3.2.1 Endotic
- •10.1.3.2.2 Aer-O-Scope
- •10.1.3.3 Robotically Driven Instrumentation
- •10.1.3.3.1 Single Access and Transluminal Robotic Assistant for Surgeons (ISIS-STRAS)
- •10.1.3.3.2 C-SPOT
- •10.1.3.3.3 MASTER (Master and Slave Transluminal Endoscopic Robot)
- •10.1.3.3.4 Endomina
- •10.2 Nontethered (Cable-Less) Systems/Modular Assembling Reconfigurable Miniature Robots
- •10.2.1 ARES
- •10.2.2 ARAKNES
- •10.3 Special Aspects of Roboterized Surgery
- •10.3.1 Haptic Feedback
- •References
- •11.1 Optical Tracking Systems
- •11.2 Electromagnetic Tracking Systems
- •11.3 Fiber Bragg Grating Sensors
- •11.4 Radio-Based Tracking Systems
- •11.4.1 Radio-Frequency Identification Devices
- •11.4.2 RFID Applications in Health Care
- •11.4.3 Bluetooth
- •11.4.4 Wi-Fi
- •11.4.5 ZigBee
- •11.4.6 Ultra-Wide Band
- •11.4.7 RuBee
- •11.5 Acoustic Tracking Systems
- •11.6 Inertial Tracking Systems
- •11.7 Others
- •11.7.1 Depth Maps, 3D Surface Reconstruction
- •11.7.2 Passive Methods
- •11.7.2.1 Stereoscopy
- •11.7.3 Monocular Shape-From-x
- •11.7.4 Simultaneous Localization and Mapping
- •11.7.5 Active Methods
- •11.7.5.1 Time-of-Flight (ToF)
- •11.7.5.2 Structured Light (Color-Coded Triangulation)
- •11.8 Strengths and Weaknesses of Real-Time 3D Surface Reconstruction Methods
- •References
- •12.1 Hospital Information Systems
- •12.1.1 Specialty-Specific Extensions
- •12.1.1.1 Picture Archiving and Communication System
- •12.1.1.2 Others
- •12.1.2 Health Informatics On-Site
- •12.1.2.1 HIS in the Outpatients (Preadmission) Department
- •12.1.2.2 HIS in the Surgical Floor
- •12.1.2.3 HIS for Multidisciplinary Conferences
- •12.1.2.4 HIS in the OR
- •12.1.2.5 HIS and Quality of Care
- •12.1.2.6 Data Mining
- •12.2 Surgical Telematics/”Telesurgery”
- •12.2.1 Teleconsultation
- •12.2.2 Telepresence
- •12.2.3 Telesurgery
- •References
- •13.2 Cadaver Studies
- •13.3 Live Animal Training


BIOMEDICAL
ENGINEERING IN
GASTROINTESTINAL
SURGERY

BIOMEDICAL ENGINEERING IN GASTROINTESTINAL SURGERY
ARMIN SCHNEIDER
and
HUBERTUS FEUSSNER
Institute of Minimally Invasive Interdisciplinary Therapeutic
Interventions (MITI), Technische Universität München (TUM)

Academic Press is an imprint of Elsevier
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our understanding, changes in research methods, professional practices, or medical treatment may become
necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and
using any infor mation, methods, compounds, or experiments described herein. In using such information or
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Typeset by MPS Limited, Chennai, India

CONTENTS
v

m
c
s

-


FOREWORD
“Biomedical Engineering” (BME) is a rather young entity in the history
of interventional medicine, natural science, and engineering. It is an
impressive subject, which is considered by the public either with unlimited admiration since it promotes significant progress in health care or
with a deep concern since it favors inhuman “apparatus-based medicine.”
The discussion of the ethical aspects of BME will not be the subject
of this book, since the debate upon the ethical frame is more or less a
luxury problem. A discussion about active life support by means of artificial ventilation, dialysis, or mechanical circulation support, etc. may be
well justified or even necessary in individual cases but it became only possible as soon as the engineers were able to provide suitable devices and as
soon as physicians were ready to use them. Hundred years ago, philosophers, theologists, and the interested public were not troubled by this
dimension of medical care, simply because the problem did not exist at
all. The technical means were not given.
In fact, nobody would be inclined to avoid (ostensibly) difficult ethical
questions by terminating the development of even more effective support
systems. On the contrary, we need more innovative devices, procedures,
and systems to intensify the fight against diseases, injuries, and other
threats of health and well-being. Insofar, any research and development
activities in BME are, beyond a doubt, morally correct and of merit as
compared to other branches of technical R&D, just to mention in particular, military technology as an example.
If it is even a moral obligation to contribute to further progress in
BME, the question of how to do it has to be answered. All those who are
involved should possess a sound and comprehensive knowledge of the relevant medical problems and, simultaneously, of the available scientific and
technical potential to solve them.
However, no individual is able any longer to maintain more than a
superficial overview of all aspects of the numerous knowledge domains.
Surgeons, for example, are considered as a rather homogenous group of
professionals, but in reality, they are highly specialized and even subspecialized. An abdominal surgeon is today no longer an adequate counterpart
for an engineer who considers to design a new operating table for spine
surgery. Likewise, a cardiac surgeon would never be able to give an expert
insight into the special requirements of visceral surgery, etc.
ix

x Foreword
The same holds true for the large community of engineers or computer scientists. One engineer might be an expert in mechanical engineering, but he/she has only a marginal knowledge of electrical
engineering. The computer scientist is, perhaps, highly reputated in modern imaging procedures, but is by far less familiar with the special problems of state-of-the-art speech recognition.
Accordingly, it becomes more and more difficult to shape purposetailored teams of all the scientific and technical experts who are required
to solve a specific medical problem successfully. The authors of this book
aim at creating a comprehensive knowledge platform to bridge the different worlds of all partners involved, including the decision makers in the
BME industry. Necessarily, many compromises have, therefore, to be
made concerning the range of medical aspects and the informational
depth of the technical chapters. The result can only be an overview.
In this book, medicine is confined to surgery—and even more exclusively focused upon visceral surgery. We deliberately renounced to cover
all aspects of surgery, since the available frame and space of this book is
limited; the book is dedicated to visceral surgery, which still is neglected
as compared to the rather copious literature upon BME in bone-, neuro-,
and ENT surgery (due to the fact that BME, in general, can be more easily applied in rigid environments). Likewise, the readers should not expect
textbook-like chapters upon the basics of mechanical or electrical engineering or of computer science. We are unable to give more than an orientation about these knowledge domains. Insofar, the visceral surgeon
who expects some information upon new sophisticated details of visceral
surgery will certainly be disappointed when reading the medical aspects
of this book. On the other hand, he could be fascinated by the promising
and realistic options of intraoperative tissue differentiation. The specialist
in navigation technology will be bored by the description of various navigation technologies, but could be very much interested in the range of
potential clinical applications.
Last but not least, we strive to point out severe deficits and clinical
challenges which still exist in our currently available therapeutic armamentarium with the hope to stimulate the readers to take active part in a
continuous improvement of surgical care.
Textbooks of this kind are mostly compiled of specialized chapters
written by various experts in their field and put together by one or two
editors.
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